1RZU,2BIS


Conserved Protein Domain Family
GT5_Glycogen_synthase_DULL1-like

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cd03791: GT5_Glycogen_synthase_DULL1-like 
Click on image for an interactive view with Cn3D
Glycogen synthase GlgA and similar proteins
This family is most closely related to the GT5 family of glycosyltransferases. Glycogen synthase (EC:2.4.1.21) catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family includes starch synthases of plants, such as DULL1 in Zea mays and glycogen synthases of various organisms.
Statistics
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PSSM-Id: 340822
Aligned: 95 rows
Threshold Bit Score: 337.999
Created: 9-Nov-2005
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
ADP-bindinghomodimer
Conserved site includes 10 residues -Click on image for an interactive view with Cn3D
Feature 1:ADP-binding pocket [chemical binding site]
Evidence:
  • Structure:1RZU: A. tumefaciens Glycogen synthase binds ADP.
  • Comment:Some of the residues involved in ADP binding bind indirectly.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                           #  #                                                          
1RZU_B          2 NVLSVSSEIYPLi-----KTGGLADVVGALPIALEahGVRTRTLIPGYPAVKAavtdpvkcfe----------ftdllge 66   Agrobacterium...
2BIS_A          5 KVLLLGFEFLPV------KVGGLAEALTAISEALAslGHEVLVFTPSHGRFQGeeigkir---------------vfgee 63   Pyrococcus ab...
XP_643268    1949 PIVFVTPEIGRFs-----TVGGVGVMLDELTRSLQllGCEVHIISPYYNYGKGgrtgylekeegirwkrnvltyvgpdrv 2023 Dictyostelium...
XP_653076     892 TIVFVTPELGRFs-----TIGGIGVLINELTKTMAelGCEIVVISPYYNMNKKgqqgylknegiqqi-gsvtvevahepv 965  Entamoeba his...
XP_001323043 1085 PIFFVTPELGPFs-----RVGGISTMVWELAKELVsiGVDVSVISPYYNIGPKgetnyltkwdikfq--rtidvyapdkf 1157 Trichomonas v...
XP_001446462 1212 PMCFCTPELGKWt-----TTGGLGVMVDELTQELAkmNEEVILITPYYHRNKKgetgyilsdgfqhi-rnieiwlqgeki 1285 Paramecium te...
XP_001027120 1218 PICFVTPEYAKWt-----KTGGLGVMTDELSRGLVdlGEDVYVVTPIYDNKLKekpdllekdgfkht-dtisyyiggtey 1291 Tetrahymena t...
NP_587978     256 CILFATLEYNIPewnikiKIGGLGVMAELMSKTLK--QYDLVWVVPCVGDITYpvaetapslv---------vkvvnqdy 324  Schizosacchar...
AAR97368     1157 KVLIATLEYEIMdwklkvKIGGLGVMSTLMGKAMT--DVDLIWVVPKVQDLEYpqgeya------------------epi 1216 Cryptococcus ...
BAA76559     1153 LILVATLEYDIPdwdikiKIGGLGVMAELMGKHLT--HHDLIWVVPRVGDVNYpdgqelaple---------vvvldqvy 1221 fission yeast
Feature 1                                                                                         
1RZU_B         67 kaDLLEVQh---------eRLDLLILDApayyersggpylgqtgkdypdnWKRFAALSLAAARIGagvl-pgwRPDMVHA 136  Agrobacterium...
2BIS_A         64 vqVKVSYEe---------rGNLRIYRIGgglldsedv-----ygpgwdglIRKAVTFGRASVLLLndllreepLPDVVHF 129  Pyrococcus ab...
XP_643268    2024 evGVHEGMd---------kGIHLHFLHHfeyfptpy------nsgspihqLKTIVLFAKASLELLcql---riLPSVVVT 2085 Dictyostelium...
XP_653076     966 scGVHYGRe---------nNVDLYFLHNydnfpmay------ppfnaerhLRSAVLLGKSSLQLLcdk---giHPSLIIT 1027 Entamoeba his...
XP_001323043 1158 evGVHYGVv---------dGVKLWFLHNytffstpy------ptgstsykLQYLIMMAKGALELLcqe---riIPSLVIT 1219 Trichomonas v...
XP_001446462 1286 imGVFEGVf---------nGVRLFWLHNeqyfpsay------agedasyvMKQLTVYAKGCLELLcqi---klIPSLIVT 1347 Paramecium te...
