Conserved Protein Domain Family
serpin

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cl38926: serpin Superfamily 
SERine Proteinase INhibitors (serpin) family
SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate blood coagulation cascades. Non-inhibitory serpins perform many diverse functions such as chaperoning proteins or transporting hormones. Serpins are of medical interest because mutants have been associated with blood clotting disorders, emphysema, cirrhosis, and dementia. A classification based on evolutionary relatedness has resulted in the assignment of serpins to 16 clades designated A-P along with some orphans.
Links
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Taxonomy: root
PubMed: 170 links
Protein: Related Protein
Related Structure
Statistics
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Accession: cl38926
PSSM Id: 476815
Name: serpin
Created: 8-Jan-2020
Updated: 4-Oct-2023
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