6X03


Conserved Protein Domain Family
Nup84_Nup100

?
pfam04121: Nup84_Nup100 
Nuclear pore protein 84 / 107
Nup84p forms a complex with five proteins, of which Nup120p, Nup85p, Sec13p, and a Sec13p homologs. This Nup84p complex in conjunction with Sec13-type proteins is required for correct nuclear pore biogenesis.
Statistics
?
PSSM-Id: 461184
Aligned: 108 rows
Threshold Bit Score: 475.629
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
6X03_A        65 SKDWELEARFWHLVELLLVFRNaDL-----DLd------EMELhPYNSR--GLFEKKLMQDNKQLYQIWIVMVWLKENTy 131  Saccharomyces ...
ENH71888      91 VKRLEREAQTWDLLRRLLPLRYdssd----------ngqSASKtEQSSVdsGDLFKSFLASDSSARERQAVIQWLQSNA- 159 
EGX90216      87 IKRIEGEVQTWDLIRRLVPLRHaaar----------anpFDEGqRNHDS--GDLLQDFLRCNPVAQERHAVLQWLQTNA- 153 
EHK40645      89 IKQLEKEVQTWDLIQRLLPLRYa--------AldsntndRPSIeTGSTQ--SDMLLEFLLADPTAQERHAVLQWLQSNA- 157 
XP_013950687  91 LKQLEKEVQTWDLIRRLLPLRYa--------TpeskandRPSIeLDTSStqSDLLLEFLLSDPTARERHAVLQWLQNNA- 161 
CCE28283     106 IRQLEKEVQTWDLFRRLLPLRYs--------GsgpepmrFSSPlPGSRKsiQDDVHDFLETNSVALERRAVLQWLQTTA- 176 
XP_007581238  98 LKQWQSEVATWELLRTLLEHDQhEPgtdpnSNkrkalagMPALhKFTPE--GEVWDRFIFEEDSARERELILRWLEDTA- 174 
EMD00818     112 LRKWQQEADIWQLFWIMLDFHYnHAar--rKEiddqlanMPPPhRYAAE--KELWERFLMESDTAKERSLVKQWLEQAA- 186 
EME48757     129 LRQWQQEVDIWELFRIMLELHHnPDvrsmqQEkedklrsLGEVhRYTSE--QDIWKRFLVHDDLAKERAMVKRWLEETA- 205 
XP_016765165 170 QRKWQQEADIWDLFRLMLELHHhPDqraqkRQrddrlreLGDVhRYTSE--AALWDRFLLTDDVAKERHLVKQWLEQSA- 246 
6X03_A       132 vmeRPKNvp-------------------tSKWLNSITSgg-lK------------------------------SCDLDFP 161  Saccharomyces ...
ENH71888     160 ----SSGpdidelahelq-qnadrgdiiaHGWLHTRSSiklrKsvtawphlldrqspaiatsfhtsdgsplvtQLDPDAA 234 
EGX90216     154 ----AGGvdidtmvedlq-rnadrgdviaHGWLHTRSKiklrKsmtgwphllerqtpsiaeshlnsdgaplvtNLDPDAV 228 
EHK40645     158 ----AAGpdiddlardll-kqadrgdivaHGWLHTRATiklrKnlttwhglldhqgpkvmeshvgkdgaplitQLDPDAI 232 
XP_013950687 162 ----ADGpdiddlardll-kqadrgdiiaHGWLHTRATiklrKnltawnglldrqqprvmeshvnkdgaplitQLDPDAI 236 
CCE28283     177 ----AAGpdidevarelq-qnadrgdiiaHGWLHTRTKiklrKsvtawprlldrqspneisshvnsdgaplvtQLDPDAS 251 
XP_007581238 175 ---DEAGediatlmeek---sgrgsgtwsQGWLDTKLKlkqeKrlrpfekspekala---hvrrddtgepvayQLDPDAP 245 
EMD00818     187 ---DHQDsdlhaiveelerksgagkglwnRGWLSTRERikgeKrirswpspsdsvqp---qirstassemlitALDPDAP 260 
EME48757     206 ---EHQEsdipgimeelekqagvgkgmwlHGVVHTRATikgeKrlrpwpnapaaalp---hitraddaeplvtQLDPDAA 279 
XP_016765165 247 ---NHQAsevagiveeleskagrgrglwsNGWMHTRERikheKrlrawpepdamplp---hlkrsdnpealvtSLDPDAA 320 
6X03_A       162 LRENTNvLDVKDKEEDHIFFKYIYELILAGA-IDEALEEAKLSDNISICMILCG------IQEYL---NPVIdtqianef 231  Saccharomyces ...
