3QYE,2G77


Conserved Protein Domain Family
TBC

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smart00164: TBC 
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Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs.
Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases.
Statistics
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PSSM-Id: 214540
Aligned: 35 rows
Threshold Bit Score: 132.43
Created: 12-Jul-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

smart00164 is classified as a model that may span more than one domain.
smart00164 is the only member of the superfamily cl47029
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3QYE_A        56 VGQGVPRHHRGEIWKFLAEQFHLKHQfpskqqP-----------------------------K-------DV-------- 91  human
EDN63937     277 SWNGIPKIHRPVVWKLLIGYLPVNTK------Rqegf----------------------lqrK-------RK-------- 313 Saccharomyces c...
EDN60130     382 HGGLENDSLRGKVWGFLLEIYPWDSS------Q-----------------------------D-------ERvqidqtla 419 Saccharomyces c...
XP_003265326  78 nGQLRSSRFRSICWKLFLCVLPQDKS------Q-----------------------------WisrieelRA-------- 114 White-cheeked G...
NP_497979     37 SGSLRSSSCRSAVWRLVLRCLPYETS------D-----------------------------WeislsrsRN-------- 73  nematode
XP_506113    419 sKLRVDYNRLKKEWWVQEDKERdd-------------------------------------fW-------RD-------- 446 Yarrowia lipoly...
NP_001023164  95 SSVSSTPQTANPIYPKLPEISDQPRS------Avpmasap----------------phggdrD-------QT-------- 137 nematode
XP_002642394 516 FWKQCRAEPTIEEWRVLEAEVRRRDE------EafraararragspvreescevfedpneptC-------SQ-------- 574 Caenorhabditis ...
NP_510095     32 CSYGVPESLRPLAWRLLLHYLPLERH------Kwqtf----------------------laeQ-------RD-------- 68  nematode
2G77_A        50 SWNGIPKIHRPVVWKLLIGYLPVNTK------Rqegf----------------------lqrK-------RK-------- 86  baker's yeast
3QYE_A        92 ---------------PYKELLKQ----LTS---------------------------------Q---------------- 103 human
EDN63937     314 ---------------EYRDSLKHtfsdQHSrd-----------------------------ipT---------------- 333 Saccharomyces c...
EDN60130     420 aeydqlkltwskdflQFDDEDEEeywnDQ--------------------------------------------------- 448 Saccharomyces c...
XP_003265326 115 ---------------WYSNIKEIhitnPRK---------------------------------V---------------- 130 White-cheeked G...
NP_497979     74 ---------------LYRAHKENhlidPHD---------------------------------Tkfsqdpefnnplasie 105 nematode
XP_506113    447 ---------------QLSRIEKDvhrtDRNi------------------------------------------------- 462 Yarrowia lipoly...
NP_001023164 138 ---------------RFARLRRLfsngKSSgknsppvdvdleklre--dcwmgiphklrpqawR---------------- 184 nematode
XP_002642394 575 ---------------HYDRENLIslfrAN--------------------------------------------------- 588 Caenorhabditis ...
NP_510095     69 ---------------NYDQMIEQiivePGTaslqqsaaqnqdndhplsdhptsdwqaffqdnkV---------------- 117 nematode
2G77_A        87 ---------------EYRDSLKHtfsdQHSrd-----------------------------ipT---------------- 106 baker's yeast
3QYE_A       104 -------------Q-----------------------------HA----------------------------------- 106 human
EDN63937     334 -------------W-----------------------------HQ----------------------------------- 336 Saccharomyces c...
EDN60130     449 -------------L-----------------------------FR----------------------------------- 451 Saccharomyces c...
XP_003265326 131 -------------VgqqdlminnplsqdegslwnkffqdkelrSM----------------------------------- 162 White-cheeked G...
NP_497979    106 qnpwntffedndlR-----------------------------DI----------------------------------- 121 nematode
XP_506113    463 ------------------------------------------tFF----------------------------------- 465 Yarrowia lipoly...
NP_001023164 185 -------------L-----------------------------LSgylptnaerrevtlqckrdeywhyveqyfhsrfdd 222 nematode
XP_002642394 589 -------------L-----------------------------HR----------------------------------- 591 Caenorhabditis ...
