Conserved Protein Domain Family
7tmA_OR5-like

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cd15230: 7tmA_OR5-like 
olfactory receptor family 5 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
This group includes human olfactory receptor family 5, some subfamilies from families 8 and 9, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.
Statistics
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PSSM-Id: 320358
Aligned: 77 rows
Threshold Bit Score: 369.144
Created: 4-Dec-2013
Updated: 25-Oct-2021
Structure
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Aligned Rows:
  next features
Feature 1:putative ligand binding pocket [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                #  ##           ###### #
Q8WZ84        25 LPLFLLFLGIYVVTVVGNLGMILLIAVSPLlhtPMYYFLSSLSFVDFCYSSVITPKMLVNFlgkkNTILyseCMVQLFFF 104 human
XP_006032294  25 ATLFVVFLLIYLITLVGNLGTMALVRVSPQlhkPMYFFLSHFSLVDAFYSTTITPNMLVALfsdsKAISfagCMVQCYIF 104 Chinese alligator
XP_002933756  31 LFLFGLFLLIYIITLFGNSFIILSVIFISSlhsPMYFFLGNLAFSDLCYSTVVTPKMLRDIvserKSITfvgCALQLYFF 110 western clawed ...
XP_005154538  23 TPLFVLFLLTYIVTLVGNVGIIILVRVSPSlhtPMYFFLTHFAFIDICYSTVISPRMLADLlsedKTISftaCMMQFFTF 102 budgerigar
XP_002943987  24 RVLFIIFLLIYIFTILGNGGLIVLIIKSPIlhtPMYFFLKHLSFIDMCYTSVIIPRTLSDLlskkKTITllaCVVQMYFY 103 western clawed ...
XP_002932419  25 PFLFIFFLLVYMITVVGNSGMVALVCSTPHlqtPMYYLLSCLSMVDLCYSSVIAPKMLADLisklKSISfigCALQFFFF 104 western clawed ...
XP_006117005  25 IPLFVMFLLIYVLTLMGNLGMMALIQADSRlhtPMYFFLSNFSLADVCYSTVITPKVLVNFlsdrKVISfteCIVQLYSF 104 Chinese soft-sh...
XP_002932831  24 TALFIIILLIYIFTIVGNCGLIVMIMTSPIlhtPMYSFLKHLAFIDMCYTSVVTPRTLSDLfskkKDISfmaCAVQMYFY 103 western clawed ...
XP_005154542  23 LCHFWLFLGISLAALLGNGLIITSTACDQHlhtPMYFFLLNLSLLDLGCILTTVPKSMANSlwdtRAISytaCMMQFFTF 102 budgerigar
XP_005529155  23 APLFGLFLLIYIVTLAGNIGLIVLVWVAPSlhtPMYFFLTHFSLADVCYSTIISPKMLTDLlfgnKTISwagCVTQFHLF 102 Tibetan ground-tit
Feature 1        #  #                                            # #####                         
Q8WZ84       105 VVFVVAEGYLLTAMAYDRYVAICSPllYNAIMsSWVCSLLVLAAFFLGFLSALTHTSammkLSFCKshiINHYfCDVLPL 184 human
XP_006032294 105 VVLGLVECYLLAVMAYDRYVAICNPllYVVIMsKRICIRLVLACYLIGFLSAGMYTGcifgGSLCGsniINHFyCDITPL 184 Chinese alligator
XP_002933756 111 AVFASTECYMLSAMAYDRYLAICQPllYAVIMnRKAIIHLAVGIYVSGFLTASIHTActltLSFCGpntINHFyCDIPPL 190 western clawed ...
XP_005154538 103 AFFGISECHLLAMMAYDRHVAICQPllYVTIIsSRVCWQLVASSYLFAFLSAIAYTWsvfgGSFCGpnrIDHFfCDEVPV 182 budgerigar
XP_002943987 104 ASLFISEVYLLSAMAYDRYVAICQPllYHVMMrKEKCIILIAICFAIGFSKSVIHAVntfsQVYCNkhhIAHFfCDMPPV 183 western clawed ...
XP_002932419 105 AALAGTETLLLSCMSYDRYVAICRPlhYRSIMtKNKCLWLILMSFSIGFSQSSVQTKcifgLEFCRrnqIDHFyCDVPPL 184 western clawed ...
XP_006117005 105 VVFGIVECYLLAAMAYDRYIAICKPllYMVIMsKGICARLVGTSYTVGFLCALLYTSctfgGSFCEsnqINHFfCDISPL 184 Chinese soft-sh...
