3QYE_A 56 VGQGVPRHHRGEIWKFLAEQFHLKHQfpskqqP-----------------------------K-------DV-------- 91 human EDN63937 277 SWNGIPKIHRPVVWKLLIGYLPVNTK------Rqegf----------------------lqrK-------RK-------- 313 Saccharomyces c... EDN60130 382 HGGLENDSLRGKVWGFLLEIYPWDSS------Q-----------------------------D-------ERvqidqtla 419 Saccharomyces c... XP_003265326 78 nGQLRSSRFRSICWKLFLCVLPQDKS------Q-----------------------------WisrieelRA-------- 114 White-cheeked G... NP_497979 37 SGSLRSSSCRSAVWRLVLRCLPYETS------D-----------------------------WeislsrsRN-------- 73 nematode XP_506113 419 sKLRVDYNRLKKEWWVQEDKERdd-------------------------------------fW-------RD-------- 446 Yarrowia lipoly... NP_001023164 95 SSVSSTPQTANPIYPKLPEISDQPRS------Avpmasap----------------phggdrD-------QT-------- 137 nematode XP_002642394 516 FWKQCRAEPTIEEWRVLEAEVRRRDE------EafraararragspvreescevfedpneptC-------SQ-------- 574 Caenorhabditis ... NP_510095 32 CSYGVPESLRPLAWRLLLHYLPLERH------Kwqtf----------------------laeQ-------RD-------- 68 nematode 2G77_A 50 SWNGIPKIHRPVVWKLLIGYLPVNTK------Rqegf----------------------lqrK-------RK-------- 86 baker's yeast
3QYE_A 92 ---------------PYKELLKQ----LTS---------------------------------Q---------------- 103 human EDN63937 314 ---------------EYRDSLKHtfsdQHSrd-----------------------------ipT---------------- 333 Saccharomyces c... EDN60130 420 aeydqlkltwskdflQFDDEDEEeywnDQ--------------------------------------------------- 448 Saccharomyces c... XP_003265326 115 ---------------WYSNIKEIhitnPRK---------------------------------V---------------- 130 White-cheeked G... NP_497979 74 ---------------LYRAHKENhlidPHD---------------------------------Tkfsqdpefnnplasie 105 nematode XP_506113 447 ---------------QLSRIEKDvhrtDRNi------------------------------------------------- 462 Yarrowia lipoly... NP_001023164 138 ---------------RFARLRRLfsngKSSgknsppvdvdleklre--dcwmgiphklrpqawR---------------- 184 nematode XP_002642394 575 ---------------HYDRENLIslfrAN--------------------------------------------------- 588 Caenorhabditis ... NP_510095 69 ---------------NYDQMIEQiivePGTaslqqsaaqnqdndhplsdhptsdwqaffqdnkV---------------- 117 nematode 2G77_A 87 ---------------EYRDSLKHtfsdQHSrd-----------------------------ipT---------------- 106 baker's yeast
3QYE_A 104 -------------Q-----------------------------HA----------------------------------- 106 human EDN63937 334 -------------W-----------------------------HQ----------------------------------- 336 Saccharomyces c... EDN60130 449 -------------L-----------------------------FR----------------------------------- 451 Saccharomyces c... XP_003265326 131 -------------VgqqdlminnplsqdegslwnkffqdkelrSM----------------------------------- 162 White-cheeked G... NP_497979 106 qnpwntffedndlR-----------------------------DI----------------------------------- 121 nematode XP_506113 463 ------------------------------------------tFF----------------------------------- 465 Yarrowia lipoly... NP_001023164 185 -------------L-----------------------------LSgylptnaerrevtlqckrdeywhyveqyfhsrfdd 222 nematode XP_002642394 589 -------------L-----------------------------HR----------------------------------- 591 Caenorhabditis ... NP_510095 118 -------------L-----------------------------SQ----------------------------------- 120 nematode 2G77_A 107 -------------W-----------------------------HQ----------------------------------- 109 baker's yeast
