Conserved Protein Domain Family
DUF4529

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pfam15032: DUF4529 
Protein of unknown function (DUF4529)
This family of proteins is functionally uncharacterized. This family of proteins is found in eukaryotes. The proteins contain a conserved VLPPLK sequence motif.
Statistics
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PSSM-Id: 464457
Aligned: 11 rows
Threshold Bit Score: 603.771
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q6AXX2         1 MDLCEESETFLENKENKKIEDAEETALTFHCPDERSERNHVCCLLGVSELTLEEDGRASEFTISTGWEEAVHGWGRTSPT 80  Norway rat
Q6P387         1 MDLCQKNETDLENAENNEIQFTEETEPTYTCPDGKSEKNHVYCLLDVSDITLEQDEKAKEFIIGTGWEEAVQGWGRTSPA 80  human
XP_006152653   1 MDLCLKNETDLEDGGYNEIQSTEETELTFTCPDERSEKNHVYCLLSISDITFQQDERANEFIIGTGWEEAVQGWGRASPT 80 
XP_021577431   1 MDLCQESETHLE---NNEIQSTEETELTFTCPDGKSEKNYVCSLLNISDITLEDDERATKLVMGTGWEEAVKGWGKVSPT 77 
XP_004842858   1 MDLCQESETDLE---NNEIQSPEETELTFTCAGERSEKNHIYCLLDISDLTLEEDAGANEFAIGTGWEEAVQGWGKTSPT 77 
1_pfamImport   1 MDLCQKNEADLD---SNEIQSTEETELSCSCPDERSERSHVCCLLSISDLTLEQDGRASEFVIGTGWEEAVQGWGKISPT 77 
XP_005195233   1 MDFGHKNETELENSENYEIESTEETELIYTCPDERSEKNHVCCLLNISDITLEQDKKAKEFVIGTGWEEAVRGWGQISPT 80 
XP_015443177   1 MDLCQKNETKLENNGNNEIQSTEKNELTYTCPDEGSEKNHVCCLLNISDITLEQDEKANEFAIGTGWEEAVHGWGQTSPT 80 
XP_005620719   1 MDLCQKKETELEISENNEIQSPEETELTYTCSDERSEKNHVCCLLNISDITLEQDEKANEFVIRTGWEEAVQGWGRTFPT 80 
XP_010596138   1 MALCQKSETDLE---NNENQNTEETEPTSTCPDERSERSHVCCLLNISDITLEQDEKANEFVIGTGWEEAVQGWGSTSPT 77 
XP_006087108   1 MDLCQKNETELENGENNQIPSTEETELNCTYSDERKEKNHVCCLLNISDITLEQDEKANKFVIGTGWEEAVQGWGKTSPT 80  little brown bat
Q6AXX2        81 ACIWSKKKVRRGRVGEGTsgGSNCLFCMSLSQGSLEPRPLsaagkl----eeaavAEVSS-----------QKNWGSEKN 145 Norway rat
Q6P387        81 ACIWPRKIPKKARVGEGA--CSDCLVCVNLSHWSLQTKPP---------------TEGGP-----------EKDQSSPSQ 132 human
XP_006152653  81 ACIWPRKRPKKAR-GEGA--GAGCLLCASLSQVSIEDKSPeave-------sevgAEAGP-----------EKDQSGPSQ 139
XP_021577431  78 ACMWPRKKLKKARVGESA--NNSCLFCISLAQASLEASPPtetgkl----eagavAEGGL-----------EKNRSSTLQ 140
XP_004842858  78 ACIWPRKKLKKARGCASA--SSSCLLCASLSPGSPEARPPtwprk------veagAEVGL-----------EGSQGS--- 135
1_pfamImport  78 ACIWPRKKLKKARVGESA--NSSCLLCLNLPQGSLEARPP---------------AEVGS-----------EKDQSSPSQ 129
XP_005195233  81 ACIWPRKKLKKARVGESA---SSCLLCVNLSHGSLEARPQseggklesgasapapAEAGP-----------EKDGGSLSQ 146
