2NRL,1LHS,3RGK,1MBS


Conserved Protein Domain Family
Mb

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cd08926: Mb 
Click on image for an interactive view with Cn3D
Animal Myoglobins
Myoglobin (Mb) is a monomeric pentacoordinate heme-bound globin protein whose expression has long been considered limited to cardiomyocytes and striated skeletal muscle cell, however it has recently been found localized in a wide variety of tissues including smooth muscle cells. As a physiological catalyst, it can modulate reactive oxygen species levels, facilitate oxygen diffusion within the cell, and scavenge or generate NO depending on oxygen tensions within the cell. Through its NO dioxygenase and nitrite reductase activities, Mb regulates mitochondrial function in energy-demanding tissues.
Statistics
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PSSM-Id: 271277
Aligned: 8 rows
Threshold Bit Score: 236.584
Created: 14-Jun-2010
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
 
heme binding
Conserved site includes 19 residues -Click on image for an interactive view with Cn3D
Feature 1:heme binding site [chemical binding site]
Evidence:
  • Structure:2NRL: Thunnus atlanticus myoglobin binds heme; contacts at 4A
  • Structure:1LHS: Caretta caretta myoglobin binds heme; contacts at 4A
  • Citation:PMID 7714901

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                       #  ## #                  #  ##  ##            
2NRL_A      2 ADFDAVLKCWGPVEADYTTIGGLVLTRLFKEHPETQKLFPKFAgia-qadIAGNAAVSAHGATVLKKLGELLKAKGSHAA 80  Thunnus atlanticus
1LHS_A      5 DEWNHVLGIWAKVEPDLSAHGQEVIIRLFQLHPETQERFAKFKnlttidaLKSSEEVKKHGTTVLTALGRILKQKNNHEQ 84  Loggerhead turtle
3RGK_A      5 GEWQLVLNVWGKVEADIPGHGQEVLIRLFKGHPETLEKFDRFKhlksedeMKASEDLKKHGATVLTALGGILKKKGHHEA 84  human
1MBS_A      5 GEWHLVLNVWGKVETDLAGHGQEVLIRLFKSHPETLEKFDKFKhlkseddMRRSEDLRKHGNTVLTALGGILKKKGHHEA 84  harbor seal
P02206      2 TEWEHVNKVWAVVEPDIPAVGLAILLRLFKEHKETKDLFPKFKeip-vqqLGNNEDLRKHGVTVLRALGNILKQKGKHST 80  Port Jackson shark
P14399      2 VDWEKVNSVWSAVESDLTAIGQNILLRLFEQYPESQNHFPKFKnks-lgeLKDTADIKAQADTVLSALGNIVKKKGSHSQ 80  gummy shark
AFM87511    2 CDWDLINKVWAKVEEDLAGNGQTVLLRLFEEHPETKAHFPKFKgip-lgqLTSNADVKTHGNTVFKALGDVVKQKGKHAS 80  ghost shark
AEM37760    2 ADYDVVLKCWSAVEADYSGIGNLVLRRLFKEFPQSLNHFPKFDgms-qadLASNGDLTAQGVTVLTKLGEVLKTRGNHGE 80  longtooth grouper
Feature 1         #  ##  ## #   ##  #                              #               
2NRL_A     81 ILKPLANSHATKHKIPINNFKLISEVLVKVMQEKAg--LDAGGQTALRNVMGIIIADLEANYKELGFSG 147 Thunnus atlanticus
1LHS_A     85 ELKPLAESHATKHKIPVKYLEFICEIIVKVIAEKHpsdFGADSQAAMKKALELFRNDMASKYKEFGFQG 153 Loggerhead turtle
3RGK_A     85 EIKPLAQSHATKHKIPVKYLEFISEAIIQVLQSKHpgdFGADAQGAMNKALELFRKDMASNYKELGFQG 153 human
1MBS_A     85 ELKPLAQSHATKHKIPIKYLEFISEAIIHVLHSKHpaeFGADAQAAMKKALELFRNDIAAKYKELGFHG 153 harbor seal
P02206     81 NVKELADTHINKHKIPPKNFVLITNIAVKVLTEMYpsdMTGPMQESFSKVFTVICSDLETLYKEANFQG 149 Port Jackson shark
P14399     81 PVKALAATHITTHKIPPHYFTKITTIAVDVLSEMYpseMNAQVQAAFSGAFKIICSDIEKEYKAANFQG 149 gummy shark
AFM87511   81 NLQALATTHINKHKIPPQNFTLITNVILKVFAEKFpgeMTAPAQEAFSKAFKAICSELEDLYKKGGFQS 149 ghost shark
AEM37760   81 IIKNLSKTHANQHKVPIGHFKVIAEILGKVMEEKAg--LDGPGQQALKRLMTAIIADIEANYKELGFSG 147 longtooth grouper

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