Conserved Protein Domain Family
PRK05222

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PRK05222: PRK05222 
5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional
Statistics
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PSSM-Id: 235367
Aligned: 538 rows
Threshold Bit Score: 938.767
Created: 9-Dec-2010
Updated: 25-Oct-2021
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
28493129    1 MLFGTILGYPRLGPRRELRDYLYSYW--QGKISEEVLEEKTRLLREETHRRLILLGLsaeNYSIPESFSYYDHVLDAAVH 78 
227831850   5 FPKATIEGYPRVGAHRELKRALESYW--SGKIDAETFESAAHSLRLDTYARLKELGLt-eDYAIPADVAYYDHVLETALT 81 
54027202    7 GYGSSILGYPRIGPHRELKRALESYW--RGSLSREELLEVGRDIQERQFNELAATGL---TQVPGNTFSFYDHVLDNALM 81 
226361253   6 AYGSSILGYPRIGPRRELKRALEAYW--HGTGTKADLVAVARDLQEETWSELAATGL---TQVPGNTFSYYDHVLDNALL 80 
226305065   7 AFGSSVLGYPRIGPRRELKRALESYW--HGTSDKDALLAVAKELQESTWSELAATGL---SQVPGNTFSFYDHVLDNALL 81 
111019113   6 AYGSSILGYPRIGPRRELKRALESYW--HGTSTKEELVTVARDLQEETWSELAATGL---TQVPGNTFSYYDHVLDNALL 80 
283458915  47 FPAATIVGYPRVGRFRELKKAQEAFW--KGKATLQELQDTAADVQRTYFERVTAAGLkadNYSIPATFSYYDQVLDVVRL 124
256831439   8 FPSATILGYPRIGDRRQLKRALESLW--AGRSNADEFAATTHQLRAATRERLAARGLgrdDSSIPESFSWYDQVLDAAVT 85 
184201737   9 LPAATILGYPRIGPDRELKRALEAHWkdPARHPASTVVDTLGALRERTTLRLRELGLgaeHAIPSEGFAV-DHVLDTALA 87 
296394315  11 EYGSSILGYPRIGPRRELKRALEGYF--HGPVTKDELKAVGLKLRDETWQELAAMGL---EQVPGNTFSFYDHILDSAVL 85 
28493129   79 VGAVPSRFSWlln-----dgiV--DLNAYFTLARGdrslaplESLRYFGSSYHYLVPEIDGNTHFALTS--HRVITQFEQ 149
227831850  82 VGAAQGE-----------------SLDNEFTLARGnkdtaplEMTKWFDTNYHYIVPEITDEQAFSARP--QRVLKIVEE 142
54027202   82 FGAVPKRF-Qpyqd-------vmdpLDFYFLMARGrpdlpplELVRYINTNYHYRQPELAPDTEFSLHP--EALLDEFDR 151
226361253  81 FGAVPERFAPlen------qlD--PLDFYFTLARGrpdfpplELVRFFGTNYHYRQPELDENTEFSLRS--ETLLDEFER 150
226305065  82 FGAVPERFKPle--------gAldPLDFYFTMARGrpdfpplELVRFFGTNYYYRQPEIDANTVFSLNS--EALLDEFER 151
111019113  81 FGAVPERF-Kples-------qldpLDFYFTLARGrpdfpplELVRFFGTNYHYRQPELDENTEFALRS--ETVMDEFER 150
283458915 125 FTLVPERL-Aeakda-----rglldLPGYFALARGtetlpplEMTKWFDTNYHYLVPEIGAGTEIKLNL--EAIDEQLEV 196
256831439  86 FGVIPDRFRSldw--------sgdLVGAYSTVARGvgddaplEMTKWFNTNYHYLVPEVDESTPFVLNP--TLVTSLVDE 155
184201737  88 LGAVPARFTAdgyspaapdtpE--GIGLLTALSRGtdrleplEMTKWFDTNYHYYVPEIGPDTPLSAHP--ESLVARYLD 163
296394315  86 FGAVSPRY-Vplra-------elddLDFYFTMCRGradfpplELVKLFGTNYHYRQPEISEDTAFAVSSyaDELLAEHAR 157
