Conserved Protein Domain Family
LRIF1

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pfam15741: LRIF1 
Ligand-dependent nuclear receptor-interacting factor 1
This family of proteins interacts with the retinoic acid receptor RARalpha and inhibit it's ligand-dependent transcriptional activation.
Statistics
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PSSM-Id: 464837
Aligned: 10 rows
Threshold Bit Score: 852.194
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_016159738   1 MYRVIQTTGPDGKNLLKLLPISKTSGSFMPLVQPPAMPNNSNANVSSPVHLTFKTQLGNTTAPSSVKIPIFQPPNPGRII 80 
NP_001120957  26 MYQVVPTIGTDGKKLLQLLPIPKSSGNLIPVVQSPVMSHGLKGNTEKPVQVTFQTQISSSSTSASVQLPVLQPANTTKYF 105
Q5T3J3        28 MYQVVQTIGSDGKNLLQLLPIPKSSGNLIPLVQSSVMSDALKGNTGKPVQVTFQTQISSSSTSASVQLPIFQPASSSNYF 107 human
XP_012405046  38 MYQVVQTTGLDGKNLLKLLPIPNSPGNLLPLVQSSVTSDTSKGNISNPVHVTIQTQLASTPTTASIQFPVFQATNSGNYF 117
XP_007485183  28 MYQVVQTTGLDGKNLLKLLPIPNSSGNLMPLVQSSVTSDTSNGNISNPVHVTIQTQLASSPANASIQFPVFQTTNSGNYI 107
XP_007664971  16 MYQVVQTSGLDGKNLLKLLPISNSPGNPMPLVSSSVTTDSSKANLASPVHVTFQTQLNSLSTGPSIQFPVFQPVTAGKYI 95 
XP_005987651  27 LYQVVQITDANGKNILKLIPASKISRSVAPTIPSSSITKGSEVNMLTPVTLQLQT---TAMNSISSEVSDFHHPTK-KLF 102
XP_419232     27 MYRVVQTTGPDGKNLLKLLPISKSSGNFVPIVQSSAMSNNPKVNVSSPVHLAFKTQLASTAAPSSVKIPVFQSPNSGKII 106
XP_010722320   1 MYRVVQTTGPDGKNLLKLLPISKSSGNSVPIVQSSAMSNNPKVNVSSPVHLAFKTQLASTAASSSVKIPVFQSPNSGKII 80  turkey
XP_027300844  27 MYRVVQTTGPDGKNLLKLLPISKSSGNFVPIVQSSAMSNNPKGNISSPVHLTFKTQLANTTAPSSVKIPVFQSPNPGKII 106 mallard
XP_016159738  81 LTRTLDKQESARAGSEKESLIP-SEAASAQSSCM---AVDGVSL-QNIAItSSSHQSSMTCMVVNTKPLPVTVKSPVLPS 155
NP_001120957 106 LTGTIDTSGKDRVTSMGTGNFT-PPISNTQNHGV---KIHRLTR-QTFTI-PPSTQNDSSYFIVNTPSLPANVNSSTLPS 179
Q5T3J3       108 LTRTVDTSEKGRVTSVGTGNFS-SSVSKVQSHGV---KIDGLTM-QTFAV-PPSTQKDSSFIVVNTQSLPVTVKSPVLPS 181 human
XP_012405046 118 LSATVDKSENARVASVGKESL--ASASTAQSNSM---KVERLAL-QKIAVsPSTTQGDTTYMLVNAKNLPVTVKSPVLPY 191
XP_007485183 108 LSRAVDKSENVRVASVGKESLT-SSCSTVQNNAM---KVERLAL-QKIAVsPATPQSDTTYMLVNTKNLPVTVKSPVLPY 182
XP_007664971  96 LTRTLDPPENVRTTSAESKSLP-SKVAAAANAPTppgAADRLSLpQNAIVsPPSTQGDTTYMLVNPKNLPVMVKSPGLPS 174
XP_005987651 103 VTRPVDPKEILGVTHGPTVVTSgSPISLTKNAAL---TVANPSS-QRLLA-SSSNSKDKMYMLISSKHLPGTVKSVALPS 177
