5GMY,6S7O


Conserved Protein Domain Family
STT3

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pfam02516: STT3 
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Oligosaccharyl transferase STT3 subunit
This family consists of the oligosaccharyl transferase STT3 subunit and related proteins. The STT3 subunit is part of the oligosaccharyl transferase (OTase) complex of proteins and is required for its activity. In eukaryotes, OTase transfers a lipid-linked core-oligosaccharide to selected asparagine residues in the ER. In the archaea STT3 occurs alone, rather than in an OTase complex, and is required for N-glycosylation of asparagines.
Statistics
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PSSM-Id: 396873
Aligned: 10 rows
Threshold Bit Score: 344.755
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5GMY_A  18 VIAALISVKLRILNPWNS---------VFTWTVRLGG---NDPWYYYRLIENTIHN----------FPHRIWFDPFTyYP 75   Archaeoglobus fulgid...
O27928  21 FFSRIETAELKGMNTADRa--------YFTDENGLPYmyePDSYYNYRLTANILDHghpg---dkiINGTPWDLHSN-YP 88   Methanothermobacter ...
O27920  13 VIFVFGFSIRMLNAGYDDp--------LYTDDDGLQYfqeSDSYYNYRLTENLAIRgipg---davIGGKIWDLHSy-YP 80   Methanothermobacter ...
O27660  24 FYIRAEASNIGGVPADAKk--------FYEDADGLPYfseMDSYYNYRLTMNYLTKgimg---dtlVDGKPYDLHSy-YP 91   Methanothermobacter ...
Q0P9C8   9 npYLVLFAMIVLAYVFSV----------FCRFYWVWWaseFNEYFFNNQLMIISNDgy-------aFAEGARDMIAGfHQ 71   Campylobacter jejuni...
Q58920  33 MLMFVSFQLRAQTADMKFaqdneflkdMFSDEHGRMYllaLDPYYYLRLSENLYNNghcgdtikvvDGKETPYDLYQyAP 112  Methanocaldococcus j...
P39007  15 ILKLVIFVAIFGAAISSR---------LFAVIKFESIiheFDPWFNYRATKYLVNNs--------fYKFLNWFDDRTwYP 77   Saccharomyces cerevi...
O94335  23 PLKVLILICIAVASVSSR---------LFSVIRYESIiheFDPWFNFRASKILVEQg--------fYNFLNWFDERSwYP 85   Schizosaccharomyces ...
6S7O_A  17 LLKLLILSMAAVLSFSTR---------LFAVLRFESViheFDPYFNYRTTRFLAEEg--------fYKFHNWFDDRAwYP 79   human
P46975  19 LLTIVVLALAWFVGFASR---------LFAIVRFESIiheFDPWFNYRATHHMVQHg--------fYKFLNWFDERAwYP 81   Caenorhabditis elegans
5GMY_A  76 YGSYTHFGPFLVYL-GSIAGIIFSATS------GESLRAVLAFIPAIGGVLAILPVYLLtREVFDKRAAVIAAFLIAIVP 148  Archaeoglobus fulgid...
O27928  89 PGNRVNYPPLILWIsLLFHNFINLFIP------FSLIETCFWLPAIIGPLAGIVMFFMV-RRYAGDLPGLLSGVLLVLAP 161  Methanothermobacter ...
O27920  81 PGVPLDYPAGILLLaVILHAITGVIAP------VSLRAVCLIMPPLLAPLAGVICFFTV-KRFQGDIPAFIAGLLLVSAP 153  Methanothermobacter ...
O27660  92 PGRPVDYPPLIVYVtSAAYRVLNFFGD------FSLKEVAFWMGAFIGSLCVIPAYLFV-RRITNDYGGFAAALIVGLVP 164  Methanothermobacter ...
Q0P9C8  72 PNDLSYYGSSLSTLtYWLYKITPFSFE----------SIILYMSTFLSSLVVIPIILLA-NEYKRPLMGFVAALLASVAN 140  Campylobacter jejuni...
Q58920 113 PGHPLPWEPPVICLaTLAIYYIWHSIDl----tVTIMNAAFWVPAVLGMLLGIPIYFVVrRVTNSNIGGIAGAIALISAP 188  Methanocaldococcus j...
P39007  78 LG-RVTGGTLYPGL-MTTSAFIWHALRnwlglpIDIRNVCVLFAPLFSGVTAWATYEFT-KEIKDASAGLLAAGFIAIVP 154  Saccharomyces cerevi...
