Conserved Protein Domain Family
Bul1_C

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pfam04426: Bul1_C 
Bul1 C terminus
This family contains the C terminus of Saccharomyces cerevisiae Bul1. Bul1 binds the ubiquitin ligase Rsp5, via an N terminal PPSY motif (157-160 in Swiss:P48524). The complex containing Bul1 and Rsp5 is involved in intracellular trafficking of the general amino acid permease Gap1, degradation of Rog1 in cooperation with Bul2 and GSK-3, and mitochondrial inheritance. Bul1 may contain HEAT repeats.
Statistics
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PSSM-Id: 367936
Aligned: 17 rows
Threshold Bit Score: 211.88
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
P48524        690 HDQENWVRLSELIPEDVKKPLEKLDLQLTCIESDNSLPH-DPPEIQSITTELICITAKSDN-SIPIKLNSELLM-NKEKL 766  Saccharomyces...
XP_001645627  678 HDKENWLKLKSTLPEDEKTSLKKLDIQLSCLLSNNSAPH-DPPEIQSVTTELICVTAKSDN-SIPIKLDSSLLM-NDEKI 754 
Q876C9        567 QEKENWERLMNLLPDGVKTPLTKLDVNLTCIQSNNSAEH-KPPEISSVTTEFVVITAKSDN-SIPIKFSTELLM-NENRL 643  Saccharomyces...
Q6FP46        714 HDQENWVRLIDLLSEEEKTPLENVNVKLKCFVSNNGPIH-QPPGIQIITTSLICITASSDN-SIPIQLSSKLLY-NEENV 790  [Candida] gla...
XP_001482769  487 KDKETQLT---------------IPIDLTYFYRINSLKQpSMPKIKSITAELTALTIKSDKyPIPVEFNHEMCFrDKEVV 551 
P53754          5 QNQKNWTNLRGLLSVEEREKLENLRLELVCMQAANSIPH-DPPEISSLETELICLTTNTKD-CKPVRFHSDLLL-KKHKY 81   Saccharomyces...
Q876B6        751 HDQENWFRLMEAVSDIERTPLTEIPIKLTSILSNNSAPH-DPPKVTSVSVQLISITGISDN-SIPIKLNSKFLM-NKEKC 827  Kazachstania ...
Q876A8        772 HDQENWARLAQLVSENERDILKNLPIKITCIESNNSIPH-DPPPIQSITTQLIVITGRSDF-SIPIKLSVDMLS-DDKRL 848  Kazachstania ...
Q875N4        634 HDQESWESLTNSLSEEENKILSKLNIHLRCIQSNNSEAH-EPPEIQSILTELVCITANSIN-CIPIKLSTEFLM-NQDKV 710  Lachancea klu...
Q6CSE2        655 HDQANWDCAQSSFLDEEMKVLDHLNIHLRCIQANSSVSH-KPPEIQAVTTQLICITSKAVS-SFPLKLNAELLL-NTEKM 731  Kluyveromyces...
P48524        767 TSIKALYDDFHSKICEYETKFNKNFLELNELYNMNRGDR-RPKELKFTDFITSQLFNDIESICNLKVSVHNLSNIFKKQV 845  Saccharomyces...
XP_001645627  755 KNMKRRFADFLAKIKEYNKKFNEKIVELNDLYNSNRSS--NRRELKFTDFVSSQIYNDVESLANIEVNTTHLNETFKKQI 832 
Q876C9        644 NELKTKFSAFQKKVTEYRKKFEENNVKLNELYNRDRGQI-IPRELLFTNFISDQLNNDVDSLAGLKVNVIDLHDIFKRQI 722  Saccharomyces...
Q6FP46        791 TTLKKTFTDYNKKITEYKALFEENEEKLNILYHGNSMLSqTNRGLKFTDFIPTNLHNDVESLMELHVDVTELHQVFRKQS 870  [Candida] gla...
XP_001482769  552 KNLKQVVDNFDRIV------IQPNKKNLQKLTYHLKHL--GSDVFK----VETKLFNDLKSLAFLST---------KYQT 610 
P53754         82 NEIKKIFKEILENIEAYRDEFTKNQTKINLLLADDARASlRNRSLDFSDLMPSSIIKDVQVLANMEANVVVMKNALKTKL 161  Saccharomyces...
Q876B6        828 DDIQKLFKSYEDKVTHYRKRFNANVDKLNELFNKGRTIS-SARELFFKDFISTLMASDIESMVNFEMKRVEINDIFKKQV 906  Kazachstania ...
