Conserved Protein Domain Family
HerA_C
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pfam05872: HerA_C 
Helicase HerA-like C-terminal
HerA is a DNA helicase able to utilize either 3' or 5' single-stranded DNA extensions for loading and subsequent DNA duplex unwinding. It forms a complex with NurA nuclease, this complex has the 5'-3' DNA end resection activity and is essential for cell viability in the crenarchaeon Sulfolobus islandicus. This entry represents the C-terminal domain of HerA which seems to be involved in the conversion of ATP hydrolysis into DNA translocation.
Links
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Statistics
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PSSM-Id: 428657
Aligned: 8 rows
Threshold Bit Score: 766.207
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q92RC7    11 TSRKPDDSINKGEYLELKFGNRHGLITGATGTGKTVTLQILAEGFSNAGVPVFCADVKGDLSGIGAMGEPKDFLLKRAEQ 90  Sinorhizobium meliloti
Q9HW92     6 ELLIGAGPDGQPVGQAWRLANRHGLIAGATGTGKTVTLQHLAESFSDAGVAVFAADIKGDLCGIAAPGNPQGKVAERIAS 85  Pseudomonas aeruginosa
CCP45304  33 vvvdGEPDPSAQIRIPLATVNRHGLVAGATGTGKTKTLQLIAEQLSAAGVAVLMADVKGDLSGLARPGEAADKTAARAKD 112
Q9CL13     2 QYLLSQTEQGQQLGITAKMANRHGLIAGATGTGKTVTLRTMAEAFSDDGVPVFLVDVKGDLSGLVKAGQFQGKIAERIEQ 81  Pasteurella multocida
Q9ABY0     9 ENEILVGLGEGPVTQRLDRSNRHGVVAGATGTGKTVTLQVLTQAFSDAGVPVFAADVKGDLSGVAIPGTPNEKMLARAAS 88  Caulobacter vibrioides
Q2YMR9    11 asRKPDDTYQQPEYLALQYGNRHGLVTGATGTGKTVSLQVLAESFSAAGVPVFCADIKGDLSGIAAAGVLNDGLKKRAAE 90  Brucella abortus 2308
Q8XXC6     3 DPILIAKNAKAELVLLPQLANRHGLITGATGTGKTVTLQTLAQGLSKIGVPVFLADVKGDLTGISQPGQPTDKLKARLEE 82  Ralstonia solanacearum
P39342     3 EPLLIARTPDTELFLLPGMANRHGLITGATGTGKTVTLQKLAESLSEIGVPVFMADVKGDLTGVAQAGTVSEKLLARLKN 82  Escherichia coli K-12

Q92RC7    91 IGLD-PYDFQEFPVIFWDLYGE-KGHRVRTTISEMGPLLLSRLMNATDAQEGVLNIAFKIADEGGLPLLDLKDLQALLNY 168 Sinorhizobium meliloti
Q9HW92    86 MPWL-NYQPKAYPTTLWDIAGK-TGHPLRTTISEMGPLLLANLLELTDSQQAALFAAFQVADREGLLLLDLKDLKALLNH 163 Pseudomonas aeruginosa
CCP45304 113 TG-D-DWVPTAFPVEFLSLGASgVGVPVRATISSFGPILLAKVLGLNATQESTLGLIFHWADQRGLPLLDLKDLRAVITH 190
Q9CL13    82 FGLGgEGYLNGYPVSFWDVFGE-TGIPLRTTISEMGPLLLSRLLNLNATQEGLLNLVFRVADDKGLLLIDLKDLRAMLKY 160 Pasteurella multocida
Q9ABY0    89 MDLV--LAPAAPPVIFWDLFGQ-KGHPIRTTISEMGPLLLSRLLELNDVQEGVLTIAFHVADKDGLLLLDLKDLQAALKY 165 Caulobacter vibrioides
Q2YMR9    91 VKLD-PYEMRAAPVIFWDIFGE-KGHPVRATISEMGPLLLSRLMNLTDAQEGVLNIAFRLADEEGLLLLDLKDLQAILTE 168 Brucella abortus 2308
Q8XXC6    83 RGLP-EPQWAGCPVTLWDVYGE-KGHPVRATVSDMGPLMLARMLELNDIQTGVLNLVFRIADDAGLALLDAKDLRAMLQH 160 Ralstonia solanacearum
P39342    83 IGVN-DWQPHANPVVVWDIFGE-KGHPVRATVSDLGPLLLARLLNLNDVQSGVLNIIFRIADDQGLLLLDFKDLRAITQY 160 Escherichia coli K-12

