Conserved Protein Domain Family
DUF2181

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pfam10223: DUF2181 
Uncharacterized conserved protein (DUF2181)
This is region of approximately 250 residues conserved from worms to humans. Its function is unknown.
Statistics
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PSSM-Id: 463007
Aligned: 55 rows
Threshold Bit Score: 230.942
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q7Q3G4         7 NLTKVTWAHAVNDAEFLTRVL-ASD----IQFIEADISLGYLKDDvNKEreIPIMAHPPATESDISLETFLQRILqfnre 81  Anopheles gambi...
1_pfamImport   1 DLTLVTWEHAVNSKEKLEKAL-AGD----SLMIEADISLGYVIGDvTKEl-RPIMAHPPANTSDLSLEDFLYIFS----- 69 
EFX69415      28 DFTQVTWAHAVDNRKKLRRAL-RGS----AMMLEADVSLGKLKSDpHSEd-RPIMAHPPISASDLSLEDFLDAVL----- 96 
EFX75485     148 DLSRIKWGHGINSKVQLNTSL-YGK----DMMIEADVSMGTIVGG-DGSi-LPIMAHPPLVSSDLSLEEFMDTIL----- 215
EFX69416      65 DLSRVKWGHGVNSKAQLSQSL-QGT----DMMIEADVSMGIVTGR-EGKf-LPIMAHPPFKSSDLSLEEFLDITL----- 132
EEC05789      24 DMSSVVWSHATNSRWKLDKALnDKQ----NPYLEADVSYADG---------IAVMAHPPVKSWDLSLKEFLRLVC----- 85 
XP_002411529  24 DVSSVRWNRATHSRALLQDALqRDS----APFVEADVVLVDG---------SAVLPRPVNENWTVSLSELLYRVS----- 85 
XP_002401368  27 DATYARWFHGTNSRRLLDEALkGDE----PVFLEADVVVEGS---------MAVLEHPLDQPWDLSLRDLLNLVT----- 88 
Q642A7       342 DGLEVEWLALEVNDKGRKAAI-TVPd--rEGMILLDVGLQEPEVGnP----VPVLRTP--GGSVLTLESCLLHLA----- 407 Norway rat
O45879        41 DGLNVRVAHGVNSWPDLVDQL-HEPflnkSMMIEGDVFMQAHRRPrHRA--VPVMKADTKLADRITFKEWLREVA----- 112 Caenorhabditis ...
Q7Q3G4        82 anDPSKVKGVKLDFKSIGAFERSIDII--RASYDM---TAFDTWINADILPGPVDNTaT-VPVDPTRFFTAARR-LGKAT 154 Anopheles gambi...
1_pfamImport  70 --KSSARKGIKLDFKSKEAFSHSEFILeaSLYNRD---VDYPVWLNADIIKGPVNSE-V-QPVDADYFLSRSVTkFPVAT 142
EFX69415      97 --DEAYYKGIKLDFKSVEVLERALRIVktR--EHK---IRVPLWLNADIIKGPVDST-S-QPIDAQLFLSLTKHyFPTAV 167
EFX75485     216 --NSGTFKGIKLDFKDIEALEPSLMAIksR--ASK---ITAPLWLNADILAGPVNAT-T-KPVDIGRFFDLTKNyFPDSV 286
EFX69416     133 --SSRTPKGIKLDFKDMEAVELSLRTIktR--ANK---IYAPLWLNADIIQGPVNAT-T-KPMDARRFLNLTKSyFPDAV 203
EEC05789      86 --STPKNTTLKLDFKSNDVLHAAFHDLdnAPVKNL-----QDLWLNADVVQGAGGAP----LVDGRRFVHMCSTrFPWAV 154
XP_002411529  86 --ATPMNVTLKLNLKSTEVLEVAKRNLleAHLQNL-----KGLWFHADILPATGGEA----PVNASYYLHQFASsFPQAV 154
XP_002401368  89 --AKPKRVTLKLDFKSTEVLPSAINVLmgALTENL-----KDLWLHADAVPGPGGKP----PVDASTFLRYTTPfHPFAV 157
Q642A7       408 --VHATRWSIHVNITEPAALRPSLATLahLSTLGH---LPWPVWVGATVSYGSFVVP-GhI--AGRELLTAVAEvFPHVT 479 Norway rat
O45879       113 ----TMNKAIKINFRSNEVVRPVLQDLyaSQADPTspvLQYPVILHANVFRSPRSVE-TeV--DPSTFVEKAKDlFPDAT 185 Caenorhabditis ...
