6SP2


Conserved Protein Domain Family
Serinc

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pfam03348: Serinc 
Serine incorporator (Serinc)
This is a family of eukaryotic membrane proteins which incorporate serine into membranes and facilitate the synthesis of the serine-derived lipids phosphatidylserine and sphingolipid. Members of this family contain 11 transmembrane domains and form intracellular complexes with key enzymes involved in serine and sphingolipid biosynthesis.
Statistics
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PSSM-Id: 460891
Aligned: 152 rows
Threshold Bit Score: 282.531
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6SP2_A        14 AMCCGGtaaSMCC---SAC--PsC--TNASSS--RFMYAFILLVGTVLG---AIAL----------SPGLQDTLKkmpfc 71 
XP_002506090  10 GSACMTat-cSCC---GSLg--kA--VSSISA--RAVYTVIFGLGMGIA---VVMR-----------DYAKPMMMeipwi 65 
XP_003062471   7 GSACMTat-------cGCLghV-GdaVAKTSA--RALYVVMFAISTALA---FVMR-----------DCAQPLLKri--p 60 
Q236K4        11 ACCCCQafcNDIC---RSLkrV-F--TLSIRQqmRLAYISLFFVFTLLT---LFSM-----------YQIPGWLGvwskf 70  Tetrahymena the...
EGR28880      10 ACCAGKefcSVICtffKCCc--kM--TMSQQI--RLSYVILNSLLFAFT---IIVL-----------HYIRDLFSyfary 69 
Q22U62         6 VCCAGRevcSACCacfKCCc--kM--TMKQQI--RLSYVLMNILFFLFA---IIVL-----------HYVQSLFDyfssy 65  Tetrahymena the...
XP_001032827   9 LCCAGKafcSNAC---GCCksL-C--KTTWKQqiRLAYIILNIVFTLFI---IFTF-----------YYLQDIFQtfsky 68 
A0CSR0        10 VCCAGTqicNLAC---CCCkyF-A--ETTLKEqiKLAYILLNYLIMAFT---VIAL-----------YYIQDFYInylhy 69  Paramecium tetr...
A0C5A5        10 LCCTGMaccKSLC---CCCkiC-C--GSTFKEqiKLAYILLNYTTIFVTmifCFFL----------QGLFDNYLS----- 68  Paramecium tetr...
XP_002180794  15 ytCCSAtn--sLC---NAClgS-T--SENSTG--RKRSVLLLTLAVAIA---LWFQydvgpaivtkSGWVWKAFQ----- 76 
6SP2_A        72 INstssys--sgalsaVSgg----sLQVDCEyalGYMAVYRVCFGMACFFALMSLIMLGVKSSRDPRSH-IQNNFWPLKF 144
XP_002506090  66 GV--------------VPgm----qPSDEWF---GQSAVYRVSLGNFMFFGGLSAMLVDCKTRSDPRDRhIHHGSWTLKL 124
XP_003062471  61 WIar-----------lAT----------------MNYAVYRISLGNFIFFGAMACALVGVKRRSDARDVhLHHGSWVLKF 113
Q236K4        71 IH--------------CPsesshpkDNMACL---GISALYRMSFSLVILFSILVLFCL----LRNEASKfVNENFWFQKI 129 Tetrahymena the...
EGR28880      70 LH--------------CPea---sgGQSQCL---GSSSVYRMSFALAILYL---AVLIAVYARNQCSKL-FNEGLWCIKI 125
Q22U62        66 IH--------------CPeq---agGKLNCL---GVSSVYRISFSLAILY---AIILLAVWARNECSKL-INEGLWLLKI 121 Tetrahymena the...
XP_001032827  69 IN--------------CPse---agGGSECL---GASSVYRMSFSLASFYLGLFLLLFICCGIEAKKM--INDGLWCFKI 126
A0CSR0        70 FG--------------CPe-----gISNLCL---GISGIYRMSFVLTIFYIIILLFMC----QKGWLAKmINDGLWLLKF 123 Paramecium tetr...
A0C5A5        69 FIs-------------CPs-----dDSSSCL---GVSSIYRICFVLMWMYIFLMILML----IRGEIAKvANEGLWPLKF 123 Paramecium tetr...
XP_002180794  77 WIpgfgkmlyhawydsCEvykdndaLLQQCA---GNAGVYRPTFVASLFFAVLAIV-----TKVEPY---LNKEVWPAKY 145
6SP2_A       145 LICFGAAIGAIFIPDGsFGP-AMMWVGLIGGLAFILVQLVIIVDFAHSLAENWIESAE----------NSRGYYYA-LAG 212
XP_002506090 125 AAWALCVIVPFLLPDG-FID-AYAWLARLGSGVFLVVQMVILLDFAFLWNETWVAREH------------VGWVVG-LLV 189
XP_003062471 114 TAWALCNVLPFFASNG-VVG-AYTWVARVASGVFLVVQMIILLDFAFFWNESWVARQH------------AGWLVG-LLV 178
Q236K4       130 IGLIALFILQMWIPND-TYI-IYGSVSKLFGVIFALFQSIMCIDLFYSWSEVWVKQYEq---------GVGIYEYL-LYI 197 Tetrahymena the...