ENH71888     235 TRQGRK-LEPQDEYFERAIWLGCWEHLRRGSsLDTIREWCQERTEMWRAISTSA------ILLSAddsQE---------- 297 
EGX90216     229 TRQDRK-LEPQDEYFERAIWLGCFEHLRRGSaLEEIRDWCQERTEMWRAISMSA------VLFTWdakPE---------- 291 
EHK40645     233 TRQGRK-LEPADEYFERAIWLGCFEHLRRGSsLEELREWCQERTEMWRAVSMSA------MPLSVddnAAP--------- 296 
XP_013950687 237 TRQGRK-LEPADEYFERAIWLGCFEHLRRGSsLEELREWCQERTEMWRAVSMSA------MLLSEddqTAL--------- 300 
CCE28283     252 MRQGRK-LEPQDDYFERAIWLGCFEHLRRGSkFEDIREWCRERTEMWRAISMSA------MPMSVeewHDGP-------- 316 
XP_007581238 246 TRQARV-LEKSDEDYEKAAWMALWEMMRRGKpWQEIRDWCNEHNEQWRAVALGKsydnqdRR------------------ 306 
EMD00818     261 TRQQCT-VEKPDAYFERAMWIACWEMLRRGKsWEEILKWCEEHNEGWRALVLAPa------------------------- 314 
EME48757     280 SRQGRV-VERKDAFFEQVMWIACWEMLRRGKsWQEVTDWCKTRNESWRALSMGK-------------------------- 332 
XP_016765165 321 TRQDRS-LERPDAYFERATWITCWEMLRRGHsWEQVSEWCEQRNESWRAIVIGKs------------------------- 374 
6X03_A       232 NTQQGIKKHSLWRRTVYSLSQQAGLDPYERAIYSYLSGAIPNQ-EVlqYSDWESDLHIHLNQILQTEIENYLLE------ 304  Saccharomyces ...
ENH71888     298 VTDTNPASLALWRRMCFSLSRSGGCDDYERAVYGVLSGDIPSVeKV--ALTWDDFLFANYNALLRTQLDNYILGqcpad- 374 
EGX90216     292 KVDAAPESLALWRRMCYALARNRGSDEHERAVYGILSGDISSVeSV--AKKWDDYLFAHYNALLRTQLDNFILGkcppd- 368 
EHK40645     297 VDDLKPEALALWRRTCFALARQGGSDDYERAVYGLLSGDISSVeKI--ARRWDDFLFANYNALLRTQFDTYVLSrcspt- 373 
XP_013950687 301 ADDLKPESLALWRRMCFALARQGGSDDYERAVYGLLSGDITSVeKI--ARRWDDFLFANYNALLRTQFDTYVLSrcppd- 377 
CCE28283     317 KTDADAASLALWRRMCFSLARQGGSDDFERAVYGILSGDITTVeNV--AKSWDDFLFANYNALLRSQIDTFMLSkcppd- 393 
XP_007581238 307 TSLRGANLGSLWRRVCYAAANAGQN-EFERAVYGLLAGDIASIePI--CSSWDDFLYVRLNNVLLSQWDQFLHArlpeg- 382 
EMD00818     315 VDSGDALSNAAWRKMCYLASESGCSNDYEAAVYGLLGGNLKAVkKV--CRTVHDHLFAYYTCVLVRHFDKYLEHhhpsr- 391 
EME48757     333 VQPTEALSTATWRSMCYLASKSTTANDYEAAVYGLLSGNVTMAqKA--ARTVDENLYVHYNAALIRQFDLYLEMhhtdrl 410 
XP_016765165 375 SDGSDVASNSAWRKMCYLASQSGCTSDFEAAVYGLLGGAVNAMqKV--CHTLDDRLYANYSSYLVRQFDLYLVNnfpdra 452 
6X03_A       305 --------NNQVGTDelilplpshaltvQEVLNRVASR-----HPSESEH-PIRVLMASVILDSLPSVIHSSVEMLLDVV 370  Saccharomyces ...