28493129  150 AKQA-GVNVRPTILGPVSLLMMSRs-----HgPNAI-NPIERLQDLVPVYSELFEKLYNSGCKFVQVDEPAVTHNTfgI- 221
227831850 143 ARAA-GYTVRPVLVGPVTLLALSK------QaEGATkQPLDHLNELVDSYLTVLAELHDAGVEWIQLAEPALVADLaaAd 215
54027202  152 AMAQ-GIELRPVVLGPASLLLLSKag--dqPgEAEF-DTLSLLDKLLPVYEELFEILAKRGATCVQLDEPAYTSER--S- 224
226361253 151 AKAR-GIELRPVVLGPVSLLLLSKvg--ptSkRHGF-STLDLLDKLLPEYELLFEQLAKAGATCVQLDEPSFTEDR--T- 223
226305065 152 AKAR-GIELRPVIMGPVSLLLLSKvgpateksdPNF-TPLDLLDALLPEYEKLFEQLAKAGATCVQLDEPSVTEDR--T- 226
111019113 151 AKAR-GIELRPVVLGPVSLLLLSKvg--ptSkRHGF-STLDLLDKVLPEYERLFEQLAKAGATCVQLDEPSFTEDR--T- 223
283458915 197 AKQA-GVKVRPQIVGPLTLLLGAKae---qGsAEDF-SPVDRLDEFVAAYAQVLEQLAERGVEWVQLDEPGLTVDRadN- 270
256831439 156 ARAQ-GFVTRPTIVGPVTFLALSKaa---tSaSTGF-DPLSRLDELVGVYVELLAVLVERGVQWVQLDEPALVSE---Nl 227
184201737 164 TLRRtGVRTRPVLVGPVTLLLLSRp----eTtDDAPvDPLGRLEDVVGLYVRILSELAAAGVQWVQLDEPALAAD---Gw 236
296394315 158 AKTR-GVELRPVVLGPVSLLLLSKra---pEaGADF-RPVDRLSDLLPAYLDLLERLAKQGAKCVQFDEPAFTSDR--G- 229
28493129  222 ----QKSQELLVDAYKFLSs--rKLRPEILVAMSYGNA--ADQVDALATTGVEAMAFNLIDGA--VPfANPS-L------ 284
227831850 216 ---dATLAAALKTAYGRILs--aEKRPQVYLTTPYGSL--NAGLDVITELQPEAVQVDLSVGT--LA-LDNS-Ylervak 284
54027202  225 ----EAELAAFERAYQRLSk--aPLRPRILVTGQYGDF--GEALTILAGTGVEAIGLDLASHRidPDeLAKV-Pgi---- 291
226361253 224 ----PEELAALARVYEKLSh--aPLRPRILVTGPYGHL--GEALAILASTKVEALGLDLVSHRlsADeLAAI-Pgm---- 290
226305065 227 ----PEELAALGRAYEKLStap--lrPRLLVTGPYGKFgeA--LNILAPTKIEAFGLDLVHGK--IT-AEEL-Aavp--- 291
111019113 224 ----PEELAALAKAYEKLSh--aPLRPRILVTGPYGHL--GEALAILASTKVEALGLDLVSHRlsADeLAKI-Pgm---- 290
283458915 271 ----AKVAELAERTYRALAa--aEKRPQILVTSPYGSL--RENLPALLGTGIEALHLDLVHGVysKAeLESVsA------ 336
256831439 228 svdaTALEQAFVAAYARLTs--aDARPNILVTAPFASL--GALAEPVLNSGVEAVAVDLVHGDl--------pAav---- 291
184201737 237 averTEIVAAVESAYRRLTf--pADRPAALVTVGYGDAg-GDALLALARTDAEALAVDLDRGD--VPgAEAL-Raw---- 306
296394315 230 ----EFDLELLGEAYAKLSspslAARPRMLVTGQYGHL--GDALPVLASSNVEAISLDLVAAPipPEeLAAL-Pgl---- 298
28493129  285 --ADKALFGGVIDGRNIWRGDLAAAYYKLERLREL-SGNVVASTSASLFHLPLSLDTE-DLGDHLKEWLAFADEKVRQVM 360
227831850 285 laEATHLSAGLVDGRNVWAANLRDLREKFETLGD----NVSVTTSVSLQHVPHTVEAEtSLPVDVATWFAFADEKIREVV 360
54027202  292 --rRKRLYAGVISGRNVWRADRYVTLEYLNELAKv-cPDLVVSTGCTLLHVPYDLLVEyDLEGNVADRLAFAKQKVGEVV 368
226361253 291 --kRKRIYAGVVDGRNVWRVDRYNTLTYLNTLKDV-VPDLVVSTSTSLLHVPYDVLSEyDIPGDVADRLAFAKQKVGEVV 367
