Conserved Protein Domain Family
BMT5-like

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pfam10354: BMT5-like 
rRNA (uridine-N3-)-methyltransferase BTM5-like
This is the N-terminal domain found in proteins from plants, yeast and humans, including 25S rRNA (uridine-N(3))-methyltransferase BMT5 from S. cerevisiae and the poorly characterized Ferredoxin-fold anticodon-binding domain-containing protein 1 from human and Heavy metal-associated isoprenylated plant protein 41 from Arabidopsis. This domain has a characteriztic Rossmann-like fold of S-adenosyl-L-methionine (SAM) binding domains. BTM5 is a SAM-dependent methyltransferase that specifically methylates the N3 position of uridine in 25S rRNA.
Statistics
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PSSM-Id: 463056
Aligned: 147 rows
Threshold Bit Score: 110.702
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EPS27353       84 LLVGEGDFSFARSLA------KQY-KCrkLCATCYDSKETLFSKY---PQAEQHIQEILDSatskskktdqenahdekdq 153 
CAQ38738      126 LCVGEGNLSFSTLLQkelrpcQ-------VVATSMESPNVLQRNYg--SIFSKNLKILESC------------------- 177 
XP_013704663   19 LLVGEGDFSFSLCLAkafgsaTN------ITATSLDTREELEQNY---KDAKNNVEELERH------------------- 70  
RID54150       19 LLVGEGDFSFSLSLGrafgsaSN------ITTSSLDSRVDVNRKY---TYGKQNVEELERL------------------- 70  
EFH50495       19 LVVGEGEFSFSLSLAkafgsaTN------ITAISLDIREELGRNY---NNGKVNVEELERL------------------- 70  
XP_009147626   19 LLVGEGEFSFSLSLAkafasvAK------ITAVSLDVRVGLGRQY---SNGDANVKELESL------------------- 70  
XP_002308746   39 LLVGEGDFSFSVSLArafgsaCN------LVSTTVDTQDNIAKKY---SNGVRNVRELEEK------------------- 90  
XP_003534991   44 LLVGDGDFSFSLCLArafgsaHN------LVATSLDSYDSIGKKY---SNGLSNVMELQER------------------- 95  
EFA79302     3218 LIVGDGDFSFTMALInkhkstHP------LLANSL-TTSELSMSPfksHEINSRMEQLNEL------------------- 3271
EGG19109       51 LLTAEGNFSYTKSLLdryshlKGFgES--ITATEY--TKQLDASI------IPVTKQLEEK------------------- 101 
EPS27353      154 qtssqsqsqtqssstqkpAPKVLFSVDARKLGtpagggkeirngyprkerkiaawklaqqaqaqaqaqaraqssgsaaye 233 
CAQ38738      178 ------------------GGIYVPEVDVEKIGeh---------------------------------------------- 193 
XP_013704663   71 ------------------GCTVIHGVNVHSMG------------------------------------------------ 84  
RID54150       71 ------------------GGTVIHGVNVHSMS------------------------------------------------ 84  
EFH50495       71 ------------------GCTVVRGVNVHSMA------------------------------------------------ 84  
XP_009147626   71 ------------------GCTVVRGINVHTMT------------------------------------------------ 84  
XP_002308746   91 ------------------GGLVFYGVDAEEMS------------------------------------------------ 104 
XP_003534991   96 ------------------GCLVFHGVDAKEMS------------------------------------------------ 109 
EFA79302     3272 ------------------GVRTIVGLNSNDISnv---------------------------------------------- 3287
EGG19109      102 ------------------GVKIMLGVDGREIGqi---------------------------------------------- 117 
EPS27353      234 lrMslsggggggGGGpWDVICFNFPHV-----------GGLSTDVNR----QVRANQ--------ELLVAFFQACVPLLS 290 
CAQ38738      194 ----------flHNT-FDVIIFNFPFVlpsddfiqtkwNIQKEKLHSdrniFLKYYKkseylllnKILYWLFKNGSLLLK 262 
XP_013704663   85 --Kdhr----vlRSVvYDRVIFNFPHA-----------GFHFG--REfdsyTILQHQ--------RVVKGFFLSARELVD 137 
RID54150       85 --Sdnr----laR---YNRIVFNFPHS-----------GLGFG--SEhesfYIMQHQ--------ALVRGFFESARKMLE 134 
EFH50495       85 --Sddr----laH---YDIIIFNFPHA-----------G---------------KRD--------KVFGGFMESAREMMK 121 
XP_009147626   85 --Sdyr----lsR---YDRIVFNFPHA-----------G---------------KHK--------DVVTGFMQSAPEMMN 121 
XP_002308746  105 --Ehff----lrTQR-FDRIVYNFPHV-----------GFLFP--EAsy-cQIQLNK--------RLIKGYLSNAKVLLK 155 
XP_003534991  110 --Qhff----lkTQR-FDRIVYNFPHV-----------GFIYP--ENsh-cQIQLNK--------RLLKGFLANAKALIK 160 
EFA79302     3288 ----------fqGQR-FKRIQWNNPWPfw--------------------slSIYKNYi------sSVLPSFYVSASQLQQ 3330
EGG19109      118 ----------fkGER-FNIIQCNCPFG-----------GSSERDRDEf----------------kTFTLEFFQSASELQK 159 
EPS27353      291 KApppvdeddeeeewgedeedeeeddsepfdfenketsgkgmrtgpGQILVSLFEGEP---------YTLWNIK-DLARH 360 
CAQ38738      263 DG--------------------------------------------GFLHLRLNDK-----------YLTC----DFANT 283 
XP_013704663  138 AS--------------------------------------------GEIHVTHKIAYp---------FTNWNIK-TLGEE 163 
RID54150      135 DEd-------------------------------------------GEIHLTHKTTRp---------FSEWEIE-TLAQE 161 
EFH50495      122 DEd-------------------------------------------GEIHITLNTLPp---------FNKWDIK-ALAEE 148 
XP_009147626  122 EG--------------------------------------------GEMHFTNMTMYp---------FNKLDIK-SLAGE 147 
XP_002308746  156 QDk-------------------------------------------GEIHVTHKEGDp---------YDKWDLV-KKAEK 182 
XP_003534991  161 KEg-------------------------------------------GEIHVTHKEGDp---------YNKWDLV-KKPEK 187 
EFA79302     3331 PG--------------------------------------------DRIHMTLVQGSe--------dFKFRQMEnPLVRA 3358
EGG19109      160 PG--------------------------------------------DRIHFALDQSKGywkerktfiYIERQREnPIVKG 195 
EPS27353      361 ---AGLQVVTSFKFPWTEYEGYSHAR 383 
CAQ38738      284 ---FSLSLVEKIDFSASYFI-YKSLR 305 
XP_013704663  164 ---EGLYCVREINFETCQYPGYSNKR 186 
RID54150      162 ---KGLRLIGLMVFDQLAFPGYSNKK 184 
EFH50495      149 ---KGLRLIQRMQFTKWAFPTYSNKR 171 
XP_009147626  148 ---NGLRLIKQMQFKKWIFPCYSNKC 170 
XP_002308746  183 ---IGLGLHEIVPFSRRDYPGYENKR 205 
XP_003534991  188 ---RGLVLQQVVPFFKDDYPGYDNKR 210 
EFA79302     3359 sfrANYRLIRKRRLSNTRYPGYFHHY 3384
EGG19109      196 sinANYKLIRKRRF-GERYPKYRHKK 220 
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