ENH71888     375 ---vasnlTQSFPSFdavqf---hgeprTVDMRLIRALeanpqIKDEANE-PNKALQASLISKEIGQHLYQQGLIISSGA 447 
EGX90216     369 ---masnlTQSFSVFdalqf----hgneAVEKRLMRLLelkpaIKDEAQQ-PIKALQASFIANDTAHHLFEQGLLIELSN 440 
EHK40645     374 ---msstlTQNFASFdavqf---lgdprGVEKRLIRSLesqerVRDEATE-PSKALQAAFVAKEVGRHLYEQGLVMTADA 446 
XP_013950687 378 ---vsstlTQNFPSFdavqf---lgkpqGVEKRLVRSLesqarIQDEATE-PSKALQAAFIAKDVERHLYEQGLVMIADA 450 
CCE28283     394 ---vvstlLQSLPAFdavef---hgddnDVQKRIIQTIgshpqVRTEASE-PNKALQASFIARELDRHLYEQGLVITAAA 466 
XP_007581238 383 ---vpqttSRLISPPstlqa---vetpsSANRYVIDYLaefgpTRQESRE-PMKMIQGALIGKSFQDLAYNMGIALSKRA 455 
EMD00818     392 ---iaslsGGRFGTDeelad---aeqeqRTVTALVSQLretpsKSSEAARaPLKIIESYLLTNEVESLATTVGTALSDID 465 
EME48757     411 prgrlhgnRDLAQDPd------------AQIVELIGALrkkptTSREAVQ-PIKIIQSYLLANDVGSLIHTLGFTISYTA 477 
XP_016765165 453 pfarsgvtEEELQDPd------------QAIYDLLARLrkepeTAKEAVQ-PMKIIQSYLIANDIGSLIHTLGFAVAYAD 519 
6X03_A       371 --------------------KgtEAsndiidKPYLLRIVTHLAICLDII------------Np-gSVEEVDKskLITTYI 417  Saccharomyces ...
ENH71888     448 nqnestly-----rskpsklEvnKErffqstQHYGLRIVAHIYLLINLMdklnskddslapAfspPEMRRSQqnLIAGYA 522 
EGX90216     441 ptrsfa--------aamvgdElaEHkyfpleQNDGLRIVTHVYILQFLLeqqdae-dhlqtEkqpQNWRFTQecIIGAYA 511 
EHK40645     447 nangqsill---psskpidsNimKKkyfsldQHQGLRLVSHIFVITTLMeklnsaqgiisgSltpPQWLSGQesILAGYT 523 
XP_013950687 451 nangksill---pssepinsSvvKKkyfnldQHDGLRIVSHVYVLTALMkkfggaqkkvsnFsppPQLTFSQesILAGYT 527 
CCE28283     467 nefstsrlvr-kgleedentIvsKYkyfdlaQHSGLRIVAHVFVLVSLLdrferqesdslePqipASWRFFQenILAAYT 545 
XP_007581238 456 nqegqst------llptvnhDtdERffgladNYDALRVVSHMLLINKAFg----------lDiddSPDRHIYenILVSYI 519 
EMD00818     466 yqrsdkedv---ihhirtppEkvLTetavavDYQALRIVATMYIVVRSLe----------yDtpsEETLLAEenVVIAYA 532 
EME48757     478 rqtgkadhmi-ldlepfwqeDsnQPeaevalNPQTLRIATHMGIMIRQLag--------gmArkeNQEREAEenVYVAYI 548 
XP_016765165 520 rqlhsmeqmivhlepfwddkRsnQPemevalDPQTLRIVVHMGIILDTLs----------pQkldWEAQSAKenTIVAYI 589 
6X03_A       418 SLLKLQGLYENIPIYATFLNESDCLEACSFILSSLED-PQVRKKQIETINFLRLPASNILRRTTqRVFDETEQeysps-- 494  Saccharomyces ...