XP_001027120 1292 qvGVHFGEy---------kGVKIYFLHNadmfpapf------agddavytVKSIALYARVTLELLcrk---giIPALIVS 1353 Tetrahymena t...
NP_587978     325 evKVFYHYk---------dNIKYVLLDSpifrkrtshdp-ypprmddissAIFYSVWNQSIAAIIrr-----eKVDIYHI 389  Schizosacchar...
AAR97368     1217 evIIFGEPylievethkldNITYVILDSpvfraqtkadp-ypqrmddlssAIFYSTWNQAIAETIrr----npIVDIYHI 1291 Cryptococcus ...
BAA76559     1222 evRVYSHNl---------rNITYILLEApvfrkqtsaep-yparmddlssAIFYSAWNQCIAGIIrr-----yPIDVYHI 1286 fission yeast
Feature 1                                                                                         
1RZU_B        137 HDWQaaMTPVYMryae----tpeiPSLLTIHNIAFqgqfganifsklalpa----------hafgmegieyyndvsfLKG 202  Agrobacterium...
2BIS_A        130 HDWHtvFAGALIkky------fkiPAVFTIHRLNKsklpafyfheag------------------lselapypdidpEHT 185  Pyrococcus ab...
XP_643268    2086 NDWFtgLVPGYAksgafgttfngtTFFHLVHNLEEayqgriypdsgddlnwihh-----lhrelivdpyshqlclnaSRC 2160 Dictyostelium...
XP_653076    1028 NDWFtgMVPAYAkygfgd-yfkqcTFFHIVHNLEKgyigdlypdtdlsyihe---------lpgelvnnpgptalnmSMC 1097 Entamoeba his...
XP_001323043 1220 NDWPtgLVAAYArqtfgs-vfegtQFLHIFHNLGIgyagkiwpsdqntgalhyl-----hnlpdelivdnfdhsfdpSLS 1293 Trichomonas v...
XP_001446462 1348 NDWFcgLIPGYLrvrrygeafagtKSFHIVHNLDPlyegrlypkpnegkldyih----elpndffvdpywqnlvinpSRC 1423 Paramecium te...
XP_001027120 1354 NDWYsgLIPGYIknktfgetfsgtKIFHIAHNLDTtyegrqypnpqqgdlgwih----elpthwlidpywknlvvnpSRC 1429 Tetrahymena t...
NP_587978     390 NDYHgaLAPIYNlpe-------viPCAISLHNAEFqglwplqssiderevcglfnvskticreyiqfgnafnlmhcgVSY 462  Schizosacchar...
AAR97368     1292 NDYHgaLAPLYIlpk-------vvPVCLSLHNAEFqglwplrtkdemkevcaafnipkevcskyvqfgntfnllhaaASY 1364 Cryptococcus ...
BAA76559     1287 NDYHgaLAPCYLlpn-------viPCVLSLHNAEFqglwplrtqaeknevcavy----nistkictkyiqfgnvfnlLHA 1355 fission yeast
Feature 1                                                                                         
1RZU_B        203 GLQTAT------ALSTVSPSYAEEIltaef----gmglEGVIGSrahVLHGIVNGid---aDVWNPATDHlihdnysaan 269  Agrobacterium...
2BIS_A        186 GGYIAD------IVTTVSRGYLIDE-------------WGFFRNfegKITYVFNGid---cSFWNESYLTgs-------- 235  Pyrococcus ab...
XP_643268    2161 ALLTCN------NWGTVSKSYLYDLlrt--------shLANLLHrfpEAFAHSNGir---vKERKQAMKAvst------- 2216 Dictyostelium...
XP_653076    1098 ALKCSD------NWGTVSKSYMQDAlkg--------spLSYHLRqfpHPFACSNGis---vVHRTEALKKispt------ 1154 Entamoeba his...
XP_001323043 1294 ALHCTD------QWATVSKKYREELleg--------spYNYFLRqfpKPFAFSNGir---fQERLKALENlkm------- 1349 Trichomonas v...
XP_001446462 1424 PLITCD------NWGTVSQSYKYELles-------splASVLRRh-pHPFAFPNGir--reQRFKVIMDKtnn------- 1480 Paramecium te...