EGR28880     126 SAVLGMYISFMFVSDS-FFN-GYRVFAQVFGGFYLLFQTIILIDIFYLWGQNWKAKYDeveaqnaennSSFNLYGIlLIG 203
Q22U62       122 FFIVGIFIGFMYVDYS-FFD-GYRDFARIFGAIFLVIQSVMLIDIFYMWGQKWKAYYDe----------GAQWMAPvLIG 189 Tetrahymena the...
XP_001032827 127 TYIILVFILVFFIPNS-FFE-GYSQFAKYVSILYMLFQSLVIIDLLYKWSQTWVKYYDq---------GNQSMKYV-LVF 194
A0CSR0       124 IFITVFFYGTLYMPNR-FFE-VFVDISIVASGIYQLFQIIIYIDIFYLWAEKWARMYDd---------GIEGMGSA-LVA 191 Paramecium tetr...
A0C5A5       124 LYIAVFFFGTLFIKNS-FFK-GYVYFAIVISGFFMIFQIIMLIDVFYLWGQSWIRIYDn---------GGEYMKYI-LII 191 Paramecium tetr...
XP_002180794 146 VVFLFAVTISMFVSSApMFTgFYLWLARFGATLFVLLQQIILIDVAYNWNEDWVDRADqadr--mdygSGANWLHA-IVA 222
6SP2_A       213 VTLLCYILSLTGITLLYIYFTTStG--CGINKFFISINLIFCLAISVISILP----AVQERLPHSGLLQSSLVTLYTVYL 286
XP_002506090 190 STIALYAGSITLVVFMYQWYAPK-GldCGRNAWLITTSLVPCVFFSALSTHP--------IAKEGSLLPSAVVTSYCVYL 260
XP_003062471 179 STIVLYAESVAVVVMAFRWFSPR-GvdCGSNDWMIGSACALCLAFSLACVHPgvkaRSRVVTLDGSLLPSAVVTSYCTYL 257
Q236K4       198 FSFGCYASTFYLIYNNYQLYP------CSGTQNLI--NILIVVAISILNLSP--------INAKPSILTCGAVCLFITYL 261 Tetrahymena the...
EGR28880     204 ITLSLYTASILLNAYNFIWFKG-----CQFNIIVNALNLLLVISITFVQFLG--------FNPSGSLLTSSAMSFYITFL 270
Q22U62       190 TAVVLYGLTITLVVLNFIWFNG-----CGLNTFINVANLILVIAITVVQLLG--------YNPHGSLICSGAQGLYMTFL 256 Tetrahymena the...
XP_001032827 195 TSLILYGLTIALNVLTFIWFKG-----CSTNTAISSVNIVILVVITFIQILG--------FNPHGSLIASGGIGLYISFL 261
A0CSR0       192 AASLTFTLALILNIYNFIWFDH--------NYIINLINIAIIILLTVVQLFG--------FNPNGSLLATGCISCYITYQ 255 Paramecium tetr...
A0C5A5       192 TTAILYGGAFTLNIFNFIWFSG-----CGTNIFMNVFTILLIVGATGVQLLG--------WNPQGSLLTSGAMAIYIVFQ 258 Paramecium tetr...
XP_002180794 223 TCVAFYVAACAGIWILYQNFTG-----CPENTWIITLTMLGVLGLTAIQLSG----------QEGSLLTSSVMSLYSVYL 287
6SP2_A       287 TWSAVANNP-EKECNpgmfgmmegfgnatttaaPSTHTT---RVTF-DTTNIIGLVVWLLCILYN--CISSA-------V 352
XP_002506090 261 CYSALASEPtEYRCN------------------PRGAYA----GDG-KASEVASTVLTLASVAYS--AVRAGssdffggV 315
XP_003062471 258 LYSALASEPsEYECN------------------PRGSETgagAGSRgGVAEIASTALTLASVAYG--ALRAGsadffggV 317
Q236K4       262 NWSAMTNIQ-QTECN------------------YYANKQ---EAFI-QIEGFIGVFLIILSLGYI--TFGTAdessrysQ 316 Tetrahymena the...
EGR28880     271 AFSGQLSSE-SG-CN------------------SAISSN----AIF-AIELSVGVAFLLVTLLYL--SFVKKninniqnQ 323
Q22U62       257 TFSAQLSGE-SS-CN------------------LAIDNN----SIF-TLELVVGLIILIVVQLYLtfGTKESsqkripvS 311 Tetrahymena the...
XP_001032827 262 TFSSQFSSP-DSECN------------------SLISNSd-nKNGF-YFDLSIAIILNFIVLMYVtfSSKEStskttqnI 320
A0CSR0       256 TFSALSSYP-NADIN------------------IFYDSE----KNM-KVQMFVNGILNFVALIYIifATQEQskqalaiL 311 Paramecium tetr...