XP_419232    107 LARTLDKQEGFKAGSDKESLTT-ESAADIQSSCV---SVDRQSL-QNAAVtSSSEQSHTAHMSVKTKDNPISVKPPVLPS 181
XP_010722320  81 LARTLDKQGGVRAGSDKESLTT-ESAADIQSSCV---SVDRRSL-QNAAVtSSSEQSHTAHMSGNTKDNPISVKPPVLPS 155 turkey
XP_027300844 107 LTRTSDKQESVRAGSETESLTA-KSAANIQSSCV---SVDRLSL-QNIAVtSSSNQSNSAYMFVNTKNLPATMKSPVLPS 181 mallard
XP_016159738 156 GHHLQIPADAEVKSVPASLLPPSIQQKILAAAATNVSGGADSTKTP-MVIYMSPVNTVKTsqVLPKHLQSFCPKP--AAe 232
NP_001120957 180 GPPLTIPAHAEVKPVLASPLPPLVQQKILGTVTTSTSGTVEASQIP-AVFYVSPVNSVKI--IVDKKTQNIYHKP--VT- 253
Q5T3J3       182 GHHLQIPAHAEVKSVPASSLPPSVQQKILATATTSTSGMVEASQMP-TVIYVSPVNTVKN--VVTKNFQNIYPKP--VTe 256 human
XP_012405046 192 GHHLQIPANAEVKSLPASSLPPPIQQKILAAAATNTSGTAEASKIP-TVIYVSPVNTVKS--VVPKTFKNICPKPpnPTe 268
XP_007485183 183 GHHLQIPANAEVKSVPASSLPPPIQQKILAAAATNTSGTTEASKVP-TVIYVSPVNTVKS--VVSKTYKNICPKPpnPTe 259
XP_007664971 175 GHHLQIPAHAEVKSVPASSLPPAIQQKILAAAAPGPSGSTEAAKTP-TVIYVSPVNTVKT--VVSKCWQAICPKPs-PPe 250
XP_005987651 178 GQHIRIPADAQVKSLAASSFSPAIQEKILVTAATNISGTNEANKTPaSVIYVSPVNTVKT--VVTKPLPVISPKPvvKPs 255
XP_419232    182 GHHLQIPADAEVKSVPASFLPASIQQKILAAAATNVTDGADSKKMP-TVIYVSPVNTVKT--ALPKCLQAVDHKP--APd 256
XP_010722320 156 GHHLQIPADAEVKSVPASFLPASIQQKILAAAATNVSDGADSKKMP-MVIYVSPVNAVKT--VLPKRLQADDPKP--APd 230 turkey
XP_027300844 182 DHHLQIPADAEVKSVPASFLPPAIQQKILAAAATNVSGGADSTKIP-TVIYVSPVNAVKT--VLPKRLQTICPKA--ATd 256 mallard
XP_016159738 233 vsktliVTTAQKG-S---GSSPEPVTSEGQQCQQTPMKWIVQETAPLSAACLIPVKSSNNVASKILKTL-SDTKNVE--- 304
NP_001120957 254 ------FSTSQIP-P---NVATKTQLNSGQHPQAAPVNLIFQEYLQPGIPCLVPVKSSNNVPSKVFNTF-VDRKTLG--- 319
Q5T3J3       257 iakpviLNTTQIP-K---NVATETQLKGGQHSQAAPVKWIFQDNLQPFTPSLVPVKSSNNVASKILKTF-VDRKNLG--- 328 human
XP_012405046 269 aakpmiLNTSQTPvK---NPAADVTNNEGQQSRDTPMKWVVKENPQ-CSPCLVPVKSSNNMASKILKTL-MDMKNVE--- 340
XP_007485183 260 paksmvLNTSQTSvK---NPGTDVSNNEGQQSRDAPMKWVVRENPQ-STPCLVPVKSSNNMASKILKTL-MDMKNVE--- 331
XP_007664971 251 askaviLTGPPTPaK---GAAPDVGAKASPPAQGTPMKWVVQRNPQCSSPCLVPVKSSNNVASKILKTL-ADMKNVQ--- 323
XP_005987651 256 tsltriTEAYEMEnRfttGMIASPALPTSNNIAQSPMKWVVQENPQFSAPCLVPVKSSTNAASQILKSLaADLQHVEqpl 335
XP_419232    257 vsktllMTAPQKA-H---SSSPETGMSDGQQCQHTPMKWIVRESPQLPAPCLIPVKSSNNVASKILKTL-SDMKNVE--- 328
XP_010722320 231 vsktllMTAPQRA-H---SSSAETGTSDGQQCQHTPMKWIVRESPQLPAPCLIPVKSSNNVASKILKTL-SDTKNVE--- 302 turkey
