1EBL,1HNJ,1HZP,1M1M,1MZJ,1UB7


Conserved Protein Domain Family
KAS_III
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cd00830: KAS_III 
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Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl carrier protein (ACP) with acyl-ACP. KASIII initiates this process by specifically using acetyl-CoA over acyl-CoA.
Links
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Statistics
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PSSM-Id: 238426
Aligned: 130 rows
Threshold Bit Score: 212.4
Created: 6-Mar-2002
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 3 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:1MJZ; Streptomyces priming beta-ketosynthase with bound acyl-CoA
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                       
1EBL_A        2 YTKIIGTGSYLPEQVRTNADLEKXv-------dTSDEWIVTRTGIRERHIAapnetVSTXGFEAATRAIEXAGIEKDQIG 74  Escherichia coli
1MZJ_A       11 FSRVLGVGSYRPRREVSNKEVCTWi-------dSTEEWIETRTGIRSRRIAepdetIQVMGVAASRRALEHAGVDPAEID 83  Streptomyces sp....
AAF84772      5 NVSIAGLAHIDAPCTLTSQEINARlqpmlerigIKSDVFADIVGINARRLWntnvqTSDVATMAARKALQDAGVAVDRIG 84  Xylella fastidio...
AAN54796      5 RVFINSLAYELAPVVVSSSELESRlaplyqkfrIPMGQLAALTGITERRWWpkghqLSDGAINAAHKAIAETGIDVAELG 84  Shewanella oneid...
NP_870717    41 DVALASIGVTIPRAQWTSEQIEKDlqplysrlkLPEGRLAMMSGIDSRRVWepgtvPSGPSIESGRKALEAASVDPNQIG 120 Pirellula sp. 1
NP_967283     7 KATIAGTGMYAPERVITNQYFNDLyk------kDIGTFLAENRNIKERRWMtedqrTSDLILPAAEQAMKTAGITAKDLD 80  Bdellovibrio bac...
ZP_00227745  49 NAALLSISHVEAPQVVPSSYFDEVlsgtlerlrLRPGLLEKVAGVRERRWWaegqkASDVAAECGAKALSEAGVDASEVG 128 Kineococcus radi...
ZP_00316611   6 ISKIAGIGAYLPKQRVTSDELMAEiast--rfgTPENYISNKIGIIERRMAdektlASDMAIMASEVALRDANVQAHEID 83  Microbulbifer de...
CAG35470      6 NVCLDTFGYSLPPRVLSSADIESSlaplydrlhLPEGRLELMSGIRERRLWpkgmkPSEAAYLAGKKTLDDGGIAAAEVE 85  Desulfotalea psy...
AAM35125      5 NVSIAGLAHVDAPHTLTSKEINERlqptydrlgIKTDVLGDVAGIHARRLWdqdvqASDAATQAARKALIDAGIGIEKIG 84  Xanthomonas axon...

Feature 1                                             #                                         
1EBL_A       75 LIVVATTSAthafpSAACQIQSXLGik-gCPAFDVAAACAGFTYALSVADQYVKSGav--------kYALVVGSDVLARt 145 Escherichia coli
1MZJ_A       84 LVVVSTMTNfvhtpPLSVAIAHELGad-nAGGFDLSAACAGFCHALSIAADAVESGgs--------rHVLVVATERMTDv 154 Streptomyces sp....
AAF84772     85 LVVNTSVSRdylepSTASIVSGNLGvgeqCIAFDVANACLAFLNGMDIAGQMLERGdi--------dYALVVNAETANRv 156 Xylella fastidio...
AAN54796     85 AVVYTGVCRdqhepATACRIAAALGvskdTAIYDISNACLGVLSGILDIANRIELGqikagmvvsceSARDIVDVTIDNm 164 Shewanella oneid...
NP_870717   121 ALIHASVCRdflepATASRVHHELGlspdCWVYDVSNACLGVLNGAVQIAGMIQSGmi--------sAGIVVGTENSRPl 192 Pirellula sp. 1
NP_967283    81 LIIVSTDTPdylspSTASVVAYRLGav-nAGTYDINTACAGFVVGCDIASKYIFADsk-------ykNVLVVGAYAMSKy 152 Bdellovibrio bac...
ZP_00227745 129 VVISTTVTRphlepAVATSVHHGMDlppsAMNFDIANACLAWVNGVQVASAMIDSGmiryavvlgaeDVRSMHEGTIARl 208 Kineococcus radi...
ZP_00316611  84 LILYCGIERdwqepATAHRIQAELGat-sAIVLDVTNACHGFLNGISIADAFIANHsa--------qTVLVCTGEKQSNl 154 Microbulbifer de...
CAG35470     86 CLLFTSVCRdmmepATSAFVHHKLGlpksCLVFDISNACLGFLDGMVMLANMIELGqv--------kNGLVVSGETAED- 156 Desulfotalea psy...
AAM35125     85 LLVNTSVSRdylepSTASIVSGNLGvgdhCVTFDVANACLAFINGMDIAARMLERGeidyalvvdgeTANLVYEKTLERm 164 Xanthomonas axon...

