Conserved Protein Domain Family
nifV_homocitr

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TIGR02660: nifV_homocitr 
homocitrate synthase NifV
This family consists of the NifV clade of homocitrate synthases, most of which are found in operons for nitrogen fixation. Members are closely homologous to enzymes that include 2-isopropylmalate synthase, (R)-citramalate synthase, and homocitrate synthases associated with other processes. The homocitrate made by this enzyme becomes a part of the iron-molybdenum cofactor of nitrogenase. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other, Central intermediary metabolism, Nitrogen fixation]
Statistics
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PSSM-Id: 274248
Aligned: 14 rows
Threshold Bit Score: 483.709
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q07179        7 LALCDTTLRDGEQTAGVAFSLAEKKAIARALDRAGVAEIEVGIAAMGWAEVAEIRAVVAEIAHATPVVWCRLRMHDLDMA 86  Rhodobacter caps...
P05345        4 VLINDTTLRDGEQSPGVAFRTSEKVAIAEALYAAGITAMEVGTPAMGDEEIARIQLVRRQLPDATLMTWCRMNALEIRQS 83  Klebsiella pneum...
Q52070       18 VIINDTTLRDGEQSPGVAFRASEKLEIAQALVNAGVRELEAGTPALGEEECVRLAILRRQLPDTVMMSWCRMNSAEIHDS 97  Pantoea agglomerans
P05342        4 VIIDDTTLRDGEQSAGVAFNADEKIAIARALAELGVPELEIGIPSMGEEEREVMHAIAGLGLSSRLLAWCRLCDVDLAAA 83  Azotobacter vine...
CAE30047     22 IVLNDTTLRDGEQAPGVAFSTAEKVAIARALARAGVPEIEAGTPAMGVDEIAAIRAIVEAGLPLTTIAWCRMRTEDVDAA 101 Rhodopseudomonas...
P54610       22 VRFCDTTLRDGEQAPGVAFTAAEKLAIAGALDAIGVHQIEAGIPGMGVTERDVLREILATDPKAEIVGWCRADHRDVEAA 101 Frankia sp. FaC1
AAR34264      9 VIIDDTTLRDGEQTAGVVFSKKEKIAIARMLDSIGVRELECGIPAMGEDERAAVRALVDLGLSARLITWNRALVADIQAS 88  Geobacter sulfur...
Q8RCF9        9 VYIVDTTLRDGEQTAGVVFANNEKIRIAQMLDEIGIDQLEVGIPTMGGDEKETVAKIAKLGLKASIMAWNRAVVKDVQES 88  Caldanaerobacter...
Q44290        4 VLINDTTLRDGEQAAGVVFTLEEKVAIAKFLDTIGVPELEVGIPAMGEEEMRAICAISNLGLKANLLAWNRAVISDIKAS 83  Nostoc sp. PCC 7120
tigr:CT1528   5 PWIIDTTLRDGEQAPGVVFSPHEKKRIAAMLAETGVDEIEVGYPAISAAERKVIREIVAMKLPVRLTSWSRANMADIELA 84  Chlorobium tepid...
Q07179       87 QKTGVKRVHFAVPTSTAQLEGKLRVDRDWILRETAALVFCASDRGLQVSVGAEDASRTDPDFLIRLAEVAAAAGAIRFRI 166 Rhodobacter caps...
P05345       84 ADLGIDWVDISIPASDKLRQYKLREPLAVLLERLAMFIHLAHTLGLKVCIGCEDASRASGQTLRAIAEVAQNAPAARLRY 163 Klebsiella pneum...
Q52070       98 ARVGMDWVDISVPASDLLREQKLHRPWPAVIASLKPLVQLAHRLGMRVCMGCEDASRSADETLHMLAEVAADLGIERMRF 177 Pantoea agglomerans
P05342       84 RSTGVTMVDLSLPVSDLMLHHKLNRDRDWALREVARLVGEARMAGLEVCLGCEDASRADLEFVVQVGEVAQAAGARRLRF 163 Azotobacter vine...
