1RQ1


Conserved Protein Domain Family
ERO1

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pfam04137: ERO1 
Endoplasmic Reticulum Oxidoreductin 1 (ERO1)
Members of this family are required for the formation of disulphide bonds in the ER.
Statistics
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PSSM-Id: 461191
Aligned: 152 rows
Threshold Bit Score: 244.013
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1RQ1_A                          27 NIRDDLSALLKSDFFKYFRLDLYKQCSF--W--------DANDGLCLN-------------------------R-ACSVD 70   baker's yeast...
WGS:AAGF:cds.TTHERM_00150029A   63 QTHLLLSHIQQQKFYRTIKVPKDQQCLYfkQ--------QEEHAVCKN-------------------------K-SCSIC 108 
Q24DE0                          73 KIYQKLDELSHTKFFRTFKVNIDTECKF-----------FSVEGICKS-------------------------Q-GCSVC 115  Tetrahymena thermophila SB210...
A0CXB3                          84 QIFPLLDELTYKKYFKIFRVNLENDCPF-----------SIGEYICTS-------------------------K-KCVIC 126  Paramecium tetraurelia...
CAM67040                        71 SLLDILNRITVSPYFRYFKVNSAKPCPY--Wa-------VSLLCTSAE-------------------------N-TCDVC 115 
Q57UW3                          73 GITGLLNNITSHPYFRYFKVNLDRECRY--Wv-------AEASCTCDS-------------------------N-GCQIC 117  Trypanosoma brucei...
jgi:MICPUN_59129                43 QLHEILAELTNTTYFRLFPVDLSRKCKF--WnkqketdeDKHEPSCSApaeedpsnpfgggssnafapaeqapT-ACSLD 119 
EFC50762                        46 KIFPILKELVSKQFFKIFKVDLSSPCPF--W--------AMK-KVCTG-------------------------KgGCSVC 89  
Q54IC1                          51 EINVLLNKIVKTRFFKYFKANLFSECPF--Wvv---------tALCGS-------------------------E-GCGVC 93   Dictyostelium discoideum AX4...
EFA76699                        50 QLNQILNKLVKTRFFRYFRVNLFAECPF--Wvv---------tQLCGL-------------------------E-GCGVC 92  
1RQ1_A                          71 VvEDWDTLPEYWQPE----ILGSFNN-DTmkeaddsddeckfldqlcqtskkpvdieDTI--------N----------- 126  baker's yeast...
WGS:AAGF:cds.TTHERM_00150029A  109 K-CEQEDIPLEWRKEdqnecyik--------------------------nndyedetTQK--------Eky--------- 144 
Q24DE0                         116 R-CDENNIPLPWKKT------DFIQQsKY---------------------------------------Dyadwaqepevk 149  Tetrahymena thermophila SB210...
A0CXB3                         127 T-CNTSEIPSNWLSP----ASSPIKQpK----------------------------------------Dnfafwdseryl 161  Paramecium tetraurelia...
CAM67040                       116 K-CDENSIPEALRADedmsELNTPDGsVAktvl---------------------qpvNLD--------D----------- 154 
Q57UW3                         118 T-CDDSGIPETLKYPydmsDVSTVERrAApdkh---------------------aakGFE--------D----------- 156  Trypanosoma brucei...
jgi:MICPUN_59129               120 L-ASKD--PGSMKWAp---ATTPVDRrITeqehvaia------------anddgandCADadlpefwmD----------- 170 
EFC50762                        90 E-CDENEIPISWKKStp-iLTDKVNKfLGlssqgkk--------------vqkwqdeDID-------------------- 133 
Q54IC1                          94 E-CDDNEIPLPWRIEd--tTSDKVDMsPPppgfq------------------kwkdkKDD-------------------- 132  Dictyostelium discoideum AX4...
EFA76699                        93 E-CDDNEIPLPWRIEd---SSDKVDMsPPppgft------------------rwkdkKED-------------------- 130 
1RQ1_A                         127 -----YCDVNd--fNGKN---AVLIDLTANPERFTGYGGKQagqIWSTIYQDNCFtigE--T--GE-----SLAKDAFYR 187  baker's yeast...
