Conserved Protein Domain Family
PARM

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pfam17061: PARM 
PARM
Human PARM-1 is a mucin-like, androgen-regulated transmembrane protein that is present in most tissues, with high levels in the heart, kidney and placenta. It has been shown to be induced and expressed in prostate after castration and may have a role in cell proliferation and immortalization in prostate cancer.
Statistics
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PSSM-Id: 465341
Aligned: 14 rows
Threshold Bit Score: 233.214
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_007495741  15 GLRVQSLP--ITTTFPVSLPEKLTTLPPTWTNPPQNTvdvSTSSSNNTQNNSSLTVT-LSAETTPLPRNISVTSRDPEST 91 
XP_005608766  15 GLRVQSMP--TPARLPVSLPEEITPPTAVWISSPESP---PASPTSGTSSNSVPPVT-ASVQTAPLPKNASIEPREEETT 88 
ELK16454     164 rLRVQGVP--TTSLLPVSLPAKITPTTATWTSSSQSP---PAFPTSGTRSNSVLPVTaASVQTSLLPKNVSIEPGEQETT 238
XP_004766322  15 GLRVHSLP--PSAPFPGSLPANALPSTAGWTSAPRSP---PASPTSGAPGHAVLPAP-ASAPAPTRPRNVSAEPGEAGPS 88 
ELW70479       3 GLRVQSEPvaTSTLLPISLPAKITPLTPTWTSSPQNTaavTTSPDSGSHSSSVPPVP-ASAPTSPLPKNSSIEP-KVGAT 80 
XP_008265964  15 GLKVQSFP--TSAPLPVSLPLKVTPPLTIWTGSPQNSsavTAPQASSPHGNSDLPVT-ASAPTSTLLKNISSEPREEAIT 91 
XP_005333293  15 GLRVQSLP--TSTSLPVSLPAKITPPASTWTSSAQNPvalTASPASGVHNTSVLPVT-DIALTSALPKHVSIEPTEEAIT 91 
Q923D3        15 GLRVQGSP--T-VPLPVSLMTKSSAPVATWTTSAPHTaraTTPVASATHNASVLRTT-AASLTSQLPTD----HREEAVT 86  house mouse
XP_003774249   9 GLKVQSLP--TSTTFPVSLPAKFTTLSSIWTSPPQNTvdvTTSSSNNTQNNSLLTVT-LSAETTPLPGNISVIPGNPEST 85 
XP_012660771   1 ------MP--IPVPWPSSLMEKIAPSTAIWTSFPQNTavtTAAPTNGTHGDAVLSAT-ASGSTSPLPKNVSAEPREEEPS 71  small-eared galago
XP_007495741  92 SKVSRQEsvvttigqegkgtEQNQSlptilPTSSQDQFTTT-VAELNSTIPEvnngTETLSTISPS----PSDIALVTSP 166
XP_005608766  89 NPTSNWEg-----------tNPDPS-----PTSGGVHLTPT-PTEDTSGTPE----VSVPATGSQS----TTESPVRTSP 143
ELK16454     239 SPTLTWEg-----------tNTDPL-----STSGGVPLTPT-PTEHSSGTPE----ASVPATGSQL----PTESPALTSP 293
XP_004766322  89 GPASPWGg-----------pSAAAS-----PASGGAPLTPT-PSERGPSTTEe---PSAPPTGSRApseaPAGSPTLPSP 148
ELW70479      81 SPALNQE-------------VTDVSftglsSTTGGVHFTPTsPEEHDQSTAE----ASVPTTGSQS----PTEPSTVTST 139
XP_008265964  92 STASKWEg-----------tTQDSSppklsTASSGNHSMPV-SEGPSWGTPQ----TSVLTTESQS----SAESSTASSP 151
XP_005333293  92 SPSSSWEg-----------tNPGPSlpgflSTSSVVHVTPT-PEEHNASSPE----VSVPAEGSQS--------PTSLSP 147
Q923D3        87 SPPLKRDv-----------nSTDSSpagfpSTSSDGHLAPT-PEEHSLGSPE----ATVPATGSQS--------PMLLSS 142 house mouse
XP_003774249  86 SKAPIQEsavtavgqeqegtAQTQSsvrtwPTSSQDEIKST-LAGLGSTTPKtrneTEAVTTASPS----PSDTEAVTSS 160
XP_012660771  72 SPAPSWKg-----------pHTDPTppglqATSSGSELTAT-PEERSSGTPE----ASVPATAPRV----PAEPPTLTSS 131 small-eared galago