XP_001027120 1430 AFMTCD------NWGTVSHSYKYQLlre-------salTPILSNf-pNAFSFPNGln---iQERLQMIKNlpts------ 1486 Tetrahymena t...
NP_587978     463 VRRHQSg----yGVVGVSNKYGQRSwvryp---vfwslKKIGQLpnpDPTDIGLSvn--pvNQQLPDFAEyas------- 526  Schizosacchar...
AAR97368     1365 ISHHQKs----iGVAGVSDKYGKRSwarypalwtlrniDSLPNPdptDIAALDEQp----lAVDKIEVDQeae------- 1429 Cryptococcus ...
BAA76559     1356 GVSYIRihqkgyGVVGVSNKYGKRSka----------rYPIFWGl-kKVGKLPNPdpldtaQLDDPTNITeeitidl-ta 1423 fission yeast
Feature 1                                       ###                                               
1RZU_B        270 lknrALNKKAVAEHFrid---ddGSPLFCVISRLt-wQKGIDLMAEAVDEIVSlg----gRLVVLGAGDVALEGALLAAA 341  Agrobacterium...
2BIS_A        236 ---rDERKKSLLSKFgm-----dEGVTFMFIGRFdrgQKGVDVLLKAIEILSSkkefqemRFIIIGKGDPELEGWARSLE 307  Pyrococcus ab...
XP_643268    2217 --dhWSAKAELQKKYfgl--vdkSIPVLSFVGRIv-lQKGVHLILNAVRELIGhy---qgKIQILIGGMANMKDPYASSC 2288 Dictyostelium...
XP_653076    1155 -ldhWECKRRLQQKYfnn--vddSIPLFGFVGRIc-eQKGVFLLLDAIWSLVKet---ngKCQFIIGGMAPMDDPYAVAC 1227 Entamoeba his...
XP_001323043 1350 --nhTEAKAFIQKKYfgs--sdpSKCLFVFVGRIv-eQKGVHLITDTFEELNRefn-grlQFIVGGQAAPDDRSYGQPVC 1423 Trichomonas v...
XP_001446462 1481 --dhLKAKEQLQKKYfgcsqlenHIVVLGFVGRVt-kQKGVHLILEVAEELIQrs---qgTVQILVGGPADMKEEYSAFC 1554 Paramecium te...
XP_001027120 1487 -ddhLKAKEKIQQKYfgfqlldnSFCLFGFVGRIt-eQKGIHLILECAEDLIRqs---ngKIQIILGGNANYKEEYAQIC 1561 Tetrahymena t...
NP_587978     527 --vrKENKRKAQEWAglt--iddEADLLVFVGRWs-vQKGIDILADLAPTLLEkf---niQLIVVGPLIDLYGKFAAEKF 598  Schizosacchar...
AAR97368     1430 -skrPEQKRQAQEWAglk--qdpDADLFVFVGRWs-kQKGVDLIADVMPSLLDkkp--kiQLICVGPVIDLYGRFAAEKL 1503 Cryptococcus ...
BAA76559     1424 eaekRAFKRDAQKWTnle--lddSADLLVFVGRWs-mQKGIDLIADIAPTLLQdf---naQLITIGPIIDLYGKFAAEKL 1497 fission yeast
Feature 1                            ##        #                 #    #                           
1RZU_B        342 srh--------hgRVGVAIGYn----EPLSHLMQAG-CDAIIIPSRFEPCGLTQLYALRYGCIPVVARTGGLADTVIDan 408  Agrobacterium...
2BIS_A        308 ek---------hgNVKVITEMl---sREFVRELYGS-VDFVIIPSYFEPFGLVALEAMCLGAIPIASAVGGLRDIITNe- 373  Pyrococcus ab...
XP_643268    2289 awsmqa--lckqfPQSFWADPd---sFFSDGPLVNLgSDFGLMPSLFEPSGVVQQEYFVAGTPVIAFKTGGLKDTVFEyn 2363 Dictyostelium...
XP_653076    1228 smkmke--mrqtfPQCFWCDPt---aFFTDGPLMNMgCDFTCMPSMFEPSGLVQQESFLGGTPVIAFQTGGLKDTVFEyn 1302 Entamoeba his...
XP_001323043 1424 grmwd---lknryPESFWADPs---aFFTDGLACCHgADYFLVPSMFEPSGIVQQEAFASGTPCIAFRTGGLADTVFEfd 1497 Trichomonas v...