ENH71888     523 NYLRLAEFHELIPLYCSILEPPRSYEVLSYNLIHENE-ASRRLLQLRLIRKAGIDVLGFVKTQAwllfddlgpaqhgcpa 601 
EGX90216     512 EYLRRASLQELIPLYCSIVEAPRSYKMLSKSLIHEDE-HNQRLIQLKLVKKAGIDVLQFVEEQAnlmyyeltidaelvhr 590 
EHK40645     524 DYLRRAGLQELIPLYCSILQAPRQYDVLSWNLIHEED-PEQRLLQLKLIKKAGIDVLKFVERQVwlfydalgekapqqas 602 
XP_013950687 528 DYLRRAGLQELIPLYCSILEAPRQYDVLSWNLIHEED-PEQRLLQLKLIKKAGIDVLKFVDRQVilfyealgskasqqaa 606 
CCE28283     546 DYLRRAKLRELIPLYCSVFNTPRRYEALSWNVIEQSD-LDVRGEQLGLIRRAGIDDSRFVESQAtlffgeldnnpklavn 624 
XP_007581238 520 DFLRMAGKIELVPLYASQLSEIRCWVTLGVASTDI-RnFEEQKLQVRLMERYNIDLDQVLENQFeYAVVTGKFrsmqgdr 598 
EMD00818     533 QAIRTMRKRLDIFVYASRLEHISAILTVARMLPDVTQ-PDEQRMMINLMREYKLDITAILQEQLgWTLASKLSsekqlkk 611 
EME48757     549 QSLRAAGKRELIPLYLSKLHASRYIVTMADILEDITS-PREQDVMLRLMRQYELDVILILRDHSqFLMNKYMSdelhpqt 627 
XP_016765165 590 QALRAAGKRDLIPVYASRLSKGAYVATMSRVLQDITD-EREQQETLGLLKQYGLDVVFILNEQLgYMLDQYLAndlgrme 668 
6X03_A       495 --------------------------neisiSfDVNNIDMHLIYGVEWL-IEGKLYVDAVHSIIALSRRFLLNGRVKALE 547  Saccharomyces ...
ENH71888     602 kegfsi---iepgpptsrsgrpvrpdffgddErFVDQAHENLIRSLEWLvLVQETWPNVLSMGTKIYKFFLRNMHLSAAR 678 
EGX90216     591 pppeihfrivdpsrptlrqgraikpdffgeeEdAIDIKDEHLIRSIEWLaLVHEKWPKVFSMGTKAYKYFLTHMHLNAAR 670 
EHK40645     603 fniis------dapstpqfgklikadffgydEgVVQNDHDRVICALEWLmMVDGMWPEVFSTGTKVYKFFLRNANLGAAR 676 
XP_013950687 607 fsiis------dgpstpqfgklikadffgyeEgVVQNGDDHVIRSLEWLlMVDGKWADVFSMGTKVYKFFLRTGRLGAAR 680 
CCE28283     625 nasfri---lepgppssrgqrrmkndffgaeEdKVDPKDINMIRALEWLlMVEKSWPQVFSIGIQVYKLFLRNGRLSAAR 701 
XP_007581238 599 iqkyeflep------akhqqwpgqrirkaflPdAVRPEDEMLIRSCEWWmHLPERWHKTFVALTESLKTFLLSGHMGAAV 672 
EMD00818     612 plrmlence-------vnnlhpgqritesflDgTMTEDDMAILRCLQWFqMVPGHWHMTFSALAEALRGCLMAGRLACAM 684 
EME48757     628 rrpakileka-----edtllypgqriilgffSdEPQEGDDAIVRSLRWFtLVDGYWQETFAALSLALRKSLVAGRLACAL 702 
XP_016765165 669 kplkmlets-------qeahhpsqriasdfvPeHSIEDDRAIVASLRWFnIIDGQWEKTFGNLSLALRKALIAGRLGCAL 741 
6X03_A       548 QFMERNnIGEICKNYEL------------------EKIAD--------------NISKDENEDQFLEEITQYEHLIKGIR 595  Saccharomyces ...
ENH71888     679 QLMKRVpFSEVLHAATEesgdemelyedipefwarQLDRRg------------iRDVTPQQALSDARNFRELENLVRALD 746 
EGX90216     671 ELMKRVpFGDMVRRIMEqdeseaphi-ddirfwedQLERSs------------iIDEKPEQVMSDARNFRDLEAIVVALD 737 
EHK40645     677 RLVEKIsFEKIIQGISGqeetdiawy-edvdfwarLLERSe------------iSNMNPERIMAEARNFRALESLVKALD 743 
XP_013950687 681 RLFERIsFEKIIQGISGqeetddiwy-edvdfwakLLERSe------------vSNMTPEKVQAEARKFRGLEALVKALD 747 
CCE28283     702 RLYRRVaFTRIMQHMTGhddpeitly-edvefwtlQLQDSg------------lGNVKPEQAMSDARNYMELEALVKALD 768 
XP_007581238 673 RLVERLpYRHVSKLKTAempf-----------lgrGIDVMededetfvnvaieeTRLYKEDLKDDSRVYYELQQLVQAIK 741 
EMD00818     685 AMCQEMsCEIISMQKSHsvi-------------qrEVNIMdksqap--ddpdsdEALEWEVLRRQARTYYELEQMVHAIV 749 
EME48757     703 QIIKEFpYDNVALRKNYkil-------------grSINPFdheg------eppcGRARWDFLRRTSRCYYELELVVRAIA 763 
XP_016765165 742 YIVDEFpYETLARRKSYqvi-------------gkSINPMdpdsd-----lsagEGSTTELLARQSRTYYELELVMTAIQ 803 
6X03_A       596 EYEEWQKSVSLLSS-------ESnIPTLIEKLQGFSKDTFELIK-----TFLVDLTSsnfa---------dsadYe---I 651  Saccharomyces ...