Q92RC7   169 M-GENASELSNQFGFISKASVGSIQRELLILEQQGAEHFFGEPALKITDIMRTTNDGRGAISVLAADKLMM-NPRLYATF 246 Sinorhizobium meliloti
Q9HW92   164 L-KDNPEILGEDRALFTGASGQALLRRLATLEQQGAEAFFGEPALQLEDILRPEPDGRGRIHLLDASRLVHeAPKVYATF 242 Pseudomonas aeruginosa
CCP45304 191 LtSDEGKVELKSLGAVSPTTAGVILRALVNLEAEGADTFFGEPELRPEDLLRVDSQGRGIISLLEFGSQAL-RPAMFSTF 269
Q9CL13   161 V-ADNAKTFQLEYGNVSAASVGAIQRALLTLENQGAANLFGEPALNLEDWLQTR-DGRGVINVLNSEKLIN-SPKMYSAF 237 Pasteurella multocida
Q9ABY0   166 V-ADNADEIGTQYGNVAPATVGAIQRKLLTLQTQGAEHFFGEPALDLSDIMRTDAAGRGYVSLLAADRLIQ-SPKLYSTF 243 Caulobacter vibrioides
Q2YMR9   169 M-AGRSDELSAKYGNVNKASVGAIQRSLLVLDQQGGSKFFGEPALRIADLMRTTTDGRGVVSVLAADKLMM-NPRLYSTF 246 Brucella abortus 2308
Q8XXC6   161 V-GEHAAEYTNQYGNISSASIGAIQRNLIGLEEQGADQFFGEPMLDIADLMQTV-RGQGVVNILAADKLLN-APKLYATF 237 Ralstonia solanacearum
P39342   161 I-GDNAKSFQNQYGNISSASVGAIQRGLLSLEQQGAAHFFGEPMLDIKDWMRTDANGKGVINILSAEKLYQ-MPKLYAAS 238 Escherichia coli K-12

Q92RC7   247 LLWLLSELFEELPEVGDPDKPKLVFFFDEAHLLFNDAPKVLVERVEQVVRLIRSKGVGVYFVTQNPLDVPEAVLAQLGNR 326 Sinorhizobium meliloti
Q9HW92   243 LLWLLAELFEQLPERGDADKPVLALFFDEAHLLFNGTPKALRDRLEQVVRLIRSKGVGVYFVTQSPGDLPDDVLAQLGLR 322 Pseudomonas aeruginosa
CCP45304 270 LMWVLADLFTFLPEVGDLDKPKLVFFFDEAHLLFTDASKAFLEQVEQTVKLIRSKGVGVFFCTQLPTDLPNDVLSQLGAR 349
Q9CL13   238 LLWLMSELFETLPEVGDPEKPKFVMFFDEAHLLFDGAPAVLVDKVEQVVRLIRSKGVGVYFVTQNPLDLPDTVLGQLGNR 317 Pasteurella multocida
Q9ABY0   244 LLWLLSELFEVLPEVGDPEKPKLVFFFDEAHLLFNDAPKPLLEKIEQVVRLIRSKGVGIYFVTQNPADIPDGVLGQLGAR 323 Caulobacter vibrioides
Q2YMR9   247 LLWLMSELFEELPEVGDPDKPKMVFFFDEAHLLFDEAPKALIDRVEQVVRLIRSKGVGIYFVTQNPLDVPETVLAQLGNR 326 Brucella abortus 2308
Q8XXC6   238 LLWMLSELFEHLPEVGDLDKPKLAFFFDEAHLLFNDAPPSLLQKVEQVVRLIRSKGVGVYFVTQNPADVPDTVLGQLGNR 317 Ralstonia solanacearum
P39342   239 LLWMLSELYEQLPEAGDLEKPKLVFFFDEAHLLFNDAPQVLLDKIEQVIRLIRSKGVGVWFVSQNPSDIPDNVLGQLGNR 318 Escherichia coli K-12

