Conserved Protein Domain Family
GIY-YIG_SF

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cl15257: GIY-YIG_SF Superfamily 
GIY-YIG nuclease domain superfamily
The GIY-YIG nuclease domain superfamily includes a large and diverse group of proteins involved in many cellular processes, such as class I homing GIY-YIG family endonucleases, prokaryotic nucleotide excision repair proteins UvrC and Cho, type II restriction enzymes, the endonuclease/reverse transcriptase of eukaryotic retrotransposable elements, and a family of eukaryotic enzymes that repair stalled replication forks. All of these members contain a conserved GIY-YIG nuclease domain that may serve as a scaffold for the coordination of a divalent metal ion required for catalysis of the phosphodiester bond cleavage. By combining with different specificity, targeting, or other domains, the GIY-YIG nucleases may perform different functions.
Links
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Taxonomy: root
PubMed: 89 links
Protein: Related Protein
Related Structure
Statistics
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Accession: cl15257
PSSM Id: 472790
Name: GIY-YIG_SF
Created: 15-Aug-2011
Updated: 4-Oct-2023
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