Q876A8        849 NNIKKTFHSYRQQVSNYQTRFQEQREKINKLYNLGTSSN-NKKVLHFKDFISDQIKSDIESLSNIEVRCDILNEIFKKQP 927  Kazachstania ...
Q875N4        711 DSVRNTYKDMHKKIKDSEEKFAQNLEKLNELYNLSRRST-AQQELRFTDFISNQLNNDVESLANLKVDVRNLPHVFKKQV 789  Lachancea klu...
Q6CSE2        732 KGITGTFHGYLQKVKDYKQKFKSNIDQLTELYNKSKSTMsSHQEIRFSDFVTPQLMNDIESLASLVIDVKSLNNIFKKQD 811  Kluyveromyces...
P48524        846 STLKQHSKHALsEDSISHTGNGSSSSPSSASLTPVTsssksslflpsgssSTSLKFTDQIVHKWVRIAPLQYKRDINVNL 925  Saccharomyces...
XP_001645627  833 QTLRSNNDIISpSMTNGGANASRSSSATRLSTTFSGsnsns-----gsktSISSKFTDQIIHRWIKKTPSSYKREVSVNL 907 
Q876C9        723 HTFEEENEDIIsKKGGSNSSLAASNNNFLQATFSNSa-------------STATKFTQQIVHTWEKVKPLQYKRDVTVNL 789  Saccharomyces...
Q6FP46        871 FFTKSTSSNDSyFNFSLSSSETIGNNASSPSEIIDAn------------nSPKPTKSETSASGWRSTGKFTFERDVNVHL 938  [Candida] gla...
XP_001482769  611 LVISDLNFSSTtEKSLVTSIEDITWQIEPTESTEYE--------------TYSKKFNVHID---LKRAKLKGSNNENSEL 673 
P53754        162 VGEKSVP-------VASSPISSIIPRTSRNKKTSPSn-------------YHHSVLSHRKSNEWNQVSSTEYKRTLLLNI 221  Saccharomyces...
Q876B6        907 LNQNDSE----------------------------------------------------LVWKPKLENSSESEAVLNVKL 934  Kazachstania ...
Q876A8        928 SSTTQTSHSPIrHLDGTLSPERRRDTVMSSPI------------------HNNTEENSAIGKGWSQVGTQEFERFVLADL 989  Kazachstania ...
Q875N4        790 QTLENKEDASPlTSSKSNSASNLLSSTFSAPSNHHNh------------tSMAAMFKNQLAHEWVKSDEAEYDREITVNL 857  Lachancea klu...
Q6CSE2        812 QTLSHASDKISgGTNLLSSDSAPLSLQAALSHSNPL--------------TQAELMKQELLHEWIESNEKEYNREVTVNL 877  Kluyveromyces...
P48524        926 EFNKDIKETLIPSFESCLCCRFYCVRVMIKFeNHLGVAKIDIPISVRQV 974  Saccharomyces cerevisiae S288C
XP_001645627  908 EYNPEIRETLVPSFESCLCCRFYCVRVSIKFdHHVGVAKIDIPVTVKNF 956 
Q876C9        790 KLNPNIKETLVPNFETCLCCRFYCIRVNIKFeNHLGSMKVDIPVDVKKL 838  Saccharomyces bayanus
Q6FP46        939 SLDPHMKETLPPNFESCLCTRFYVVRVCIKFdHHIGTATLDIPVSVKRI 987  [Candida] glabrata
XP_001482769  674 LFDN---YTLVPSFQLCFLSRLYYIKIMVHL--HSGE--------ILQI 709 
P53754        222 KYNDDFKATIVPSFESCLCSRSYFLRVKLHFdKGVGSAEIDIPVQVKNS 270  Saccharomyces cerevisiae S288C
Q876B6        935 DFNQNINVTIIPNFETCLCCRFYFLRVNVKFdNNIGSTKIDIPVNVKKF 983  Kazachstania servazzii
Q876A8        990 EMTRDIGETLIPSFESCLCCRFYAIRVNIKFdSHIGSASLDIPINVKKM 1038 Kazachstania exigua
Q875N4        858 QLNNDIKETIVPTFESCLCCRMYYVKVDIKFeNHIGTVTAHVPIRIRKL 906  Lachancea kluyveri
Q6CSE2        878 VLDTEIKETLVPTFESCLCSRMYCVRVNVKFeNNIGTTSIDVPVRIRYL 926  Kluyveromyces lactis
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