Conserved Protein Domain Family
group_II_RT_mat

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TIGR04416: group_II_RT_mat 
group II intron reverse transcriptase/maturase
Members of this protein family are multifunctional proteins encoded in most examples of bacterial group II introns. These group II introns are mobile selfish genetic elements, often with multiple highly identical copies per genome. Member proteins have an N-terminal reverse transcriptase (RNA-directed DNA polymerase) domain (pfam00078) followed by an RNA-binding maturase domain (pfam08388). Some members of this family may have an additional C-terminal DNA endonuclease domain that this model does not cover. A region of the group II intron ribozyme structure should be detectable nearby on the genome by Rfam model RF00029. [Mobile and extrachromosomal element functions, Other]
Statistics
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PSSM-Id: 275209
Aligned: 121 rows
Threshold Bit Score: 351.375
Created: 9-Oct-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
ZP_13300096   45 LDILWRAWEEVKENGGSGGIDGITFEQIERDg-VETFLRTIEEDLKRrkYRPSPVRRVMIPKPD--G-SQRPLGIPTIRD 120 Leptospira sant...
ZP_13884144   42 NQVLGMAWTQVRANKGAPGIDRLSIEQVEKEigVGNFLRDIQKKLVAkrYVPQPVRRVYIPKSD--G-KERSLGIPVIAD 118 Escherichia col...
ZP_08623276   42 KDVLLKAWNQVKANAGSAGIDSQTIEDVKTYg-EAKFLAEIEKELLEgtYQAMPVKRVQIPKKD--G-SKRPLGIPTVKD 117 Acetonema longu...
EKD85697      42 MEVLETAWKQVLKNRGTCGYDGVTLEDVKLRg-VNEFLEEIRKSLVFrtYRADPVKRVYIPKSD--G-SLRPLGIPTVKD 117 uncultured bact...
WP_000561483  42 KDILKVAWFYVKRNKGSAGIDDFTIEEIEAYg-VQKFLDEIEDQLRNkkYQPKAVKRVYIPKAN--G-KKRPLGIPTVRD 117 Streptococcus a...
WP_011779439  56 gDVLWEAWERVRKNRGAAGVDRVTLVAVEEYg-VDRMLRELRHDLREgvYCPAPARRVEIPKPR--G-GTRPLGIPTVRD 131 Mycobacterium v...
WP_014095942  42 KDILEEAWKRVKQNGGAGGVDKVSIEDVKAYg-EEKLLNEIAEELRTekYRCKPVRRTYIPKQD--G-RKRALGIPTIKD 117 Bacillus coagulans
WP_011988638  41 EDILLKAWKQVKANKGSGGIDDMHIDDVIKYg-ENKFLKEIQQKLIEnnYHPKPVKRVFIPKKG--G-KKRPLGIPIIKD 116 Clostridium klu...
WP_011598972  48 RDVLWRGWVAVRRNNGAPGIDRITLEEVEEYg-VARLLDELAVELKEgsYRPLPARRVFIPKPG--TvEQRPLSIPSVRD 124 Rhodococcus jostii
WP_011436613  47 gDVLERAWALVRANRGAPGIDRTTIAQVEEYg-VSRLLDELGGELREggYRPLPVRRVEIPKPGdkG-ASRPLSIPAVRD 124 Frankia sp. CcI3
ZP_13300096  121 RVVQQACKIVIEPIFEANFLNSSFGFRPKRSAVQATIEVEASLVR---NWwVIDADIQKYFDTIDHELLMKLVRKRVSDR 197 Leptospira sant...
ZP_13884144  119 RVVQAAVKIVIEPLFEASFKDFSYGFRPRRSAQQALREIYKWLNFk-cHW-VVDADLKSYFDTIPHDKLLLSVRTRVIDR 196 Escherichia col...
ZP_08623276  118 RVVQTAAKIIIEPVFEADFKECSYGFRPKRNAHMALNRLKDLRNQg-yYW-ILDADIKGYFNNINHDKLLRLVEMRISDR 195 Acetonema longu...
EKD85697     118 RVVQMALLLIIEPIFEADFLDCSYGFRPDKSTHQAIDAMVQAINEg-kHE-IYDADLEKYFNSIPHDKLIKAVEKRIVDN 195 uncultured bact...
