7KC4


Conserved Protein Domain Family
MIG-14_Wnt-bd

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pfam06664: MIG-14_Wnt-bd 
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Wnt-binding factor required for Wnt secretion
MIG-14 is a Wnt-binding factor. Newly synthesized EGL-20/Wnt binds to MIG-14 in the Golgi, targetting the Wnt to the cell membrane for secretion. AP-2-mediated endocytosis and retromer retrieval at the sorting endosome would recycle MIG-14 to the Golgi, where it can bind to EGL-20/Wnt for next cycle of secretion.
Statistics
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PSSM-Id: 461980
Aligned: 58 rows
Threshold Bit Score: 124.673
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
7KC4_B       178 ECDVLPFMEIGSVAHKFYLLNIRLPVNE-----KkkinvgigeikdIRLVGIHQNGGFTKVWFAMKT--FLTPSIFIIMV 250
Q54BT0       147 QCNTFTLIDEEDLESMSYAVDISIVSENttivgD------------IDFDVWRNSSSFSSFEIVTHL--TLLIISSIAII 212 Dictyostelium d...
EGC31269     150 PCNTLTIIDEEVLDYVLYTVQISIVSESta-igD------------INFTAWRAHDSFSSFEIGVHL--TLVIISCIGIV 214
EFA74716     140 ECTSFTLVDEEVLLYDQYIVSIGLLNGQni-vgD------------VVFTVWRAHEKFSSFEIAVHL--SWMIISSVGII 204
EGG14622     144 SCSMINIVDFQTLDYQAYDLKVYYIGEYdq-igD------------VVFDIWRTKDSFTNFEISLHI--AWVIISSIGIV 208
EAY20131     155 LTTSITLFTDIILDYNKVEIDLTFDHPyth-------------fssFILTYSIGTPDHAYFQIYFRF--LFSIVSAIFLA 219
XP_001309127 155 ETYPIILYTQKLLNFDSIHFECTIDVPpmy--------------tsLTLRFVHGFTQYTIFQIYFKL--IFALIELIFLV 218
XP_001320784 147 TSDQILLYSSPLIEYDAIRIDIVVTDAehl--------------raAQVSHYLATIQHSYYEIYFRT--AFAIIEFMLLI 210
EFC46545     192 LCDPITLFYESHIRHPYYRIGVSFLNSR-----Elydntl-idphfVKMEFESYNAAYSNWELGWRYsiIFITAPLCIAF 265
EFC38142     243 GCSAITLFHSRVIRYSNYKMNLTILNLE-----Nvyrsg--llenaIETSLQSNNPQYSMYELGFRM--TFSVLSILHWI 313
7KC4_B       251 Wy---WRRiTMMSRPPVLLEKVIFALGISMTFINIPVEWFSIGFDWTWMLLFGDIRQGIFYAMLLSFWIIFCGEHMMDQH 327
Q54BT0       213 Gfl-iAMR-SFSLINWAFEQKFLFALFFGILLANNPFYGIQYATQGAFFPFLNAFFDVIFLSIFSLYSLMVLDRIRLESK 290 Dictyostelium d...
EGC31269     215 Gfl-vAMR-TYSLIKWTFEQKYLFAIFFVLLLSNNPLYGLQYATQGWFFPFCNALFSIIFLSIFSLYSLMVLDRLRTDTK 292
EFA74716     205 Lyl-fFMR-KYVSTKWSLEQKFLFILLLSLVLSNNPFFGFQFISQSAFFPFINSLFAILFLAAFSMYSLVILDRMRLESV 282
EGG14622     209 Lyl-vYMR-HTRMMDWSMEQKFLFALLISVLLSNGPFYVLQFAIRGWFMPFLNSFFQTLFLSVFCLYSLTILDKMRQGEV 286
EAY20131     220 Lml-yFLR-GLEVKLWHLEQKLTVPLVALLIFYNNPFYIFHVYNPSPVFVILDRILDSIFHSYMCFFILVLFDSLRY-KN 296
XP_001309127 219 Lfv-lRLS-TAQFKYWHLEQKLTCPLLLLSFLYNNIFEFFFVKHKSNSVVLLEILVNSLFSAYLKFFILVLFDSLRY-KN 295
XP_001320784 211 Lfv-fSLR-KVSYSFWHLEQKLTLHLQFLSMLFNNPLIYLTITYPSKTGLILDILIKSIFTTYFRYFVLVLFDSLRY-KN 287
EFC46545     266 Iia-nIIR-SH-FVNWATEQKWIGLLLIFLVLYNNPIFALIFTAGNWAFSFINIVFIISFVCFLMFVVLVFTDSLVIPQK 342
EFC38142     314 AflvvTFW-SQQLRNWHTAQKWLVVLLFLHFWYHDPLYPAMMWTGWEGFPVVDIILSVTFVYGFLLYLLIFFHSVFKAPQ 392
7KC4_B       328 ErNHIAG-YWKQVGPI----AVGSFCLFIFD--------MCERGVQLTNPFYSIWTtdigTELa---mAFIIVAGICLCL 391
Q54BT0       291 K-VEWDYsTISKIVVV----VIFMILGLILF--------SWINVRDRKDPIIGSAT----SES-----GIQALFYLVATV 348 Dictyostelium d...