Q92RC7   327 IQHALRAYSPREQKAVKTAADTFRPNPDFNCADVITNLGTGEALVSTLEGKGSPSIVERTLVRPPASRLGPLTDAERQKV 406 Sinorhizobium meliloti
Q9HW92   323 IQHGLRAFTAKEQKSLRAVADGFRPNPAFDTLGVLTELGIGEALVGTLEEKGTPAMVQRVAVAPPYSRIGPLSDSERAEL 402 Pseudomonas aeruginosa
CCP45304 350 IQHALRAFTPDDHKALRKTVRTYPKTDVYDLESALTSLGTGEAVVTVLSEKGAPTPVAWTRMRAPRSLMAAIGAEAIGAA 429
Q9CL13   318 VQHALRAFTPRDQKAVKAAAETFRTNPKINVTETITSLGVGQALVSFLDEKGMPIPVEVAFIFPPRSQLKPIAQEERDAW 397 Pasteurella multocida
Q9ABY0   324 VQHALRAYTPADQKGLKAAAQSFRVNPGFDTAETIQALGVGEALVSTLDEKGAPRIVQKTLIRPPASRLGPLTPQERAAL 403 Caulobacter vibrioides
Q2YMR9   327 VQHALRAYTPRETNAVKTAADTFRPNPDFNTFQAITSLGTGEALVSTLQAKGVPSMVQRTLMRPPSSRIGPLTPEERAQI 406 Brucella abortus 2308
Q8XXC6   318 VQHALRAFTPRDQKAVKAAATTMRANPEFSIEQAIGELAVGEALISMLDEGGRPEITQRAFVVPPASRIGPISDDERRAL 397 Ralstonia solanacearum
P39342   319 VQHALRAFTPKDQKAVKAAAQTMRANPAFDTEKAIQELGTGEALISFLDAKGSPSVVERAMVIAPCSRMGPVTEDERNGL 398 Escherichia coli K-12

Q92RC7   407 VDVSPVRGLYDEDFERDSAYEMLAKRAAKAAEQAEAARQAEEKpaedt---------------------sggsRWTlPGF 465 Sinorhizobium meliloti
Q9HW92   403 VQRSPLKGRYDQPIDRESAYEVLANKAGAKPEVQGQATAQQES------------------------------SSG-VGG 451 Pseudomonas aeruginosa
CCP45304 430 AQASSLQAVYGQTIDRPSAHEILSAKLAPAQEAPAQEAPAPRg------------------------------QYDpLPW 479
Q9CL13   398 VKDDDIYPFYRELIDNESAFEVLNQQADLAAVAQKQ--AEQAQqe---------------------------eESGlMGS 448 Pasteurella multocida
Q9ABY0   404 HAESPVAGVYDTAEDRDSAYEILQGRAAQAQRQAEAERQETEAd----------------------------qRAAaEAK 455 Caulobacter vibrioides
Q2YMR9   407 IAASPVAGQYDQPLDRDSAFEMLARKAADAAAAQQKTGQEEEg------------------------------GGGlLGD 456 Brucella abortus 2308
Q8XXC6   398 MAGSLVAGRYDTPIDRESAYEKLTGRVASTGQSPASAPAPGPLgtdfgasagtvpapvpapvpapapaqapagNGGgIGG 477 Ralstonia solanacearum
P39342   399 INHSPVYGKYEDEVDRESAYEMLQkGFQASTEQQNNPPA---Kgke------------------------vavDDGiLGG 451 Escherichia coli K-12

Q92RC7   466 GDDTAEApsgkqarprssgykrETIMEAAMKSVARTVATQVGRALVRGILGSL----KR 520 Sinorhizobium meliloti
Q9HW92   452 MAGQILG---------------SLLSNSTVKSAMRQAANQLSRELVRGLLGSLmggkKR 495 Pseudomonas aeruginosa
CCP45304 480 PDDFEVPpmpapv----epqgpaVWEEILKNPTVKSVLNTTAREITRSIFGTgr--rRR 532
Q9CL13   449 LSRMIFGtkkrge----kltvtEEIVSGVAKSVGRSIRTQVTKQIMRGILGAL----KK 499 Pasteurella multocida
Q9ABY0   456 VREREAArearesr--prasgrQTMVEAFAVTLVRTVASQAGRELMRGLLGGLsggaSR 512 Caulobacter vibrioides
Q2YMR9   457 IIGTALGtgrr--------sgrQTVAEAAMKSVVRSVGSSLGRALVRGILGGFrr---- 503 Brucella abortus 2308
Q8XXC6   478 WLQDAAGailtkgt--grsgrgDSVVEALAKSAARSIGSQVGREIVRGVLGSLlggsKR 534 Ralstonia solanacearum
P39342   452 LKDILFGttgpr------ggkkDGVVQTMAKSAAR----QVTNQIVRGMLGSLlggrRR 500 Escherichia coli K-12
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