WP_000561483 118 RVVQTAVKIVIEPIFEADFQEFSYGFRPKRSANQAIREIYKYLNYg-cEW-VIDADLKGYFDTIPHDKLLLLVKERVTDK 195 Streptococcus a...
WP_011779439 132 RVAQAAAKIVLEPIFEADFMSCSYGFRPKRSATQAMERLRVGFIEg-sQF-VVEFDIANFFGEIDHDRLLAEVSRRVSDR 209 Mycobacterium v...
WP_014095942 118 RVVQMATKIVIEPVFEANFQPCSYGFRPKRSAKQAMDRIFEVADKggaLW-VIDADIKDYFGSINHDKLLLLVKQRITDR 196 Bacillus coagulans
WP_011988638 117 RVVQMATKIVIEPVFEADFKEYSYGFRPKHNQHQALDVIRKKCNNk-gWW-VLDADIKSYFDNINHDKLMILIKQRVSDR 194 Clostridium klu...
WP_011598972 125 RIVQAAWKLVAEPVFEADFLPCSFGFRPRRGAHDALQVLIDESWRg-cRW-VVETDIANCFEAIPIEKLMQAVEERVCDQ 202 Rhodococcus jostii
WP_011436613 125 RVVQTAVKIVLEPVFEADMAGCSFGFRPRRSAHDALQVLVDACGKg-rRW-VVETDIADCFTAIPFEGLMQTIKERVCDQ 202 Frankia sp. CcI3
ZP_13300096  198 RVLKMIRQWLMAGVVENG-KFQPTKIGSPQGGVISPLLANIYLHVFDMYW-----QN-KY----QhL-GRLIRYADDFVI 265 Leptospira sant...
ZP_13884144  197 PVVKLIEMWLKAGVMGEV-DQKNSDTGTPQGGVISPLLANLYLHWLDHVW-----EK-QGfnqrWhD-AHLVRYADDFVI 268 Escherichia col...
ZP_08623276  196 RIVSLIRKWLQAGIMDGG-ELVESEIGSLQGGVISPLLSNIYLNYLDTLW-----ER-NY----ShL-GELIRYCDDFVI 263 Acetonema longu...
EKD85697     196 RVLNLIKMWLKAPIWEKGkPMDRNNVGVQQGGVISPILSNLYLHWFDKIF-----CSsKGprewAn--AVLIRYADDIVI 268 uncultured bact...
WP_000561483 196 SIIKLLSLWLEAGIMEDN-QVRSNILGTPQGGVISPLLANIYLNALDRYWknnrlEG-RG----H-D-AHLIRYADDFVI 267 Streptococcus a...
WP_011779439 210 RVLKLLRLWLQAGVMVDG-VVSRTVAGTPQGGVISPLLANIYLHVLDTEL-----AR-RN----V---GELVRYADDGVV 275 Mycobacterium v...
WP_014095942 197 RVLKLIKGWLKAGVLEDS-QYSESTVGAPQGGVISPLLSNVYLNYFDIYW-----NKaFG----H-L-GELVRYADDFVI 264 Bacillus coagulans
WP_011988638 195 RMLKLIMKWLKVGVMEDG-EYKESEMGSPQGSPISPLLSNIYLNYFDVVW-----DK-YY----K-HlGTLVKFADDFIV 262 Clostridium klu...
WP_011598972 203 PFLKLLRVMLRAGVMEEG-QVRRPVTGTPQGGVASALLCNVYLHRLDRAW-----DV-DE----H-G-V-LVRYADDALV 268 Rhodococcus jostii
WP_011436613 203 AMLRLVRAVLRAGVMRDG-EVRRPVSGMSQGGPLSPLLCNVYLNRLDREW-----DD-------G-D-GMMVRFADDIVV 267 Frankia sp. CcI3
ZP_13300096  266 ICRYRIDaeRALKAVTHIMKR-LKLNLHPAKTKLV--QMEke--gFDFLGFYFRkshS-EKTGKLVPYFw------PSKK 333 Leptospira sant...
ZP_13884144  269 LCKKQPK--FYLDQARKVLGR-LGLTLNAEKTKVV--NATks--pFEFLGHRFAvqpS-KKDGKLKTYYy------PSPK 334 Escherichia col...
