4NPX,4U12


Conserved Protein Domain Family
DUF2018

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pfam09442: DUF2018 
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Domain of unknown function (DUF2018)
Acid-adaptive protein possibly of physiological significance when H.pylori colonizes the human stomach, which adopts a unique four alpha-helical triangular conformations. The biologically active form is thought to be a tetramer. The protein is expressed along with six other proteins, some of which are related to iron storage and haem biosynthesis.
Statistics
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PSSM-Id: 430614
Aligned: 16 rows
Threshold Bit Score: 69.2328
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4NPX_A         36 FNKTPKEKFIEIIQNGNLGALEKVFEEFFADHIAXVELLEKQ-GLT---EXDVKNFILE--NGDFIEERQNDIYIELGAK 109 Campylobacter ...
CBG40521        8 LQGDPLQKWREIVFHANRNIAEKQLDLLLTRVAIVEKILQEA-DLEerySKLRRQLGGDqeLQSEIHARKVDLAIESMAS 86 
Q7VFF4          5 FEGTPLQKWQEIILNASPTLVGLELEALLERIAVYEALLEHQ-GIDi--ESAFVNYRFDetHKEALRVAKDNLAIESMAK 81  Helicobacter h...
EFR46876        6 FEGSPLQKWQEIIRNASPTLVGLELERLLERVVVYEALLEQK-GVDv--DKAFKAYYFDetRKEEIESGKQNLAITSMAT 82 
WP_013890330    9 LAGDPIQKWGDVILHASSKRTREELERLLEAQALCEILLEDL-GLQdkfSALLKQQHVDgaLQERVQAKKMDLAIQSMAL 87  Helicobacter b...
4U12_A         10 FEGNPLDKWNDIIFHASKKLSKKELERLLELLALLETFIEKE-DLEekfESFAKALRIDeeLQQKIESRKTDIVIQSXAN 88  Helicobacter p...
WP_006656961    5 FEGLPQDKWTEIVLNASHSSSSVELRRILERLAAMEILLEKR--LGetwEEELQYLLSSeeVSEEIHTHTQNLAIESMGN 82  Helicobacter c...
Q7MR83          8 FEGTPEERWLEILFHANRTLAQNELLFLLERLSLLEHSLDS---LDpswEERLKAq----eNLSEVKKKMGSLAIESMGR 80  Wolinella succ...
WP_012082399    9 LGGSPKSRFLDIVFHANRNVVEKELEEIMEWMAALELIVEQKcGMDv--EKEVRNILFDdsKKKDLENKVNSLYIEYMGK 86  Nitratiruptor ...
jgi:Saut_0902  14 FGGSPRSKFMDVVFNANNDIVRQELENFIEKAATMELMLEEQlGEDv--DDAIARYKNS--HLDDVNTKTKSIFVEIMGS 89 
4NPX_A        110 ILG-HE 114 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819
CBG40521       87 ILSeNE 92 
Q7VFF4         82 ILGnYE 87  Helicobacter hepaticus
EFR46876       83 ILGnYE 88 
WP_013890330   88 VLSgHE 93  Helicobacter bizzozeronii
4U12_A         89 ILSgNE 94  Helicobacter pylori 26695
WP_006656961   83 ILTqNE 88  Helicobacter canadensis
Q7MR83         81 ILSqNE 86  Wolinella succinogenes
WP_012082399   87 ILSqSE 92  Nitratiruptor sp. SB155-2
jgi:Saut_0902  90 ILSqSE 95 
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