ENH71888     747 SLETVASLAELTNEd------QKkKREFWNAIGDEVKNTKENMQpl-lkNWLLVGIEeg------------------dqE 801 
EGX90216     738 SLETIASLVILSAEm------PTtNRKFWGGVGDGIKAAKENMQpl-lkGWLVASIAgenstllegvtmwtddsTegdeE 810 
EHK40645     744 ALETVASLMVLSTEl------THgDRDFWGPASEGIKNVKEFMKpl-lkGWLIPAIKgg------------------deE 798 
XP_013950687 748 GLETIASLMLISTEl------SHgDRDFWGPAGEAIKNVKDYMRpl-lkGWLLPAIKsg------------------dsE 802 
CCE28283     769 TLETIASp-------------DLtNKQFWQRVGEEITTATDNMQpl-lkNWLLPGIEng------------------dhE 816 
XP_007581238 742 MLDEWRIEEAELIKyatplksTGgAMPPKNKIRTLLESVCEAVQpl-lgDWLTHACD-----------------EheaqQ 803 
EMD00818     750 SLAHWAEVERPFTSa------PRqGSSVPQSLRQAKAALDEAMQpl-laGILQHPET-----------------EkeqkE 805 
EME48757     764 SLHEWRIREAEYTQn------ALrMSSAPPLLKTAKEEVDLAMNavltrKLLTHPVG-----------------HdeamD 820 
XP_016765165 804 ALASWRAEEEAYTLk------KPkLSGAGPTLKASKEAVDEAMLpvvegNLLLNPVD-----------------EeeaaD 860 
6X03_A       652 LYEIRALYTPFLLMELHKKLVEAakllkipKFISEALAFTSLVANENDk-IYLLFQSSgKLKEYLDLVARTA 722  Saccharomyces cerevisi...
ENH71888     802 LRDLRQAYLPETVLAYVGTLHFAgtg-lsrDNLLECMELASIIAERDSd-LSVAFIEAgRMKELVEVFAASS 871 
EGX90216     811 LRKIRREYLPETILAYVSALHFAgtg-lsrDNLLESMELATVVAERSSd-LTSVFSATkRMTELVEALAACS 880 
EHK40645     799 LRDIRAAYLPETVLAYISALQFAgtg-lsrDNLLECMELASLVAERESd-LKDAFTDAhRMTELVEAFAACS 868 
XP_013950687 803 LRDIRAAYLPETILAYISALHFAgtg-lsrDNLLECMELAALVAERESd-LKEVFTEAkRMTELVEAFAACS 872 
CCE28283     817 LKQLRDAYLPETILAYISALHFAgtg-isrDHLLECMDLASVIAERNSd-LSGTFVDAgRMKELVEALTACS 886 
XP_007581238 804 LIHIRRAYLPEVIIAYNSVLHSAahm-vgrDNITRCMDLATAVAAPDNidLTATFLDTgRMQELVQAFAQSS 874 
EMD00818     806 LEEVRVAYLPEIILAYNSALYTAgpt-isrDAYIESMDLSVAVADERNg-LAEAFTKAgRMRELVTSFAQAS 875 
EME48757     821 LDIIRREYIPEVIIAYNTVLHSAgsi-itrNNLVQSMDLSVAVANEQNg-LTDCFLEArRMKELVTSFAQTS 890 
XP_016765165 861 LELIRKWYFPELIIAYNAVHHAAgym-isrEHLVKSMDLSVTIANDDYh-LSETFVAAgRMRELVDSFAHTS 930 
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap