1QKQ,1A3K,3GAL,1QMJ,1A78,1GAN,1C1L,1SLT


Conserved Protein Domain Family
GLECT
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cd00070: GLECT 
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Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may be involved in differentiation, cell-cell interaction and cellular regulation.
Links
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Statistics
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PSSM-Id: 238025
Aligned: 91 rows
Threshold Bit Score: 74.9779
Created: 1-Nov-2000
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:sugar binding pocket [chemical binding site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                            # # #                # # 
1QKQ_A      7 PYTEAA----SLSTGSTVTIKGRPlvcf-lnepYLQVDFHTEmke----esdIVFHFQVCFGr-----------RVVMNS 66  human
NP_503154 153 PFVSSIv--gGLFAGRAIVVSGMVlpgfasdrkRFQIDLCCGllidgdhmdnKALHFNPRFDaktgwfsgpgddKLVINS 230 Caenorhabditis ele...
7508735     8 GVPTALsifePLQDGSTISVHGHVrhg---hhkNFAVELLSGp--------nVVLHVNFRFHhe---------hVVVMNS 67  Caenorhabditis ele...
NP_509649  10 PSAHAIr--eQLRAGSEIHVRGHVthk---hhkDFSVELLSGp--------hIVLHVNFRFEhd---------hIVAMNT 67  Caenorhabditis ele...
NP_611349   4 EFAGNLs--hPLEFGHVLEVVAKTidg----aaRFHINLCTAkstvd-pnadIGLRFSCYFRn----------dVIVRNS 66  fruit fly
7496156    13 TFALPF----GVRSGLQIAVNGLVkh-----kkDFVVNLISGg--------nIALHVNFRFEkq---------kIVAINA 66  Caenorhabditis ele...
NP_608487 135 VPKYFNdqigKLSEGISFTVTGNLsvn----ceRFSINLVYNnds-----rdVALHINPRLPq----------nYIVRNT 195 fruit fly
Q09605      9 VPSVYQie-eNLKAGVEIEVNGAVlhg---ndrDFAIELLSGt--------nIVLHVKFEFNge---------hSIVLNS 67  Caenorhabditis ele...
AAF51563   78 HRRKHFkviqCPRPGLCFVFHGMIlma----ceHFVIDFLTKqgseiceecdVLLQIGSRLPq----------nYITRNS 143 fruit fly
NP_611349 162 KAFSNDqp-iLFSPGHVIVLTARCfen---kkgQFIIKFMDSdt------krEELHFSVRFDe----------kAVVRNS 221 fruit fly

Feature 1           #  # #                                                                    
1QKQ_A     67 REYg-AWKQQVESk------nMPFQD--GQEFELSISVLPDKYQVMVNGqsSYTFDHRIkp---eaVKMVQVWRDISLTK 134 human
NP_503154 231 FVSg-RWGNEERFd-------NPFKE--GEPFQIRIMVFEKYFKISASGkhMCDFPHRVpv---esIRTISINGNIRVDY 297 Caenorhabditis ele...
7508735    68 QFSg-MWGPEIRHk-------NPLHH--SEHFHLSIKVHAGYYHISVNGhhLADYPHRYpy---qsVQAIGLKGDVHVDK 134 Caenorhabditis ele...
NP_509649  68 CTNg-AWGAEIRHh-------NPLKH--HDHFNLSIHVHEGYYHISVNGehLADFPHRFpv---esVQAIGLKGAAHIDE 134 Caenorhabditis ele...
NP_611349  67 RINg-AWGEEESHvmdpntlpNPIVS--GEFFLVYILCCEDSFAISINSreFCRFRYRMpl---gtIRALEIRDQIQVIK 140 fruit fly
7496156    67 KIDn-AWGNEISHa-------NPLHH--DQAFDLQIRVYPGYFHITTNGvlLGDFPHRLpf---esIQAINLEGKVHINN 133 Caenorhabditis ele...
NP_608487 196 KVQd-IWGNEEVSs------aLPFLLsrGEEFSIQVLVTEACYMISVNGqhFAAYTHRIpy---rdVRILEVKGDVSNVE 265 fruit fly
Q09605     68 LINg-EWGPQLRHs-------HFLKR--HDPFHVRIYVHEGYYNITVNSdlLVEFDHRFpv---vaVQGIGIKGSVDIES 134 Caenorhabditis ele...
AAF51563  144 RLKg-KWGPEENSsy----ltFQLNR--GKSFWMQILLTEECFFISVNGyhFAKYFHRMpyrwleaVDVLGDVSDIVIDT 216 fruit fly
NP_611349 222 MNKnfDFGSEERHg------gFPFVF--NQQFKLALAFTEREVLTAVDGynFFSYTWRTpn---amMNLVGFKVTSINGL 290 fruit fly

Feature 1       
1QKQ_A    135 FN 136 human
NP_503154 298 VE 299 Caenorhabditis elegans
7508735   135 VH 136 Caenorhabditis elegans
NP_509649 135 IS 136 Caenorhabditis elegans
NP_611349 141 QV 142 fruit fly
7496156   134 VQ 135 Caenorhabditis elegans
NP_608487 266 MK 267 fruit fly
Q09605    135 IV 136 Caenorhabditis elegans
AAF51563  217 YY 218 fruit fly
NP_611349 291 VV 292 fruit fly

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