226305065 292 niKRKRIYAGVVDGRNVWRVDRFNTLTYLNELKDv-vPDLVVSTSSSLLHVPYDVLSEyDIPGDVADRLAFAKQKVGEVV 370
111019113 291 --kRKRIYAGVVDGRNVWRVDRYNTLTYLNTLKDv-vPDLVVSTSTSLLHVPYDVLSEyDIPGDVADRLAFAKQKVGEVV 367
283458915 337 --AGVHLVAGVVNGRNVWRADVRAALKTLEALPGaseGAVSVASSTSLQHVPHDLALE-DPAEVPVDGLAFADQKVAEIA 413
256831439 292 -pDGVTLVAGVVNGRNVWRCDLDQARRVLEGVHA---GSVAVSTSTSLQHVPHTVADEpTLDPTLASWLAFADEKISEVV 367
184201737 307 --gERPVVAGVVGGRTVWRTDLAGATDTLDRLRAaarGPVAVGTATPLLHVPHDVTQEtGLDPDVRSWVAFADQKVTEVV 384
296394315 299 --rRKRLYAGVVSGRNIWRNDRLDTLGYLTELKNv-vPDIVVSTSTTLLHVPYDVLAEyDLPEELDGRLAFAKQKVGEVV 375
28493129  361 ILARG---LEYGVGCIYE--HLDSAANSLSDRMTT-PGVR--VEEVRQALQDLGESDFCR------PPREQQQGCNHAS- 425
227831850 361 ALSAGpldAPE---------AYAQADRAVRTRAES-SRTH--DQAVQDRTAQLPEGQVQR------QPEFAERNKAQEAl 422
54027202  369 SLAKA---LTE--GPSD------------KWRKRPrEVHFkqKHAVRQRVYSITPDMRSR-------EPYAERRAAQQAr 424
226361253 368 SLAKA---LTEGP------------SDRWRKRPTSvHFKL--KHAVRARVNAIKPDDR-I------RAPYEERRVAQQEr 423
226305065 371 SLAKA---LTE--GPSD------------KWRKRPtKVHFklKHAVRARVNAIKPEDRVR-------APYEERRKAQQEr 426
111019113 368 SLAKA---LTE--GPSD------------KWRKRPtSVHFklKHAVRARVNAIKPGDRLR-------VPYEERRLAQQEr 423
283458915 414 LLARG---LAE--GEAAVepELKAADEALARFAAD-PRKH--NDEIRARAAAVTAEDFDR--------PTIDVRRAAQAd 477
256831439 368 TLARG---LTQGWDAVAS--ELDDARTVLAARAAA-PGVT--VPHVRERVAGITHADLARttidgkRASIASRVAQQQEr 439
184201737 385 ELARG---VEHGWEAIT---QTLETDARIRAARAAhPATH--RPEVRERTAAVRGEDRVR-------ASAVERRAAQHEr 449
296394315 376 ALTKA---LRE--GAPA------------SWSRTS-PAKPhvNQAVRDRVAAVKDEDRVR-------PPYEERRALQEEr 430
28493129  426 --LPILPMVGIGEFSDGTPFVNNDGIPNNNPQAAISFQE----------------DLDILAVQRLGDIDPIQRFASRMHG 487
227831850 423 -gLPQLPTTTIGSFPQTAEIRAARAAHRKGELSDADYTEalrnevksvielqerlGLDVLVHGEPERNDMVQYFAELLDG 501
54027202  425 lnLPPVPATTLGSFPQTGKIRQARYDLDQGRLSYEEYRKrieaeieatirlqediGLDVLVHGEHERNDMVQYFAELLDG 504
226361253 424 lnLPLVPATTLGSFPQTDAIRRARYELGQGRLEWDEYYKriqaeiestirlqediGLDVLVHGEHERNDMVQYFAELLEG 503
226305065 427 lnLPLVPAQTLGSFPQTDAIRQARYELGQGRLEWDDYYKriqeeiertirlqediGLDVFVHGEHERNDMVQYFAELLEG 506
111019113 424 lnLPLVPATTLGSFPQTDAIRQARYELGEGRLEWEEYYKriqaeiestirlqediGLDVFVHGEHERNDMVQYFAELLEG 503
283458915 478 lnLPKLPTTTIGSFPQTAEIRRRRAEARAGKISAEELNGflrdeiasviklqeelGLDVLVHGEAERNDMVQYFAENFDG 557
256831439 440 lqLPPLPTTTIGSFPQTADIRRARAQWTRGDLTDADYQVqmrteiervirlqedlGLDVLVHGEAERNDMVQYFAEHLDG 519