WGS:AAGF:cds.TTHERM_00150029A  145 ---dwYWSLNq--eNDFKd--GEYVDLVENIEGYTANKEPN---IWKIIYTEDCF------Q--GQq---lSSEKMVLNS 203 
Q24DE0                         150 itdewQWRVEe--fNESE---GSYVDLKDNVEAFTGYQGQN---IWKLIYEENCF---Q--G--EDl----CLEQRALNR 210  Tetrahymena thermophila SB210...
A0CXB3                         162 spsewIWHVEd--iENDK---GVYVDLKLNPEAFTGYQGQH---IWDVIYRENCY---Q--Gs-LNe---mCKEKRALNK 224  Paramecium tetraurelia...
CAM67040                       155 -----WGDWLk--aDDG----AEYVDLASNPEGNTGYSGPLaaqVWRAIYAENCL---S--Sd-KDg---tCQELSILRT 214 
Q57UW3                         157 -----EIKPId--pDRD----ATYVDLLQNPEANTGYSGPKaarVWQAVY-NNCN---IdgLpsNDtagvenREKALLRQ 221  Trypanosoma brucei...
jgi:MICPUN_59129               171 -----MCGYDapppGSEDhgaLEYVNLQLNPERWTGYNGSH---VWSAIYEENCL---Kq-Sg-SVdd--mCYEERVLYR 235 
EFC50762                       134 -----CWTKKe--gDGAK---LTYINLLRNPETRTGYSGEEasrVWNAIYGVNCF---V--Nr-NLnd--mCFEERVFYK 195 
Q54IC1                         133 -----MWVVVa--gPDSE---STYVDLSKTPESNTGYDGSS---VWSAIYNENCF---H--Rp-VDq---mCLEERVFYK 190  Dictyostelium discoideum AX4...
EFA76699                       131 -----MWVIPy--gSDAD---TSYVNLGETPEAYTGYDGSS---VWRSIYNENCF---T--Rp-LEq---mCFEERVFYK 188 
1RQ1_A                         188 LVSGFHASIGTHLSKEYLN---------------------TKTGKWEPNLDLFMARIGNFPDRVTNMYFNYAVVAKALWK 246  baker's yeast...
WGS:AAGF:cds.TTHERM_00150029A  204 IISGFHASISSHICEFYQDl-------------------sKEEAKLNPSWEFYFEKVGNYEDRIKNLLFYYEFLLRAVQK 264 
Q24DE0                         211 ILSGLHASVSTQLSELYIDf-------------------nKNRTKMYPNWKLYFEKVGNYPERIHNLYFYYSVLLRAINR 271  Tetrahymena thermophila SB210...
A0CXB3                         225 LVQGLHTSISTQLSEFYVD---------------------LSTNKTYPNYPMYFERVGNHPERIRNLFFLYSVLLRAVQL 283  Paramecium tetraurelia...
CAM67040                       215 LLSGLHMSINIHVCTSFYKdpelsspqrnagiynnpnisfF------PNCQMYNKRIAPFPDFVGNLYILYQFTLRALAK 288 
Q57UW3                         222 LLSGLHTSITMHVAAFFYNdtkgdsplrslgvlnnpnisfY------PNCGMF-RRIVKNDEFIRNLFVVYQFVLRALAK 294  Trypanosoma brucei...
jgi:MICPUN_59129               236 LLSGMHASVNIHIALKAKTpkk----------------gvVGREDWSADPARFAAHYGQHPERLRNLHFSFVVLLRALRK 299 
EFC50762                       196 LISGLHISITMKIARYYTLkfgh--------------denPTYDSYTPNYEMFEKAILPFPDRVKNLYFLYTFTLRALQK 261 
Q54IC1                         191 LISGLHSSITIHIALFYNQdktlst---------ydsngnEIEPHWEHNSNLFKQRFANHPGRIENLYFTFLFILRSIGK 261  Dictyostelium discoideum AX4...
EFA76699                       189 LISGLHASITTHIAYFYEKd--------------------RFSGEWQKNPMHFKTAFENHPDRIDNLYFTFLFVMRAVSK 248 
1RQ1_A                         247 IQPYLPEfs-----fcD----LVNKeiKNKMDN--VI-SQLd---------TKIFNEDlvfand---------lsltlKD 296  baker's yeast...