XP_015443177  81 ACIWPRKKLKKVKVGESA---SSCLLCISLSQGSPETKPQseaekl----esgalAEASP-----------GKDQGSLSQ 142
XP_005620719  81 ACIWPRKKPKKARVGEVA---SGCLLCGSLSQGSTEARPQagklg------sgvpAEVGP-----------EKDQGSPSQ 140
XP_010596138  78 ACIWPRKKVKKARAGESA---SSCLLCVNISQGRPEARLQmdpgkl----earalAESGP-----------RKDQSSPSQ 139
XP_006087108  81 ACIWPRKKCKKAKVGESV---SGCLLCVSLSQGTPEAGPQ---------------TEAGSlesralaeagsEEDRGGPSQ 142 little brown bat
Q6AXX2       146 WNSPSQGP--ASREPNKLCFPTYLHGEKKSLQMKEFIWCMEEWGIPEAVSSKACR---NPSSSTDQGLSISDAVATKALV 220 Norway rat
Q6P387       133 TQAAPQGPstASRAISDICFPTYFRAEKKSLQIKEFIWCNKDWAIPGTNRGKASG---NPSGGAHRGLSIPGPLTSRALL 209 human
XP_006152653 140 TQGSSPDPktASREINKTCFPTYFPGQKKSLQIKEFIWCSEDWAISEPLRGKAPR---SPCIGADRRVSISDALTSKALL 216
XP_021577431 141 SQGSYQRPttTSREVNKICFPSYVHGEKKSLQIKEFIWCVEDWATLENNSGKTTG---NLSGGANRGLSISDSLTSKALL 217
XP_004842858 136 -----QGPntAPREASRICFPHDVPEGKKSLRMKEFIWRLEDWAIPG-VRGAAAE-------RAPTAPTVSDSLSSKAHL 202
1_pfamImport 130 SQGPPQGPttASREISKIYFPTYIHGEKKSLQIKEFIWCMEDWAVPKTVRGKAPR---SPGGGADRGLSISDSLTSKALL 206
XP_005195233 147 TPGIPPGSttTSREVNKICFPTYSQGEKKSLQIKEFIWCLEDWATPETVRGKDPR---RPWRGTDRILPASDSLTSKALL 223
XP_015443177 143 MQRPPQGPttATRDISKICFPSYSQGEKKSLQIKEFIWCLEEWAVPETVRGKDLS------GGSDRGPSISDSLTSKALL 216
XP_005620719 141 TQGTPQGPtaASREISKICFPTYSQGEKKSLQIKEFVWCKEDWATTETIRGKDPR-------SASRGPSISDSLTSRALL 213
XP_010596138 140 SQGSPHGPntSSREISKTCFPYHGHNEKKSLQIKEFIWCTDHWTASETVKGKDLKsheHPGGNTDKGFSISDSLTSKALL 219
XP_006087108 143 TQLPTGCPttASRNISKMCSPSHSQGEKKSLQIKEFFWCMEEWAIPETGRDQDSN------SRTDQGPSISNSLNSKALL 216 little brown bat
Q6AXX2       221 VLPPLKSS-SHNLDSLSKKSRNIFWQPEEKVLGVEKDECMACPDELKGVDGKGEKAHFELASRLKVTNILPFPPTV-TRT 298 Norway rat
Q6P387       210 VLPPLKASlSNALDVLGKKSKNSFLQSEEKVLDVEKDGCVAYAYGLKTADGKGEKRASELAKHPMVNDTPSSPSPA-AQI 288 human
XP_006152653 217 VLPPLKASpPNALDVLGKKSKNFLLQSEEKVLNVEKEECVTGVHGMKL----GDRKAIELAKHLKVKDSPPFPSPV-AQT 291
XP_021577431 218 VLPPLKPSpSSGLEILGKKSKSVTWQLEDKVPSVEKDECVACAHELKTVDGKDEKRPLEVAK-LKVHDTPPFPSPA-LWT 295
XP_004842858 203 VLPPLRASaQSRL------SKNLFCQSEEEAPSVDKEE---------GVDGKGEQEPLELAGHLPLGDARPGPGPApAAR 267
1_pfamImport 207 VLPPLKASpPNGLD----KSKNFLLQLGEKVPSVEKDECVVRAYGLKTIGGEGEERP-KLARHLKVNDVRPFLSPG-AQT 280
XP_005195233 224 VLPPLKSSpPDGLDVLGKKTKNFFLRPEEKGLSVEKDECVAYAYGVKAVDGAGEKQPTELARHHRVKDMQPFLTPV-ART 302