184201737 450 lrLPLLPTTTIGSFPQTTEIRATRAAHRAGRLDDAAYTEairreiartvraqeelGLDVLVHGEPERNDMVQYFAEALDG 529
296394315 431 fqLPKAPTTTLGSFPQTPHIRRARYELGEGRLSWEEYRAlvrdeieriirlqediGLDVLVHGEVERNDMVQYFAELLEG 510
28493129  488 FAITHNGWVQSIGPHSVCPPILWGDVSRI------TPMS-SWIEYTQTLTEKSVKPVLPGPLTLLMSCFVREDQPFQETA 560
227831850 502 FVVTENGWVQSYGSRCTRPPIVVGDISRP------KAMTtEWAKFAQSLSEKHVKGMLTGPVTILAWSFVRDDVHQSVSA 575
54027202  505 FATTHFGWVQVYGSRCVRPPIIYGDVSRP------APMSvDWITYAQSLTDKPVKGIVTGPVTMIARSFVRQDQPLYETA 578
226361253 504 YAFTHNGWVQAYGSRCTRPPILYGDVSRP------KPMTvEWIAYAQSLTDKPVKGMLTGPVTMIARSFVRQDQPLYETA 577
226305065 507 YAFTHNGWVQAYGSRCTRPPILYGDIARP------KPMTvEWIAYAQSLTDKPVKGMLTGPVTMIARSFVRQDQPLYETA 580
111019113 504 YAFTHNGWVQAYGSRCTRPPILYGDVSRP------KPMTvEWISYAQSLTDKPVKGMLTGPVTMIARSFVRQDQPLYETA 577
283458915 558 FATTRHGWVQSYGSRCTRPSILFGDVKRHgeglrgEAFTvPWSSHAQSLSDKPVKGMLTGPVTILAWSFVRDDQPRRETA 637
256831439 520 FVVTENGWVQSYGSRCTRPSIQWGDVSRP------APITtQWATYAQSLTPKPVKGMLTGPVTIMAWSFIREDLPLAETA 593
184201737 530 FATTRHGWVQSYGSRCTRPSILFGDVSRP------APITvDWTGYAASLTDRPVKGMLTGPVTILAWSFVRDDAPAAEVA 603
296394315 511 FATTRHGWVQVYGTRSVRPPIIYGDVSRR------KPMTvEWITHAQSFTSKPVKGVLTGPVTMLARSFAREDLPQQQIA 584
28493129  561 QQIAIAIRDDIADLQRSGIRAIQIDEPALEEFLSIYDNAR----YCAPQVFRLATSSAKPEVQIHLHLRPPNLVETIDII 636
227831850 576 DQLGVALADEVCDLEEAGIDIIQIDEPALRELLPLREKDRkaylDWAVRSFRVVSLQAKPETQIHTHLCYSEFGQIIDAV 655
54027202  579 DQVALAIRDEVVDLEKAGIAIIQVDEPAIREMLPLRAEGRaeylRWAVGAFRLATSGVRPDTQIHTHIGYSGRTEVVDAI 658
226361253 578 DQLALVIRDEIADLEAAGIAIIQVDEPAIRELLPLRENGReaylEWAVDAFRLATGAAKPETQIHTHLTYTSRASVVDAI 657
226305065 581 EQLALVIRDEIADLEAAGIAIIQVDEPAIRELLPLREDGReaylEWAVDAFRLATGGAKPETQIHTHLTYSARSSVVDAI 660
111019113 578 DQLALVIRDEIADLEAAGIAIIQVDEPAIRELLPLRENGReaylEWAVDAFRLATGGAKPETQIHTHITYTSRASVVDAI 657
283458915 638 NQVALALADEIADLEEAGIRIIQVDEPALRELLPLRRDEQpqylDWSVNSFRLATSGVKDSTQIHTHLCYSEFNEIIDSI 717
256831439 594 KQIGLALRDEVGDLEAANIAVIQVDEPALRELLPLKKADHkdylDWSVSSFRLATTGVRPDTQIHTHLCYSEFNDIIDAI 673
184201737 604 DQVALALRDEITDLEAAGTAVVQVDEPALRELLPLREADRpaylEWSVGSFRLATGAAATDTQIHTHLCYSEFETVLDAI 683
296394315 585 DQIALVVRDEIEDLEQAGIGIIQVDEPAIRELLPLRAQGRrkylDWAVAAFRLATAGARPATQIHTHLEYSSLGLVVEAF 664
28493129  637 NDLDVDVISAEIVPYTFGLPAQK---ClmeirRRIPLCLYFHDANFSRMPSVDECRYLIDTLVRDVDGATLakqfddmhi 713
227831850 656 AGLDADVTSIEAARSRMELLEDIde------kFHSEIGPGIYDIHSPRIPSVAEMAELIRAALKNVPVERL--------- 720
