Conserved Protein Domain Family
T4_deiodinase

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pfam00837: T4_deiodinase 
Iodothyronine deiodinase
Iodothyronine deiodinase converts thyroxine (T4) to 3,5,3'-triiodothyronine (T3).
Statistics
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PSSM-Id: 279210
Aligned: 3 rows
Threshold Bit Score: 401.165
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
P55073  38 LCAQTASCLVLFPRFLGTAFMLWLLDFLCIRKHFLGRRRRgqpepevelnsegeevppdDPPIcVSDDN-RLCTLASLKA 116 human
Q92813   4 LSVDLLITLQILPVFFSNCLFLALYDSVILLKHVVLLLSR-------------------SKST-RGEWR-RMLTSEGLRC 62  human
P49894   8 LWLRRLWVLLQVAVQVAVGKVFLKLFPARVKQHIVAMNGK-------------------NPHFsYDNWApTLYSMQYFWF 68  dog
P55073 117 VWHGQKLDFFKQAHEGGPAPNSEVVLPDGFQS-----------------QHILDYAQGNRPLVLNFGSCTUPPFMARMSA 179 human
Q92813  63 VWKSFLLDAYKQVKLGEDAPNSSVVHVSSTEGgdnsgngtqekiaegatCHLLDFASPERPLVVNFGSATUPPFTSQLPA 142 human
P49894  69 VLKVQWQRLEDRTEPGGLAPNCPVVRLSGQR------------------CNIWDFMQGNRPLVLNFGSCTUPSFLFKFDQ 130 dog
P55073 180 FQRLVTKYQRDVDFLIIYIEEAHPSDGWVTTDSP---YIIPQHRSLEDRVSAARVLQQGA---PGCALVLDTMANSSSSA 253 human
Q92813 143 FRKLVEEFSSVADFLLVYIDEAHPSDGWAIPGDSslsFEVKKHQNQEDRCAAAQQLLERFslpPQCRVVADRMDNNANIA 222 human
P49894 131 FKRLIEDFCSTADFLIIYIEEAHASDGWAFKNN----VNIRTHQTLQDRLQAARLLLDRA---PPCPVVVDTMRNQSSQF 203 dog
P55073 254 YGAYFERLYVIQSGTIMYQGGRGPDGYQVSELRTWLERYD 293 human
Q92813 223 YGVAFERVCIVQRQKIAYLGGKGPFSYNLQEVRHWLEKNF 262 human
P49894 204 YAALPERLFVLQEGRILYKGKPGPWNYHPEEVRAVLEKLH 243 dog
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