2D4E


Conserved Protein Domain Family
ALDH_F8_HMSADH
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cd07093: ALDH_F8_HMSADH 
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Human aldehyde dehydrogenase family 8 member A1-like
In humans, the aldehyde dehydrogenase family 8 member A1 (ALDH8A1) protein functions to convert 9-cis-retinal to 9-cis-retinoic acid and has a preference for NAD+. Also included in this CD is the 2-hydroxymuconic semialdehyde dehydrogenase (HMSADH) which catalyzes the conversion of 2-hydroxymuconic semialdehyde to 4-oxalocrotonate, a step in the meta cleavage pathway of aromatic hydrocarbons in bacteria. Such HMSADHs seen here are: XylG of the TOL plasmid pWW0 of Pseudomonas putida, TomC of Burkholderia cepacia G4, and AphC of Comamonas testosterone.
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Statistics
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PSSM-Id: 143412
Aligned: 37 rows
Threshold Bit Score: 586.454
Created: 14-Dec-2008
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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NAD bindingcatalytic
Conserved site includes 21 residues -Click on image for an interactive view with Cn3D
Feature 1:NAD binding site [chemical binding site]
Evidence:
  • Structure:2D4E: Thermus thermophilus 5-carboxy-2-hydroxymuconate semialdehyde dehydrogenase Hb8 with bound NAD cofactor, defined using 3.5 A.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                        
2D4E_C        46 SLDPATNEVLGVAARggerEVDRAAKAAHEAFQRws--rtKAKERKRYLLRIAELIEKHADELAVMECLDAGQvl-rIVR 122 Thermus thermop...
ZP_01000294   33 VTDPATGREVAILREsdadQVDRAVAAARAAFPAws--rtTVADRQRALMAIHDAILANADELARLETLNTGIplgqTRT 110 Oceanicola bats...
YP_511717     31 IVNPATGGPAGTLQEadaaEVAEAVRAARTAFDKtdwprwSVPRRQALLLAIRDKIVEHADKLAHLECIALGVplkeLKA 110 Jannaschia sp. ...
ZP_01625102   39 VHFPGTGESIASLQEddatQVIAAVNVARERFRSgdwskcTTTEKQSVFRAAAQAIRNNAHELALQESLCAGLpfahLAS 118 marine gamma pr...
YP_643813     34 DISPITNEPIAEVSRageaEVDAAVRAARDAFPGwa--alGPAGRAPYLHRLADLIDANVERLAAVECMDMAMllrsLRA 111 Rubrobacter xyl...
YP_497880     32 RCPFDWSWKLADISRgtvtTAAQAAQAATDAFPAwa--alSAAERGAYLHRLADLIEANVEKLAMIECLDMGMllesLRL 109 Novosphingobium...
YP_001413061  32 NFSPIDGSHLGDLSAggkaEADAAVAAARKAFPAwa--alGPKGRLPILKKFAEGIKARVNDLAAVETMDNGSllmgNVH 109 Parvibaculum la...
CAA86041      21 TTNPATGEVLADVASggeaEINQAVAAAKEAFPKwa--nlPMKERARLMRRLGDLIDQNVPEIAAMETADTGLpihqTKN 98  Escherichia coli
NP_887286     20 TINPATQETLAEVAAggeaEVHAAVAAAKAAFPKwa--glPAAERARLVRKLGDLIAAHVPEISRTETNDCGQtiaqTGK 97  Bordetella bron...
ZP_00208087   19 NLNPATNEVICQIAAggeaEVARAVAAAKEAFPKwa--glAPAQRAKLLRKVGDLINQHVDEIAKLESLDTGQsywrTKK 96  Magnetospirillu...