XP_015443177 217 VLPPLKTSaPNGLDGLGKKSKNFPLQPEEKVLSMQKDACVACEYGLKTVNGKDEKRPAELAKHLKVNCRQPFPSPG-ART 295
XP_005620719 214 VLPPLKASpPNGLDVLGKKSKNFFLQPEEKVLGVEKDECVACTYGLKTVDGKGEKRPVELAKHPKVNDTLPFPPRV-APT 292
XP_010596138 220 VLPPLKASpPNGLDVLGKKSKNVFLQQEEKGLSVEEVECVACTCGLKTVDGNGE-RPVELAKHLKVKDSPPSPPPA-AWP 297
XP_006087108 217 VLPPLNSSaPHGLDVQGKKSKNLLVQPEEKVLSVKKDECVACAYGLKIVEGKDGKRPFELANHLKVNCMQPFPSPM-VGT 295 little brown bat
Q6AXX2       299 HLLsAESQRCCLHWSLLPQKSSVFPPNPTNIHYLATLQVLGQQGGQNCRTRLKAKEAKPPRTTPKHIVTEAKQESRPHVL 378 Norway rat
Q6P387       289 SLL-TDPEQRCLHWSLLSEKNLACPPDPSNVRYLAALQLLQKRGVQSYKSKFKAKEPRSPVITRKHVLPKAKQENRPQML 367 human
XP_006152653 292 SLL-ADAQQCLLHWSLLPEKSLVCPPNPSSVRYLATLQLLQKQGVQNYKAKFKAKEQR-PVIVQKHILTEAKQENGPQTV 369
XP_021577431 296 SPL-ADIEQCCLHWPFLPEESPLGPSNPGPVHYLATLQLLQKQEVQSYKAKFRAKELRPPRNTQKHVLPGARQENRPRML 374
XP_004842858 268 SLL-AHAERCCLSWSLLPERS------PGSLPYFATVQPLQKRGMQSYRAKLKARGLGLPRNSQKLAFPEARRENRPPVL 340
1_pfamImport 281 SLL-SDPEPCS-----LPENKQMCLPSPSTAHYLTTLKLLQRQGMQHYKAKFKAKMQKPPVNTQKHGVTGAQEDDRPQTL 354
XP_005195233 303 PLL-PEPEPCCLHWSRLPEKNLLCPPC-----YLATFQLLQKQGARNYKARLKAREPRPPMKTPKRVLTEAKQENRPQML 376
XP_015443177 296 LLL-ANPERCCLHWSLLPEKNLACPPNPSNVHCLATLQLLQKQGVQSYKTKFKAREPRPPMNTQKYVVKEAKLENRPQTL 374
XP_005620719 293 PLL-ANVEPCCLQWSLLPERNLLCPPNPSNVHYLTTVQLLQKQGMQNYKAKFRAREPRPPINTQKRILTETKQENRLQML 371
XP_010596138 298 ALL-ADPKPCCLHWPLLPERSLLCPPTPSNVRYLASLQLLQKQGMQNYKAKFKPKEPQPPMSTQKRIFMEAKQEKRPQTL 376
XP_006087108 296 NLL-ANPELGSLHWSLLPKKNLMCPPNPNSVHCLRTMQLLQKQKEQSYKATFKARELRPPMNTQKCILKEAKQENRPHPL 374 little brown bat
Q6AXX2       379 ESKVFPKPLLPSLTVSR-------VVIPVSTHRVL 406 Norway rat
Q6P387       368 ETKVFPRPVLPSLTVSR-------VIIPVSTHRIL 395 human
XP_006152653 370 DSKLFPSPLLPSLTVSR-------VVIPISTHRLL 397
XP_021577431 375 ETEMFPRHLLPSLTGSRdqfgrceTVMPFCWHRDS 409
XP_004842858 341 ETDVLPRSLLPALTVSR-------VVIPVSTHRVL 368
1_pfamImport 355 DSRVLPGALLPSLTVSR-------VVIPVSSHRFL 382
XP_005195233 377 ETKVFSRPLLPSLTVSR-------VVIPISTHRLL 404
XP_015443177 375 ETNVFSRPLLPSLTVSR-------VVIPVSTQRLL 402
XP_005620719 372 ETKVFPRTLLPSLTVSR-------VVIPVSTHRLL 399
XP_010596138 377 ETKAFPTPLLPSLTVSR-------VVIPVSTHRLL 404
XP_006087108 375 ETNVFPRPLLPSLTVSR-------VVIPTSTHRFL 402 little brown bat
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