Conserved Protein Domain Family
Smac_DIABLO

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pfam09057: Smac_DIABLO 
Second Mitochondria-derived Activator of Caspases
Second Mitochondria-derived Activator of Caspases promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway, and by opposing the inhibitory activity of inhibitor of apoptosis proteins (XIAP-BIR3). The protein assumes an elongated three-helix bundle structure, and forms a dimer in solution.
Statistics
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PSSM-Id: 462664
Aligned: 11 rows
Threshold Bit Score: 299.451
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_005989033  19 RRRAP-LVAErsshrllgavssvSVPRGT--------------WSRLV-LGFGATLCAVPISQKTESvSLSHGALIKRAV 82 
XP_027325975   8 LRSCRsLLRR-------------GFPVLAaarrqpglsggsrrWQQALgVGLGAALCAVPVIEKQNSsSLSNDALIKRAV 74 
NP_001232563   8 LRSCCsVLRR-------------SFPVLAgvrqrgl-agrsgqWHQA--VGLGVALCAVPVVEQQSSgSLSNDALIRRAV 71 
Q5RBH2         9 SRSVTlLFRYrq---------clCVPVVAnfkkrcf-selirpWHKTVtVGFGVTLCAVPIAQKSEPhSLSSEALMRRAV 78  Sumatran orangutan
XP_008248773  42 SRSASaWLRRg-----------rCVPAAAggpkrcf-selvrpWRRAAaVGLGVTLCAVPIAQESEPhSLSNDALMKRAV 109
Q0IJ31         9 IWSFSyILRE-------------SFPIVSrrncvs---llrasWRKVLsVGVGTSVCAIPVGQRSEP-TLSSESLIKRAV 71  tropical clawed...
NP_001229963  13 LSYAAsLLSSggscqa--grrlfLLPGIF--------------RKHWRtLSVTGAICAVPFLQKPE--NLSHEDLVRRAS 74 
NP_956640     43 KHKTSvLCNSsvhq-----rilqRLPNVA--------------RSNAVpFSVGTGLCAVPFTQQVE--NLSHESLIRRAS 101
XP_003968615  15 RRAACvLLNYrnh--------aiQNPGKWan----------ilYTSLAsFTIGAGFCAVPFKQADQ---LSHDSLIKRAA 73 
XP_015197532  15 RCSWSvLSSSrhr--------ivRIPLLL--------------RSNFLsLGAGGGLCAVPFSKQAE--NLSHEALIRRAS 70  spotted gar
XP_008118066   8 wlrtwcFLARq------------SRPLLAplrtrca-sglrgpWSKAAaLGLGATLAAIPITQKHDPsSLSNEALIRRAA 74  green anole
XP_005989033  83 SLVTDSANTYLSQTTLALIDALTEYTKAVHILVSLQQQYANLVGKINPKEEEAIWQVIIGARVEMNEKQQEYLTFESNWV 162
XP_027325975  75 SLVTDSTSTLLSQTTYALIEALTEYTKAVYTLVSLYKQYSNLLGKMNSEEVDAVWQVVIGARVDMTTKQQEYLRLESSWM 154
NP_001232563  72 SLVTDSTATLLSQTTYALIEALTEYTKAVYTLVSLYKQYSNLLGKMNSEEVDAVWQVVIGARVDMTTKQQEYLRLESSWM 151
Q5RBH2        79 SLVTDSTSTFLSQTTYALIEAITEYTKAVYTLTSLYRQYTSLLGKMNSQEEDEVWQVIIGARAEMTSKHQEYLKLETTWM 158 Sumatran orangutan
XP_008248773 110 SLVTDSTSTFLSQTTYALIEAITEYTKAVYTLISLYRRYASLLGKMNSQEEDEVWQVIIGARVEMTSKQQEYLKLETTWM 189
Q0IJ31        72 SLVADSSSTFLSQTTYALVESLTEYTTAVYTLISLQQKYTSLLDKMNSNEESAIWQVIIGARVQMKQLKEQYLKYESSWQ 151 tropical clawed...
