6LPH,1M1L


Conserved Protein Domain Family
SUFU
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pfam05076: SUFU 
Suppressor of fused protein (SUFU)
SUFU, encoding the human orthologue of Drosophila suppressor of fused, appears to have a conserved role in the repression of Hedgehog signaling. SUFU exerts its repressor role by physically interacting with GLI proteins in both the cytoplasm and the nucleus. SUFU has been found to be a tumour-suppressor gene that predisposes individuals to medulloblastoma by modulating the SHH signaling pathway. Genomic contextual analysis of bacterial SUFU versions revealed that they are immunity proteins against diverse nuclease toxins in polymorphic toxin systems.
Links
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Statistics
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PSSM-Id: 461543
Aligned: 112 rows
Threshold Bit Score: 59.2474
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
6LPH_A                  52 LDYISM------YNYPGdvdrnvPPHWHYISFGLSDLHGDERvhlrEEGvTr----sGMGFELTFRLAKteielkqqiE- 120
Q0AP68                  39 FQIVEVaypdpvADR------------AFATLGLSNLRVCasn-----------pnqMIGTELIIGLSq----------- 84  Maric...
Q8CMI1                  50 HGVFKSp-------pNGn-----RSTWAYITSGMSNPWET----------NepeehsGLGVEFIIETE------------ 95  Shewa...
SLUandSVAtrep:TPE_1362  37 IDILSC------DDPTD------SEVKFYSTIGLSGYPNPIN----IKDgs----vaNIPVELLMAGYK---------E- 86 
faib:Ccan_23810         36 IDILSI------DDPLN------TENSFYSTIGLSDFPNKIE----MNDns----mlNIPVELLMCGYK---------K- 85 
WP_012247547            27 IDILVV------DDSPD------DGLVSYSTVGLFETELRH-----GDGkp-----lpMRIELCAEAPQ---------E- 74  Borde...
ACR30093                37 laVLSV------ADAPD------EDVVSYSTAGLCEFAL--------DTgg-----fdTRIELCGAMPD---------D- 81 
Q5F702                  26 LNIAAI------PSSPN------RDLKTYITLGLSKHDLn----------------yKSRFEILFVCSlk---------- 67  Neiss...
WP_005371593            27 LQVVCF------EDSPF------KSVDTFFTVGLSHHELRISde------------kKVRQELVFPLSG---------Sd 73  Methy...
jgi:Bphy_7308           28 LRVVRF------PNQPF------QGASTFATLGLSESKVSLP----NGN--------HCGQELLFAAWD---------Ry 74 

6LPH_A                 121 ----NPEKPQRPPTWPANLLQAIGRYCFQ----T-GNG----LCFGDN-IPWRK-SLDGS----T-TSKLQNLLVAQ--- 177
Q0AP68                  85 ---------kHAGSWVLQMLERLAKSVIGgedpVgPGWgsnpVGPGWVsM------------------------IFDplp 131 Maric...
Q8CMI1                  96 ----------KEETWAVEVLQMLMAYNLL-------------LAAGQM--GDFPlLGDgdrvplalSDAIRTMMFTQpv- 149 Shewa...
SLUandSVAtrep:TPE_1362  87 ----YEQIPN--------ILSTASFFIIK----NkWN-----CQPGTV-F---EtIVSDY----Yr-CDMKHIMFTPpf- 135
faib:Ccan_23810         86 ----YDKIGN--------ILATVSFYISK----NkWT-----CQPGTV-F---EnIVSDY----Yv-SQMQHIMFVRpf- 134
WP_012247547            75 ----QEFWGN--------ILSTAAFGLMR----DgHA-----ALPGSA-L---PdCVGEY----YpDATVPHLYLCVpfs 125 Borde...
ACR30093                82 ----VAHWPD--------ILAAAAFELAA----AaSP-----VRPGVV-V---ReVVARC----YpKTTVPHLYLSIpfi 132
Q5F702                  68 --ydENQIFP--------FLRWLAETIIE----NkKI-----LLRGQV-Vy----LPRSI----VnSTKMDALYVSApf- 118 Neiss...
WP_005371593            74 tstaENMV-S--------LLLFICELILK----DhNA-----LLRGQV-Ir----LPVDA----AkKLGFDAVYCTIpv- 125 Methy...
jgi:Bphy_7308           75 ---qAPHVGS--------FLLTFGAQVRN----RqRA-----LLRGDV-I---G-PSAPL----IpGVAANAIYASNpv- 124

6LPH_A                 178 ---------DPQLGCIDTPTGT-------VDFCQIVGVFDDELEQASRWNGRGVLNFLRQDmqtgGDWLVTNMDRQ 237
Q0AP68                 132 tapwfdrfyLSELKTISPSTGDeitrindVSILSVVPISESEHEFIAQSGSIEFDRALA-N----LRAHPWDLDRA 202 Maricauli...
Q8CMI1                 150 -------sfPHCF---SLKSGR-------VDLLQVVGITPAELQVAKQTSSDKIRTQLISK----LGSLVTSKERE 204 Shewanell...
SLUandSVAtrep:TPE_1362 136 -------lwEDKLSRVEI-DNRk------IYPLLLVPISDKELEYKSKYGTDALE-TLFEN----EAIDIFDIKRK 192
faib:Ccan_23810        135 -------lwEDKLSDLKF-GKKk------IHCLLCIPISEKELRFKEENGLTSLEKMLFQQ----KNIDIFDIERE 192
WP_012247547           126 -------wqDGEFRRLEL-GGQi------INWLQAFPISDAELAYLKTHGADAFE-DLLLE----HDPDLYDLERD 182 Bordetell...
ACR30093               133 -------wnDGEFPECRL-DGMr------INWLQCFPVSDEEARLASELGADRFE-SRLDE----AGIDTYDLRRK 189
Q5F702                 119 -------yfDDDFQVCYGEHy-------nIVFPLLVPLYKQEAELVEKKGWNAFEQFLLDN----EVGNLSDMNRK 176 Neisseria...
WP_005371593           126 -------fmGDAFATFSGSEp-------pTVVVWSIPIYTSEANYVNANGWNKFED-LLEE----KDPDLFSLERE 182 Methylomi...
jgi:Bphy_7308          125 -------iyPEELARY---DDDgs----pTVFVWLVPLMEAEGRFAKTQGWNQFE-DALEK----ANPDLLDLDRS 181
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