WGS:AAGF:cds.TTHERM_00150029A  265 SSEVFVNfp-----ykTgd-lESDKevVQLIKGfiSQiTSQnr--------vlQFDVNlfkdq----------dsveiKR 320 
Q24DE0                         272 AESVIRNyn-----ftTgd-fQEDAktYQLVGDilDYtTSQcd---------qPFHEEilfntd---------qgrkyKK 327  Tetrahymena thermophila SB210...
A0CXB3                         284 ATPGIQKheins------msfdEDTrsQYLLNNilNLgNSQcs---------kAFDEQqffnq----------itfeqKK 338  Paramecium tetraurelia...
CAM67040                       289 SRSFFTNdvsifntgargeatLTDL----------QLhDNIkelfnsrlicSPTFDEGaflese---------kgrslIP 349 
Q57UW3                         295 TKRAFLAnsslynsgfngaatDGDV----------RLySNIgelfssklfrVATFDEQkffesp---------gahllVR 355  Trypanosoma brucei...
jgi:MICPUN_59129               300 AAPTLGVmd-----lsLgqdkAEDArtGALMRR--LLdTHIlssc---sgvFGAFDESmlfrggagvngeasspvaelKS 369 
EFC50762                       262 AAPFLKSyn-----fnTen-eMEDLetSALMSKllENkMCGi-----------AFDEKqmfkse---------emadlRT 315 
Q54IC1                         262 LNHFFTDyq-----fnTgn-qLEDQktKELVQQllQTkLMCq----------pNFDETllfkdt--------ydkdnlIG 317  Dictyostelium discoideum AX4...
EFA76699                       249 IDGFLHEyq-----fnTgn-eIEDKqtYQMVQTllKQqVSCt----------pSFDESllfkdt---------dkqnlIS 303 
1RQ1_A                         297 EFRSRFKNVTKIMDCVQCDRCRLWGKIQTTGYATALKILFEINDadeftkqhiVGKLTKYELIALLQTFGRLSESIESV 375  baker's yeast...
WGS:AAGF:cds.TTHERM_00150029A  321 NYQKYVKNIAQLMDCVSCEKCKLFAKIQVQGISLAMNIIFADNSde------rVKYMKRNELIALINTLHKSSESIQII 393 
Q24DE0                         328 HYQQYIHNITKIMDCVECEKCKVFGKMQVYGIGVALKILFSDDSst------qIQKLQRNELITLINAFVKCASSLDVV 400  Tetrahymena thermophila SB210...
A0CXB3                         339 DYQRYIHNISRIMDCVECQKCRVFGKMQTYGLGTALKILFSESPse------fSGKLKRNELVALINTFGKVSSSVKSI 411  Paramecium tetraurelia...
CAM67040                       350 QFKAMMLNVTRLMDCVTCEKCRIWGKLETKGIAVAMKVIMNPENe--------RITLDRSEMVTLVNLARQLAFSVRNA 420 
Q57UW3                         356 QMKRVVHNVTTLMDCVTCEKCRAWGKLETAALATALKIVFGSAEn--------VVELNRGERVALINFARQLAISVKNV 426  Trypanosoma brucei...
jgi:MICPUN_59129               370 QFKGVFHNISEVMDCISCQKCKLHGKLQLLGLGTALKVLLLPEHl-------hATALSRSEVVALVNTVAKFSHAILAA 441 
EFC50762                       316 QMKASFRNISSIMDCVACEKCKMWAKLDVLGLATALKINLDGDHv--------FHTLQRNEIVALINSFKQHSQSIYNY 386 
Q54IC1                         318 QFKEHFQNISSILNCVTCEKCKLYGKVQTMGLGTALKILFDDN----------IQSIQRNEIIALFNTLRQLSNSIHGI 386  Dictyostelium discoideum AX4...
EFA76699                       304 QFKGHFQNISSILNCVTCEKCKLYGKMQTLGLGTALKILFDEN----------QSSLQRNEIIALVNTLRQLSNSIKAV 372 
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