NP_001229963  75 SLVTDSANTFLSQTTLALIDSFTGYIKAVNILVELHKQYEASISKFTPEEENAIWKVILGQRQEVIGRRKNCTHFESCWM 154
NP_956640    102 CLVTDSANTYLSQTTLALVDALTQYAKALHTLISLQKRYIASIGKLSPVEEDSIWQVIIGQRVEVSDRLEECKRFESNWM 181
XP_003968615  74 SLVTDSSTTLLSQTTLALIDAITDYSKAVHTLIALQKRYLDSLGKLSPAEEDRIWQVIIGQRAEVNDRRDQWLRFESTWG 153
XP_015197532  71 SLVTDSANTYLSQTTLALVDALAQYAKAVHTLIALQKRYMNSIGKLTPAEEDAIWQVIIGARVEMNDKLDTCRHFESNWM 150 spotted gar
XP_008118066  75 SLVTDSTGTLLSQTTYALIDALTEYTTAVYTLVSLYQKYAHLIGKMNSKEEDAVWQVIIGARVEMTEKQQEYLKLESRWM 154 green anole
XP_005989033 163 SAVNLSQVAAEAAYQAGADQASVTVHTCVQLAQKQVADMQQLALNAESKLAEVQVEEIr-kTSERERTASKNTGtrkkTE 241
XP_027325975 155 TALRLSEMAAEAAYQSGADQASVTARSHIQLVKSQVQEVRQLSQKAETKLAEAQTEEL---IKAQGEESSLPQG----VI 227
NP_001232563 152 TALRLSEMAAEAAYQSGADQASVTARSHIQVVKSQVQEVRLLSQKAETKLAEVQTDEL---IKATGEDSSLPQGvlgnAD 228
Q5RBH2       159 TAVGLSEMAAEAAYQTGADQAPITARNHIQLVKLQVEEVHQLSRKAETKLAEAQIEELrqkTQEEGEERAESEQ------ 232 Sumatran orangutan
XP_008248773 190 TALSLSEMAAEAAYHTGADQASVTARSHVQLVKSQVQEVRQLSQKAEIKLAEAQTQELrqkTQERGEGRPEPEPe----- 264
Q0IJ31       152 RAVSLSEMAAEAAYQSGADQASVTVRNHIQIVQTQVQQARNQAHIAEVQLAASQTDEIkrtITE--DKGNPPSGgsprSS 229 tropical clawed...
NP_001229963 155 TAVNLSQQAAEAAFNAGADQASVAAQSSLQVAQSQVEQVKQLMLEAEIQLKDSKAEYSe-rLQ---------------VA 218
NP_956640    182 NAINICELSAEAAYNSGAEHACTATKTNLQVAQSKVEEIRKISKEAEKKLAETKAEEIq-rMAEYASS----------ID 250
XP_003968615 154 SAVKLCETAAEAAYASGAEHASISVRTNMQVAQAQVDEARKLSAEAERKLAEAKVMEVe-rMSQRVTS----------ME 222
XP_015197532 151 NAINLSELAAEAAYNAGADQASVTARTNLNMAQTQVEEMKRLSSEAEKQLAEVKVEEIq-rTAAQAAA----------TR 219 spotted gar
XP_008118066 155 TALRLSEMAAEAAYQSGADQASVGTHNHIQLVRTQIQEARQLSQKAESKLAEVQTEELmklKEEEALAAARRQAsveeAE 234 green anole
XP_005989033 242 AEET--------EdDipEQYLRED 257
XP_027325975 228 GSTD--------AgE--DPYLRED 241
NP_001232563 229 D----------------DPYLRED 236
Q5RBH2       233 -----------------EAYLRED 239 Sumatran orangutan
XP_008248773 265 ----------------qEAYLRED 272
Q0IJ31       230 LSEE--------E-EipEAYLRED 244 tropical clawed frog
NP_001229963 219 LSED--------E-DipDAYLRED 233
NP_956640    251 IHDL--------E-DvpEAYLRED 265
XP_003968615 223 NNEE--------E-EvpDAYLRED 237
XP_015197532 220 AFEKagkgdalsEdDvpEAYLRED 243 spotted gar
XP_008118066 235 -----------------EAYLRED 241 green anole
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