NP_510095    118 -------------L-----------------------------SQ----------------------------------- 120 nematode
2G77_A       107 -------------W-----------------------------HQ----------------------------------- 109 baker's yeast
3QYE_A       107 --------ILIDLGRTFPTHPYFSA------------------------------------------------------- 123 human
EDN63937     337 --------IEIDIPRTNPHIPLYQF------------------------------------------------------- 353 Saccharomyces c...
EDN60130     452 --------ISKDVRRCDRNLEIFQY------------------------------------------------------- 468 Saccharomyces c...
XP_003265326 163 --------IEQDVKRTFPEMQFFQQ------------------------------------------------------- 179 White-cheeked G...
NP_497979    122 --------IGKDVSRTFPEIEFFQ-------------------------------------------------------- 137 nematode
XP_506113    466 --------AECDAKKDGDDDNYDKDefgf--------------------------------------------------- 486 Yarrowia lipoly...
NP_001023164 223 qnadtfrqINIDIPRMCPLIPLFQQk------------------------------------------------------ 248 nematode
XP_002642394 592 --------IDKDVERCDRNLMFF--------------------------------------------------------- 606 Caenorhabditis ...
NP_510095    121 --------IDKDVRRLYPEIQFFQLlsrfphqhgmkyplsrrvinhqelhsqefganrdgivgcvktniakqsqdenqap 192 nematode
2G77_A       110 --------IEIDIPRTNPHIPLYQF------------------------------------------------------- 126 baker's yeast
3QYE_A       124 ----------------------------------Q------------------------------------LGAGQLSLY 133 human
EDN63937     354 ----------------------------------K--------------------------------------SVQNSLQ 361 Saccharomyces c...
EDN60130     469 ----------------------------------NtidglppppqqlpanennstspesandesddaddgvRNPHLIHLQ 514 Saccharomyces c...
XP_003265326 180 ----------------------------------E------------------------------------N--VRKILT 187 White-cheeked G...
NP_497979    138 -----------------------------------------------------------------------NTSIRQMMS 146 nematode
XP_506113    487 ------------------------------ssqiN------------------------------------SNIHLIQLR 500 Yarrowia lipoly...
NP_001023164 249 -------------------------------------------------------------------------mVQEMFE 255 nematode
XP_002642394 607 ----------------------------------S------------------------------------NKDNLESLR 616 Caenorhabditis ...
NP_510095    193 nsefhwhqffeysykfsqeslvfrkncfnlmpniL------------------------------------NQFIIKIVE 236 nematode
2G77_A       127 ----------------------------------K------------------------------------S--VQNSLQ 134 baker's yeast
3QYE_A       134 NILKAYSLLDQEVGYCQGLSFVAGILLLHM-----------------------------S-------------------- 164 human
EDN63937     362 RILYLWAIRHPASGYVQGINDLVTPFFETFlteylppsqiddveikdpstymvdeqitdL-------------------- 421 Saccharomyces c...
EDN60130     515 NILITYNVYNTNLGYVQGMTDLLSPIYVIMk----------------------------E-------------------- 546 Saccharomyces c...
XP_003265326 188 DVLFCYARENEQLLYKQGMHELLAPIVFVLhcdhqaflhasesa-qpseemktllnpeyL-------------------- 246 White-cheeked G...
NP_497979    147 DILLVYAKEHPFVNYRQGMHEILAPLIFVIy----------------------------Sdneafqhakendelkmltve 198 nematode
XP_506113    501 DMLITYNQHNKNLGYVQGMSDLLSPLYVVLq----------------------------D-------------------- 532 Yarrowia lipoly...
NP_001023164 256 RILYIWAIRHPASGYVQGINDLVTPFFVVF-------------------------------------------------- 285 nematode
XP_002642394 617 RVMYTYVRRNLEEGYTQGMCDLLAPLLVTFe----------------------------D-------------------- 648 Caenorhabditis ...
NP_510095    237 RILFIYAKLNPGVQYVQGMNELVAPIYYVFandadd------------------ewaayA-------------------- 278 nematode
2G77_A       135 RILYLWAIRHPASGYVQGINDLVTPFFETFlteylppsqiddvkikdpstymvdeqitdL-------------------- 194 baker's yeast
3QYE_A       165 --------------EEEAFKMLKFLMFDMGLRKqYRpdmi-------------------------ilqiQMYQLSRLLHD 205 human
EDN63937     422 --------------EADTFWCLTKLLEQITDN--YIhgqp-------------------------gilrQVKNLSQLVKR 460 Saccharomyces c...