Q7Q3G4       155 LSIGWTTRWGpDF--------SEGlYTESQVDAMIDAIRAngIDKVgn--aITFPVRGG-IVANSVTNMIRLFCALkdTN 223 Anopheles gambi...
1_pfamImport 143 LSVGWTTRFGnGI--------DKGeYTVGIIEEMTDALNRnlVTSP-----VTFAVRAA-IAAQSYEQLSNL-IGSsvPG 207
EFX69415     168 ISAGWTTKl-----------aKEGyYTLDQCRNMKDALIAaqVTAP-----VTFPVRAG-LVANLESRQNILWLLSeiPG 230
EFX75485     287 LSVGWTTRFGpQMtwpl-qiiNEGsYTMDHMIQMRDALHAaqIRQP-----VTFPIRAG-LSTSPESQRNILWLLEqiEN 359
EFX69416     204 LSVGWTTRYGpDVsswplqiiNEGsYTMNHMIQLRDALRAaqIRQP-----VTFPIRAG-LCTTPESQRSIIWLLEqvED 277
EEC05789     155 ISPGWTTL-------------PQStYTWGQVEAMARLL----LCEAplpprTTFPVRAS-LVATSIPQLSWLLDVT--RN 214
XP_002411529 155 VSVGWTTY-------------PETfYTWEVVDRMTRLL----LCGPhlparVSIAARAS-MLPNSVAQVSWMLDVI--PQ 214
XP_002401368 158 VSLGWTTK-------------NKGaYSWRNVETMARLT----RCGQpylrrVAFSVRAS-MVENSLPQLAWLVDVV--PN 217
Q642A7       480 VAPAWPEEML-----------GSG-YQEQMVTEMLELCQG--LRQP-----VSFQLQAGpLGQSPANTVARLLAFS--PR 538 Norway rat
O45879       186 LSLGWTKQ---SNfshlhpkfKK--LSWRQLFHILEYISR--LDQP-----VMLSVRLS-VAAHSKEQLLWLLGMD--QS 250 Caenorhabditis ...
Q7Q3G4       224 nVTFTIW-SSADDA-VNVEKLREFIFTTGLDRTYVDVPDDLH 263 Anopheles gambiae str. PEST
1_pfamImport 208 -TTLTIW-CGSNDK-TDLNLLRRLIHGIGRDKIYLDLPPEMI 246
EFX69415     231 -STVTIW-SSYGDE-VDVFGLLDFIDAIGKEFIYIDVHSGLR 269
EFX75485     360 -SSLTVW-SSQYDI-VDVPALMKLVNHIGKENIFVDVPSGLS 398
EFX69416     278 -STLTIW-SGPFDT-VDVPGLMKLIKHVGTKRIYIDVSSGLL 316
EEC05789     215 -STLTVW-ASDNDP-WATEGLVRLRQELPWSSVYYDLPGQQD 253
XP_002411529 215 -ASLSIW-AQDNDP-RVTDTLIQLRKALPWSVVYYDLSEEQR 253
XP_002401368 218 -STLSVW-YPSSEA-PPTEALLKLRQTIPESSVVYDLPRDYP 256
Q642A7       539 -ATVTVYhSSAGNSyADVWAGLWAARAVDRTRVYYRIPQEYR 579 Norway rat
O45879       251 -ISLLLW-SDAEDHvTNWTPIVELRRSTTKNRILYDLDPKHR 290 Caenorhabditis elegans
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