3CW1,2Y9A


Conserved Protein Domain Family
Sm_E

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cd01718: Sm_E 
Click on image for an interactive view with Cn3D
Sm protein E
The eukaryotic Sm proteins (B/B', D1, D2, D3, E, F and G) assemble into a hetero-heptameric ring around the Sm site of the 2,2,7-trimethyl guanosine (m3G) capped U1, U2, U4 and U5 snRNAs (Sm snRNAs) forming the core of the snRNP particle. The snRNP particle, in turn, assembles with other components onto the pre-mRNA to form the spliceosome which is responsible for the excision of introns and the ligation of exons. Members of this family share a highly conserved Sm fold containing an N-terminal helix followed by a strongly bent five-stranded antiparallel beta-sheet. Sm subunit E binds subunits F and G to form a trimer which then assembles onto snRNA along with the D1/D2 and D3/B heterodimers forming a seven-membered ring structure.
Statistics
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PSSM-Id: 212465
Aligned: 45 rows
Threshold Bit Score: 88.7648
Created: 7-Mar-2002
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 24 residues -Click on image for an interactive view with Cn3D
Feature 1:heptamer interface [polypeptide binding site]
Evidence:
  • Structure:2Y9A; Human spliceosomal U4 snRNP core domain hetero-heptamer, contacts at 4A

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                     #           # #  #      ####   #       #        # # #####  #######
3CW1_E        11 QKVMVQPINLIFRYLQNRsRIQVWLYEQVnMRIEGCIIGFDEYMNLVLDDAEEIHskTKSRKQLGRIMLKGDNITLLQS 89  cattle
2Y9A_E        11 QKVMVQPINLIFRYLQNRsRIQVWLYEQVnMRIEGCIIGFDEYMNLVLDDAEEIHskTKSRKQLGRIMLKGDNITLLQS 89  human
AAG00463       5 TKQMVKPTVVVHRYLKESqRVCVWLVHETkMKIEGVLLGYDEFMNVVLGDATEVHlkTGEVVQLGKILLRSDNVGVIHP 83  Trypanosoma brucei
EAA17647       9 QKIMTQPINQIFRFFTNQtVVQIWLYDKPhTRIEGKILGFDEYMNMVLDESKEISvkKNTKKELGKILLKGDTITLIME 87  Plasmodium yoeli...
EAL49252       7 TKAMILPVKFIVNLAKHKqRVSIWLFENTaLRIEGTLSGFDQYINLVLTDTEEVYlkTNTRRKIGTILLKGENISVISK 85  Entamoeba histol...
XP_001471048   6 TKTITNPLTTIFGFLQKQvRVQIWLFENTeIKLEGKIIGFDEYMNMVLDETSEVDckTNQKREIGRILLKGENITLIRN 84  Tetrahymena ther...
CBZ50244      12 QKIMTQPINLIFRFFTQRmRVQIWLYEQPdMRIEGRIMGFDEYMNMVLDDAEEVYlkKRTRIPVGRILLKGENVTLIMA 90  Neospora caninum...
XP_002787488   8 QKIMTMPINLIFRYLTEKtRIVVWLYDHKdLRMEGVILGFDEYMNVVLDDAEEVNtkKDTRRPVGRILLKGDNITLMHA 86  Perkinsus marinu...
XP_002677279   5 QKMMTQPITQVFEYLKQGsRIQIWLYENTdLRIEGNILGFDEYMNIVLDETEEIYtkKSQRKKIGRILLKGDNISLIRD 83  Naegleria gruber...
XP_001432059  11 QKKITQPLHAFFTLFTEKtQLEIWLVENDnLRIQGKLAGFDEYLNLVLDRAVEYDrkTKATKELGKILLKGENIVLVRT 89  Paramecium tetra...

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