Conserved Protein Domain Family
COX17
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pfam05051: COX17 
Cytochrome C oxidase copper chaperone (COX17)
Cox17 is essential for the assembly of functional cytochrome c oxidase (CCO) and for delivery of copper ions to the mitochondrion for insertion into the enzyme in yeast. The structure of Cox17 shows the protein to have an unstructured N-terminal region followed by two helices and several unstructured C-terminal residues. The Cu(I) binding site has been modelled as two-coordinate with ligation by conserved residues Cys23 and Cys26.
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Statistics
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PSSM-Id: 428283
Aligned: 91 rows
Threshold Bit Score: 56.0332
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
CCF48986     19 EGIKPCCACPEAKAARDECFFKFGhSVeehgesarKCQDLVKAHRECMAKLGYK 72 
A0D9G5       15 QECKACSACPETRQLRDECIIFNG-EE--------QCKKEIENHKVCLKKYGFE 59  Paramecium tetraurelia
A0E6J0       13 EPLRPCCACPDTRNLRDECIISFG-EE--------KCSKEIENHKLCLKKLGFE 57  Paramecium tetraurelia
XP_001421377 17 KPKKICCACPETKRARDECVVTHGaDEd------gACREKIEQHLKCLRAEGFD 64 
EFJ10712     15 PKKKICCACPDTKKLRDECIAEHG-ED--------ACGKWIDVHLRCLREEGFN 59 
EFH70680     27 PKKRICCACPDTKKLRDECIVEHG-ES--------ACTKWIEAHLSCLRSEGFK 71 
XP_021857911 40 PKKKICCACPDTKKLRDECIVQNG-ED--------ACGKWIEAHKQCLRAEGFN 84 
EFA75384     19 PKKKICCACPDTKKLRDECILTNG-ED--------KCFEFIEKHKMCLRAEGFD 63 
EGC30737     18 PKKKMCCACPETKKTRDECIVNNG-ED--------KCAQFIEAHKACLRSEGFD 62 
XP_002261774 21 PKKKICCVCLETKKLRDECIVKLG-EE--------QCRKYIEDHNQCLRNEGFD 65
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