CAE30047    102 LKAGVAMVNVSVPVSDVQIAAKLGGKRSNAIETVKRVVGYARDRGLDVAVGGEDSSRADPEFLAEVIATAKASGARRFRI 181 Rhodopseudomonas...
P54610      102 ASCGLVTAHLTIPVSDLHLKSKLERDRAWARRRVRDCVVDGTDRGMRVSVGFEDASRADDAFVTDLAGELRDVGVTRLRW 181 Frankia sp. FaC1
AAR34264     89 IDCGITAVDISLSVSDQMIAHKLRKDRRWVKEQLRHSLGFAKEKGLYVSVGGEDSSRADLLFLVELMEVARDMGADRFRF 168 Geobacter sulfur...
Q8RCF9       89 LECGVDAVAISISTSDIHIEHKLKKTRQWVLDSMTEAVRFAKKEGVYVSVNAEDASRTDMNFLIEFARCAKQAGADRLRF 168 Caldanaerobacter...
Q44290       84 VACGMERVHIAIPVSGIQIAAKFHGQWRVSLQRLKDCISFAVDQGLWVAVGGEDSSRADENFLLDVALYAQEWGASRFRF 163 Nostoc sp. PCC 7120
tigr:CT1528  85 AECGTDAVHISFPASRLYLELIHKKD-DWIQEQLHALVSKARERFDFVSVGGQDATRSSTDFLQRFMLDAEAAGAKRFRI 163 Chlorobium tepid...
Q07179      167 ADTLGLLDPLGAFRLVAELSARI-SLPIEMHAHNDFGMATANTIMAAHAGATHLSVTVNGLGERAGN-AACEEVGAAL-E 243 Rhodobacter caps...
P05345      164 ADTVGLLDPFTTAAQISALRDVW-SGEIEMHAHNDLGMATANTLAAVSAGATSVNTTVLGLGERAGNaAAWKPSALGLeR 242 Klebsiella pneum...
Q52070      178 ADTLGILDPFSTFTRISALRQHW-HGGLEIHAHNDLGMATANTLAAVRAGATHVNTTVLGLGERAGN-AALESVTLSLdR 255 Pantoea agglomerans
P05342      164 ADTVGVMEPFGMLDRFRFLSRRL-DMELEVHAHDDFGLATANTLAAVMGGATHINTTVNGLGERAGN-AALEECVLALkN 241 Azotobacter vine...
CAE30047    182 ADTLSVLDPFSSHALLATLRAST-DLELEFHGHDDLGLATANTLAALRAGASHASVTVIGLGERAGN-APLEEVAVALkQ 259 Rhodopseudomonas...
P54610      182 ADTVGLLDPVSAYDRLGRLVRAV-PGPWEIHAHDDFGLATANTIAAVQAGFTWVSTTVLGLGERAGN-APIEEVAMALrH 259 Frankia sp. FaC1
AAR34264    169 CDTLGILDPFTMYEKVRTLRTAVpELDIEVHTHNDLGMATANAIAGIKAGARFVNTTVNGLGERAGN-AALEEVVMALkL 247 Geobacter sulfur...
Q8RCF9      169 CDTVGFLDPFKTYEMVKAIKDAV-DIEIEMHTHNDFGMATANALAGVKAGAKFVGVTVNGLGERAGN-AALEEVVMALkY 246 Caldanaerobacter...
Q44290      164 CDTVGVLDPFTTYGKVKLLVSAL-TIPVEVHTHNDFGMATANALAGIKAGASSVNTTVIGLGERAGN-AALEEVVMAIkR 241 Nostoc sp. PCC 7120
tigr:CT1528 164 ADTVGIATPVSVMALGAALRQSS-SLPLEFHAHNDLGMATANAFTALNEGFEAVSVSVTGLGERAGN-AALEELAMALaL 241 Chlorobium tepid...
Q07179      244 AGGIDTGLDLCALPELSAVVAKASGRAFRA-QKPITGDDwLFAHESGIHVDAILKRADTYEDprCAPARFG-RERQIVIG 321 Rhodobacter caps...
