2L89,1H3Z


Conserved Protein Domain Family
PWWP_ScIOC4-like
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cd05840: PWWP_ScIOC4-like 
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PWWP domain found in Saccharomyces cerevisiae ISWI one complex protein 4 (ScIOC4) and similar proteins
ScIOC4 functions as a component of the ISW1B complex, which acts in remodeling the chromatin by catalyzing an ATP-dependent alteration in the structure of nucleosomal DNA. The ISW1B complex acts within coding regions to control the amount of RNA polymerase II released into productive elongation and to coordinate elongation with termination and pre-mRNA processing. The family also includes Schizosaccharomyces pombe PWWP domain-containing proteins 1 and 2 (SpPDP1 and SpPDP2). SpPDP1 associates with Set9 to regulate its chromatin localization and methyltransferase activity towards H4K20. Members of this family contain a PWWP domain. The PWWP domain specifically recognizes DNA and histone methylated lysines.
Links
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Statistics
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PSSM-Id: 438965
Aligned: 31 rows
Threshold Bit Score: 89.6684
Created: 28-Nov-2007
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 3 residues -Click on image for an interactive view with Cn3D
Feature 1:putative methyl-histone binding site [polypeptide binding site]
Evidence:
  • Comment:the aromatic residues form the three-walled methyl-lysine cage that directly participate in histone methylated lysine binding and recognition.
  • Comment:Pdp1 associates with Set9 to regulate its chromatin localization and methyltransferase activity towards H4K20.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1               #  #                                                       #          
2L89_A      9 GDRILVKAPGYPWWPALLLRRketkdsl----------------------------ntnssfnVLYKVLFFp-DFNFAWV 59  fission yeast
CCG83996   92 GDLVKVKLPGYPWWPAVIVTPehfpaaalaarp-------------------qaktrkdgtsaTTYPVQFLg-APEYYWS 151 Taphrina deformans...
ODV93234    6 EELVLSKIPGYAAWPAIICPEsrlpanvl--------------------------sqkpkvkhAVYPVFFLg-DNTFFWN 58  Pachysolen tannoph...
SSD60340    6 GQSILVKVKGYPAWPGMIIPHelvpekikatytsqqs----------dikhtgrstrstinnsNMICVKFYc-DDNYTWI 74  Saccharomycodes lu...
RPB27139  173 EDLVLHKLKGYPPWPAVVLSDevaelkpdlmkar----------------pgklkakaedvvrGAYPVAYLhnLLEFSYA 236 Terfezia boudieri ...
ODV97194   10 GQLVYSKIQGFPKWPAVIVPEdlvpvsvld-------------------------skptrdskNFYPVFFLgsEPSYYWN 64  Pachysolen tannoph...
OEJ86046    4 EKSILVKVKGYPSWPALVIPTekipkrll--------------------------gskttspeNHYCVKFYn-DNDYIWL 56  Hanseniaspora osmo...
EWC48037  176 GMIVLARLKGYSPWPAIIVEEdmlppavlkarpkdstskrkgkfsmvgipddeipvaargssaGHWPLMFLdnFDSFSWT 255 Drechslerella sten...
RDW74064  156 GDYFFARLKGYPPWPCIICSEdmlppsllksrpqtamqe-------dgtykpayadggpktkdRTFPIMYLa-TNEFGWH 227 Coleophoma crateri...
RPA77337    6 GDLLLARLRGYPPWPAVILNEelaqmtvlwatkp-----------------kyygrtdvsddkLVYPVAYLpdLDTFNWM 68  Ascobolus immersus...

Feature 1                                                      
2L89_A     60 Kr-------NSVKPLl-dSEIAKFLGssk---rksKELIEAYEASKTPP 97  fission yeast
CCG83996  152 Kp-------TDIKRLs-qDEVKANLEpgkk--stpKGLKAAYHHAQLGP 190 Taphrina deformans PYCC 5710
ODV93234   59 Sa-------KNLTKId-iEYIEKFLEnpk---kckGNLRKAFEIAKTNP 96  Pachysolen tannophilus NRRL Y-2460
SSD60340   75 Npknk-savDTWQLLnteDIINDMLAkeenkrrsnKKLCDAYKVALFYL 122 Saccharomycodes ludwigii
RPB27139  237 Pi-------SDLEPLt-kDSIKSFVAkg-----rkKDLIYAYEVAKVGM 272 Terfezia boudieri ATCC MYA-4762
ODV97194   65 Ry-------DSLSPLd-vEECEKSLKka------kTGLKRALKHATDIS 99  Pachysolen tannophilus NRRL Y-2460
OEJ86046   57 KksktmslaKQYDLLdsaEKITALIDkeaskrktnDKLIKAYQMVLEQV 105 Hanseniaspora osmophila
EWC48037  256 Mf-------TEITLLd-eAAIDAFSPrg-----kaKDIVKAYENAKKGL 291 Drechslerella stenobrocha 248
RDW74064  228 Sn-------TDLSDId-lDTVGEATAlk------kKDLKEAHKIASEKH 262 Coleophoma crateriformis
RPA77337   69 Sp-------YEFLPLk-pDDPPKKMT---------KQLKAAFEKASAGV 100 Ascobolus immersus RN42

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