Feature 1                                                       ###     #                 # ##   
2D4E_C       123 AQVARAAENFAFYAEYaehameDRTFPvdrdWLYYTVRVPAGPVGIITPWNAPLMLSTWRIAPALAFGNTVVLKPAEwsP 202 Thermus thermop...
ZP_01000294  111 MHIPRAAQNFRFFAEFinq-dnGEVFTqepgYMSLVTHEPMGVCALIGPWNMPLGLTAMKMAGALAFGNTCVVKPSEitP 189 Oceanicola bats...
YP_511717    111 RHMLRAAENFRFFAEYigq-arGDLYDqtpgYRTIVTREPVGVAALIAPWNAPVALASMKLAAALAFGNTCVLKPSEqtP 189 Jannaschia sp. ...
ZP_01625102  119 RQIPRAAENFDFFADYigq-laGETYDqlhdYRTVVTRQPAGVAAIFTPWNACLALSSMQIASCIAFGNSCVLKPSEfaP 197 marine gamma pr...
YP_643813    112 RVIRRGARNYRAYADLaas-yeERDWRsq-gTWNRVQRMPAGPAAIITPWNAPFMLSTWKTAPALAAGCTVVLKPAEwsP 189 Rubrobacter xyl...
YP_497880    110 RVILRGAANFRNYADLat--ghEERVWssrgTLNRVIRMPAGPALIITPWNAPFMLSTWKCAPALAAGNTVILKPADwsP 187 Novosphingobium...
YP_001413061 110 RVVPRAAQNIEFFADWalt-ldGHSIDsp-eVVNHVRYDPAGVAVLITPWNAPLMLTTWKVGPALAAGNTVVVKPPEwaP 187 Parvibaculum la...
CAA86041      99 VLIPRASHNFEFFAEVcqq-mnGKTYPvvdkMLNYTLVQPVGVCALVSPWNVPFMTATWKVAPCLALGNTAVLKMSElsP 177 Escherichia coli
NP_887286     98 QLVPRAADNFYYFAEMctr-vdGHTYPtp-tHLNYTLYHPVGVCALISPWNVPFMTATWKVAPCLAFGNTAVLKMSElsP 175 Bordetella bron...
ZP_00208087   97 MLVPRAADNFYFFADTcqh-vdGETYPtn-dHLNYTIYQPVGVVGLISPWNVPFMTATWKTAPCLAFGNTAVLKMSElsP 174 Magnetospirillu...

Feature 1                                   #   ##             ###  #  #              ##         
2D4E_C       203 FTATKLAEILKe-aDLPPGVFNLVQGFGeeaGAALVAHPlVPLLTLTGETETGKIVMRNAAdhLKRLSPELGGKSPALVF 281 Thermus thermop...
ZP_01000294  190 LTLARLFEILAasgALPEGVINLVNGRGhvtGTALSGHPdIDMVSFTGGTETGARILTALArgIKGGAMELGGKSPSIVF 269 Oceanicola bats...
YP_511717    190 FALHLLVRLLHd-aGLPDGVVNLVNGRGdvtGAALAAQDgVDLISFTGGTTTGRTIMAEAGrrLVPCTMELGGKSANIVF 268 Jannaschia sp. ...
ZP_01625102  198 LAVLQLVRLLEs-vGLPTGVVNVVNGRGsvtGAALATAAgVDRISLTGRGDTARKVMAAAAaqLTPVHFELEGNSANIIF 276 marine gamma pr...
YP_643813    190 LSCSLLADLVAe-aGFPPGVFNVVQGIGeeaGAALVAHPlLRRVSFTGSPETGRSIGVAAAknLVPFTAELGGKGPLIVF 268 Rubrobacter xyl...
YP_497880    188 LSASILADLIEe-aGFPAGVFNIVQGLGaelGNALTSDPrIKRISFTGSVPTARVIGKAAAenIVPLTAELGGKSPLLVF 266 Novosphingobium...
YP_001413061 188 LTCSLMADIAHa-aGVPAGVLNVVQGIGeeaGDALVNHPdVDRISFTGSTDTAKIIGQAAArsITPMSAELGGKSPFIVC 266 Parvibaculum la...
CAA86041     178 LTADRLGELALe-aGIPAGVLNVVQGYGataGDALVRHHdVRAVSFTGGTATGRNIMKNAG--LKKYSMELGGKSPVLIF 254 Escherichia coli
NP_887286    176 LTAARLGELALe-aGIPPGVLNLVHGYGrdaGEPLVAHPdVRAVSFTGSTATGNRIVQAAG--LKKFSMELGGKSPFVIF 252 Bordetella bron...
ZP_00208087  175 LSADRLGQLILe-aGIPAGVFNIVHGYGsavGEALVKHPdVRGVSFTGSTATGNRIIQSGG--LKKYSMELGGKSPNIVF 251 Magnetospirillu...