XP_007495741 167 QASVS---PSSSPSWlPPKVSPTS-IVTDPITAENTTHQEEGERSLGTPTatt-------------------lgAEHTPN 223
XP_005608766 144 QAPASspsPSPLSTSpPPEVPSAS-ISTNYSSTETSTKPTGGPTTPESPV------------------------EEHSSS 198
ELK16454     294 QAPASs--PLPLSTS-PPEVSSVS-VGTNHSSAENSTKPTGSPTTPESPA------------------------EEHSSG 345
XP_004766322 149 QAPASs--PPPLSTSpAGEVWSASpTSANHSSAHTSTQPTGAPTPPGSPTppgsptpprspappgspappgsptEEPSSA 226
ELW70479     140 PAPASs--PSSLSVS-PPEISSVP-VTSNHSSTATNIQPTGAPTAPASPT------------------------EEHSSG 191
XP_008265964 152 HTPASs--PSSPSTS-PPEVPPAS-ITVDHSSTMTTTQPTGAPTTPESPT------------------------EEHSSG 203
XP_005333293 148 QAPASs--PSSSSSTlPPEILSAS-VTSNHSTTVTSTQTTGAPATSESPT------------------------EEHSSG 200
Q923D3       143 QAPTSa--TTSPATS-LSESLSAS-VTSSHNSTVANIQPTEAPMAPASPT------------------------EEHSSS 194 house mouse
XP_003774249 161 QAS------SSLPSWlPPKISPTS-VITNSITAKSTTHKESSEEFLGTPTatp-------------------hgADLHPN 214
XP_012660771 132 QAPTSs-pPSSPSDS-PLAISSPS-VTTSHSPTETSAQPTRAPTAPESPT------------------------EEPTSG 184 small-eared galago
XP_007495741 224 EPTTHPRSSGPMTEETTSQVTVPNY---EVEGTDSGTVSPRIIMEEVEHALSSGSIVAITVTVIAVVLLVFGVAAYLKIR 300
XP_005608766 199 HTPTSHATAELVPTETTPQTTVPAIvtcVLLDME-TTTSSVVIMQEVEHALSSGSIAAITVTVIAVVLLVFGVAAYLKIR 277
ELK16454     346 YTPTSHATSELLPTETIPQTTVPAKvtcILVDMETTTAPKRVIMRDVEHALSSGSIAAITVAVVAVVVLVFGVAAYLKIR 425
XP_004766322 227 HTPTSHATAQPRPADTTPQATAPAKvtcLMVDME-TTASPGVIMQEVEHALSSGSIAAITVTVIAVVLLVFGVAAYLKIR 305
ELW70479     192 HTPTSHATVQPESKEKTPQATVLEPetcELMD--TTTASPVVIMQEVEHALSSGSIAAITVTVIAVVLLVFGVAAYLKIR 269
XP_008265964 204 HVPTPQPTAEPVPQEGTPQETESGMvm-----cEFETTTPFVIMREVEHALSSGSIAAITVTVIAVVLLVFGVAAYLKIR 278
XP_005333293 201 HTPTSQATMEPVPKEKTQQETEPKTvi-----cESETTTTFLIMQEVEHALSSGSIAAITVTVIAVVLLVFGVAAYLKIR 275
Q923D3       195 HTPTSHVTAEPVPKEKSPQDTEPGKvi-----cESETTTPFLIMQEVENALSSGSIAAITVTVIAVVLLVFGGAAYLKIR 269 house mouse
XP_003774249 215 GTPTFPASSGPKMEETTSQVTLPNY---EVEGTDGNTVSPRIIMEEVEHALSSGSIVAITVTVIAVVLLVFGVAAYLKIR 291
XP_012660771 185 HTPTSHASVGPVPEERTSPTPASSKamcELMDVETTTTFPRLIMREVEHALSSGSIAAITVTVIAVVLLVFGVAAYLKIR 264 small-eared galago
XP_007495741 301 HSSYGRLLDDHDYGSWGNYNNPLYDDS 327
XP_005608766 278 HSSYGRLLDDHDYGSWGNYNNPLYDDS 304
ELK16454     426 HSSYGRLLDDHDYGSWGNYNNPLYDDS 452
XP_004766322 306 HSSYGRLLDDHDYGSWGNYNNPLYDDS 332
ELW70479     270 HSSYGRLLDDHDYGSWGNYNNPLYDDS 296
XP_008265964 279 HSSYGRLLDDHDYGSWGNYNNPLYDDS 305
XP_005333293 276 HSSYGRLLDDHDYGSWGNYNNPLYDDS 302
Q923D3       270 HSSYGRLLDDHDYGSWGNYNNPLYDDS 296 house mouse
XP_003774249 292 HSSYGRLLDDHDYGSWGNYNNPLYDDS 318
XP_012660771 265 HSSYGRLLDDHDYGSWGNYNNPLYDDS 291 small-eared galago
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