XP_001446462 1555 aqnmir--lksiyPRNFWADPs---aFFMDGTLVNVgCDFGLMPSLFEPGGIVQHEFFIGSTPVIAFKTGGLRDTVHEyd 1629 Paramecium te...
XP_001027120 1562 aekinylrnkhpnNFWGDPDLf----FRDGPLINVG-CDFGLMPSKFEPGGIVQHEFFVGSTPVIAMKTGGLQDTVTDfn 1636 Tetrahymena t...
NP_587978     599 myim------eryPGRVFSKPe---fVHLPPFIFEG-ADFALIPSRDEPFGLVAVEFGRRGAICIGSRVGGLGEMPGW-- 666  Schizosacchar...
AAR97368     1504 ar---------lmEMYPDRVYskpefTALPPYLFSG-ADFALIPSRDEPFGLVAVEFGRKGALGVGSRLGGLGLMPGW-- 1571 Cryptococcus ...
BAA76559     1498 nalm------kkyPKRVYCRPe---fTHLPPCIFSG-ADFVLIPSRDEPFGLVAVEFGRKGALGIGARVGGLGQMPGW-- 1565 fission yeast
Feature 1                                                                                         
1RZU_B        409 haalaskaatGVQFSPvt-------lDGLKQAIRRTVRYYHd-------------------pKLWTQMQKLGMKsd---- 458  Agrobacterium...
2BIS_A        374 ---------tGILVKAgd-------pGELANAILKALELSR---------------------SDLSKFRENCKKram--- 413  Pyrococcus ab...
XP_643268    2364 tnt---etgnGFTFEAhkhtdyvqavHRAINIFNNTHHYEKi-------------------rKCAEESVLDMSVva---- 2417 Dictyostelium...
XP_653076    1303 pid---ktgnGFVFQGfahgdlvfaiQRAIKIFQNPEEYKVl-------------------rSNAAKSVLDLTDva---- 1356 Entamoeba his...
XP_001323043 1498 rek---rtgnGVVFWAhr-------hRDFIMAVERAIALFNe-------------------pDLYNTMRKNAFEsvlste 1548 Trichomonas v...
XP_001446462 1630 qkq---qkgsGFIFDQyn-------rGNFLYSIDRALQLYKn-------------------qDQYTQLRKNAFDaaid-- 1678 Paramecium te...
XP_001027120 1637 eqt---ekgsGFTFEHhn-------sHGFAYAVTKALKLFKn-------------------eSLYNKLRKSSFQaa---- 1683 Tetrahymena t...
NP_587978     667 ----------WYSVESss-------tAYLLKQLEKSCTLALks-----------------tpEMRHKLRIAALQqrfp-- 710  Schizosacchar...
AAR97368     1572 ----------WFPVESsa-------tVHMLSQLTKTIKLALks-----------------tpEERAILRARSAVqrfp-- 1615 Cryptococcus ...
BAA76559     1566 ----------WYSVESnats---hvlQQFEEACRKALSSSAekrallraksakqrfpvlewiSKLDHLMDNCIRlnvgqr 1632 fission yeast
Feature 1                                          
1RZU_B        459 -----------------vsWEKSAGLYAALYSQ 474  Agrobacterium tumefaciens
2BIS_A        414 ----------------sfsWEKSAERYVKAYTG 430  Pyrococcus abyssi
XP_643268    2418 -----------------eaWAKEFSRMRRSIWS 2433 Dictyostelium discoideum AX4
XP_653076    1357 -----------------iaWGTEFGRLKKKVFV 1372 Entamoeba histolytica HM-1:IMSS
XP_001323043 1549 --------------tvaraWAREFARLFQKIYD 1567 Trichomonas vaginalis G3
XP_001446462 1679 ---------------vadvSRAWAQEYYRLFEK 1696 Paramecium tetraurelia
XP_001027120 1684 -----------------idVSEVSKAYEGEFYR 1699 Tetrahymena thermophila SB210
NP_587978     711 ----------------vdeWVALYDRLIRNCIK 727  Schizosaccharomyces pombe 972h-
AAR97368     1616 ----------------vveWRQRLEDFQRRSII 1632 Cryptococcus neoformans var. neoformans
BAA76559     1633 qqgssshsmkfrskndlssIKLSTKEGLENEEN 1665 fission yeast

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