Conserved Protein Domain Family
Glyco_transf_54
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pfam04666: Glyco_transf_54 
N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region
The complex-type of oligosaccharides are synthesized through elongation by glycosyltransferases after trimming of the precursor oligosaccharides transferred to proteins in the endoplasmic reticulum. N-Acetylglucosaminyltransferases (GnTs) take part in the formation of branches in the biosynthesis of complex-type sugar chains. In vertebrates, six GnTs, designated as GnT-I to -VI, which catalyze the transfer of GlcNAc to the core mannose residues of Asn-linked sugar chains, have been identified. GnT-IV (EC:2.4.1.145) catalyzes the transfer of GlcNAc from UDP-GlcNAc to the GlcNAc1-2Man1-3 arm of core oligosaccharide [Gn2(22)core oligosaccharide] and forms GlcNAc1-4(GlcNAc1-2)Man1-3 structure on the core oligosaccharide (Gn3(2,4,2)core oligosaccharide). In some members the conserved region occupies all but the very for N-terminal, where there is a signal sequence on all members. For other members the conserved region does not occupy the entire protein but is still to the N-terminus of the protein.
Links
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Statistics
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PSSM-Id: 461384
Aligned: 17 rows
Threshold Bit Score: 289.594
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q9VUH5        30 MDITKIEP----VEPRVVKNKTkvprmyaktinhdgnwetivtnpeLKPRYRVGGGRTGVQ-FVIGVPTVLRPKKNYVLQ 104 fruit fly
Q9D4R2        96 ETLPNQFEvlkyFLPHLRTAGK------------------------LYPAIATSKGRAGVS-FALGISTINRGNHTYLKQ 150 house mouse
XP_025318086  96 ETVSDTFEilkfFFPHLRKVGR------------------------IYPDVIFGKKRTGVS-FALGISTVNRGNQSYLSQ 150
XP_015197538  48 LNSEKNLQ----SFTELQNDSSpl---------------------nISYHFLAGFPVQKQKyLTVGLSSVKRKKGNYLLE 102
NP_776132     64 SKIKNHLK----YFTEMQESSHvl--------------------qhVTYTVLAGASYQPKRmLTVGIFSVPHSHRTHLLD 119
XP_012041315  53 PSRTNYVE----TFKDMQKNSEpl--------------------knVDSCILIGAPPVKKRlLTIGISSMKRPQRSYLLD 108
XP_005622219  52 PGRTNPLE----TFKNMQKNSEll--------------------knINSHILIGAPPMKKKlLTIGISSVQHPHGSSLLD 107
XP_004756382  53 PGRTNHLE----TFKNMQKKLElf--------------------knINAQILIGAPPLKKKlLTIGIASVQHSSGSYLLD 108
XP_001632563  58 LNLPSIYH----LMPHLMDHPDs-----------------------LAPALRLGKDRVGVS-LVFGIPTIRRQKSSYLLN 109
Q9VUH4       129 IRLPNAYH----FLPHLLDDAGs-----------------------LRPAYLQSKGRSDVS-IVLGVPTVRREKQSYLLG 180 fruit fly

Q9VUH5       105 TVDCLIRRMTPEQRDNCLIVIFVGETKLQFAKFIVRELRVNHSTHMQAGLIDVIAPPLNYYPNFSRLHITLNDDpqrVQW 184 fruit fly
Q9D4R2       151 TLTSVLSRMTPEEEEDSVVIVSVADTDESYLKSVVRMVKTKFRKQVQSGVLEVISIPTLFYPQTLLDKKTKTDS---ESW 227 house mouse
XP_025318086 151 TLNSVVSRMSPSEEKDSVVIVSVADRNEDYLKYVVDMITKRFKRQLKSGSLEVISIPAFFYPNILPLTQSTEDSgklESW 230
XP_015197538 103 TLNSIFTQSSDEELKEMVVVVLLADFDKDWNIQVVKDISLRFPHHVLKGHLMVIHAPQEQYPHLEGLKRNFNDApdrVYF 182
NP_776132    120 TMTSLFQASSEQDLEYMLVLVLLSDTDPTWLNQTVANISGLFMPHIDSGRLLVVHGRLG-----GSRAKSRNDTspcGKL 194
XP_012041315 109 TLESLFYSSSLSEQKHFIVLVHLADPDPMWHSQMISNISTIFKPYIQASQLVVINTPLKSYLPLKSLKRNFNDTptyVAF 188
XP_005622219 108 TLQSLFFASSSSERKHFIVVVHLADPDPKWLGQMISNISTLFKLYIQAGQLVVINTPLTSYLLLNNLKKNFNDIpahVAF 187
XP_004756382 109 TLQSLFIASSSSEQKHFTVLVHLADPDPKWLDHMISNISTLFKPYIQARQLVVINTPRKNYLLLKDLEKNFHDTpayVAF 188
XP_001632563 110 TLASLLDGMNQDDKDDTVIVVFIAETDAGYVKQIATSVSERFPADIEAGLIEVVAPHASFYPDLDNLPLTFGDSkdrVKW 189
Q9VUH4       181 TLHNLIENMNDEEQNETLIIVYIGETDMESVQLIARQIESSFDQHVESGLIDIIAPAPSYYPNFERLRITLNDPlerVKW 260 fruit fly

