1SOU,1YDM,3HY6


Conserved Protein Domain Family
5-FTHF_cyc-lig

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pfam01812: 5-FTHF_cyc-lig 
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5-formyltetrahydrofolate cyclo-ligase family
5-formyltetrahydrofolate cyclo-ligase or methenyl-THF synthetase EC:6.3.3.2 catalyzes the interchange of 5-formyltetrahydrofolate (5-FTHF) to 5-10-methenyltetrahydrofolate, this requires ATP and Mg2+. 5-FTHF is used in chemotherapy where it is clinically known as Leucovorin.
Statistics
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PSSM-Id: 396398
Aligned: 18 rows
Threshold Bit Score: 155.159
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1SOU_A   3 KSELRKKVLH-KRINLSeEERRRLSEKVISNLKSLPEFKKS-KKV--------ALYCPI-KGEVDLTPLFPEVLKEKELI 71  Aquifex aeolicus
P44905   6 RQQIRTEIRK-IRANLTaLQQHQAEQSVTQHALNLIEQRQA-KNI--------ALYFSF-DGEISTKALIQSLWMQNKNV 74  Haemophilus influenza...
O83692   4 KQNARRIASA-RLRAFR-ASPTAPAYPAHSLFTAQTAYQRA-RTV--------FFYAPL-PLEIDPYALAYTAENAGKHV 71  Treponema pallidum
O26306 134 DGGERLVEYH-IWDLLVeKGVSKRP---HGRIPDFKGSFDAaKRLsrtvewerAGVVFC-SPDSAQSPVRRLVLEAGKDL 208 Methanothermobacter t...
Q9SRE0  92 KWVIRKK----MWDLMEaRNYAMSPRPVHHRIPNFVGASAAaRKLaeldafrmAMVVKV-NPDSPQKQIRFLTLSGEKKL 166 thale cress
P40099   4 KQLLRRQIKR-VINALDyDIIAAESHTISQAVRSLIASANS-RRV--------ACYMSMdKGEVTTGEIIKNLFQDGQEV 73  Saccharomyces cerevis...
Q9XWE6   8 KSELRQFMKT-LLGKISkEETQRQTEAVFEKIIESKWFQES-KRL--------SVYVST-SGEIQTDSIIQKALEMGKEV 76  Caenorhabditis elegans
3HY6_A  10 KRSLRGELKQ-RLRAMSaEERLRQSRVLSQKVIAHSEYQKS-KRI--------SIFLSM-QDEIETEEIIKDIFQRGKIC 78  human
P80405  10 KRSLRAELKQ-RLRAISaEERLRCQRLLTQKVIAHRQYQKS-QRI--------SIFLSM-PDEIETEEIIKDIFQQGKVC 78  rabbit
Q9ZD82   3 KQELRFYFKDlLIKKQDkINSNLVKDSLITKINWLLKKLRV-KTV--------GLYYPL-KYEINLLAIINLLPEIK--F 70  Rickettsia prowazekii
1SOU_A  72 LPKVEGNEI--------------------------SLYRVHSPACLGVGAFG--------IMEPVEGERVNPE-----DV 112 Aquifex aeolicus
P44905  75 YLPVLHPFTkh----------------------ylLFLRYLPDTPMKQNQFG--------IWEPKLNVQNVLPl---nEL 121 Haemophilus influenza...
O83692  72 ALPRVSGNDlhfhavtya---------cttrpsvsCFTTLCPRTRGIREPDAhsprlyppHPSPNTPAQRTLA-----LP 137 Treponema pallidum
O26306 209 IMPTPKIKDgyl--------------------ligGDVPDAEAASTIGGAYM--------YGSPIREFP---------QV 251 Methanothermobacter t...
Q9SRE0 167 LTPQPRLRTgff--------------------svlESDLLKPETIMEACTSV-----------GVAKYGRAIGldekiKV 215 thale cress
P40099  74 FLPRCTHTSeskhfklredhhphlifhrmsslkmvR-------DLKPQGPYQ--------LKEPEPHIEESD------IL 132 Saccharomyces cerevis...
Q9XWE6  77 FIPQFTKGStam--------------------dmvRVPDQTAFDNLPSTLWG--------IRQPEPKWKWQSYhe-tgPL 127 Caenorhabditis elegans
3HY6_A  79 FIPRYRFQSnhm--------------------dmvRIESPEEISLLPKTSWN--------IPQPGEGDVREEAls-tgGL 129 human
P80405  79 FIPRYRLQSnhm--------------------dmvKLASADEISSLPKTSWN--------IHQPSESDTREEAla-tgGL 129 rabbit
Q9ZD82  71 FLPKIKNEI--------------------------RYCAYNFNDALVLGKCK--------TYEPINNNFI--------IP 108 Rickettsia prowazekii
1SOU_A 113 DFIAVPGVAFD-LEGYRLGFGKGYYDRLLKRVKG-------LKVGVAYSFQVFE-RLPRDA---WDIPVDVLVTE 175 Aquifex aeolicus
P44905 122 DILFTPLVAFD-KKGNRLGMGGGFYDRTLQNWQNks----fIPVGLAYQCQQVE-NLPTEH---WDVPLFDILVG 187 Haemophilus influenzae Rd ...
O83692 138 LLIVVPALAFS-TNGARLGRGGGHYDRFLARIAAtipagsyYTLGLCFDCQIMA-VIPQEA---HDQSVHAVLTE 207 Treponema pallidum
O26306 252 DLVVEGSVAVD-LQGNRLGKGGGYGDREISELRGqgaidedTPLATTVDELQIIrRVPVEE---HDEMINMIVTP 322 Methanothermobacter therma...
Q9SRE0 216 DLIVIGSVAVNpQTGARLGKGEGFAELEYGMLRYmgaiddsTPVVTTVHDCQLVdDIPLEKlaiHDVPVDIICTP 290 thale cress
P40099 133 DVVLVPGVAFDiKTGARMGHGAGYYDDFFQRYKIlhegqkpLLVGLCLMEQVAS-PIPLEK---HDYSMDCIVCG 203 Saccharomyces cerevisiae S...
Q9XWE6 128 DLILAPGVAFS-PYGLRCGHGKGYYDRFFSTHHKhfpenspKKIGLALREQIIG-TIPISE---TDVELDEVIYE 197 Caenorhabditis elegans
3HY6_A 130 DLIFMPGLGFD-KHGNRLGRGKGYYDAYLKRCLQhqe-vkpYTLALAFKEQICL-QVPVNE---NDMKVDEVLYE 198 human
P80405 130 DLIFMPGLGFD-RNGNRLGRGRGYYDTYLQRCLQqqg-akpYTIALAFREQICP-QVPVDD---TDVSVDEVLYV 198 rabbit
Q9ZD82 109 ELVIIPGLAFS-KDGYRLGYGKGYFDQYLNNHQNi------FTVGVCLKEQLID-NFPIES---HDYKLDLMISV 172 Rickettsia prowazekii
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