Conserved Protein Domain Family
NMD3

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pfam04981: NMD3 
NMD3 family
The NMD3 protein is involved in nonsense mediated mRNA decay. This amino terminal region contains four conserved CXXC motifs that could be metal binding. NMD3 is involved in export of the 60S ribosomal subunit is mediated by the adapter protein Nmd3p in a Crm1p-dependent pathway.
Statistics
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PSSM-Id: 461505
Aligned: 180 rows
Threshold Bit Score: 132.804
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q5JGP6             6 CYRCGISEregGpLiEGLCQVCYRKE-NPVLLIENE-In---TELCQNCGSYKKRgVWVDp-hS-YELEELIFEVAENAl 78  Thermococcu...
CBRAS:TCELL_0394   4 CLNCGREVs-dEdYvNGYCIDCFRKIgNPFTK--QVsLe---LKVCSRCGSIFYKgEW---------HQDSMENIVRRYl 68 
WP_011839391       5 CVRCGRRVsedEpLiNGYCIDCYLKY-KGIFVTKPV-Ln---ITICPRCGSWMYRgEWRDp--L--PLREIIRRILISEa 75  Staphylothe...
jgi:Tagg_0968      4 CVRCGKEVs-dEeIvGNYCVDCYVKH-LTPFKDKPR-Le---VMVCPKCGAWFYKgEWNHp--L--EENEVLRRIAIWGs 73 
CBRAS:DKAM_1085    7 CVKCGREFk-qEdLiNSLCVNCYLKY-HGVFKETPH-Ve---LTICPKCGSWYFKgAWHPs--L--DIREVIRRELLADl 76 
CBRAS:FFONT_0821   5 CPICGREEsknLpFvGGICVECYLNK-N------PLeIkaitLNKCKICGKIRYKnDWi------FANENFYSEIFAKEv 71 
imbp:Hbut_1236    10 CARCGKPLt-pGdSvGPFCLDCYVEM-FKLLCVPER-Vr---FDYCKYCGAYRIGhRWQSggeLeEAVQRFVEEVAGGV- 82 
jgi:Pyrfu_1371     9 CIRCGRRIaasEpViDGMCLECFLEE-RKLVEIPGR-Ld---FEYCRSCGAIRYGyRWVEqlpLeEASRRYLELYLSERv 83 
Q9Y9F4             7 CASCGRGS---EvLlRGLCPECFDRR-YGVVEGLPWeLv---VDVCTSCGRVRIGhKWLEyatAeEAVGLMLSSMSLKPv 79  Aeropyrum p...
WP_011838704       5 CIYCGAEDtpdNpVvEGVCLRCRIKR-GEIIEQVKReIr---VDFCKVCGAVRIGyKWIDtngFnEALHHIVYNQLKELv 80  Staphylothe...
Q5JGP6            79 -----lEALEdsfs---dkirEY-E-VVSP---EEL-EETEEIpvgraivsfepvdyhieyfpaiityEVRVKARThelq 144 Thermococcu...
CBRAS:TCELL_0394  69 --------Ldnqak---ymiaSA-ElISVEpsgEPReSAK----------------------------GVYVQNWLfg-i 107
WP_011839391      76 -----yRFIdrqh----vnllDA-TiLSEPykiNES-QYAVKA-------------------------LLHVVIE----- 114 Staphylothe...
jgi:Tagg_0968     74 -----kRFLreev-----evlDV-SvVKSLhkiSASeHGV----------------------------TLNYQLLIk--- 111
CBRAS:DKAM_1085   77 -----hRFLyeni-----sviEV-DvVSDIykiNAG-EYGVKA-------------------------IFTMEVD----- 114
CBRAS:FFONT_0821  72 eknnkkKFIQfgld---lkavPY-KeKVLVtvqNEIgKYET--------------------------------------- 108
imbp:Hbut_1236    83 ---------KpcrpevrgfsvEGvEpLTKPswrTIY--------------------------------AIRYSIQVq--- 118
jgi:Pyrfu_1371    84 ---------KpahalvedvkiVNiEpLQYPswrSVY--------------------------------RVVVEARLk--- 119
Q9Y9F4            80 ------------------------HpVERVeleDWAlETRLDW-------------------------RTRVRLRFr--- 107 Aeropyrum p...
