Conserved Protein Domain Family
PRAP

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pfam15314: PRAP 
Proline-rich acidic protein 1, pregnancy-specific uterine
PRAP, or proline-rich acidic protein 1, is a family of eukaryotic proteins. PRAP is abundantly expressed in the epithelial cells of the human liver, kidney, gastrointestinal tract, and cervix. It is significantly down-regulated in hepatocellular carcinoma and right colon adenocarcinoma compared with the respective adjacent normal tissues. In the mouse it is expressed in the epithelial cells of the mouse and rat gastrointestinal tracts, and pregnant mouse uterus. This article describes the isolation, distribution, and functional characterization of the human homolog. PRAP was abundantly expressed in the epithelial cells of the human liver, kidney, gastrointestinal tract, and cervix. PRAP plays an important role in maintaining normal growth suppression.
Statistics
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PSSM-Id: 464639
Aligned: 13 rows
Threshold Bit Score: 51.6978
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_019664964  98 PEPDRDDLYHPPPgegEEAQEEAGLWSRALSPPRGLQGPEEDRDHIYH 145
XP_005320900  95 PELDLDSLYHPPV---EEVQGKERPWSPVLLPRQVLEGPEEDLDHIYH 139
Q9ES75       100 PELDLDSIYHPMS---EDVQNEEVPQSRPILYRQVLHGPEEDLDHISH 144 Norway rat
XP_023417278 162 PEPDLDSLYHPAS---QEIQVKEEPLLRAMLSRQVLRGPEKDLDHIYH 206
EHB00969      93 PETDHDSLYHPES---EEIQVEEEPFSWAVLSRQVLQGPEEDLDHIYH 137
ELW67312     250 PEPDHDHLYHPLP---EEAQGEERHWLWAMLFHQVLQGPEKDQDHIYH 294
XP_012663250  95 PEPDHDSLYHSLT----EDQGGTRPWLRALPSHQVLRGPEEDRDHIYH 138
XP_008977210 105 PEPDYDGLYHPSP---EEDQGAEEPQLWVVPNRQVLQGPEKDQDHIYH 149
Q96NZ9       105 PEPDHDSLYHPPP---EEDQGEERPRLWVMPNHQVLLGPEEDQDHIYH 149 human
XP_023492214  98 PEPDYDSLYHPPP---EEAQEEAGPRSQVLLSRQVLRGPEEDRDHIYH 142
XP_001927920  93 PEPDRDHLYHSWP---QEAQEEARPWARALPPRQVLQGPEEDRDHIYH 137
XP_590365     96 PEPDWDSLFHDGP---EEVLEEARPWARVLPPRQVLHGPEEDRDHIYH 140
KFO58812       8 PKEDRDHLHHPQD----DTREANARVPFWMLSLEVQNGPEEDRDHLYH 51  American crow
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