2R19


Conserved Protein Domain Family
outer_YhbN_LptA

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TIGR03002: outer_YhbN_LptA 
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lipopolysaccharide transport periplasmic protein LptA
Members of this protein family include LptA (previously called YhbN). It was shown to be an essential protein in E. coli, implicated in cell envelope integrity, and to play a role in the delivery of LPS to the outer leaflet of the outer membrane. It works with LptB (formerly yhbG), a homolog of ABC transporter ATP-binding proteins, encoded by an adjacent gene. Numerous homologs in other Proteobacteria are found in a conserved location near lipopolysaccharide inner core biosynthesis genes. This family is related to organic solvent tolerance protein (OstA), though distantly. [Cell envelope, Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides, Transport and binding proteins, Other]
Statistics
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PSSM-Id: 274384
Aligned: 39 rows
Threshold Bit Score: 105.769
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2R19_A         1 AVTGDTDQPIHIESDQQSLDMQ-GNVVTFTGNVIVTQGTIKINADKVVVtRp-GGe-----Q-GKEVIDGYG---KPATF 69  Escherichia col...
WP_005771762  29 ALSSDQFKPYHVRSIEVIYRRP-DHITLYHGDVYATQGTTWISGDKVIVyHn-PTt-----N-RIVRLKAIG---HPAHY 97  Coxiella burnetii
WP_011215024  23 ALPFDKEKMVQVVSDSADLNQK-NHQGVYIGNVEFVQGSTNLRAEKAITqGd-AK------N-QLTLAIAEGskdKQAHY 93  Legionella pneu...
WP_011370396  25 etnANESLPIEIKADSLVSQDQ-KGQSVYSGRVIITQGTTVIHGDKVTIfHp--N------R-KVIKAIVIG---QPATF 91  Thiomicrospira ...
WP_011399055  26 dLLNGSDEPVRIKAGRWERDGQ-KGIDTYIGNVVITQGKSSIEADKVVLyT--DD------K-GISRFQATG---KPAHL 92  Hahella chejuensis
WP_012537554  35 AEQGLGKGPIQISADALHGENKpQQQAVYTGNVVMTQGDVVVHADKLTVdA--IA------G-KVHQATAVG---SPVTF 102 Acidithiobacill...
WP_011116168  11 CMCMNAADTLEVSAKVFQSDLK-NGLTELSGEVLVVKGEDKLWADKVVIeTn-KK------N-KPQKYTATG---N-VRF 77  Helicobacter he...
WP_011187685  22 STAFAKDAPIYIEANHMTSTEN-TNTVFFEGDVDAKQDDVRIRSNKMTVfYs-KAskgeksQ-QVKKIICTG---N---- 91  Desulfotalea ps...
WP_004512085  25 pkggrqgQPITIKSNELSTDSR-HNTATFTGKVIARQGDLTIYADKLVVhYkaDG------G-DLDRVEASG---N---- 89  Geobacter metal...
WP_011341686  26 SATAGKAQPLEITSQKLEADGT-LKKVVFVGKVVARQDGLTIRSSKLIVaYg-QS------GtRVSSIEAIG---DVV-- 92  Pelobacter carb...
2R19_A        70 YQMQDNGK-P-V-EGHASQMHYELAKDFVVLTGNAYLQQVD--SNIKGDKITYLVKEQKMQAFSD--KGK-----RVTTV 137 Escherichia col...
WP_005771762  98 STMPDNQK-A-RlYAQAETILYFPAKAQVLLIKNARVTQKQ--NILTGPHIWYDIKKQTVISTVP--NGKg----NTTVV 167 Coxiella burnetii
WP_011215024  94 WTTTAPDKpP-F-HAYADTIKYYPLKHLIELIGNARIEQGP--NSLSAAKISYDTQEQHVLSHSD--EKT-----RTTII 162 Legionella pneu...
WP_011370396  92 KRFLPEEK-NwI-DGRADTITYHAERRTVLLEGHAFVNQEGk-NSISGPEILYNLNDKTLSAKGN--KTEk---kRITVI 163 Thiomicrospira ...
WP_011399055  93 VQFDAEKQtE-T-HAYAESMDYDRSQSKVVMRNHARILQDN--SSVEGEEIIYFTDKRLVTAKGAssGNQt---eQVEII 165 Hahella chejuensis
WP_012537554 103 TMSAAQ-----R-HGYGDTLVYKPGKGEIVLTGNAHLWQKK--NEISGQQVTYFLQTQQTAVTAA--PGK-----RVQSI 167 Acidithiobacill...
WP_011116168  78 YAKMPN-K-E-M-RGKAKKAVYNVIKDEYQLIDSAMLEEIGkkNIIRGNMIVFNPQSQEAFVKGS--SQKp---gMMTFI 148 Helicobacter he...
WP_011187685  92 -TEVTRG--E-W-LGTGQRMVYTTKDKKIVLTGNAKAWQNQ--NMVSGETITYFLDQKRSEVVGT--PQKnkkpsRVNMT 162 Desulfotalea ps...
WP_004512085  90 -VRIVQGD---R-LATARDGVYQSAEQKIVLTGDPKVFQGE--NTVSGKVITYFVDEEKSIVTGG--Pd-----tRVEAV 155 Geobacter metal...
WP_011341686  93 VQKDD------R-TATAGRGLYNVAEGTVVLTETPRVQQGD--NSVEGDEIVFYLEEDRSIVKSQ--SGs-----RVRAI 156 Pelobacter carb...
2R19_A       138 LVPS 141 Escherichia coli K-12
WP_005771762 168 IEPQ 171 Coxiella burnetii
WP_011215024 163 IYPE 166 Legionella pneumophila
WP_011370396 164 FEPE 167 Thiomicrospira crunogena
WP_011399055 166 YHPp 169 Hahella chejuensis
WP_012537554 168 FYPa 171 Acidithiobacillus ferrooxidans
WP_011116168 149 MEDK 152 Helicobacter hepaticus
WP_011187685 163 IIQN 166 Desulfotalea psychrophila
WP_004512085 156 ITPK 159 Geobacter metallireducens
WP_011341686 157 LTPg 160 Pelobacter carbinolicus
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