O94335  86 LG-RVAGGTLYPGL-MVTSGIIFKVLHllr-inVNIRDVCVLLAPAFSGITAIATYYLA-RELKSDACGLLAAAFMGIAP 161  Schizosaccharomyces ...
6S7O_A  80 LG-RIIGGTIYPGL-MITSAAIYHVLHffh-itIDIRNVCVFLAPLFSSFTTIVTYHLT-KELKDAGAGLLAAAMIAVVP 155  human
P46975  82 LG-RIVGGTVYPGL-MVTSGLIHWILDsln-fhVHIREVCVFLAPTFSGLTAIATYLLT-KELWSPGAGLFAACFIAISP 157  Caenorhabditis elegans
5GMY_A 149 GqFLQRSILGFNDHHIWEAFWQVSALGTFLLAYNRWKghdlshnltaRQMAYPVIAGITIGLYVLSWGAgf--------- 219  Archaeoglobus fulgid...
O27928 162 V-YFSRTVPGFFDTDMFNIIFPLLVIFFLLKATETKN----------NYMFPLLLSSFSLALLSLSWNG----------- 219  Methanothermobacter ...
O27920 154 F-YLVKTVYGLYDTDMLILTLSMAVLFLFIEADAREV----------NRVPLSAIGGFILFLFSITWSGwq--------- 213  Methanothermobacter ...
O27660 165 T-YVAHTYAGFFDTDMFNFVLPLFVFWFFTEGMLASSm--------rGKVGYALAAAVSILVFSAAWVGy---------- 225  Methanothermobacter ...
Q0P9C8 141 S-YYNRTMSGYYDTDMLVIVLPMFILFFMVRMILKKD--------------FFSLIALPLFIGIYLWWYpss-------y 198  Campylobacter jejuni...
Q58920 189 G-LLYKTCAGFADTPIFEVLPILFIVWFILESIHSQEktalfkkdlkNPISLFVIAALIIELIIGAYLNiasgesvvias 267  Methanocaldococcus j...
P39007 155 G-YISRSVAGSYDNEAIAITLLMVTFMFWIKAQKTGS------------IMHATCAALFYFYMVSAWGGy---------- 211  Saccharomyces cerevi...
O94335 162 G-YTSRSVAGSYDNEAIAITLLMSTFALWIKAVKSGS------------SFWGACTGLLYFYMVTAWGGy---------- 218  Schizosaccharomyces ...
6S7O_A 156 G-YISRSVAGSYDNEGIAIFCMLLTYYMWIKAVKTGS------------ICWAAKCALAYFYMVSSWGGy---------- 212  human
P46975 158 G-YTSRSVAGSYDNEGIAIFALQFTYYLWVKSLKTGS------------IMWASLCALSYFYMVSAWGGy---------- 214  Caenorhabditis elegans
5GMY_A 220 iIAPIILAFMFFAFVLAGF----------VNADRKNLS---------------LVAVVTFAVS--ALIYLPFAFNy---- 268  Archaeoglobus fulgid...
O27928 220 -WAYIFYIIIISSILYMTL----------CKLKGKAVM---------------GFSRKIAVFV--IISLLIIGLAg---- 267  Methanothermobacter ...
O27920 214 vMFYVTLVTFIILILTSGS----------RKPLRNILG---------------NIPTGLHGSVypFNLFNHLELIk---- 264  Methanothermobacter ...
O27660 226 iFYLAVLIVFVAAYLVISRyilgekpageFEGKLDWLIhq-----------reLFPLLILIIAggVLVGVFGGFSslag- 293  Methanothermobacter ...
Q0P9C8 199 tLNVALIGLFLIYTLIFHR----------KEKIFYIAVils----------slTLSNIAWFYQsaIIVILFALFAleqkr 258  Campylobacter jejuni...
Q58920 268 iLFYTVSLAFILAGLIIAGikklkgneleFELFALLAViltavspkmwgawwyGFDVITAFLViyIIALALLKSQvkik- 346  Methanocaldococcus j...
P39007 212 vFITNLIPLHVFLLILMGR----------YSSKLYSAY---------------TTWYAIGTVA--SMQIPFVGFLpir-- 262  Saccharomyces cerevi...
