Conserved Protein Domain Family
SNAPC2

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pfam11035: SNAPC2 
Small nuclear RNA activating complex (SNAPc), subunit 2
This family of proteins is snRNA-activating protein complex subunit 2 (SNAPc subunit 2). The SNAPc complex allows the transcription of human small nuclear RNA genes to occur by recognition of the proximal sequence element, the TATA box. The family functions both to specifically recognize the proximal sequence element present in the core promoters of human snRNA genes and to stimulate TBP recognition of the neighbouring TATA box present in human U6 snRNA promoters.
Statistics
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PSSM-Id: 463210
Aligned: 25 rows
Threshold Bit Score: 201.121
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
CDQ63997       3 PPSRSRIQPTRYVnkktektaskrkpkFACTG---WSRTEQQVLLRCLNKqnkmtggIHGA---IDLEALHEKLPKQSRE 76 
XP_001376853   3 PPLRRRAAPARYRglapaa----------vrtgslWTPREKQQLLRLLQA--------LDGetePAAAELRQGLPHRSEA 64 
GCF44566       3 PPSRRRSVPARYAldsv---------------vhaWSDREKRRLLRALRA---------HGegpLRPELLKKYLPGREEA 58 
XP_001923727   3 PPRRQRTVPSRFhktpeqe--qidsarSLCKG---WNRKDLHSFLQALKQqqd----fesE---IDLTEIQKKIPQRSLK 70 
XP_010903962   3 PPSRLRIKPTRFVskktdntgtkrkpkIAFTG---WSRTEQQILLRCLNSqskktagIHGA---IDLEALHAKLPKRSTE 76 
XP_008326430   3 PPPRFRVKPVTCVlkek--------------kenkWQLREQKELIAALKIlksrhesTTED---IDYGFIAERLPNRSES 65 
XP_007532915   3 PPPRRRAIPARYL--------------GETTRppaWSAREKRQLLRLLQA-------RREQp-ePDAADLARELPGRSAE 60 
XP_004080053   3 PPPRKRGKPNRPTptegpr-----------kpprrWNKTEEKTLLNALQKlgr-talADGDtdnIDYSFLGKRLPKRSVA 70  Japanese medaka
XP_020512177     --------------------------------------------------------------------------------     ballan wrasse
XP_016535005     --------------------------------------------------------------------------------     Amazon molly
CDQ63997      77 EIQSQLESLMMHVLRAVVGQV-----KKQRSEQKAALKPIQLWAELAHDMAG-ALEEPITSAFAQMLVISATEPGSLTNS 150
XP_001376853  65 EIQDFLQSLKRRVAREVIQQEhrccqKEQRLHKTQVPAPIEVWTDLAEKVTS-QLEEAMTTAFSQILTIAATEPVSLLHS 143
GCF44566      59 EILVYVQLLKERVAREAVKAQyq--sLKHQRQKGPTPAPIEVWTELAEKLTG-SLQNSTTTAFSQVLTVASTEPLSLLHS 135
XP_001923727  71 QIENLINKVKLRVLQKVFKQV-----KSQRKKERKAKVPIETWGEMVQKIST-SHGKTISAAFSQMLVVAATEPCSLMHS 144
XP_010903962  77 EIQSQLECLMMRVLRSVVIQV-----KSQRSEQKVAMKPIQQWAELAHDMAG-ALEEPITSAFAQMLVISATEPGSLKNS 150
XP_008326430  66 EIQSCIESLTNKVITIASTTV-----KQQQAGKETAKQPIEGWTCLASQIAG-TLEESISSAFSRMLTVSSTEPLTLKNN 139
XP_007532915  61 EIQTFIELLKSRVVREAIKRLrp---gSPPPEDRQTPAPIEVWLDLAEKLSGpPLEEALSTAFSQVLTIAATEPLSLLHS 137
XP_004080053  71 EIRSVVDALKDKAISSAALKL-----RRRKRDEKVARKPIEEWANLASTLAG-SLEGTVDAAFSQVLIVSSTEPCTLRNC 144 Japanese medaka
XP_020512177   1 -----------------------------------------------------mkllsglkrqsrttmgagdldprdlkk 27  ballan wrasse
XP_016535005   1 -----------------------mkppprnrtkrelsswtetpkscrktnckwerpelkrllkglkalsqttrgglqeid 57  Amazon molly
CDQ63997     151 DPPREdylpkqqrsnfktipprpiptpispktlapsgv-------------------------------skspivfnias 199
XP_001376853 144 IPEKP--------------------------------------------------------------------------- 148
GCF44566     136 VPPKPvktq----------------------------------------------------------------------- 144
XP_001923727 145 EPPHPvtqtpvfsrlypahtpnttsrptts-----------------------------------------------gvs 177
XP_010903962 151 DPPREgyiskpqssnlktiparpi-------------------------------------------------------- 174
XP_008326430 140 VPLQIinedtdqdntclpvpgspsgtsytdppmlheypslnspigegqngrnslasqvpsaashledsetctpqflnpvs 219
XP_007532915 138 KPPKT--------------------------------------------------------------------------- 142
