Conserved Protein Domain Family
UBCc_UEV

?
cl49610: UBCc_UEV Superfamily 
Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain/ubiquitin E2 variant (UEV) domain
The family includes ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain and ubiquitin (Ub) E2 variant (UEV) domain. They belong to the ubiquitin-conjugating (UBC) superfamily that represents a structural domain with an alpha-beta(4)-alpha(3) core fold. E2 is part of the ubiquitin-mediated protein degradation pathway in which a thioester linkage forms between a conserved cysteine and the C-terminus of ubiquitin, and complexes with ubiquitin protein ligase enzymes, E3. This pathway regulates many fundamental cellular processes. There are also other E2s which form thioester linkages without the use of E3s. Several UBC homologs (TSG101, Mms2, Croc-1 and similar proteins) contains the UEV domain, which lacks the active site cysteine essential for ubiquitination and appear to function in DNA repair pathways.
Links
?
Taxonomy: root
PubMed: 312 links
Protein: Related Protein
Related Structure
Statistics
?
Accession: cl49610
PSSM Id: 483950
Name: UBCc_UEV
Created: 4-Oct-2023
Updated: 4-Oct-2023
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap