5DUQ,2OAY,5DU3


Conserved Protein Domain Family
serpinG1_C1-INH

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cd02050: serpinG1_C1-INH 
serpin family G member 1, plasma proteinase C1 inhibitor
Plasma proteinase C1 inhibitor (C1-INH/C1IN) is a protease inhibitor of the serpin family. It plays a pivotal role in regulating the activation of the classical complement pathway and of the contact system, via regulating bradykinin formation, inhibiting factor XII and kallikrein of the contact system, and via acting on factor XI in the coagulation cascade. This subgroup corresponds to clade G of the serpin superfamily. SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate blood coagulation cascades. Non-inhibitory serpins perform many diverse functions such as chaperoning proteins or transporting hormones. Serpins are of medical interest because mutants have been associated with blood clotting disorders, emphysema, cirrhosis, and dementia. A classification based on evolutionary relatedness has resulted in the assignment of serpins to 16 clades designated A-P along with some orphans.
Statistics
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PSSM-Id: 381006
Aligned: 14 rows
Threshold Bit Score: 556.98
Created: 9-Nov-2004
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
reactive centerputative
Conserved site includes 25 residues -Click on image for an interactive view with Cn3D
Feature 1:reactive center loop (RCL)
Evidence:
  • Comment:depending on the conformational state, the RC loop is surface accessible in the active form or buried and inserted as the central beta strand in the inactive form.
  • Structure:5DU3_A: Human C1-inhibitor, active form, open RCL
  • Structure:2OAY_A: Human C1-inhibitor, latent form, RCL inserted into beta sheet

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                        
5DUQ_A        19 HSTEAVLGDALVDFSLKLYHAFSAMKKveTNMAFSPFSIASLLTQVLLGAGENTKTNLESILSYPKDFTCVHQALKGFTT 98  human
2OAY_A        26 HSTEAVLGDALVDFSLKLYHAFSAMKKveTNMAFSPFSIASLLTQVLLGAGENTKTNLESILSYPKDFTCVHQALKGFTT 105 human
5DU3_A        18 HSTEAVLGDALVDFSLKLYHAFSAMKKveTNMAFSPFSIASLLTQVLLGAGENTKTNLESILSYPKDFTCVHQALKGFTT 97  human
CAD58653     246 RPWEAMLGESLNEFSMKLYAHLSQSQPm-KNLLFSPISISGVLTHLLLGARGKTRRDMETALCLSHDFFCVHSEMKKLKL 324 rainbow trout
CAF93615     228 RSDEAVLQESLAEFSMKLYSFLRESLPs-DNILVSPLSISTLLSHLLLGARGKTQRAIESALSVPHEFSCIHFHIKKLKE 306 Tetraodon nigro...
NP_001117851 246 RPWEAMLGESLNEFSMKLYAHLSQSQPm-KNLLFSPISISGVLTHLLLGARGKTRRDMETALCLSHDFFCVHSEMKKLKL 324 rainbow trout
XP_020786214 233 RVTGPVLRESVTEFSFKLYSIFGESQQh-KNLLYSPLSITGALTHLLLGSRNITRAALEGALFLPPRFHCVHSEMKRLRE 311 great blue-spot...
XP_015676035 155 AEDEQKLAEALSRFSLEFYKIAVQKND--GNMVFSPLSIITTLSNLLLGACDETKDRLESLLFYPKEFTCVHRALKVLGK 232 Protobothrops m...
XP_005295009 226 KEESPRVATALTDFALKFYSKLAKGKGtsSNVVFSPFSVALALSHLLLGARGETKGRLESILAYPSDLVCVHAPLQRLLK 305 western painted...
