Conserved Protein Domain Family
LIN37

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pfam15306: LIN37 
LIN37
LIN37 is a component of the DREAM (or LINC) complex which represses cell cycle-dependent genes in quiescent cells and plays a role in the cell cycle-dependent activation of G2/M genes.
Statistics
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PSSM-Id: 464632
Aligned: 32 rows
Threshold Bit Score: 97.0965
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_015787331         91 PREDEYSKSSS------FILRLFDRTVDL--SEFctkysDTDPPLYPICRAWARNSDL----------SNEQDSVDEDQT 152
XP_001849685         59 SAAIRHQHSST------FIMKLFDRSVDL--ARF-----PEATALYPVCRAWMQNTPR----------VARRDEVVEGVP 115
Q7K159              107 AAVAQKAPGET------YVMRLFERSLDL--SKY-----QDKTPLYPICRAWMANQPKnp-------aVGAFQTDASLTA 166 fruit fly
XP_001995326        114 NQTGTKPHSES------YVMRLFDRSLDL--SKY-----EDKTPLYPICRAWMANQPRnp-------nVAIYKTDGSVPI 173
WGS:AAPU:GI20623-PA 114 NNAAQKSHSES------YVMRLFERSLDL--SKY-----KEKTPLYPICRAWMANQPRnp-------nVAVYNTDGTVPI 173
EGT52158            111 STSLMDSPRKTmtrdskIMFELRGKPFEMvaGRF-----EEE---YSLGRAWVKGHMNsey-----epIRTQRTEFASNL 177
EFO90216            112 STSLLDSPRKTmtrdskIMFELRGKPFEMvaGRF-----EEE---YSLGRAWVKGHMNndy-----vpINTKRTEFAPNL 178
2_pfamImport          1 SNSLMDSPRKTmnrdskIMFELRGKPFEMvaGRY-----EEE---YSLGRAWVKGQMNtey-----dpIKTKRTEFAPNL 67 
Q23482              112 STSLMESPRKTmtrdskIMFELRGKPFEMiaGRF-----EEE---YSLGRAWVKGHMNney-----epIKAQRTDYAPNL 178 Caenorha...
XP_001750304         55 QSPAQQRYSKAp-----HIMTLFDKDINL--AAV-----SPTTALYSAARSWMYMDTSgywlrrrrapVAQDATA----- 117
XP_015787331        153 AANDLEAMGIge---pdKSTGLYVLPPPDPKPVDdngneidlRLPKSST---------IKkglcTNLIDKSLNSMTDKN- 219
XP_001849685        116 EPRELQVDVLery-nrkELDQIEKMPGPAESELEaf---------------------vREerfaERGEEMGTGEEEVLG- 172
Q7K159              167 TKREDNGEEIlsqiksgEIKVINQLPQAKSTDLP--------IIPPRLE---------FSqedkKREKALQGAS------ 223 fruit fly
XP_001995326        174 VKREDNAEEIlaqlrsgELKVVKQMPKPRDTDMD--------PIPQRLP---------QPn--hKDSGNLEGAS------ 228
WGS:AAPU:GI20623-PA 174 VKREDDAEEVlskllsgELKVLKQMPQARKTEMS--------PIPPRLP---------NPq-----DEKLKGAS------ 225
EGT52158            178 AVEYLACREI------------YKMPRPDKS------------LPELPV---------RPprqdKFDRNVDPRF------ 218
EFO90216            179 AVDYLACREI------------HRMPRPDEN------------VPELPV---------IPtkidKFDDQVDPRY------ 219
2_pfamImport         68 AVDYLSCREI------------HRMPRPDNT------------VPDFAV---------CPeptdEFDADVDPRY------ 108
Q23482              179 AVDYLACREI------------HRMPRPDKS------------IPELPI---------VPsridEFDATVDPRY------ 219 Caenorha...
XP_001750304        118 ----------------------FDLPSPTLPLEP---------APALALefwpnafdqAAnrlpETRSNIDQALVTQDAr 166
XP_015787331        220 ---RDALLDASLS---RWRTIRQEWREASLLN-------Q-ERYRPSFTVIQ 257
XP_001849685        173 ---REELLKGHKA---RWSGIKRRWVGHRRNY-------L-GKYQQSFDLLD 210
Q7K159              224 ---TSDLLSSNMN---RWKKVRGHWIKHIKKY-------EkERYEVIDKIMS 262 fruit fly
XP_001995326        229 ---KDKLLASNMT---HWKQVRCHRLKHAQAY-------ErARYEIINQIID 267
WGS:AAPU:GI20623-PA 226 ---KEELLAENIG---HWKRVRSHWLKHAQKY-------ErERYEIIDQIMD 264
EGT52158            219 ---FTDLKNEHVR---HWKEVKKEWCAHQRRR-------D-ARYSRSIALIE 256
EFO90216            220 ---LSDLKTEYIR---HWKEVKKGWCAHQRDR-------N-ARYAKSIQLIE 257
2_pfamImport        109 ---LTNLKNEYVR---HWKAVKREWCSHARLR-------T-ARNARSIELIQ 146
Q23482              220 ---ETDLKNEYIR---HWKQVKKGWCAHQRRR-------T-APHARSIALIN 257 Caenorhabditis elegans
XP_001750304        167 iepLKTIGSARVDgryQLRQMKEHWVNRHRARcldyncrRsSIYAASVRVIQ 218
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