3QYE_A 107 --------ILIDLGRTFPTHPYFSA------------------------------------------------------- 123 human EDN63937 337 --------IEIDIPRTNPHIPLYQF------------------------------------------------------- 353 Saccharomyces c... EDN60130 452 --------ISKDVRRCDRNLEIFQY------------------------------------------------------- 468 Saccharomyces c... XP_003265326 163 --------IEQDVKRTFPEMQFFQQ------------------------------------------------------- 179 White-cheeked G... NP_497979 122 --------IGKDVSRTFPEIEFFQ-------------------------------------------------------- 137 nematode XP_506113 466 --------AECDAKKDGDDDNYDKDefgf--------------------------------------------------- 486 Yarrowia lipoly... NP_001023164 223 qnadtfrqINIDIPRMCPLIPLFQQk------------------------------------------------------ 248 nematode XP_002642394 592 --------IDKDVERCDRNLMFF--------------------------------------------------------- 606 Caenorhabditis ... NP_510095 121 --------IDKDVRRLYPEIQFFQLlsrfphqhgmkyplsrrvinhqelhsqefganrdgivgcvktniakqsqdenqap 192 nematode 2G77_A 110 --------IEIDIPRTNPHIPLYQF------------------------------------------------------- 126 baker's yeast
3QYE_A 124 ----------------------------------Q------------------------------------LGAGQLSLY 133 human EDN63937 354 ----------------------------------K--------------------------------------SVQNSLQ 361 Saccharomyces c... EDN60130 469 ----------------------------------NtidglppppqqlpanennstspesandesddaddgvRNPHLIHLQ 514 Saccharomyces c... XP_003265326 180 ----------------------------------E------------------------------------N--VRKILT 187 White-cheeked G... NP_497979 138 -----------------------------------------------------------------------NTSIRQMMS 146 nematode XP_506113 487 ------------------------------ssqiN------------------------------------SNIHLIQLR 500 Yarrowia lipoly... NP_001023164 249 -------------------------------------------------------------------------mVQEMFE 255 nematode XP_002642394 607 ----------------------------------S------------------------------------NKDNLESLR 616 Caenorhabditis ... NP_510095 193 nsefhwhqffeysykfsqeslvfrkncfnlmpniL------------------------------------NQFIIKIVE 236 nematode 2G77_A 127 ----------------------------------K------------------------------------S--VQNSLQ 134 baker's yeast
3QYE_A 134 NILKAYSLLDQEVGYCQGLSFVAGILLLHM-----------------------------S-------------------- 164 human EDN63937 362 RILYLWAIRHPASGYVQGINDLVTPFFETFlteylppsqiddveikdpstymvdeqitdL-------------------- 421 Saccharomyces c... EDN60130 515 NILITYNVYNTNLGYVQGMTDLLSPIYVIMk----------------------------E-------------------- 546 Saccharomyces c... XP_003265326 188 DVLFCYARENEQLLYKQGMHELLAPIVFVLhcdhqaflhasesa-qpseemktllnpeyL-------------------- 246 White-cheeked G... NP_497979 147 DILLVYAKEHPFVNYRQGMHEILAPLIFVIy----------------------------Sdneafqhakendelkmltve 198 nematode XP_506113 501 DMLITYNQHNKNLGYVQGMSDLLSPLYVVLq----------------------------D-------------------- 532 Yarrowia lipoly... NP_001023164 256 RILYIWAIRHPASGYVQGINDLVTPFFVVF-------------------------------------------------- 285 nematode XP_002642394 617 RVMYTYVRRNLEEGYTQGMCDLLAPLLVTFe----------------------------D-------------------- 648 Caenorhabditis ... NP_510095 237 RILFIYAKLNPGVQYVQGMNELVAPIYYVFandadd------------------ewaayA-------------------- 278 nematode 2G77_A 135 RILYLWAIRHPASGYVQGINDLVTPFFETFlteylppsqiddvkikdpstymvdeqitdL-------------------- 194 baker's yeast