XP_019370136 186 LEDKARVARALTDFALKFYKAAGQMEGmgTNMVFSPLNVALGISHLLLGAQGDTRERLSSLLSYPPDLPCVHGPLKQLIK 265 Gharial
Feature 1                                                                                        
5DUQ_A        99 KG---VTSVSQIFHSPDLAIRDTFVNASRTLYSSSPRVLSNNSDANLELINTWVAKNTNNKISRLLDSLPSDTRLVLLNA 175 human
2OAY_A       106 KG---VTSVSQIFHSPDLAIRDTFVNASRTLYSSSPRVLSNNSDANLELINTWVAKNTNNKISRLLDSLPSDTRLVLLNA 182 human
5DU3_A        98 KG---VTSVSQIFHSPDLAIRDTFVNASRTLYSSSPRVLSNNSDANLELINTWVAKNTNNKISRLLDSLPSDTRLVLLNA 174 human
CAD58653     325 KLqdtLKMASQIYYNPNMKLSESFTNQSMQFYDADPVKLTNTSEVNVEMINSWVAKQTNNKIKELVDSVPAHTELLLLNT 404 rainbow trout
CAF93615     307 KLdtsLQMASQIYYHPDINLSESFTNHSIQFYEAVPTRLLETSEENTNMINSWVANKTNNKIQRLVDSVSSSTQLMLLNA 386 Tetraodon nigro...
NP_001117851 325 KLqdtLKMASQIYYNPNMKLSESFTNQSMQFYDADPVKLTNTSEVNVEMINSWVAKQTNNKIKELVDSVPAHTELLLLNT 404 rainbow trout
XP_020786214 312 KLsgsLQMASQIFYNTESNLTTSFVKQSGEYYDSEPVKLKEDSLENVHMINSWVANKTKNKITELVKDVSQQTKLMLLNA 391 great blue-spot...
XP_015676035 233 SEa--LTSANAIFYQSALKMGSGFRNLTSTFYQTKLKLLSNNTNQAVTDINSWVSERTGNKIKKLLDDLDADTQMVLLNA 310 Protobothrops m...
XP_005295009 306 SQa--LISASALFLRQGLHLNEAFRNQSLHFYNSRPQMLSGNETQDLQLINKWVRVMTKGKIKRLLKELEPDVQLVLLNA 383 western painted...
XP_019370136 266 SKa--LLTASQIFHRKGLQINKAFLNHSRRFSDSRPQALSGNETLDLQRINKWVSEKTNGKIKKLMEDLATDVQLVLLSA 343 Gharial
Feature 1                                                                                        
5DUQ_A       176 IYLSAKWKTTFdpKKTRMEPFHFKN-SVIKVPMMNSKKYPVAHFIDQTLKAKVGQLQLSHNLSLVILVPQNLK-HRLEDM 253 human
2OAY_A       183 IYLSAKWKTTFdpKKTRMEPFHFKN-SVIKVPMMNSKKYPVAHFIDQTLKAKVGQLQLSHNLSLVILVPQNLK-HRLEDM 260 human
5DU3_A       175 IYLSAKWKTTFdpKKTRMEPFHFKN-SVIKVPMMNSKKYPVAHFIDQTLKAKVGQLQLSHNLSLVILVPQNLK-HRLEDM 252 human
CAD58653     405 VYFNGQWKMKFd-AKSKTFPFVKLNgDTVKVPVLYSAKYKLAVQYVPAVKAQVAMFPLSGASSLFILLPPTTKlTDLQLV 483 rainbow trout
CAF93615     387 VSFKGQWELKFd-SKPKKRHFTKPNgDLVSVWVLYHQSYPLAMTLDTDLKAMVARFALTGETSLYVLLPASHTmADLQQV 465 Tetraodon nigro...
NP_001117851 405 VYFNGQWKMKFd-AKSKTFPFVKLNgDTVKVPVLYSAKYKLAVQYVPAVKAQVAMFPLSGASSLFILLPPTTKlTDLQLV 483 rainbow trout
XP_020786214 392 VSFNGLWTIKFd-EKPSKGYFTKLDgDMIKVPTLRNDDFQGSMVFVPELKAQVMRFELTGNNSLYILLPQSHKaSDLQQV 470 great blue-spot...
XP_015676035 311 VYFHSKWKTIFkkKNTILEDFYRPGlPSIKVPTMTSKKYPVASYFDPNLQAKVARFQLHHNLSLVILIPRSQL-TSLSEI 389 Protobothrops m...
XP_005295009 384 VYFQSKWKTTFkvKNTVNETFYRPGqASIQVPMMTSKKYPLAFFNDPNLQAKVGRLQLSHNVSLIVIVPQLVS-QMLAEV 462 western painted...
XP_019370136 344 IYLQSKWKTTFnvKDTQLENFYRQDkSSVKVPMMTSKKYPLASFTDSSLQAKLGRLQLSNNMSLVIIIPQRFS-QILADV 422 Gharial
Feature 1                                                                                        
5DUQ_A       254 EQALSPSVFKAIMEKLEMSKFQPTLLTLPRIKVTTSQDMLSIMEKleffDFSYDLNLCGLTEDpDLQVSAMQHQTVLELT 333 human
2OAY_A       261 EQALSPSVFKAIMEKLEMSKFQPTLLTLPRIKVTTSQDMLSIMEKleffDFSYDLNLCGLTEDpDLQVSAMQHQTVLELT 340 human
5DU3_A       253 EQALSPSVFKAIMEKLEMSKFQPTLLTLPRIKVTTSQDMLSIMEKleffDFSYDLNLCGLTEDpDLQVSAMQHQTVLELT 332 human
CAD58653     484 EGKMTDRAVSQMVEQMNQVSPQATEVTLPKIKLDIRTEMNTLLRKiglsELFDSANLCGLYPDnELLLTEARHRAFLSLT 563 rainbow trout
CAF93615     466 EERMTDTALLRMIHNMKTIVPQKAEVILPRIKLDVKPDMFMLMKKlglmSLFEDANLCGLYSEdRLVLDEVRHRGFLALT 545 Tetraodon nigro...
NP_001117851 484 EGKMTDRAVSQMVEQMNQVSPQATEVTLPKIKLDIRTEMNTLLRKiglsELFDSANLCGLYPDnELLLTEARHRAFLSLT 563 rainbow trout
XP_020786214 471 ESRLTDSAVHQMINQIREAAPQRIQVTLPQIKLNTEQDMNVMIKKlglfSLYESPNLCGLYAEePLVLEEAKHKAFLSLT 550 great blue-spot...
XP_015676035 390 EERLTATVVMSALNRLKALPLKPTIVTLPKFKLESSQDLAEIIGEmd-fGLFYDADLCGIAQNePVVVSSAKHKAVLQIS 468 Protobothrops m...
XP_005295009 463 QQKLTKETFAAVMKKLMGTPFKPTVVSLPKLKLDSSQNLLDILGEmd-yGIFYDSNLCGISEAeDLLVTSAQHRAMLELN 541 western painted...
XP_019370136 423 EEKLNTELFSAVMDKLMGIPFKPTVLTMPKFKLDSSQDLMAILGEid-yGLFFDANLCGISEDeELAVSAVQHRAVLELS 501 Gharial
Feature 1         #########################                    
5DUQ_A       334 ETGVEAAAASAISVARTLLVFEVQQPFLFMLWDQQhKFPVFMGRVY 379 human
2OAY_A       341 ETGVEAAAASAISVARTLLVFEVQQPFLFMLWDQQhKFPVFMGRVY 386 human
5DU3_A       333 ETGVEAAAASAISVARTLLVFEVQQPFLFVLWDQQhKFPVFMGRVY 378 human
CAD58653     564 EEGVEAGAATSLSFSRSFSSFSALRPFLMILWSDQaKVPLFVGRVT 609 rainbow trout
CAF93615     546 EQGVEAVAVTSVSFSRTYISFSALQPFVFLLWSDQaNVPLFVGRVI 591 Tetraodon nigroviridis
NP_001117851 564 EEGVEAGAATSLSFSRSFSSFSALRPFLMILWSDQaKVPLFVGRVT 609 rainbow trout
XP_020786214 551 EQGVEAAAVTAMGFSRSHLSFSALRPFLLLLWSDSaQVPLFIGRVL 596 great blue-spotted mudskipper
XP_015676035 469 EEGVEGAAATAVSLARIATMFEVQQPFLFLIMGGQ-GVPIFLGRVT 513 Protobothrops mucrosquamatus
XP_005295009 542 EEGVEAAAATAFSVARTAWVFDVQQPFLFVLWNDDhSFPIFMGHVN 587 western painted turtle
XP_019370136 502 EAGVEAAAAMAISVARSALFFEVQQPFLFLVWNDQhGFPIFMGRVN 547 Gharial

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