Conserved Protein Domain Family
Osteoregulin

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pfam07175: Osteoregulin 
Osteoregulin
This family represents a conserved region approximately 180 residues long within osteoregulin, a bone-remodelling protein expressed highly in osteocytes within trabecular and cortical bone. A conserved RGD motif is found towards the C-terminal end of this region, and this is potentially involved in integrin recognition.
Statistics
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PSSM-Id: 399867
Aligned: 12 rows
Threshold Bit Score: 244.761
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q8K4L6        30 EDrSSCGNQDSIHKDLAASVYPDPTVDEGTEDGQGALLHPPGQDRYGAALLRNITQPVKSLVTGAELRREGNQEKRPQSV 109 house mouse
XP_003414137 129 ED-QSISNKENAYDDLKMPIYPESTRNNGAQNGDDAISKQHEQEEYSAALVRNNMQHLMGPVTVTALLREDDKKKKPRNV 207
XP_019817681  96 ED-YIISSKENAHSDLKMSIYPESKGKHRAEDRDSAIRKLHSQEGYGAALIRNSMYHGMEPRTVTELLGGENKENKPRNV 174
XP_003985237 129 ED-DTINNKENAHSDQKRYIYPESTGNNGVDDGDNAISKLRDQEEHGTALIRNNMQHIMEPGTVTELLAEENKENQHRNV 207
XP_004756164 129 ED-DSINNQGNAHSDLKMSIYPESTGNKGAEDEDNVVNKFRNQEEYGATLIRNNLQYIMEPRTVTELLAEENKENKPKNV 207
XP_023493519 122 ED-YRISKKENARNDLKMSTYPESTGNNGAKDGDDAVSKLHDQEEYSAHLLRKNMQHIMEPGTVVELLGEENKENKPRKV 200
ELK13678       3 eD-FSTSNKENAHNNLKVSIYPGSTGNNGAEDGDTVISKLHDQEEYSAALTRNNMQHIMEPGAVTELLGKENKEIKFRKV 81 
ELW70200     108 EG-Y-ISKKENTHNDVQMPIYSNATGDQEAEGGDDAASRLHDQEEYGAALTRNQMQHRMGPVTVTKLVGKGSKENKPRNA 185
EGW12409      22 ED--STNNKGGTNENLTASVYPEPSGDKGAENLEDILRNLPDQERHDAILARSIMQPIKRPVTGIERSGDENKEKKPKTV 99 
ACS37551      22 EDgSSGGNQGNIH---LASVKPEPTVGKGTEGGRDAPLHLPDQNRQGATLLRNITQPVKSLVTGTEVQSDRNKEKKPQSV 98 
XP_003790071 131 ED-YSITNKENVHNDLKMSMYLESPGNNEADNGDDAVIKLHDQEEYSAALIRKNTQPVKGPVAVMKLLGEANKKNKPRNV 209
BAC11386      98 KE-YSISNKENTHNGLRMSIYPKSTGNKGFEDGDDAISKLHDQEEYGAALIRNNMQHIMGPVTAIKLLGEENKENTPRNV 176
Q8K4L6       110 LSVIPADVNDAKVSLKDIKNQESYLLTQSSPVKSKHTKHtrqTRRSThylTHLPQIKKTPSDLEGSGSPDLLVRGDNDVP 189 house mouse
XP_003414137 208 LNKILRGANYAEALPKGKKNHQRHAQAQNIPVQSKSTHR---IQHNR---KQLPKVKTIPSDFEGSGYTNLQERGDNDIS 281
XP_019817681 175 LGKIPADANYAKAPSQ-LKNHQRDSQAQNIPVKSKSTHL---TQHNMdylKQLPKVKKIPSDFEGSGYPDLQGRGDNDLS 250
XP_003985237 208 LSKIPASVNYVKVPSKDRKNYQRDPQAQNIPVKSKSTRL---TQYNTdysKQLPKLKKIPSDFEGSGYPDLQGRGDNDIS 284
XP_004756164 208 LSKIPASMNYVKVSSKDRKNYQRDSQAQNIPVKSKSTYH---TQHNIdypKQLPKVKKVPSDFEGSGYPDLQERGDNDLS 284
XP_023493519 201 VSKIPAGASYAKGPSKDKKSHQKDPQAQNIPVKSKSTYR---IQHNTdylKQLPKVKKIPSDVEGSGYPDLQERGDNDIS 277
ELK13678      82 LSKIPTSVSYAKAPLKGQKNHQRDPQAQKIPVKSKSTHH---IQHNTdylKQLSKVKKIPSDFEGSGYPDLQERGSNNMS 158
ELW70200     186 LSRMPAGANHARAHWKGKKNHRRDKQAENSPGDSKSPHH---RQQNTdylKQLPKVKHVPSDFEGSGYTDLQERGDNAFP 262
EGW12409     100 PSMIPADVRDAKDHLKHTGNQERHLPSQNSPAKSKGTHQ---IRRSThylTHLPQIRKIPSDFEGSGSPDTQVRGDNNVP 176
ACS37551      99 LSVIPTDVHNANDYSEDTENQQRDLLLQNSPGQSKHTPR---ARRSThylTHLPQIRKILSDFEDSASPDLLVRGDNDVP 175
XP_003790071 210 LHRIAAGVNYATAHSKDKKNPQRHSQVQNSPVKAKSSHH---IQHNTgslKHPSKVKKIPSDFEGSGYSDLQGRGDNDIS 286
BAC11386     177 LNIIPASMNYAKAHSKDKKKPQRDSQAQKSPVKSKSTHR---IQHNIdylKHLSKVKKIPSDFEGSGYTDLQERGDNDIS 253
Q8K4L6       190 PFS 192 house mouse
XP_003414137 282 PFS 284
XP_019817681 251 PFS 253
XP_003985237 285 PFS 287
XP_004756164 285 PFS 287
XP_023493519 278 PFS 280
ELK13678     159 PFS 161
ELW70200     263 PFS 265
EGW12409     177 PFS 179
ACS37551     176 PFS 178
XP_003790071 287 SFS 289
BAC11386     254 PFR 256
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