Feature 1                               #                                                        
2D4E_C       282 ADaDLERALDAVVFQIFSFnGERCTASSRLLVEekIFEDFVGKVVERARAIrvGHPLDpeteVGPLIHPEHLQRVLGYVE 361 Thermus thermop...
ZP_01000294  270 DDaDLDRAIDGAMLGSFMNnGQMCLAGSRLFVQrgVADRFIEAFTDRTRALriGDPFDpateVGPMINEAQLKRVERFVA 349 Oceanicola bats...
YP_511717    269 ASaDRDRALDAALASIYSNnGQQCLAGSRIFVEraIADDFISDFVARARSIriGSPTDdsteLGPLATAAHRDRVLEFAR 348 Jannaschia sp. ...
ZP_01625102  277 DDaDIDRAIDGALVSAFGNsGQICIAGSRILVQqnIADRFIDAFVARTKNLqvGDPLDnrteVGPMAFAQHQQKVLNYFA 356 marine gamma pr...
YP_643813    269 EDaDLDAAARRAAGQYDDA-GQVCLAGTRLLVQesVAEEFLELFHRYADEHvlGDPRSehttVSPLIHPDHLRRVEGFVE 347 Rubrobacter xyl...
YP_497880    267 ADaDIDAAAKKAAGQYDDS-GQVCMAGTRIIVEesVKDEFLAKFHAYADAHvmGDSRDaattMSALIHPVHVERVLGFIE 345 Novosphingobium...
YP_001413061 267 ADaDLDAAAQTVAGQYMNA-GQVCLAGTRIMVEkkIEEEFLEKVRGAASHMivGDPRDkdtrVGPLIHKEHFARVAGFVE 345 Parvibaculum la...
CAA86041     255 EDaDIERALDAALFTIFSInGERCTAGSRIFIQqsIYPEFVKRFAERANRLrvGDPNDpntqVGALISQQHWEKVSGYIR 334 Escherichia coli
NP_887286    253 DDaDLDRALDAAIFMIFSNnGQRCTAGSRILVQqsIYADFTQKFVERARRIrvGDPLDegtiVGPLISPAHLAKVRGYIE 332 Bordetella bron...
ZP_00208087  252 DDcDFERAVDAAIVAVYGNnGESCTNGTRILVQdgIYDRFVAALAERTKKVvvGDPLDeatnVGPMITRDHWKKVTGYIE 331 Magnetospirillu...

