1BQ0,1FPO,1N4C,1WJZ,2CTQ,2CUG,2DN9,2GUZ,2O37,2OCH,2QSA,2QWO,2YS8,2YUA,3BVO


Conserved Protein Domain Family
DnaJ
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cd06257: DnaJ 
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DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, an important chaperonine family. Hsp40 proteins are characterized by the presence of a J domain, which mediates the interaction with Hsp70. They may contain other domains as well, and the architectures provide a means of classification.
Links
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Statistics
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PSSM-Id: 99751
Aligned: 153 rows
Threshold Bit Score: 36.3693
Created: 8-Jan-2008
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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HSP70
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:HSP70 interaction site [polypeptide binding site]
Evidence:
  • Structure:1QWO; Bovine auxilin crosslinked with Hsc70
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                   ###                     #  ##  ##  
1BQ0         4 DYYEILGvs-----------------ktAEEREIRKAYKRLAMKYHPDRnqgd-------------keaEAKFKEIKEAY 53   Escherichia coli
2QWO_B      17 NIRALLStmhtvlwagetkwkpvgmadlVTPEQVKKVYRKAVLVVHPCKatgqp----------yeqyaKMIFMELNDAW 86   cattle
P43613      44 NFYKFLKlpk---------------lqnSSTKEITKNLRKLSKKYHPDKnp----------------kyRKLYERLNLAT 92   baker's yeast
Q10247      32 TPYEILElp-----------------rtCTANDIKRKYIELVKKHHPDKmknasqlaptesppeinkhnEEYFRLLLAAN 94   fission yeast
O14213       9 DCYEILQvn-----------------hdSDLQEIKANYRKLALQYHPDRnpgi-------------edyNEIFSQINAAY 58   fission yeast
Q06166    1564 EFHNILSih-----------------edRDLMELKRILYNLFLEYNPHMnnkq------------kaelDKKFSEMNVVH 1614 malaria parasite...
O96122     500 TYYDILNvy-----------------ptSELSEIKSNYYNLALKYNPESnlgn-------------aeaLTKFRDINEAY 549  Plasmodium falci...
O96276     697 TYYDLLNve-----------------pdASFDEIKHSYRKLALQYHPDKnind-------------peaNEKFQKINEAY 746  Plasmodium falci...
O96277     195 TYYDILNin-----------------anSKLEEIKEKYYEVASKYHPEKnign-------------dkaFKKFELINSAY 244  Plasmodium falci...
Q9VNE8       3 DFYELLNvp-----------------stASFDEIKCSYKQLILQCHPDKlrqlddp------npgseaqNSDFNAINAAW 59   fruit fly

Feature 1           
1BQ0        54 EVLTD 58   Escherichia coli
2QWO_B      87 SEFEN 91   cattle
P43613      93 QILSN 97   baker's yeast
Q10247      95 ALLSD 99   fission yeast
O14213      59 NILSN 63   fission yeast
Q06166    1615 QILNY 1619 malaria parasite P. falciparum
O96122     550 QILSL 554  Plasmodium falciparum 3D7
O96276     747 QVLSD 751  Plasmodium falciparum 3D7
O96277     245 QILSN 249  Plasmodium falciparum 3D7
Q9VNE8      60 NTLKD 64   fruit fly

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