A0C5A5       259 AYQAQSSWP-DTECN------------------SLSKSE----GTR-IVEIVVGILLTVVSLLYL--TFGTSnssatniV 312 Paramecium tetr...
XP_002180794 288 AYSMVSKNP-NASCN------------------PQLGSN------D-VWSIVIGLTLTAVSLAWTgwSWTAEerlnvdgV 341
6SP2_A       353 EVSk------------iSHDNSEKRVLTEALSDT-------EAG-----TDGS-----------------------GKPS 385
XP_002506090 316 NLG-------------------DGDGDYAALSGAemgggtdADAgdadsEDDV-------------------------GG 351
XP_003062471 318 DGDg-------------DDGDGDGGVDASALLGGggdgggsDSD-----DEENgg--------------------vGARG 359
Q236K4       317 IPSgdnlmaslrkseleEKDSDDDDFLIEAGYSDvvd--leQDAidltkIEKRnsqkkddsnksaestaqavrkelKRLR 394 Tetrahymena the...
EGR28880     324 QNK----------------------------KEDlek--eqASL-----VQNQ-------------------------QQ 343
Q22U62       312 QNVel----------ngAILADKDQEEESEENDIddeengsHHQ-----INKQnkepiqqnsqeqkqlspeeiefeKYQK 376 Tetrahymena the...
XP_001032827 321 INN------------------APQALLADN-KDDeedksldQNKvsnqnAYENnsmqqpqgqq---qqqsqnlnqqQANL 378
A0CSR0       312 DKS------------------NEKKRSNQNSNQQieiemtsTQQ-----MNEA-------------------------KA 343 Paramecium tetr...
A0C5A5       313 QLEsk----------deKLENQQREANQAEGNQDeeqqllqQQQk----LEEA-------------------------KA 353 Paramecium tetr...
XP_002180794 342 QSAksv--------tgaHPIGGNGQINLDVPFLDaed--qpRQG-----LVTD-------------------------SD 381
6SP2_A       386 TDTETEG-VTYS----WSMF-HLVFVCASLYVMMTLTNW--YKPHSe---iEL--FNGNEASMWVKIVSSWLGVFIYGWS 452
XP_002506090 352 AASYPSGpVSYS----YSFF-HFIFALASMFLAMLMTGWgrDDYK------GAerVDVGWASVWVKMCSVWVTAGLYTWS 420
XP_003062471 360 KASYPSGpVSYN----YAFF-HFIFALASAYLAMLMTGWgdRAFED-----GGapVDVGWASVYVKYASLWVTGLLYTWS 429
Q236K4       395 EMRQLRRmKDYKtn-tYIYF-HAIMILSSFYIVMLLTNYgaIQIDEk---iDWttYKTSNSSMNIKFGISYFTTFIYIWT 469 Tetrahymena the...
EGR28880     344 LNQQQDElEIYKntnnYIIF-HMVMFVSSIYCAMLITNWggSSLN------NFtiYQPSQTSYWIKIICSWISSILYIWT 416
Q22U62       377 CDKKLRP-YIYSn--tYIIF-HIVMLTSSVYGSMLLTNWgsPDMNa----sTFnmYKPSESSYWVKIVVSWASSLLYIWT 448 Tetrahymena the...
XP_001032827 379 SDEDKNDiRRLVviqqFKAF-YVVMFFVSIYTCMLITNWgsPDFSNn----TFqlYQESSASYWIKIIIAWLTAAIYIWT 453
A0CSR0       344 LIEQIEL-QPYStn-qYIVF-HIVMTFCSMYMAMMITNWgsPSIRv----gTFelYMPSQLSYNVKIGSSWICSGLYFWT 416 Paramecium tetr...
A0C5A5       354 LVKQAEM-LPYTtn-qYLIF-HTIMFITIIYMMILLTNW----TY-----------QPNKLAYWVKMITSWLAALLYIWT 415 Paramecium tetr...
XP_002180794 382 GPAARSGrVANA----HVWKlNVVMLLISCFVAMTLTGWgtIEELDenanaANptVGRVNMAMLG--ISQWLAIGLYVWT 455
6SP2_A       453 LAAPIVLTNR 462
XP_002506090 421 LIAPALFPDR 430
XP_003062471 430 LVAPAVMPDR 439
Q236K4       470 IVAPLIFPDR 479 Tetrahymena thermophila SB210
EGR28880     417 LIAPRVFPNR 426
Q22U62       449 LVAPSIFPDR 458 Tetrahymena thermophila SB210
XP_001032827 454 LIAPKIFPNR 463
A0CSR0       417 LIAPRVLPDR 426 Paramecium tetraurelia
A0C5A5       416 LIAPHIFPDR 425 Paramecium tetraurelia
XP_002180794 456 LLAPRLYPDY 465
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