O94335 219 vFITNMIPLHVFVLLLMGR----------YTSKLYIAY---------------TTYYVIGTLA--SMQVPFVGFQpvs-- 269  Schizosaccharomyces ...
6S7O_A 213 vFLINLIPLHVLVLMLTGR----------FSHRIYVAY---------------CTVYCLGTIL--SMQISFVGFQpvl-- 263  human
P46975 215 vFIINLIPLHALALIIMGR----------YSSRLFVSY---------------TSFYCLATIL--SMQVPFVGFQpvr-- 265  Caenorhabditis elegans
5GMY_A 269 ----PGFSTIFYSPFQLLVLLGSAVI--AAAFYQIEK-----WNDVG-FFERVGL---GRKGMPLAVIVLTALI------ 327  Archaeoglobus fulgid...
O27928 268 ----RLGYALIFPTFFKFTFKSLSAGgwPGIFESISE-----LSAPT-FDEFLSLp--GPVNMGIGLFGFVIIG------ 329  Methanothermobacter ...
O27920 265 ---------LIMTPLHIHDLVDKSIWypWPDSYTTVA-----ELQPAyMDKVLGHi--SPALTVLGAAGIPAYY------ 322  Methanothermobacter ...
O27660 294 avggLIGATQIQATAQTTAYPNVYVSvsELQVPEFITtgagnIFLPGqNTIVGGVg--GLLVFIIGVLGVGALVwkyrqp 371  Methanothermobacter ...
Q0P9C8 259 lnfmIIGILGSATLIFLILSGGVDPIlyQLKFYIFRSdesanLTQGFmYFNVNQTiqeVENVDFSEFMRRISGSe----- 333  Campylobacter jejuni...
Q58920 347 efinIGNLKNIVYLSIFYIFGSFVLLvaIYGMGIAISpitspLGYNQiLSTYTQTtgwPNVYTTVAELAKPSSWseiftn 426  Methanocaldococcus j...
P39007 263 -sndHMAALGVFGLIQIVAFGDFVKG--QISTAKFKV-----IMMVS-LFLILVLg--VVGLSALTYMGLIAPW------ 325  Saccharomyces cerevi...
O94335 270 -tseHMSALGVFGLLQLFAFYNYVKG--LVSSKQFQI-----LIRFA-LVCLVGLa--TVVLFALSSTGVIAPW------ 332  Schizosaccharomyces ...
6S7O_A 264 -sseHMAAFGVFGLCQIHAFVDYLRS--KLNPQQFEV-----LFRSV-ISLVGFVl--LTVGALLMLTGKISPW------ 326  human
P46975 266 -tseHMPAFGVFGLLQIVALMHYARN--RITRQQFMT-----LFVGG-LTILGALs--VVVYFALVWGGYVAPF------ 328  Caenorhabditis elegans
5GMY_A 328 ------------MGLFFVIS------------PDFARNLLSVVRVVQPKGGALTIAEVYPF-FFTHNGEF---TLTNAVL 379  Archaeoglobus fulgid...
O27928 330 ------------SIMLRDEIkrv-------hlPDFSWYPFILIGIWLIIGLAAYSLSTRFA-LLVIPPLI---IFLGLLM 386  Methanothermobacter ...
O27920 323 ------------M--LYRRKg-------------SVGLPVIFISVWIATGALMLLEGIRFVmILIAPLSV----SAGIFT 371  Methanothermobacter ...
O27660 372 evvveesenrprAGKKSKFMrkkraavaseemRHRYLLYAVLMAVWLIMSGYAVTKGSRFIpTFAMPLGLsagIFTGFLV 451  Methanothermobacter ...
Q0P9C8 334 ------------IVFLFSLFgf--------vwLLRKHKSMIMALPILVLGFLALKGGLRFT-IYSVPVMAl--GFGFLLS 390  Campylobacter jejuni...
Q58920 427 aigsdtiaivgiLGILLSFLslr------yekVKLDIKYSILLAIWLAVTLYAATKGIRFAaLATPPLAIglgIFVGQLE 500  Methanocaldococcus j...
P39007 326 ------------TGRFYSLWdt--------nyAKIHIPIIASVSEHQPVSWPAFFFDTHFL-IWLFPAGV---FLLFLDL 381  Saccharomyces cerevi...
O94335 333 ------------TGRFYSLWdt--------nyAKIHIPIIASVSEHQPPTWSSLFFDLQFL-IWLLPVGV---YLCFKEL 388  Schizosaccharomyces ...