XP_027300844 257 vsktliMTATQMA-----NCSSETVKSDDQKCQQTPMKWIVQESPQLSSPCLIPVKSSNNVATKILKTL-SDMKNVE--- 327 mallard
XP_016159738 305 VNPANILPPCSNGPGGNQTKITPLKENALVMYNGKVyLLTKRGSDVLSA-----QAEKQT--------SSSADGLLkKET 371
NP_001120957 320 DNTVGTPLLSTNSSSRTQSISVPIKDDGLIMFNGKV-LLNKKGTYGLPS-----KIDQQN--------SVSSDIPL-KDS 384
Q5T3J3       329 DNTINMPPLSTIDPSGTRSKNMPIKDNALVMFNGKVyLLAKKGTDVLPS-----QIDQQN--------SVSPDTPVrKDT 395 human
XP_012405046 341 TSSLNMPPLCSGTSGGTQAKITPIKDNALVMFNGKVyLLAKKGSEVLPS-----QTDQQN--------SVASDASPrKDM 407
XP_007485183 332 TGSLNMSSLCSSTSSGTQAKITPIKDNALVMFNGKVyLLAKKGSEVLPS-----QTDQQN--------SAAPDASPrKDT 398
XP_007664971 324 STSAGILPLCSGGSAGSQSKITPIKDNALVMFNGKVyLLAKRGSEVLVP-----QVEPQSppssssspSSSSDIMSrKDP 398
XP_005987651 336 STNAAMPLLSTNSPESPSVKSAAAKKNALVMCNGKVyFMAKQGPEVGTTspkqnQSKDQA--------TCSQSNEVqNLQ 407
XP_419232    329 VNSANILPLCSSGSGVSQTKITSIKDNALVMYNGKVyLLTRRGSDVLSA-----QADMQA--------SSSYSASLkKGT 395
XP_010722320 303 INSANILSHCSTGSGVSKTKITSIKDNALVMCNGKVyLLTRRGSDVLSA-----QADVQA--------SSSYGASLkKGT 369 turkey
XP_027300844 328 VNSANILPLCSSGPGGSQTKITPFKDNALVMYSGKVyLLTKRGSDVLSA-----HVDKQA--------SSSSDASLkKET 394 mallard
XP_016159738 372 PKQIDSTKVNKITSKVVNLVLSK-SKgvvLSQKDPKPCTVSKNSSPVA--LRNDLKSTPAAPLVSG---ANQQDPTVIQR 445
NP_001120957 385 SQVVSSSLVTEISREVLSSVLVK-SK---SFQLKTKSLSNSQPAPMAHikPEKSEKVERPSFSVTSphtTNQSTHCLKQS 460
Q5T3J3       396 LQTVSSSPVTEISREVVNIVLAK-SK---SSQMETKSLSNTQLASMANlrAEKN-KVEKPSPSTTNp-hMNQSSNYLKQS 469 human
XP_012405046 408 SQTPNSNSVTKITNEVVNIVLAK-NKt--IPQKETKLISDTQLASEPVpsLEKNNKVECTSLSAQSpqhVTQPL-CLEQC 483
XP_007485183 399 SQISNSSS---ITNEVVNIVLAK-NKt--APQKETKLLSDTQLASEPApnLEKNNKVECASLSALNpqhAKQPISHVEQC 472
XP_007664971 399 PQLADSS-VSKITSEVVNIVLAKrNNslaTPQKDTKEGGEGQLDSESA--TEKKPRAGSALLSTPRphkVNTPIGQGEQG 475
XP_005987651 408 ARTLDSVAISKIS-KAVRAVLSK-NMgskLPQIN---LPRSEKSVQTT--LKRHVKTE-ACQEFPStkkENQRVLHVK-- 477
XP_419232    396 SKLIDSTEVTKISSKVVNLVLSK-SKgmpLPQKDPKVCSNSKVSSSGG--LRNDLKSTSAALVTPS---AEEQSSTVNRG 469
XP_010722320 370 SKLIDSTEVTKISNKVVNLVLSK-SKgmpLPQKDPKVCTNSKVSSPGS--LRNNLKSVPAALVIPS---VEEQSSTVNQG 443 turkey
XP_027300844 395 SKLIASTEVTKITNKVVNLVLSK-SKgmvLSQKDSKMGANAKVSPSAG--LRSDLKSAPAALVTPS---VKQRSSTVIQG 468 mallard
XP_016159738 446 QS--LPFTKSVScSGVIPVPAVGMQENVwq---------nGKDMSHS----PKAAGAvl-pqAKQECAVGEDWPKIPCEK 509
NP_001120957 461 KI--VFINPVFS-DGFRTGQNTPRKENL------------IQNIRSS----VDAATV-----TSQQCVFRDQEPQTQYEM 516
Q5T3J3       470 KT--LFTNPIFP-VGFSTGHNAPRKVTAviyarkgsvlqsIEKISSS----VDATTV-----TSQQCVFRDQEPKIHNEM 537 human
XP_012405046 484 KT--APIKLNLP-DVVSPAQNAKKETSVsh---------tKEK--SS----SDDTTT-----TSKHCVYTDQEPKNQGEM 540
XP_007485183 473 NT--VPIKLNLP-DVISPVQNAIKETSInh---------tKEA--GS----ADDPTI-----TSQHCVPTHQEPKNQGEM 529
XP_007664971 476 KTaaLPREPSLP-RGVGTDANAILERDGgs---------sKEKFSSP----ADPATV-----SSHRCTFTDQKPKIQGAM 536
XP_005987651 478 -----PQNEELQ------------RENGdlsnf--svskeREEILNTipknISLMSSelygrTGDMQQHSDVNPS--SDT 536
XP_419232    470 KS--LPFMESIS-SGMTPVTAVGMQETTyq---------dDKEMIHS----SKAASAvl-pqSEHECAFSEDWQKVQCKK 532
XP_010722320 444 KS--LPFMESIS-SGMTPVMALGMQENAcq---------dGKEmiHSpkaaSAVLpqseh-----erafsEDWQKVQRKK 506 turkey
XP_027300844 469 KS--LPLTMSIS-SGATPITAVGTQENVfq---------gGKEMIHS----PRAASAvl-pqSKQECAFSEDWQKVQHEK 531 mallard
XP_016159738 510 MDSPGKVIQIKHQEHPHW---------RQYLELRKKFGLFKEERVYLMRIPLRAFCEnpeERVCSSDSLE---RKNDSCs 577
NP_001120957 517 ASILKKDIQERSNKKYSQgnhtkasylKNDAEFKKIFGLTKDLRVCLTRIPDHLSST---KSFDSFNNLM---KSSSYK- 589
Q5T3J3       538 ASTSDKGAQGRNDKKDSQgrsnkalhlKSDAEFKKIFGLTKDLRVCLTRIPDHLTSG---EGFDSFSSLV---KSGTYK- 610 human
XP_012405046 541 AFVLETYTHSRSQRESCP---------KEYAELRKNFGITKDLRVRLTRIPLFDSTS-----LYSPTSLT---NNISSK- 602
XP_007485183 530 ALVLETHFQSRSQKESCR---------REYAELRKKFGITKDLKVNLTRILAFDST----TSLYSPSSLT---NSVSSK- 592
XP_007664971 537 APAPEGEAPAGREPKTCR---------KQEAELRKKFGLVRDLRVRLTRIPVFRDAE---ERKSPPGGLE---NHHSFQ- 600
XP_005987651 537 MFSSVKETLGRSKEKGLYn--------ESDDQLRKKFGLNADVRVHLNKIPIQSFSVv-sKKHASPSAVT---EMEDPS- 603
XP_419232    533 MYSVGKVNQIRDQEKPHW---------KQYLQLRRKFGLYKEERVYLKRIPLTTSCEkpdERLCSSNSLE---RKNDSCp 600
XP_010722320 507 MYSLGKVNQIKDQEKPHW---------KQYFQLRTKFGLYKEERVYLKRIPLTTYREkpd---erVSSSNsleRKNDSCp 574 turkey
XP_027300844 532 MDSQGKVNQIKHQEKPHW---------KQYLELRRKFGLTKEERVYLKRIPLITSSEkpdERVCSSNNLK---TRNDSCv 599 mallard
XP_016159738 578 ssslDVEIRSHhqg----cvEEKKiivdleEDLIRKRKINSSPLLDSGKRR-----RTSIKPATSPS--LEITSSTSSAL 646
NP_001120957 590 ----DANVVMK---------EEKK------QSFSKKRNAKPMKKMDYTKRR-----KIENASDMVMNvmNGTDVANSQLL 645
Q5T3J3       611 ----ETEFMVK---------EGERk----qQNFDKKRKAKTNKKMDHIKKR-----KTENAYNAIIN--GEANVTGSQLL 666 human