54027202  659 EELDADVTAIVATRSIEWVLKALkedAagghgLSHGVGPGVYESRSARIPDIDELDELLSAAAEAVTPERL--------- 729
226361253 658 ERLDADVTAIVATRSITWVLDAIkerA-----LTHGVGPGVYESRSARIPDIDELDELLTEASESVSLERL--------- 723
226305065 661 ERLDADVTAIVATRSITWVLEALkegA-----LTHGVGPGVYESRSARIPDIDELDELLTEASESISLDRL--------- 726
111019113 658 ERLDADVTAIVATRSITWVLDAIkerA-----LTHGVGPGVYESRSARIPDIDELDELLTEASESISLERL--------- 723
283458915 718 NALNADVTSIEAARSHMELLADIpe------tFVSGLGPGVWDIHSPRVPSQEEIESLLKAAIGYGTIADL--------- 782
256831439 674 DHLGADVTSIEAARSRMEVLGALavsG-----FGRGVGPGIYDIHSPRVPSVEELAELLDLAVRSVRPELL--------- 739
184201737 684 EGLDADVTTLEASRSGSGIVDGLaaaD-----FPRDVGPGVWDIHSPRVPTFEEVAGRVRHAAHAIGADRV--------- 749
296394315 665 EQMDCDVTALVATRSISWVLQQLrngG-----LTRDVGPGVYESRSARIPDIDELDERIAEALKFVEFDRL--------- 730
28493129  714 agftagcaftainprdicvpraddagipslgsgadhalerqkatyipggihnlwigliyshsgynaFVYDSAYMRDIYIG 793
227831850 721 ------------------------------------------------------------------WVNPDCGLKTRGYE 734
54027202  730 ------------------------------------------------------------------WANPDGGLKTRHYW 743
226361253 724 ------------------------------------------------------------------WANPDGGLKTRHYW 737
226305065 727 ------------------------------------------------------------------WANPDGGLKTRHPW 740
111019113 724 ------------------------------------------------------------------WANPDGGLKTRHYW 737
283458915 783 ------------------------------------------------------------------WVNPDCGLKTRDYE 796
256831439 740 ------------------------------------------------------------------WVNPDCGLKTRGYD 753
184201737 750 ------------------------------------------------------------------WVNPDCGLKTRAWP 763
296394315 731 ------------------------------------------------------------------WVNPDGGLKTRHYW 744
28493129  794 NELQFVKNMTQAVLLLR--------KEFTS 815
227831850 735 ETEASLRNMVLARDEVR--------ASL-- 754
54027202  744 QLEPSLRNMVAAARRIR--------RRVQA 765
226361253 738 QLEPSLRNLVAAAKRLRrrsekeesed--- 764
226305065 741 QLEPSLRNMVAAARRLR--------RRAEQ 762
111019113 738 QLEPSLRNMVAAAKRLR--------RRAEK 759
283458915 797 ETKQSLRHLVDATKAIR--------ASL-- 816
256831439 754 ETVASLRNLVQAAHDVR--------AHVAV 775
184201737 764 ETRAALDRLVAAAVTVR--------GELAR 785
296394315 745 QLQPSLRNMVAAARRHRrrsaalgqA---- 770
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