Feature 1                                                                                       
1EBL_A      146 cd-------ptdRGTIIIFGDGAGAAVLAASee-----------pGIISTHLHADGSYGELLTLpnadrv---------- 197 Escherichia coli
1MZJ_A      155 id-------ladRSLSFLFGDGAGAAVVGPSdv-----------pGIGPVVRGIDGTGLGSLHMssswdqyv-------- 208 Streptomyces sp....
AAF84772    157 yektl-ermsapGVTEQEFREEMAALTLGCGav----------amVLARTALVPDAPQYKGGVTrsatewnk-------- 217 Xylella fastidio...
AAN54796    165 ladpt-mqnfaqSLATLTGGSGAVAVILTDGslplt----nvrkhQLLGASHLSAPQHHQLCQWglqevg---------- 229 Shewanella oneid...
NP_870717   193 meatiaslnaddQLTRKTVKPAFASLTIGSGscawllthrdlnpgATILEHAIARAHTAHHHLCrsdqdta--------- 263 Pirellula sp. 1
NP_967283   153 ln-------fddYKIASLFADGAGAVILQPSkd----------dtGFIDSQMYTDGQYHDYMGIyaggtaqpvt------ 209 Bdellovibrio bac...
ZP_00227745 209 qregitrkdflnEFATMTLGCGAAAAVIGRAdehp-------eahRIVGGVSRAGTAHHELCIGd--------------- 266 Kineococcus radi...
ZP_00316611 155 tyeai--dqlkkLSSKEEFRKRLGGLTVGDAggamiiq-rgnehsGFQKMNFMSDGSHTNLCYYkhtd------------ 219 Microbulbifer de...
CAG35470    157 ------------LLESTIAALNADETFTRKTikss------faslTIGSGSVGCFMRRAEAGETkprlvrgvwrtdtdhi 218 Desulfotalea psy...
AAM35125    165 tspdvteeefrnELAALTLGCGAAAMVMARTelvp-------dapRYKGGVTRSATEWNKLCRGnl-------------- 223 Xanthomonas axon...

Feature 1                                                           #                           
1EBL_A      198 ------npensiHLTXAGNEVFKVAVTELAHIVDETLAANNNDRSQLDWLVPHQANLRIISATAKKLgxs-xdNVVVTLD 270 Escherichia coli
1MZJ_A      209 ----edpsvgrpALVMDGKRVFRWAVADVVPAAREALEVAGLTVGDLVAFVPHQANLRIIDVLVDRLgvpehvVVSRDAE 284 Streptomyces sp....
AAF84772    218 -----lccgnldRMVTDTRLMLIEGIKLAKKTFVVAKQVLGWAVEELDQFVIHQVSRPHTEAFIKSFgid-paKVMTIFR 291 Xylella fastidio...
AAN54796    230 ------hniyreFMRTDAVTLLKEGVELAKHTWEHFLAQRNWLVEQVDKVICHQVGASNRKQVLSALnip-peKEFPTYQ 302 Shewanella oneid...
NP_870717   264 ------gagmqpLMETDSETLMAEGIATGVAALNELLQQSGWSRDQIDRSVCHQVGSRHRIGMLEAMqlp-etRDSVTFP 336 Pirellula sp. 1
NP_967283   210 ---hqvvenkghLLAFPKRIPPETNGIHWPRLTNILLDRIQKKPSDIKHFFITQFNVQSIYETLDKLelp-rdRAHYVMD 285 Bdellovibrio bac...
ZP_00227745 267 ------------MNHMKTDAKLMLTEGIEIVVDAFNAGDELWGWRDAEKFVIHQISKVHTETLVERIgvd-aaKVPMTFP 333 Kineococcus radi...
ZP_00316611 220 ---------sgtQGQMLMREITVQILRLHKMFIDSTYELLGWQPESIDKLFCHQTGAKPHQGMASLAhqp-inKAPITYD 289 Microbulbifer de...
CAG35470    219 hlcqgdaqggetTLMQTDSEELLLRGVDTAAAAWDAFAAPGWRNEEVDAYCCHQVGVAHFRMLFDRLgls-eeKNFQTLP 297 Desulfotalea psy...
AAM35125    224 -----------dRMVTDTRLLLIEGIKLAQKTFMAARQVLGWAVDELDQFVIHQVSRPHTAAFVKSFgid-paKVMTIFG 291 Xanthomonas axon...

Feature 1          #                                         
1EBL_A      271 RHGNTSAASVPCALDEAVRDgrikpgQLVLLEAFGGGFTWGSALV 315 Escherichia coli
1MZJ_A      285 DTGNTSSASVALALDRLVRSgavpggGPALMIGFGAGLSYAGQAL 329 Streptomyces sp. R1128
AAF84772    292 EYGNIGPASVPIVLSKLKELgrlkkgDRIALLGIGSGLNCSMAEV 336 Xylella fastidiosa 9a5c
AAN54796    303 LLGNMGTVSLPVTAAMAHDQgflrpgDQVSFLGIGSGLNCMMLGI 347 Shewanella oneidensis MR-1
NP_870717   337 ALGNTGSVALPLTVAAAAATgelsagDRTAMLGIGSGINSVMIAA 381 Pirellula sp. 1
NP_967283   286 RFGYTGSASIGMAVADAANQkkmkkgDLVFMLGSGGGMSMAALAL 330 Bdellovibrio bacteriovorus HD100
ZP_00227745 334 QWGNVGPISLPMTLAATAPEls--pgDRVIAMGVGSGLNTAMLEL 376 Kineococcus radiotolerans SRS30216
ZP_00316611 290 NYGNLTSASIPVNMFLNRPQr----gEKILIMGTGSGLSVCQSGL 330 Microbulbifer degradans 2-40
CAG35470    298 FLGNVGTVSAPITLAMAMEEgafkpgERAVMLGIGSGINSIVLGI 342 Desulfotalea psychrophila LSv54
AAM35125    292 EHGNIGPASVPIVLSKLKELgrlkkgDRIALLGIGSGLNCSMAEV 336 Xanthomonas axonopodis pv. citri str. 306

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