3QYE_A 165 --------------EEEAFKMLKFLMFDMGLRKqYRpdmi-------------------------ilqiQMYQLSRLLHD 205 human EDN63937 422 --------------EADTFWCLTKLLEQITDN--YIhgqp-------------------------gilrQVKNLSQLVKR 460 Saccharomyces c... EDN60130 547 --------------EWKTFWCFTHFMDIMERNF-LRdqsg--------------------------iheQMLTLVELVQL 585 Saccharomyces c... XP_003265326 247 --------------EHDAYAVFSQLMETAEPWF-STfehdgqkgketlmtpipfarpqdlgptiaivtkVNQIQDHLLKK 311 White-cheeked G... NP_497979 199 eedilnclfckeylEQDSYNLFCSVMLEVSRWY-EEptvtespkrpipkep---ymrvqdsapasrlmeDLIDIGNLLHE 274 nematode XP_506113 533 --------------DTLAFWAFSAFMERMErnylrd---------------------------qsgmrnQLLCLDHLVQF 571 Yarrowia lipoly... NP_001023164 286 --------------LSEFIPQDVEVGSFDVSQL-Pleqcq-------------------------lieaDSFWCVSSLLD 325 nematode XP_002642394 649 --------------EALTLECFSILMIRQRGKF-Pqrpg---------------------------mskCLLNLRSLIQV 686 Caenorhabditis ... NP_510095 279 --------------EADTFFCFQQLMSEVKDNF-IKkldd-------------------------sncgIESSMSAFHNL 318 nematode 2G77_A 195 --------------EADTFWCLTKLLEQITDN--YIhgqp-------------------------gilrQVKNLSQLVKR 233 baker's yeast
3QYE_A 206 Y---HRDLYNHLeE-HEIGPSLYAAPWFLTMFASQFPLGFVARVFDMI--FLQ-----G--T--EVIFKVALSLLGSHKP 270 human EDN63937 461 I---DADLYNHFqNe-HVEFIQFAFRWMNCLLMREFQMGTVIRMWDTY--LSE-----T--S--Qevtssysmssndikp 525 Saccharomyces c... EDN60130 586 M---LPELSEHLnKc-DSGNLFFCFRMLLVWFKREFEMEDIMHIWENFwtFYY-----S--S--QFQLFFMLAILQKNSQ 652 Saccharomyces c... XP_003265326 312 H---DIELYMHLnR-LEIAPQIYGLRWVRLLFGREFPLQDLLVVWDAL--FAD-----GlsL--GLVDYIFVAMLLYIRD 378 White-cheeked G... NP_497979 275 I---DPTLAKHLs-tLDIPPQLYGIRWLRLLFGRELPLHDLLFLWDVL--LID-----R--PiaPLAKCMFVSLLVQIRH 341 nematode XP_506113 572 M---LPSLYKHLeKt-ESTNLFFFFRMLLVWFKRELLWDDVLRLWEVL--WTDy---lS--S--QFVLFVCLAILDKHKD 638 Yarrowia lipoly... NP_001023164 326 S---IQDNYTFAqPg--IQRKVLQLRHLMSRVDRPLHKHLESNGIEYL--QFA--------F--RWMNNLLMREIPLRAT 388 nematode XP_002642394 687 V---DPQIYGLIaDidYAQALSFAFRWFLLDFKRELSYECTYKVWEVI--WAAqrlriT--N--DFSIFFGLATITNYHD 757 Caenorhabditis ... NP_510095 319 IstfDTELHKHLtLtLEIKPQFYAFRWLSLLLSQEFPLPDVITLWDAL--FSDp---qR--F--ALLQYVCLAMMELKRE 389 nematode 2G77_A 234 I---DADLYNHFqNeH-VEFIQFAFRWMNCLLMREFQMGTVIRMWDTY--LSE-----T--S--Qevtssysmssndikp 298 baker's yeast
3QYE_A 271 LIL 273 human EDN63937 526 pvt 528 Saccharomyces cerevisiae YJM789 EDN60130 653 AIL 655 Saccharomyces cerevisiae YJM789 XP_003265326 379 ALI 381 White-cheeked Gibbon NP_497979 342 LLL 344 nematode XP_506113 639 VMI 641 Yarrowia lipolytica CLIB122 NP_001023164 389 IRL 391 nematode XP_002642394 758 VLI 760 Caenorhabditis briggsae NP_510095 390 PLI 392 nematode 2G77_A 299 pvt 301 baker's yeast
Jiyao W et al.(2023). "The conserved domain database in 2023.",