WP_011838704      81 kpgigvDDLr----------iDGyElVTSA-------SWRTVV-------------------------RVYFRGIYggk- 117 Staphylothe...
Q5JGP6           145 rElHD----ERKKVTVYVRQ------TVCPRCQKFLGGYFEAILQVRAEdrplteEERKAIGKLVEEKVdeimRK-D-RM 212 Thermococcu...
CBRAS:TCELL_0394 108 vLnKKhfvqFNQDVRISVSR------TICPRCLARASRKISAVVQVRGV-------NAQAHRGLVEGVI----MSnPgYS 170
WP_011839391     115 ---EYyplnLEKEIVLNINR------KVCPKCLAYAGKSHRALVQIRSVngsfsrEEEKIINKAISDPG---------VA 176 Staphylothe...
jgi:Tagg_0968    112 ---gIhpvnFELEVPVRITY------KPCPSCLARAGGSHKALVQVRVEgevdieELAEEVEELLVKAG---------LS 173
CBRAS:DKAM_1085  115 ---GRhvvkVNQVVITKLRY------RTCDKCMRRTTGSHKVLVQVRFEplenieGLRHEVMELLRDLE---------IG 176
CBRAS:FFONT_0821 109 ----------------YLDPiidykfTICPQCLARKAGSYDSVIQIRGTnkl-dfEDKKIIMNLIEKLPy------D-LK 164
imbp:Hbut_1236   119 --gVDkpisQTYRVEVRASP------TICPTCKDVRGGEYNVLLQVRGI-------KPAELARLLGPLL----DSsEqIQ 179
jgi:Pyrfu_1371   120 --gVEepvrQEYVVEVRAVP------SLCPACKNDRGGDYNVLVQVRGR-------IDAKLVEVLGRIL-----DsGrVA 179
Q9Y9F4           108 aNyRDtlfrVSRVIVLRLNP------STCPLCIVRRSGEYDTLVQVRGY----------RAGEAVEKTL----NSlD-PR 166 Aeropyrum p...
WP_011838704     118 ------efvYPLDFIVYLNP------TKCPRCKMIESGEFEAVVQIRDV-------HVKDLEKALEKIF----SRdKrLR 174 Staphylothe...
Q5JGP6           213 GFIQDTIEKEEGLDFYMGSTSAARKLAQAIKERFGGKI-SEAYELVGMDRQTSREVYRTSVSVRI 276 Thermococcus kodakarensis ...
CBRAS:TCELL_0394 171 EYLVDVEDAPNGFDIRFVDQLPARRLAYELARLLGGHV-KETFKSTRYDARKGVWQGIHTFSVRL 234
WP_011839391     177 GDIVEIKKNKYGLDVKLLTSVAAKRLSTILSRLTGAKI-IESFKPVRYNPDKGRWSGITTLSVRL 240 Staphylothermus marinus
jgi:Tagg_0968    174 SSVTEVEVVKEGVDVKFEDPVAARKLSSILSRKYGAST-AESFRSTRFDAHEGKWRGVVTLSVRI 237
CBRAS:DKAM_1085  177 ESIIEVMELREGLDIKFEDIVSPRKYVNILVKKYGAKT-SESFKSTKYDFQEGKWSGVMTISVRI 240
CBRAS:FFONT_0821 165 QHIVTITENKDWIDVEIVGHEKARLIASFLSEKLGGET-KQTFKLIST-KK-GERNSRLTISLRI 226
imbp:Hbut_1236   180 NSIVDIVEYNNGVDFLLLDRGSAAKIIKEIKKKYIVVT-RTTGEDVGITST-GHMRRRTVIAVRV 242
jgi:Pyrfu_1371   180 PWVVDIIEDKRGIDILLRDRGAASRIVSELSKYFVVDV-KRSAETVGMTST-GIERRRLTISVRV 242
Q9Y9F4           167 EAPIDVVPVRGGVDVYFHHRGAAARFVSRLASTARVRVsRVEHEHVGTSSL-GRRRSRKTILVRL 230 Aeropyrum pernix
WP_011838704     175 QDLVDYIEVKNGIDIYFYNHGAARKLSRKLSNMLGLVI-KENYEVAGM-RS-GKQRARLYVSLKp 236 Staphylothermus marinus
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