Feature 1                                                          # #                           
2D4E_C       362 AgkreGARLLVGGERaktsfr--gedlsrGNYLLPTVFVGen-hmKIAQEEIFGPVLVAIPFKdEEEALRKANDTKYGLA 438 Thermus thermop...
ZP_01000294  350 SgledGAELIAGGARhea--------lpdGFYIQPTAMIAqsnalAICQEEIFAPFATIQIFDdEEEVVGRANDSIFGLV 421 Oceanicola bats...
YP_511717    349 TapqdGVEILTGGGVpgdlr----ddisgGHYIEPIAAFApgnasVVCQQEIFGPFATFQIFDsYNQVISAANNTEFGLV 424 Jannaschia sp. ...
ZP_01625102  357 LaentDATLLTGGRAmpe--------lggGYFVAPTVFKVldnnsPLCQEEIFGPVVTIQIFNeDEEAWTIANDSPFGLI 428 marine gamma pr...
YP_643813    348 RarreGHRVLRGGRRsp----------agPLFYQPTLIEPlsndaEIVQREVFGPVLTLQTFAdEEEAVSLANSTEYGLS 417 Rubrobacter xyl...
YP_497880    346 RaraaGDAIVRGGRLwk----------egSNWIEPTLIEPknnqsEVVQSEVFGPVLTFQTFRdEAEGVALANSTAYGLS 415 Novosphingobium...
YP_001413061 346 RaradGAVPLWGGNRan----------fgELYFEPTLFANitpelEIAQREVFGPVLTWQNFSsDDEVIELANNTRYGLA 415 Parvibaculum la...
CAA86041     335 LgieeGATLLAGGPDkpsdlp---ahlkgGNFLRPTVLADvdnrmRVAQEEIFGPVACLLPFKdEAEGLRLANDVEYGLA 411 Escherichia coli
NP_887286    333 LgskeGATMLCGGLDrpsyapeldarvrdGNFVWPTVFADvdnrmKIAQDEIFGPVACLIPFRdEAHAIELANDIEYGLS 412 Bordetella bron...
ZP_00208087  332 LgikeGARVVAGGLGepeglp---ahlknGNFVKPTVLADvdnswRVAQEEIFGPVACVIRFKdEAEALKIANATTYGLA 408 Magnetospirillu...

Feature 1                                            #                            
2D4E_C       439 AYVFTRdLERAHRLALeLEAGMVYLNSHnVRHLPTPFGGVKGSGDRREGGTYALDFYTDLKTIAL 503 Thermus thermophilus
ZP_01000294  422 GYVWTRdLERAFRLSRgLQTGTVLVNTPiMRDLRTGFGGIRQSGIGREGAKGSRAMFTEMKSTIV 486 Oceanicola batsensis HTCC2597
YP_511717    425 SYVWSDhLPTVERAVRdLRSGVVWVNTTmTRELRAPFGGFKSSGVGREGGEACERFYTEPKTVTV 489 Jannaschia sp. CCS1
ZP_01625102  429 GYCWTEsLHRAQLFQQrLEAGTLWLNTPiARDLRAPFGGFKASGIGRDGPRHAADFFTEEKATIA 493 marine gamma proteobacterium H...
YP_643813    418 GIVYTSsMGRADRVGRaVRAGVVWVNTFlVRDLTAPFGGMGISGIGREGGDYALDFYSDLKTLQI 482 Rubrobacter xylanophilus DSM 9941
YP_497880    416 GIVYTGsAERAERVGRqVRGGTVWVNTFlVRDLTAPFGGIGISGIGREGGDYALDFHSDLKTLQI 480 Novosphingobium aromaticivoran...
YP_001413061 416 GTLFSRnEKRAMDIASrVTAGTLWVNCFfVRDLAAPFGGAKDSGIGREGGTWSFDFYTDIKNISV 480 Parvibaculum lavamentivorans DS-1
CAA86041     412 SYIWTQdVSKVLRLARgIEAGMVFVNTQnVRDLRQPFGGVKASGTGREGGEYSFEVFAEMKNVCI 476 Escherichia coli
NP_887286    413 SYVWTEsVGRAHRVAAaIEAGMCFVNSQnVRDLRQPFGGTKASGTGREGGTWSYEVFCEPKNVAV 477 Bordetella bronchiseptica RB50
ZP_00208087  409 SYVWTEnGAKAIRMAEgIEAGLVFVNSQnVRDLRQPFGGIKGSGTGREGGHYSYEAFLEVKNVCV 473 Magnetospirillum magnetotactic...

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