6S7O_A 327 ------------TGRFYSLLdp--------syAKNNIPIIASVSEHQPTTWSSYYFDLQLL-VFMFPVGL---YYCFSNL 382  human
P46975 329 ------------SGRFYSLWdt--------gyAKIHIPIIASVSEHQPTTWVSFFFDLHIT-AAVFPVGL---WYCIKKV 384  Caenorhabditis elegans
5GMY_A 380 HFGALFFFGMAgi------------------lYSAYRFLKRRSFPEMALLIWAIAMFIALWGQ-NRFAYYFAAVSAVYSA 440  Archaeoglobus fulgid...
O27928 387 GVMASYLKGSP---------------------SMRLRRSGNVFILSLVVMLSTISFIQAYEIQ-FVPIVDDDFVAASYWI 444  Methanothermobacter ...
O27920 372 GILLDCSRKFR-----------------------FRWIKGVLFILIIFTVSAQLAISGNMVADlKPGYNDYFEESAHWIA 428  Methanothermobacter ...
O27660 452 EYLRVRFTTTSs--------------------LALIVFVAAVAMVMPFGVSVAVKLLAGVLAAgFIYSVKKPEIRAPFMM 511  Methanothermobacter ...
Q0P9C8 391 EFKAILVKKYS-----------------------QLTSNVCIVFATILTLAPVFIHIYNYKAP-TVFSQNEASLLNQLKN 446  Campylobacter jejuni...
Q58920 501 RFLKMKSDIAIfgigipagifgllilskysakISQILLPTTYVPIIAYGFLIVLALLAIYKIS-DIISTLNDKKETIIKV 579  Methanocaldococcus j...
P39007 382 KDEHVFVIAYS---------------------VLCSYFAGVMVR-LMLTLTPVICVSAAVALS-KIFDIYLDFKTSDRKY 438  Saccharomyces cerevi...
O94335 389 RNEHVFIIIYS---------------------VLGTYFCGVMVR-LVLTLTPCVCIAAAVAIS-TLLDTYMGPEVEEDKV 445  Schizosaccharomyces ...
6S7O_A 383 SDARIFIIMYG---------------------VTSMYFSAVMVR-LMLVLAPVMCILSGIGVS-QVLSTYMKN-LDISRp 438  human
P46975 385 NDERVFIILYA---------------------VSAVYFAGVMVR-LMLTLTPAVCVLAGIGFS-YTFEKYLKDEETKERS 441  Caenorhabditis elegans
5GMY_A 441 -----LAlsvvfdklhl-------------yralenaigARNKLSYFRVAFALLIALAAIYPTYILADAQS 493  Archaeoglobus fulgidus DSM 4304
O27928 445 -----KN--------------------------------ETSMDTVVITEWGYGHPLATFSQRPVLMDGGM 478  Methanothermobacter thermauto...
O27920 429 e--------------------------------------NTPSDAVIITEWSYGHFYASEADRPVVYDGRL 461  Methanothermobacter thermauto...
O27660 512 vlvvlAAvapsvsgahsittsvapgtddgmwnsmqwvkkNTSRDTVVMSWWDFGHLFAVAADRPVTFDGGS 582  Methanothermobacter thermauto...
Q0P9C8 447 ---------------------------------------IANREDYVVTWWDYGYPVRYYSDVKTLVDGGk 478  Campylobacter jejuni subsp. j...
Q58920 580 stlllCIgvvipplsavvpfsvaptfnngwkegldwikaNTPNNSVITCWWDNGHIYTYEARRMVTFDGGS 650  Methanocaldococcus jannaschii...
P39007 439 -----AIkp-----------------------------aALLAKLIVSGSFIFYLYLFVFHSTWVTRTAYS 475  Saccharomyces cerevisiae S288C
O94335 446 -----SEeaasaksknkkgifs--ilsfftsgsknigiySLLSRVLVISSTAYFLIMFVYHSSWVTSNAYS 509  Schizosaccharomyces pombe 972h-
6S7O_A 439 dkkskkq-------------------------qdstypiKNEVASGMILVMAFFLITYTFHSTWVTSEAYS 484  human
P46975 442 -----SSqsgttkdeklydkaak-nvksrnandgdesgvSSNVRTIISIILVIFLLMFVVHATYVTSNAYS 506  Caenorhabditis elegans
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