P05345      243 CLGVETGVHFSALPALCQRVAEAAQRAIDP-QQPLVGEL-VFTHESGVHVAALLRDSESYQS--IAPSLMG-RSYRLVLG 317 Klebsiella pneum...
Q52070      256 CLHLDCGIDFTELPALCRLVAAAAGRTIDV-QHPLVGGQ-VFTHESGLHVAALLRDPRSYQG--IDPSLVG-REFNLVLG 330 Pantoea agglomerans
P05342      242 LHGIDTGIDTRGIPAISALVERASGRQVAW-QKSVVGAG-VFTHEAGIHVDGLLKHRRNYEG--LNPDELG-RSHSLVLG 316 Azotobacter vine...
CAE30047    260 LYGRDTGIVLSELGNVADLVATAAARTIPL-NKAIVGEH-VFTHESGIHVDGLLKDQRTYQS--LDPNLFG-RSNRIVIG 334 Rhodopseudomonas...
P54610      260 LLKLPIDLDTTSFRTLAQLVV---GWPLPAgKKAVVGES-VFAHESGIHVHGILRHPATYEP--FDPEVGG-R-RRLTVG 331 Frankia sp. FaC1
AAR34264    248 ACGCDPGIDTQRFHEISRFVGRASQRPVPP-WKAVVGER-VFSHESGLHADGVIKNPLNYEG--FDPAEVG-LRRHIVVG 322 Geobacter sulfur...
Q8RCF9      247 VYKMDLGIDTSRFREISEYVALASGRPLPP-SKAIVGKN-VFAHESGIHVDGALKNPYTYEV--FDPQEVG-LERQIVIG 321 Caldanaerobacter...
Q44290      242 IYGVDMGIDTPRLLELSQLVAAASGANVPP-WKAIVGEN-TFAHESGIHAHGVLQNPDTYEP--FAPEEVG-WERRLVVG 316 Nostoc sp. PCC 7120
tigr:CT1528 242 NGDFDTHLDTSMLSRLCDAVATASGRAIQE-QKPVVGRS-AFQHESGIHCAALLQDPLSYQP--FLPSRVGrSDFEIVIG 317 Chlorobium tepid...
Q07179      322 KHSGSAGLRAALLEAGLPADDAVLDRLKPLLRAHAVRVKR-PVEAGDLRRMV 372 Rhodobacter capsulatus
P05345      318 KHSGRQAVNGVFDQMGYHLNAAQINQLLPAIRRFAENWKR-SPKDYELVAIY 368 Klebsiella pneumoniae
Q52070      331 KHSGRQAVSGICARLGYILSETQTLLMLQEVKRFAEHFKR-NPGEDEVIAMC 381 Pantoea agglomerans
P05342      317 KHSGAHMVRNTYRDLGIELADWQSQALLGRIRAFSTRTKRrSPQPAELQDFY 368 Azotobacter vinelandii
CAE30047    335 KHSGLSAITSSLAKLDLPATADEAQGILAKVRRYAVTHKG-PVGNETLIAIW 385 Rhodopseudomonas palustris CGA009
P54610      332 KHSGRASLRHALEQCGITAEESELEPLVEQVRLAATRHKR-GLDSRDLPGTS 382 Frankia sp. FaC1
AAR34264    323 KHSGTSGLVERFRSMGVELAREEAAELMDEVRAVAQRLKR-PLSDGDLRRLY 373 Geobacter sulfurreducens PCA
Q8RCF9      322 KHSGTAALINKFKEYGRVLTEEEANLLLPHVRKMAIQLKR-PLFDKELMYLY 372 Caldanaerobacter subterraneus subsp. tengcon...
Q44290      317 KHSGRHSVSNLLEQHGIFLNPEETQSVLDAVRQQSIKKKR-SLTTEELLNLV 367 Nostoc sp. PCC 7120
tigr:CT1528 318 KHSGTAAIIAHFNRRGITISKKEARELLDLIRSQSDRLKR-ALRTDEIDALR 368 Chlorobium tepidum TLS
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