Q9VUH5       185 RTKQNLDYIYLMSYAKSRGLYYLQLEDDVMANVGFMDYIQKFAVLHGSfriaqqIDWIVMSFSELGFIGKLFRTSVLSSF 264 fruit fly
Q9D4R2       228 QIKQVLDFCILMLYAQPKATYYLQLEDDIVAKKMYFTKMKDFVNSLTS------KNWFFIEFSVLGFIGKLFRSKDLTDF 301 house mouse
XP_025318086 231 RIKQVLDFCFLMLYAQPKAMYYLQLEDDIIAKKMYFTKITDFVHNGTS------NNWFYIEFSILGFIGKLFKSEDLTDF 304
XP_015197538 183 RSKQNVDYAFLFNFCANLSRYYVMIEDDVLCSKNFFTSIKKFLTSRKD------SFWVTLEFSKLGYIGKLYHSSDLPRL 256
NP_776132    195 YSRQKTSLALLMNFALNLSEYFLLLGDNVKTAPKFLANVFWALPAWKQ------LPWVSLDFSSMPLSGKVFHTEDLSRF 268
XP_012041315 189 RSKRNMDYAFLMNFATNHSDYFLMIEDDVKCVPGFVTQIATTVSAWEN------KPWVTLEFSPLGFTGKLFRTKDLPCF 262
XP_005622219 188 YSKQKMDYAFLMNFATNHSDYFLMIADDVKCAPGFVTQIATIVSAWEN------RLWMTLNFSQLGFIGKLFHTRDLPRL 261
XP_004756382 189 HFKQNMDYAFLINFATNLSDYFLMIEDDVTCAPGFVTQIATAVSAWRN------KPWLTLNFSQLDFTGKLFRTRDLPCL 262
XP_001632563 190 RTKQNLDFCYLMMYSQKKARFYVQLEDDVVATPGFANTIRTFAIQQDS------NRWLMLEFSSLGFIGKLFRSTDLNKL 263
Q9VUH4       261 RSKQNLDFAYLMAYAHSKGTFYVQLEDDILTKRQFITTMKKFALIKSAltkpdqPEWFVLDFCQLGFIGKMFKSAELPYL 340 fruit fly

Q9VUH5       265 VAYLKLFYNDQPIDWLLQSFVTLQSCRWDSvSDPECQRDFESRLLRSSQSQFQHMGAQSSLADKQQYQKDAFF 337 fruit fly
Q9D4R2       302 VHFFLMFYETKPIDILLDDIFLIRVCISGE-PVRSCLQRKKGFRIQYRPSLFQHVGTQSSFPGREQHLKDNYY 373 house mouse
XP_025318086 305 VRFFLMFYKDKPIDLLLGDIFQVKMCDPGE-TPEKCAERNKHIRIRYKPSLFQHVGIQSSFPGREQYSKD-IY 375
XP_015197538 257 AQFLFLFYQEMPCDWLLGHFRALLA---------------QKEVIRFRPSLFQHVGLYSSFQGTKNHLKDDDF 314
NP_776132    269 VSFLLLFPKDIPTHLLLSEFRLLLS---------------QNVPIRLSPSVFYRMDRDSEFEDTCFPAKRDKD 326
XP_012041315 263 VNFLLLFYQEMPCDSLLSHFHDLLM---------------QQTPVQFLPSLFQHMGNYSSSEGKFNSLKDIEF 320
XP_005622219 262 VQFLLLFCQEMPCDYLLSNFYDLLI---------------QQTPIQFFPSLFQPMGNYS-FEGKFKSLKDKEF 318
XP_004756382 263 VHFLFLFYQKMHCDYLLTHFHDLLM---------------EPAPIQFFPSLFQRMGNYSFFDSKFNSLKDKEI 320
XP_001632563 264 IEFFLMFHKDKPVDWLLDHILWVRVCNPEK-DQAHCNREKSQLRIRFKPSQFQHVGKESSLKGKRQNLIDKDF 335
Q9VUH4       341 ITYFQMFYNDKPVDWLLTYFIESKVCRTDK-DQKHCNAEKAKYWQHFRKSLFQHIGTSSSLKGKVQKLKDKQF 412 fruit fly
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