Conserved Protein Domain Family
Conotoxin_I2
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pfam17557: Conotoxin_I2 
I2-superfamily conotoxins
Conotoxins (or conopeptides) are the peptidic components of the venoms of marine cone snails (genus Conus). They are classified in one of three ways: gene superfamily, cysteine framework or pharmacological family. Several distinct cysteine frameworks have been described in conotoxins. Members of this family display a XI cysteine pattern (C-C-CC-CC-C-C) and belong to the I2- superfamily conotoxins. Family members such as Kappa-conotoxin ViTx and Kappa-conotoxin SrXIA inhibit voltage gated potassium channels (Kv).
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Statistics
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PSSM-Id: 375216
Aligned: 31 rows
Threshold Bit Score: 33.4783
Created: 26-Mar-2022
Updated: 13-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q5I4E5       26 CIPEGSSCSSSGSCCHK-SCCRWTCNQPCLIPGKRAKLL 63  cloth-of-gold cone
AFU50784     31 CTEEGDYCAYDFECCFL-NCCYGMCMGVCS-GRKRAHLH 67 
6_pfamImport  1 CRFEDDHCTVDTDCCSL-NCCYGTCTGYCG-GGKRAQLH 37 
7_pfamImport  1 CQIEDESCTVDTQCCSG-NCCYGTCLGFCS-GRKRAHLH 37 
C7DQX7       27 CDLEGMFCMYDFECCLS-ECCMGICAFGCTKRAQRQKLL 64  Conus litteratus
AMP44661     26 CHHEGLPCSSDDGCCGM-ECCNGVCSSSCG-NGRRRQVP 62 
AFR68329     18 CGAAGLPCPLNDPCCADmDCCGDVCSLSCDKKGRRQALM 56 
C7DQX8       28 CRNEGAMCSFGFQCCKK-KCCMSHCTDFCRNPGKRAHGH 65  Conus planorbis
P0DKM1       28 CRPEAAYCEYNEQCCID-KCCQASCSDACRTPGKRVHGH 65  Conus ferrugineus
8_pfamImport  1 CDQEETFCTVDPECCLL-ECCSGKCSSPCM-PGKRALRQ 37
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