XP_002932831 104 AAFFGAEILLLAAMAYDRYAAICRPlvYHIIIkREVCRRMIIACYAISFLHSFIHTKnifsHSYCNnyqISHFfCDAPPV 183 western clawed ...
XP_005154542 103 AFFATVECHLLAMMAYDRHVAICQPllYVTIIsSRVCWQLVASSYLFSSVSAIIYTWsvfgGSFCGpihIDHFfCDVVPV 182 budgerigar
XP_005529155 103 ALFVTAECHLLAAMAYDRLVAVCHPlsYVMVMsPRACWQLVAWSYLVASLSALVYTGstfgGSFCGprhIDHFfCDASPV 182 Tibetan ground-tit
Feature 1                  #  ### ### ##                                            #  ## ##  #  
Q8WZ84       185 LNLSCSNthlNELLLFIIAGFNTLVPTLAVAVSYAFILYSIlhirssEGRSKAFGTCSSHLMAVVIFFGSITFMYFKPps 264 human
XP_006032294 185 LKLSCSCsynNRMVVFALSSVGGAVTVMIILISYFYILSTIlrmhtaQSRSKAFNTCGSHLSIVSLFYGTGFFMYLQPss 264 Chinese alligator
XP_002933756 191 MELSCSDtyiHKTVIFVVVFCLGLFNVAIILASYFYIFYTIihmqssRGRHKAFSTCSSHLLCVSLFYGTVFFMYLRPas 270 western clawed ...
XP_005154538 183 LKLVCSDthsSEMVIFAFLTINEVGTIVVILLSYVSIIRTVlrmcsaQSRARAFHTCASHLTAVSMYFGPAFFMYLQPps 262 budgerigar
XP_002943987 184 LKLSCSDtsvTELLVFAIVGFNSFVCISVIVISYSYIFSTIltiqsaQGRLKAFTTCSSHLISVGTLFGTLMYMYLRPns 263 western clawed ...
XP_002932419 185 LKISCSDtfhCNMTTVFFICSFGVGSMVNILVSYTLIVSSVlqikssSGRGRAFSTCSSHLTCVCIFYWTVFFIYLRPps 264 western clawed ...
XP_006117005 185 LQLSCSEirnNEMVIFAFVGLNGIGTAGITFISYFYILSTIlkmqstQGRSKAFNTCASHLTVVSLFYGTGFFMYLQPss 264 Chinese soft-sh...
XP_002932831 184 LKLSCSDtslTQLLIFAIVGVYSSTCASLILTSYIHIFSAIlrikstQGRQKAFTTCSSHLVSIGTLFGTMIYMYLHPna 263 western clawed ...
XP_005154542 183 LKLVCSDthrSEMVIFAFVTINVVSAVVVILLSYISIIRTVlrmcsaQSRARAFHTCSSHLMAVSLFFGTVFFTYLQPps 262 budgerigar
XP_005529155 183 LRLVCSDtrgSEVAIFALATANGLGTSMVILLSYGRILHTVlgmpsaPSKARAFHTCASHLVSVSVFYGTLFFMYLQPas 262 Tibetan ground-tit
Feature 1           ## ###  #  ##              
Q8WZ84       265 snSLDQEKVSSVFYTTVIPMLNPLIYSLRN 294 human
XP_006032294 265 -sHNGQDKVASVFYTVVTPMLNPLIYSLRN 293 Chinese alligator
XP_002933756 271 kySVSQDKVVSVFYTMIIPMMNPIIYSLRN 300 western clawed frog
XP_005154538 263 -sHRSLDKVVSIFYTVVTPMLNPFIYSLRN 291 budgerigar
XP_002943987 264 sySNDQDKVVSVFYTMVIPMLNPVIYSLRN 293 western clawed frog
XP_002932419 265 ssFDRRDKVASVFYTMVIPMLNPLIYSLRN 294 western clawed frog
XP_006117005 265 -sHTGLDKVASVFYTMVTPMLNPLIYSLRN 293 Chinese soft-shelled turtle
XP_002932831 264 -sNADQDKVVSVFYTMVIPMLNPIIYSLRN 292 western clawed frog
XP_005154542 263 -sHRNLDKVVSIIYAVVTPMLNPFIYSLRN 291 budgerigar
XP_005529155 263 -rHGSRDKVASVFYTVVSPMLNPFIYSLRN 291 Tibetan ground-tit

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