Conserved Protein Domain Family
TMEM138
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pfam14935: TMEM138 
Transmembrane protein 138
This family of proteins is found in eukaryotes and members are approximately 160 amino acids in length. There are two conserved sequence motifs: YYY and DPR. This transmembrane protein belongs to a family found in eukaryotes and is involved in the biogenesis and degradation of ciliated cells. Mutations in this protein cause the disease Joubert syndrome(JBTS) where the cilia becomes non-motile. Ciliopathy can be severe since cilia provide the cell with large amounts of information through signals. Ciliopathy can affect cell behaviour as the appropriate signals between the cell and its environment are not made, which can affect cell survival.
Links
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Statistics
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PSSM-Id: 434328
Aligned: 21 rows
Threshold Bit Score: 105.4
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_001962712  82 AILFFVIQDVLIIAEYVLFTFTLHSTCVHQVGASHIILRNCKLFLVSVTIYFLLSASQHFWIVSQYR-LAPGNETteWPL 160
1_pfamImport   1 LFVVFIVQDAFLLMAVTCLCFSLFRTNVFKAGFVELLLYGFKGTIIFAALYIILTVSLQTFLLLLRW-EQPIDYN--WPG 77 
XP_001869684  40 IIFLFLAQDVCLILSFTAIIFSLYSTYVYQAGMAHLLYEKFRVPLLVAMMYFILCISLHTWQVVDHH-KSPYLFQ--WPK 116
OWR45793      38 LLVLFIFQDLFLILSITMMLMTFFSTYLFQAGLVEVLIRKFRAAGSVIVSYLAASVLLHTAWLMQKW-SDPES-V--STP 113
XP_002425851  38 QLVAFIFQDVFIVISLTVTLIGFFSTYVFQAGLVELLFDRFRLAILISVFYFIITIILHAWLLTIRW-NNPNNFN--WTD 114
EFN66129      40 LLVLYVIQDFCLIAALTLLLVNFFSTYIFQAGLIQLLYTRFRITLILCIIYMILSISLHTWHITIHW-SSPLKHY--WTK 116
XP_002126014  37 QLVLFILQDICLVFQLVVLCLEIFNTATSQAGFISVMMKKFAPCLLTTLLYLVLSIALCAKTLMLRW-NDTTVNV--YAD 113
ESN93779      38 ILIIYFVQDICILLSAIALFLVFIETYLFQAGLIFLLIDKFKKTIFTILFYLCITVALHAWGLVCSW-SNPLYYT--EVP 114
EEY59631      48 dsivsFVQVLLQIAALVNLLLLLGGTFLFRSGLFGMLYSHFRLVLLVHLLYICLTIILGIVRMNLLSpGNEHVDI--WDA 125
CAP21918      36 LLLIYILQDTLLIMSSLVLFVSFTATFVFQLGLIHIVLVQFLPTIIMSIFYTFVSIGYHYTSLSSTW-EDQTVNI--FLE 112

XP_001962712 161 -GLIALSVIQRIVSVFYYYSCKSTALTMADPRFKeeYVDWIVEQ 203
1_pfamImport  78 -LLSALYIIQRFFAVLFYYFYKRSSLRLSDHRFY--DEEWVKHT 118
XP_001869684 117 -ALTALFIIQRLFSPLYYYLYKRSALKMSDPRFYe-NLDWITSa 158
OWR45793     114 -FLIVLFTFQRCLSPWYYFFYKRAALRVSDPRFYe-DIDWISQQ 155
XP_002425851 115 -GLTIFFSCQRMFSPIYYYSTKRAMLRISDPRFYq-SLDWISRh 156
EFN66129     117 -GFHILYSIHRTVAVLYYYFYKRASLRIGDPRFYk-GSIWVQKQ 158
XP_002126014 114 gGFFAVYILQRLWSPIYYYTYKRTAMRLADSNFYk-NTDWLRRQ 156
ESN93779     115 -GYTALYALQRLTAVVYYYLYKRTSLRLSDPRYYa-DSQWIRDM 156
EEY59631     126 rGYAAFSGIHKIGALCYYACSIVAVEKLRKHKYYs-PEYWMRr- 167
CAP21918     113 tHLLIFFIFHKVISCIFYSFYKRTALQISDPKYNs-DSTWLREL 155
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