EDN60130     547 --------------EWKTFWCFTHFMDIMERNF-LRdqsg--------------------------iheQMLTLVELVQL 585 Saccharomyces c...
XP_003265326 247 --------------EHDAYAVFSQLMETAEPWF-STfehdgqkgketlmtpipfarpqdlgptiaivtkVNQIQDHLLKK 311 White-cheeked G...
NP_497979    199 eedilnclfckeylEQDSYNLFCSVMLEVSRWY-EEptvtespkrpipkep---ymrvqdsapasrlmeDLIDIGNLLHE 274 nematode
XP_506113    533 --------------DTLAFWAFSAFMERMErnylrd---------------------------qsgmrnQLLCLDHLVQF 571 Yarrowia lipoly...
NP_001023164 286 --------------LSEFIPQDVEVGSFDVSQL-Pleqcq-------------------------lieaDSFWCVSSLLD 325 nematode
XP_002642394 649 --------------EALTLECFSILMIRQRGKF-Pqrpg---------------------------mskCLLNLRSLIQV 686 Caenorhabditis ...
NP_510095    279 --------------EADTFFCFQQLMSEVKDNF-IKkldd-------------------------sncgIESSMSAFHNL 318 nematode
2G77_A       195 --------------EADTFWCLTKLLEQITDN--YIhgqp-------------------------gilrQVKNLSQLVKR 233 baker's yeast
3QYE_A       206 Y---HRDLYNHLeE-HEIGPSLYAAPWFLTMFASQFPLGFVARVFDMI--FLQ-----G--T--EVIFKVALSLLGSHKP 270 human
EDN63937     461 I---DADLYNHFqNe-HVEFIQFAFRWMNCLLMREFQMGTVIRMWDTY--LSE-----T--S--Qevtssysmssndikp 525 Saccharomyces c...
EDN60130     586 M---LPELSEHLnKc-DSGNLFFCFRMLLVWFKREFEMEDIMHIWENFwtFYY-----S--S--QFQLFFMLAILQKNSQ 652 Saccharomyces c...
XP_003265326 312 H---DIELYMHLnR-LEIAPQIYGLRWVRLLFGREFPLQDLLVVWDAL--FAD-----GlsL--GLVDYIFVAMLLYIRD 378 White-cheeked G...
NP_497979    275 I---DPTLAKHLs-tLDIPPQLYGIRWLRLLFGRELPLHDLLFLWDVL--LID-----R--PiaPLAKCMFVSLLVQIRH 341 nematode
XP_506113    572 M---LPSLYKHLeKt-ESTNLFFFFRMLLVWFKRELLWDDVLRLWEVL--WTDy---lS--S--QFVLFVCLAILDKHKD 638 Yarrowia lipoly...
NP_001023164 326 S---IQDNYTFAqPg--IQRKVLQLRHLMSRVDRPLHKHLESNGIEYL--QFA--------F--RWMNNLLMREIPLRAT 388 nematode
XP_002642394 687 V---DPQIYGLIaDidYAQALSFAFRWFLLDFKRELSYECTYKVWEVI--WAAqrlriT--N--DFSIFFGLATITNYHD 757 Caenorhabditis ...
NP_510095    319 IstfDTELHKHLtLtLEIKPQFYAFRWLSLLLSQEFPLPDVITLWDAL--FSDp---qR--F--ALLQYVCLAMMELKRE 389 nematode
2G77_A       234 I---DADLYNHFqNeH-VEFIQFAFRWMNCLLMREFQMGTVIRMWDTY--LSE-----T--S--Qevtssysmssndikp 298 baker's yeast
3QYE_A       271 LIL 273 human
EDN63937     526 pvt 528 Saccharomyces cerevisiae YJM789
EDN60130     653 AIL 655 Saccharomyces cerevisiae YJM789
XP_003265326 379 ALI 381 White-cheeked Gibbon
NP_497979    342 LLL 344 nematode
XP_506113    639 VMI 641 Yarrowia lipolytica CLIB122
NP_001023164 389 IRL 391 nematode
XP_002642394 758 VLI 760 Caenorhabditis briggsae
NP_510095    390 PLI 392 nematode
2G77_A       299 pvt 301 baker's yeast
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