2CW9


Conserved Protein Domain Family
Tim44
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smart00978: Tim44 
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Tim44 is an essential component of the machinery that mediates the translocation of nuclear-encoded proteins across the mitochondrial inner membrane.
Tim44 is thought to bind phospholipids of the mitochondrial inner membrane both by electrostatic interactions and by penetrating the polar head group region.
Links
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Statistics
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PSSM-Id: 214950
Aligned: 123 rows
Threshold Bit Score: 67.3486
Created: 13-Jul-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2CW9_A        41 VLTEILRVD--PAFDKDRFLKQCEnDIIPNVLEAXISGELDILKDWCYEATYSQLAHPIQQAKALGLQFhSRILDIDNVD 118 human
XP_001372116 121 AIRKVREYD--ADFRTKTFPEKAQ-QIFVEAHQCLNTSDHDRLHALVTERCFPEMVWDIQLKTVHWNFVeSLEPPRVVHV 197 gray short-tail...
CAF95337      40 AIRKIKDHD--SEFSTKDFAEQAQ-EIFIEAHNCLTNFNKEKLHSLLTERCYPEMTRGNRYKTIRWRFVeSLELPKVVHA 116 spotted green p...
NP_001180514 120 ALRKVKDHD--PNFSTKTFPEVAQ-EIYVEAHNSLANFNKQKLHSLVTERCYPDMVRGNRYKTIRWSFVeSLEPPRVVHV 196 chicken
XP_001982246 152 AVRKIRSYD--ENFSSDDFGAEAQ-DIYIQAHTHMAAKDKYKIREFVSERCYPEMMHNVKDKTIRWKFLqSLEPPRVVHA 228 Drosophila erecta
NP_001027509 121 AIRKVKEYD--SEFTTKTFPEKAQ-ELFIAAHQCLTKFDRHELHTLVTERCYPEMVRGNRYRTIQWSFVeSIEAPRVVQV 197 western clawed ...
XP_312541    143 AIRKIRNYD--EDFEPPEFATLAQ-DIYIEAHKTLCEKNKYKLREIVTERAYPELMHNVADKTIRWQFLkSLEPPRVVHA 219 Anopheles gambi...
NP_497347    158 GTNRIRKKQgfEKFDIKTFCAKAE-DIYVQAHRALEQRDKTAMYKYITEYAFAKMWPDVENGSVRFELIsVLEPSRVVAV 236 nematode
NP_001119286 143 AYAIAKLRK--TGYSKNTFYIEAL-ELYKQINIQMANGEKKTIRKNVTERMYSALKNEIKQREAMWDGVyWEMVEPVVKI 219 thale cress
YP_001248549  92 eLIKLKSKV--PSFNINRFYNTAI-NVIKMIIEAVQNVDYKTIFSLLDKRFVDQFHQMSSKYA-----------NIHVNS 157 Orientia tsutsu...

2CW9_A       119 ------LAXGKXve---qgPVLIITFQAQLVXVVRNPKgEVVEGDPDKVLRXLYVWALCR-DqdeL-N-PYAAWRLLDI 185 human
XP_001372116 198 rc--pnMV--SEgn---iyGQVTVRMHTRQTLAIYDRFgRLMYGQEDVPKDVLEYVVFER-Hl--T-N-PYGAWRMHGK 264 gray short-taile...
CAF95337     117 rc--pdMVSKGnl-----yGQVTVRMHSRQTLAIYDRFgRLMLGNEEQPKDVLEYLVLER-H---LvN-PYGRWRLHGK 183 spotted green pu...
NP_001180514 197 rc--tsVV--NQgn---lyGQVTVRMHTRQTLAIYDRFgRLMYGGEKLPKDVLEYVVFERyL---V-N-PYGTWRMHGK 263 chicken
XP_001982246 229 rv--teVITKen-----qfAQVTVRFHSQQMLAIYDRFgRLMHGSEIITKDVLEYVVFEK-Hi--S-N-EYGKWRLHDK 295 Drosophila erecta
NP_001027509 198 rc--peMVSKGnl-----yAQVTVRMHNKQSLTIYDRFgRVMCGSEE-PRDVLEYVVFER-Hm--V-N-PYGTWRMHGK 263 western clawed frog
XP_312541    220 rc--tdVITKen-----ifAQVTVRFHSQQTLAIYDRFgRLMHGSETVAKDCIEYVVFEK-H---LaN-EYGVWRLHEK 286 Anopheles gambia...
NP_497347    237 rc--fdNPPKSgn----diAQITVRMHTRQKLAVYDRFgGLLLGSEDEEKDVVEYVVFEN-H---I-AvVDGEWRLHGK 304 nematode
NP_001119286 220 rtlqarLIGIDRtdlkkafIQLTLEFLTKQKFEAYDAKgNVAAGDKNKEVLVRDIWVFEK-S---LfH-TGAYWRLCGr 293 thale cress
YP_001248549 158 in--fkLSNLNSlg---nnIFIKIRI-------------------EINGNKLKEEWTFSK-Ni--T-T-PGPQWYLSNI 207 Orientia tsutsug...
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