XP_004080053 145 DPPRDnksstsfgppvrivplkpasrpptpvfskspa------------------------------------------- 181 Japanese medaka
XP_020512177  28 siktrsvqeiqsevdslkdkvissasfeferrrrqerkvkkpielwtdmassvtgsleetintafaqmlvvssteprtlr 107 ballan wrasse
XP_016535005  58 yavlkkdiptrsiseisamvdslknniissarfqlrmknwqekqfrrpieewthmastlagtlekvisaafsqmlvvsst 137 Amazon molly
CDQ63997     200 tpqpppavsgvpatqpstmnpgSGaskqrGRTTTPAsTVGALPQPGCSnssILsqiqegsaistlltvpmpvqslsasls 279
XP_001376853 149 ----------------------TQ-----ASERQLL-CKDSNPQEELPpeaP---------------------------- 172
GCF44566         --------------------------------------------------------------------------------    
XP_001923727 178 psssvstasavsfirpdssssaAGhigksDTVSSSLhQEPVMPEASTp----T--------------------------- 226
XP_010903962 175 ----ptpvsvtppahpralnspTGaiskyGGNTs----------------sIPsth------------------------ 210
XP_008326430 220 patdsafevepqsihitqdgskQPsg-ttSDLSPSSsPH---AAVPSSat-iV--------------------------- 267
XP_007532915 143 ----------------------TK-----AREPQLF-LSAPAGQKEAT---AQtdgpapgvpgpape------------- 178
XP_004080053     --------------------------------------------------------------------------------     Japanese medaka
XP_020512177 108 ncdppniqrqtsdqsrpvgrtvpprpifrptplagvfspaptllvlktpaptmgparrlpapskvllvpllqgepstktg 187 ballan wrasse
XP_016535005 138 epctlrncepkqdprpaaacrpvpcvgehpsavlliapapagsgnrrrpapsqavrtptrrilprqerpavpstaaastl 217 Amazon molly
CDQ63997     280 gptttlqsqsvaqggahgqtmsnvpsAQLAVTSSPaPADVskqqqpSAa-----------------------------AS 330
XP_001376853 173 ------------------------------------------------------------------------------KP 174
GCF44566     145 ---------------------------------------------------------------------------qcsSP 149
XP_001923727 227 --------------------------SSSSQSQSEaEAAVsspvssRP------------------------------SP 250
XP_010903962 211 ------------------------qsNHPTVTVSPvAGDVstrqlpLAasgssa-------------------ssgpaAA 247
XP_008326430 268 --------------------------TPYSNTSPSsSVTSsssapfNSstqavp-------------------tsptlQR 302
XP_007532915 179 ------------acgsthgapgpaleSSGPAPGAP-GPALessgpaPGapgptlkfsgptpgapgpalessgpapgapGP 245
XP_004080053 182 -----pstgpsrtlpapsptprvpqnvvrppqekpgtPSPttpdppASpsseiq-------------------tgpppSP 237 Japanese medaka
XP_020512177 188 asaapllsdsrycippaclqdprhpgypgyrtchtqsesaaggtitqkpseqqissppssapspaaspsisslistlatk 267 ballan wrasse
XP_016535005 218 ltgcptpaapllsetlpafvsprslkpltpsasgsvsaaaqsavvlcLpvssfs-------------------sphstVP 278 Amazon molly
CDQ63997     331 SIRPQPQ----HPgagprkskhadentprytGLGSIVDFEKIYRFLSMVHVQSECFKLTPMESAIILDLLMSLPEELPLL 406
XP_001376853 175 TQEASCG----VPgtcdtevktshsecssatNRNFVIDFEKIYKYLSSISRSGKGLELSPGESAVLLDLLMSLPEELSHL 250
GCF44566     150 SAHNERR----ENsa---------------eEQGFHVDFESIYKYLSMLSRGSKAPELSPAEAAVVLDLLLSLPEELVFL 210
XP_001923727 251 STSSNKP----SPislellghd---ypckprimKSVVNFDKIYAYLSDMDSKTCSSALSSMECAVLLDLLMCLPEELPLL 323
XP_010903962 248 GARPTHQ----HTsagprrskhadgntprytGLGCIVDLEKIYRFLSTIHIQSECFKLTPMESAVVLDLLMSLPEELPLL 323
XP_008326430 303 ASNKRVN----SKrkkdv---------sktcTDKRAVNFENIYRYLSVTDKPDEKCHLTPMESAIVLNLLMSLQEQLSLL 369
XP_007532915 246 APESSGP----AL------------------PGPLTVDFEKIYKYLASVSRGNQGPELSAAEAAVVLDLLQALPQELPRL 303
XP_004080053 238 DIPSASTsalaQPsssdagseqkapnpqrvmEVKQIVDFERIYKFLSVVHKPEEESRLTSMESAIVLDLLMSLPDELPLL 317 Japanese medaka
XP_020512177 268 ptppppsspaaalpaglgrscmlkedspriiGVKCVVDFERLYRYLSVILKPDEECHLTPMEGAIMLDLLMSLPEELPQL 347 ballan wrasse
XP_016535005 279 LSNTAAE----LPatsgqsskhaavdgpetvGVNFAVDFEKIYKFLSVVQNPSKDYNLTPMESAIVLDLLMSLPEELHYL 354 Amazon molly
CDQ63997     407 DCARLQHHLLQ----V-------------------------------------------Herfsapvpkvtqegtgtgrp 439
