4CHL,4YSK,4YSL,4EFZ,3TP9,3R2U,2GCU,4YSB


Conserved Protein Domain Family
POD-like_MBL-fold
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cd07724: POD-like_MBL-fold 
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ETHE1 (PDO type I), persulfide dioxygenase A (PDOA, PDO type II) and related proteins; MBL-fold metallo-hydrolase domain
Persulfide dioxygenase (PDO, also known as sulfur dioxygenase, SDO, EC 1.13.11.18) is a non-heme iron-dependent oxygenase which catalyzes the oxidation of glutathione persulfide to glutathione and persulfite in the mitochondria. Mutations in ethe1 (the human PDO gene) are responsible for a rare autosomal recessive metabolic disorder called ethylmalonic encephalopathy. Arabidopsis thaliana ETHE1 is essential for embryo and endosperm development. Bacterial ETHE1-type PDOs are also called Type 1 PDOs. Type II PDOs (also called PDOAs), are mainly proteobacterial. These enzymes belong to the MBL-fold metallo-hydrolase superfamily which is comprised mainly of hydrolytic enzymes which carry out a variety of biological functions.
Links
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Statistics
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PSSM-Id: 293810
Aligned: 330 rows
Threshold Bit Score: 150.628
Created: 20-May-2009
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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active siteFe binding site
Conserved site includes 9 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:4YSL: Pseudomonas putida PDO binds glutathione and one ferrous iron
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                       #   #         
4CHL_A      8 LLRQMFEPvsCTFTYLLGDresrEAVLIDPVLe---------tAPRDAQLIKEl--GLRLLYAVNTHCHADHITGSGLLR 76  human
4YSL_A      8 HVDAFYDEatSTISYLVMDretrQCALIDSVLdydpksgrtcsASADRLVERVnelNASVRWVLETHVHADHLSAAAYLK 87  Pseudomonas putida F1
ELR18608   11 LLLELNGGe-ACKTYLIADrqrrKAALLDPLKq---------nIPKYLGVLAYh--QLQLEYIFDSHSHADHFTAGFELA 78  Acanthamoeba caste...
KGB53975    2 YFASFRDGe-GCKSYIVGCtetcAAAIIDPALd---------lVDRYIGEVNRq--GLRVRYIIDTHTHADHFSGAQALK 69  Sphingopyxis sp. LC81
ABV38377    4 IFHRIRTEr-GCQSYLIGCsetnSAIIIDPEIs---------qMEHYLGLASHd--GLAIHYLLDTHTHADHFSASKQLA 71  Shewanella sedimin...
EPX61210    5 IFEELNGGa-SCRTYLISSawtrEAIIVDPVLe---------lVPGYLRRLGKd--RLQLIAVVDTHTHADHLSGGRELA 72  Cystobacter fuscus...
AFT66463    2 FFQELNNI--NCKTYLIADldagQAAIIDPVDs---------yIDRYLAILAYh--RLTLKFVADTHTHADHRSACTALR 68  Cycloclasticus sp. P1
GAN33262    2 IFKQLNKT--SCKTYLIGSentkEAIVVDAVLe---------qVNEYVSLIKNe--GLKLTHVLDTHTHADHISGSGALA 68  Candidatus Brocadi...
AHM57934    2 LFEQLNPH--SCKTYLIANdd-nSAVIIDPVIe---------hFKFYIELLKEr--KLKLTHVIDTHTHADHISAGSALR 67  Eubacterium acidam...
EJL34867    2 LFEQVTTG--GCQSYLVGCpdtlSAVLIDPEIs---------qIDRYRALAAKh--GLRVRYVIDTHTHADHFSAAKQMG 68  Caulobacter sp. AP07

Feature 1                                                                   #                 
4CHL_A     77 SllpGCQSVISRl--------------------sGAQADLHIEDGDSIRFGRFALETRASPGHTPGCVTFVLNd--hSMA 134 human
4YSL_A     88 Ek-lGGHTAIGAhitqvqkvfgalfnaepgfardGSQFDVLLEDEEGFRIGNLQARALHTPGHTPACMSFMIEdageIAV 166 Pseudomonas putida F1
ELR18608   79 Ml-tEGKLAMHEna-------------------pAPKVKVHVRDGDVLRVGDIEVKVMHTPGHTPDSIALYLPr--lGHL 136 Acanthamoeba caste...
KGB53975   70 Ha-fGAPIVMHRfs-------------------pSPYVDLHVEDGHSLPLGAMRMKIWHTPGHTRDSMAIHVA----DRV 125 Sphingopyxis sp. LC81
ABV38377   72 Sq-lKVPVIMHCns-------------------pAPFVDMYVDDGEIIIVGKLRLTIMHTPGHTADSICIVMK----DRV 127 Shewanella sedimin...
EPX61210   73 Rm-mGAVHMGAP----------------------AHAVQRPLGEGDELAVGDVRVRVWASPGHTADGLVLVLD----DRV 125 Cystobacter fuscus...
AFT66463   69 Rl-tNCLVMMHEls-------------------pQPTVDKRYIDGDELTVGNIHIKVLHTPGHTPDSVSFYVNd---DRV 125 Cycloclasticus sp. P1
GAN33262   69 Dl-tGAVYVMHQns-------------------pVRCVAFHVPDGFDCHLSDIPVKVMHTPGHTKDSMCLIFS----DRI 124 Candidatus Brocadi...
AHM57934   68 Da-tGCEYVMHEna-------------------pSKCVSIRVEDGDVLNISGMEFKFLYTPGHTKDAVSIIVG----DKL 123 Eubacterium acidam...
EJL34867   69 Em-lGAPTVMHHas-------------------pAPHVGLRLDDDDVLIVGNLRIRALHTPGHTGDSMCLVVE----DRV 124 Caulobacter sp. AP07

Feature 1        #  #     ###                                 #
4CHL_A    135 FTGDALLIRG--CGRTDFqqgcAKTLYHSVHEKIFTLPgdCLIYPAHDY 181 human
4YSL_A    167 FVGDTLFMPDygTARCDFpgadARTLYRSIRRLLAFPDq-TRLFMCHDY 214 Pseudomonas putida F1
ELR18608  137 YSGDTLMIGG--TGRTDFaggdPGQSYDSIQRMFALPEd-TVLWPGHDY 182 Acanthamoeba castellanii str. Neff
KGB53975  126 FTGDTLLIGG--TGRSDLpsgdPDQLFDSLFGKLLTLPdeTLVFPAHDY 172 Sphingopyxis sp. LC81
ABV38377  128 FTGDTLLLGG--TGRTDLpsgdPERLYDSLFNGLLKLSadLKVYPAHAY 174 Shewanella sediminis HAW-EB3
EPX61210  126 LTGDTLLIGA--TGRTDLptgdPEAEYESLERLLSLPDd-TLVFPAHDY 171 Cystobacter fuscus DSM 2262
AFT66463  126 LTGDVILIQG--TGRSDFaggnAGDQYDSITDKIFTLPdkTLLFPAHDY 172 Cycloclasticus sp. P1
GAN33262  125 LTGDTLFLDDggAGRTDLpggdPGEHWESLQKIMQLPDh-LVVYPAHEY 172 Candidatus Brocadia sinica JPN1
AHM57934  124 LTGDFLFLDDggAGRDDLpggdPADHWESLKKLDELPDe-LVVYPAHEY 171 Eubacterium acidaminophilum DSM 3953
EJL34867  125 FTGDTLLIGG--AGRTDLptgdPDQLYDSLFGKLLTLDpaLLVYPAHDY 171 Caulobacter sp. AP07

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