EGC31269     293 E-TEWTFsTISKVVLV----GIFTILGIALF--------SWINIRDRKDPIIGPAT----SQN-----GIQILFYLVATI 350
EFA74716     283 E-NHMGPgYLLKGLLV----LLFSVLGTTLF--------TWINLRDRKDPILGPAT----AVS-----GIQILFYFVTTS 340
EGG14622     287 L-NYYSVyHLAKNAMV----AIFTIGGIVLF--------AWINIRDHKNPVVGPTT----SVN-----GLQALYYFEAIL 344
EAY20131     297 RkTDRCF-YIPKIIMC----SIILIVYSIHG--------IYDKLHLIAEHNKNYN-------------TTAITSVAEMVV 350
XP_001309127 296 RkTDKCF-FVPKIILC----SIIYLADVVSEig----ftVFDK-------------------------KIIFMAYFNIVL 341
XP_001320784 288 RkTDPCF-FVPKILFSfamfATIYLNTMITElpsylpfeLSDE-------------------------VKKYIDTADTAL 341
EFC46545     343 DrSFLWF-YIPKIVLV----GILFVFVITTF--------TYVRLQEQEDPGYNLGI----VqglssyqTLGIIVVLIMLV 405
EFC38142     393 DrTFMNF-YLTKIIIV----GIGYILTLILM--------IWSRVYNVANPSSVDIS----Svpg--yaYLLAANIVFLVL 453
7KC4_B       392 YFLFLCFMVFQVFRNISGKQSSlpamskvrrlhyEGLIfRFKFLMLITLACAAMTVIFFIVSQvteghwkwggvtvqvnS 471
Q54BT0       349 FICILLWILLLVITAFPIAYAR------------QYLFaKYLFTAVPIVVFVISILIGIIAGTfgpl---------npnS 407 Dictyostelium d...
EGC31269     351 FICILLWILLLVITSFPVAYAK------------KYNFaKFLFISIPILVYVFSILFGIFAGTfgpl---------nptS 409
EFA74716     341 FVAILLWISMLVVMTAPTIANR------------KFLIpKFLFTAAPISIYVISLLAGIFAGTfgpl---------npdA 399
EGG14622     345 LFVIVIWIVVLIILTIPTLSGK------------HHLIpRFTVIAAPISLYVLSVISGIFAGTfgpl---------nptS 403
EAY20131     351 YLTFLLYTILSILISASRVDVT------------E----RYKFNIYLSSGLIAVIIMGACQALssfkl-------fsesS 407
XP_001309127 342 FCGYIVWCIFCIIVASIQVDIT------------E----RYKYIIYLVSGSVSIALIFLYGVIfsflp------kfkdsA 399
XP_001320784 342 FGVYLVWAAITTLFAGCQVDIT------------E----RYKYVIYIISGIAALALLATSELLfkffk------ffqdsS 399
EFC46545     406 YIFVLIYYLMRVIEKHRMNLLP------------KRNAwRSKVIWFLTITMVIGTIVEIFLYVfskd---------wnsS 464
EFC38142     454 WGIDLAYYIFRAMGAVGK--LK------------AKYSsRFRV---VGSFSFIVAACFIGLTIagngf------rtdvqS 510
7KC4_B       472 AFFTGIYGMWNLYVFALMFLYAPSH 496
Q54BT0       408 LSVMYFNVLNNVFVAIVAYSYWPNA 432 Dictyostelium discoideum AX4
EGC31269     410 LSVTYFNVLNNVFTAILAYSYWPSA 434
EFA74716     400 LSTMYFTTLNNVFAMIIAYSYWPRE 424
EGG14622     404 LSYSFFIAMDNVFVAMCAYSYWPTK 428
EAY20131     408 LSFVIKFAVENIFSFLMVYFHWPYE 432
XP_001309127 400 LRFVGVYSIQNVFVLLMAYFHWPYE 424
XP_001320784 400 LQFVEQFSIYNVFSMLMVYFHWPFE 424
EFC46545     465 AQFLSYFMFYSLYVWLITILYWPSF 489
EFC38142     511 LTFLLLHGIVYVYFASLSFLLMPGK 535
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