XP_012405046 603 ----ESKIIVDlts----ekEEESqeltvqQDLDKKRKAKTVMKVDSTKKK-----KSGNDVNSSMD--TGTDHTIPQVL 667
XP_007485183 593 ----ESEIIVDltt----gnDEESqelilqQDLDKKRKAKTVIMEDNTKKK-----KSGNDGSTSGL--IGTDSTSPQIL 657
XP_007664971 601 ----EAKFRVEptg----gkEEPNkketveQDLDKKRKAK-VQKTTSAKRR-----KPGPDCPVSPN--PHGNSPRPQRQ 664
XP_005987651 604 ----GMEFMTKldspmtkniEGNEvkikseQGSARKRKSADAEIVGQAKKRpntfeNSSNRDSESPC--STSSGPNSKRF 677
XP_419232    601 ssslDVTITDQhqe----wiEEEKailnleEGLSKKRKTK-SSLPDSGKRR-----RTSVKSATSSS--TEDSSPSSITH 668
XP_010722320 575 ssslDVTITDQhrkcikee----kvilgleEGLSKKRKTK-SSLPDSGKRR-----RTSVKSATSSG--TEDSGPSSITL 642 turkey
XP_027300844 600 ssslDVTITNQhqe----cvTEEKiiv-dleDTSKKRKIKSSSVSDSGKRR-----KTSVKSTTSSN--SEDAGPSSILL 667 mallard
XP_016159738 647 --AISPPAASpQPSVPPGSATGSQGRDSEQDVLPWHSDTAHPGISvlVTSEEDTSVLEGSFRDDAFPVAPPDLDETIRDE 724
NP_001120957 646 ssILPISDIA-QHNIITSHSTTREDKRTETEHCCHEKQEKGTLSS--STSFEQSNYFNKNYTEDIFPVTPPELEETIRDE 722
Q5T3J3       667 ssILPTSDVS-QHNILTSHSKTRQEKRTEMEYYTHEKQEKGTLNS--NAAYEQSHFFNKNYTEDIFPVTPPELEETIRDE 743 human
XP_012405046 668 nsTLPNSALLpQSNNLTGCMKSHQENSPELELHAPGGLDRGTRSPasVSFEQDPPDSQDCYIDESFPTTLPELDETIRDE 747
XP_007485183 658 nsISPDSALSlHSSNLIGYTKFSEENSSELELPNQDGLDRSTDSPasASFEQDPPDSQDCYIDDSFPTTLPELDETIRDE 737
XP_007664971 665 psGGARSAESrEAGHPVT-TSPVQETSSEPEACSPNNLPSSTWSPacALFEPDLPICQGAFTEDTFPSTPPELDETIRDE 743
XP_005987651 678 ssKLVKTQERfPANSEADSKVLFLEQKSEESSNSNSAVEKENMNSilGTSAEPEKHHGEICTGDFFPVEPLDSDITPGDE 757
XP_419232    669 nrSVSPPPALsQQSISTDFISST---DAEREPSSQNSDVTDSDIPvlVSCEDHASLFEGSFRNDTFPLTPPDLDETIRDE 745
XP_010722320 643 nrSVSPPPALlQQSISTDFISSA---GAEQEPCSQNSDVTDSDIPvlVSSEDHASLFEGSFRDDAFPLTPPDLDETIRDE 719 turkey
XP_027300844 668 nrSASPPPVLlQQSISTDFVTSSVGRDSEQETCSQNSDVIDSHIPvlVSCEDHTSVFEGSFRDDAFPLTPPDLDETIRDE 747 mallard
XP_016159738 725 KIKRLKQLLREREAALEEMRREMQQ 749
NP_001120957 723 KIRRLKQILREKEAALEELRKKMHQ 747
Q5T3J3       744 KIRRLKQVLREKEAALEEMRKKMHQ 768 human
XP_012405046 748 KIKRLKQLLKEREAALEEIRKKMQQ 772
XP_007485183 738 KIKRLKQLLKEREAALEEIRKKMQQ 762
XP_007664971 744 KIKRLKQLLREREAALEEMRKKMHQ 768
XP_005987651 758 KIRKLKELLREREAALEEIRKKMFY 782
XP_419232    746 KIKRLKQLLREREAALEEMRKKNAA 770
XP_010722320 720 KIKRLKQLLREREAALEEMRKKNAA 744 turkey
XP_027300844 748 KIKRLKQLLREREAALEEMRRKMQQ 772 mallard
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