ZP_08623276  264 VCRRYKElnHARKYIGDVLAR-LELELHQTKTRIV--HNQlgkpgFNFLGFHHKkieA-ERKDGTVKVVat---rwASKE 336 Acetonema longu...
EKD85697     269 MAKFIGP--KIKEWIQKVIEErFCLKINPAKTKIV--KLKdnkafVNFIGFTIR-----ILRSGKVQIQ-------PKKE 332 uncultured bact...
WP_000561483 268 LCSN--NpkKYYQYAKQRIDK-LGLTLNEEKTRIV--HATe---gFDFLGYTLRkskShKSGKYKTYYY-------PSRK 332 Streptococcus a...
WP_011779439 276 LCRSAAQaeHALAAVGEILAS-LGLRLHPDKTKVV--DLReggegLDFLGCHFRarmS-GRLWEQRRIVryylhrwPSQT 351 Mycobacterium v...
WP_014095942 265 LCKRLSHaeEALRAVKWIMRK-LELTLHSEKTRLVdmYFGkd--sFDFLGFNNRfqrF-RNKSWQWYWTlq---qvPSKK 337 Bacillus coagulans
WP_011988638 263 ISRTKKEiyHAYNAVKKIFKR-LELQLHPDKTRFV--NMWdgkegFDFLGFHHRrslV-ENGKGQRYHTti---qvPNQK 335 Clostridium klu...
WP_011598972 269 MCRSRRQaeAALTRLRELLAD-LGLEPKEAKTRIV--HLRvggegVDFLGFHHRlvnA-PARPGRRPFPfla--rwPADK 342 Rhodococcus jostii
WP_011436613 268 MCWSEDQavRAMDCLVRLLAD-LGLETKAAKTRIV--HLQvggdgLEFLGFHHRlvlS-RGDRGRRRVAfla--rwPSDR 341 Frankia sp. CcI3
ZP_13300096  334 AMKSIRSKIRNLTTRRW-Y--RLs-L-E--E-IVK-NLNPAIRGWRNYFRAGNSTRK-FQELDSYVLYRLFHFARKRG 401 Leptospira santar...
ZP_13884144  335 SMKTVKRKIREVTQKGQ-H--WD--L-P--A-LIRmKINPILRGWGNYFRTCNSRMH-FRSIANYTTWALCIMLRKKH 402 Escherichia coli ...
ZP_08623276  337 SRNKMREKIRSLLAPRR-E--FYksL-D--D-MVN-ELNRVLRGFKNYYAIGKGERWkLAQIDNYVLLRFVIWSNGKR 406 Acetonema longum ...
EKD85697     333 AIKKAKLRIRELTSVKW-G--YL--EiV--K-VIK-RLNLFLVGWGKYFNKGSPSDA-YQEINWYVEQRLRNFLERRS 400 uncultured bacterium
WP_000561483 333 SMKSIKGKVKDVIQTGQ-H--LN--L-P--D-VME-RLNPMLRGWANYFKAGNSKQH-FKSIDNYVIYNLTIMLRKKH 399 Streptococcus aga...
WP_011779439 352 AMVRLREKVRERTGRNRvG--FD--I-R--D-VIA-VLNPILRGWGNYFRTGNAADK-FRQIDHYVTRRLKELLIKKR 419 Mycobacterium van...
WP_014095942 338 AMKKMRANIKEVFASPS-KllLS--M-E--K-MVK-LLNPKIIGMRNYYTRRFARPW-LWKIDKYINHKFTRWYNRKk 406 Bacillus coagulans
WP_011988638 336 AMKNMRRKIKEVLGNRS-N--LK--M-DmyD-LVQ-IMNKKIVGLKNYYNLKYSGKQ-LNKIDWYIIERFTIWYNNKk 404 Clostridium kluyveri
WP_011598972 343 AVRHARERIRELTDRSRlL--LP--T-E--V-VVQ-DLNLFLNGWAAYFKYGNSAHR-FGVIREYVRMRMALFIGKRH 410 Rhodococcus jostii
WP_011436613 342 AMQHARDRIREITGRSR-L--LL--N-P--EaVVR-ELNLFLRGWAGYFRYGYSARR-LAMIRRFAQVRLARFVRARH 409 Frankia sp. CcI3
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