XP_001376853 251 PCEKLQTHMASsyrkL-------------------------------------------V-------------------- 267
GCF44566     211 DIMKLKNHMYKcyaeL-------------------------------------------Nghya---------------- 231
XP_001923727 324 DCKGLQHHLLQ----L-------------------------------------------Hsqlsk--------------- 341
XP_010903962 324 DCARLQHHLLE----V-------------------------------------------Hkrfsapvpkaaqgrictgks 356
XP_008326430 370 DYTAFHKHLTQ----I-------------------------------------------Tklfkslr------------- 389
XP_007532915 304 PCGALTEHLLDayahL-------------------------------------------T-------------------- 320
XP_004080053 318 DCNGLHNHMMK----M-------------------------------------------Yscltasadsvaatqll---- 346 Japanese medaka
XP_020512177 348 DCKELQKHLKQ----VyqslsssadsmtardvlkdlqgqlstptespaaperdesdaqqNltdahsdgva---------- 413 ballan wrasse
XP_016535005 355 DCKNLQKHLIQ----M-------------------------------------------Hqslsaphcsmpakqlmsklk 387 Amazon molly
CDQ63997     440 wssaagdqrrqdgatdggailvavttppsldagdkvga------plqvqqgsqveggrgvaisgmpdglgsdgmectstn 513
XP_001376853     --------------------------------------------------------------------------------    
GCF44566         --------------------------------------------------------------------------------    
XP_001923727     --------------------------------------------------------------------------------    
XP_010903962 357 tslneegtkaedqgrpvghrggndegetpvttpphqavrdaavapletlpkspvdgeqdvsirgmpdgqgsdgaessltn 436
XP_008326430     --------------------------------------------------------------------------------    
XP_007532915     --------------------------------------------------------------------------------    
XP_004080053     --------------------------------------------------------------------------------     Japanese medaka
XP_020512177     --------------------------------------------------------------------------------     ballan wrasse
XP_016535005 388 t------------------------------------------------------------------------------- 388 Amazon molly
CDQ63997     514 qgvaatvvpanlvagcsnsvakDGavplqgSTEeRAGTETVAPSQDNGQAQGQTPTtndTSAKSGTATQR--KSD----- 586
XP_001376853 268 ----------------------RPqagsspGHSdPGQAPTVEDDEDGTSTSNGPGRmgsPSPESPASSGLncPRDtlpsg 325
GCF44566     232 ------------------gerrTQadssqsNNSsRDSCHMSLPVYQITNCHPQHKEfasSTDAPSAEAPEasVMD----- 288
XP_001923727 342 -------------------------------ptvkpESYSNGPLSGEANSSTSAQKpsaAAGSSEKHGPVkdSED----- 385
XP_010903962 437 qdaastaasgnlvagcsdfsaeDGaalapgSTQeRVGSETFTPLQASGHDQGQPLLpndTSVKSGKAKQR--KAD----- 509
XP_008326430 390 ----------------krvdaqRDkkssgsSITtVDDDNIVGTDDSAGATDGGHQHltdGHSSETDATSDsdEAD----- 448
XP_007532915 321 ----------------------AP------QPH-LDMGSPEPGSEDAGAPSQAPEDt--------------gPGApg--- 354
XP_004080053 347 -------selkdggggqtgeqrDEassgtaAEEvQPP--------------------------AGSSSSQsqDSN----- 388 Japanese medaka
XP_020512177 414 ------------pqpqdaesqsSEssna----------------------------------------tsqqDAD----- 436 ballan wrasse
XP_016535005 389 ---------------------------------vrhdergpaptgdpsqrcsqEAEtgdAAGRGATSSGQseDAD----- 430 Amazon molly
CDQ63997     587 ----WEKAGLCPLNPFMVPLKLLARkQIQSLD 614
XP_001376853 326 qqqlWQELEFCPLNPFLIPLELLSRaAPPEGL 357
GCF44566     289 ----WKTLGICPLNSFLLPLDILARkEMNLDR 316
XP_001923727 386 ----WASAGICPLNPLSVPVTLLKRkSVDCDK 413
XP_010903962 510 ----WKKAGLCPLNPFVVPLKLLARrTVQPVE 537
XP_008326430 449 ----LLELF-PPLNPFVVPVTLLRRkNLTSAT 475
XP_007532915 355 --taWQATGVCPLNPFLVPLGLLGQ-VDTPVR 383
XP_004080053 389 ----QCKTV-PPLNPFMVPLSLLVRkAENTDG 415 Japanese medaka
XP_020512177 437 ----VPGVC-PPLNPFMVPVKLLKCrKVPLQT 463 ballan wrasse
XP_016535005 431 ----MSDFL-PPLNPFLVPLSLLMRkesse-- 455 Amazon molly
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