1RZU,2BIS


Conserved Protein Domain Family
GT5_Glycogen_synthase_DULL1-like
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cd03791: GT5_Glycogen_synthase_DULL1-like 
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Glycogen synthase GlgA and similar proteins
This family is most closely related to the GT5 family of glycosyltransferases. Glycogen synthase (EC:2.4.1.21) catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family includes starch synthases of plants, such as DULL1 in Zea mays and glycogen synthases of various organisms.
Links
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Statistics
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PSSM-Id: 340822
Aligned: 95 rows
Threshold Bit Score: 337.999
Created: 9-Nov-2005
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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ADP-bindinghomodimer
Conserved site includes 10 residues -Click on image for an interactive view with Cn3D
Feature 1:ADP-binding pocket [chemical binding site]
Evidence:
  • Structure:1RZU: A. tumefaciens Glycogen synthase binds ADP.
    - View structure with Cn3D
  • Comment:Some of the residues involved in ADP binding bind indirectly.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                           #  #                                                          
1RZU_B          2 NVLSVSSEIYPLi-----KTGGLADVVGALPIALEahGVRTRTLIPGYPAVKAavtdpvkcfe----------ftdllge 66   Agrobacterium...
2BIS_A          5 KVLLLGFEFLPV------KVGGLAEALTAISEALAslGHEVLVFTPSHGRFQGeeigkir---------------vfgee 63   Pyrococcus ab...
XP_643268    1949 PIVFVTPEIGRFs-----TVGGVGVMLDELTRSLQllGCEVHIISPYYNYGKGgrtgylekeegirwkrnvltyvgpdrv 2023 Dictyostelium...
XP_653076     892 TIVFVTPELGRFs-----TIGGIGVLINELTKTMAelGCEIVVISPYYNMNKKgqqgylknegiqqi-gsvtvevahepv 965  Entamoeba his...
XP_001323043 1085 PIFFVTPELGPFs-----RVGGISTMVWELAKELVsiGVDVSVISPYYNIGPKgetnyltkwdikfq--rtidvyapdkf 1157 Trichomonas v...
XP_001446462 1212 PMCFCTPELGKWt-----TTGGLGVMVDELTQELAkmNEEVILITPYYHRNKKgetgyilsdgfqhi-rnieiwlqgeki 1285 Paramecium te...
XP_001027120 1218 PICFVTPEYAKWt-----KTGGLGVMTDELSRGLVdlGEDVYVVTPIYDNKLKekpdllekdgfkht-dtisyyiggtey 1291 Tetrahymena t...
NP_587978     256 CILFATLEYNIPewnikiKIGGLGVMAELMSKTLK--QYDLVWVVPCVGDITYpvaetapslv---------vkvvnqdy 324  Schizosacchar...
AAR97368     1157 KVLIATLEYEIMdwklkvKIGGLGVMSTLMGKAMT--DVDLIWVVPKVQDLEYpqgeya------------------epi 1216 Cryptococcus ...
BAA76559     1153 LILVATLEYDIPdwdikiKIGGLGVMAELMGKHLT--HHDLIWVVPRVGDVNYpdgqelaple---------vvvldqvy 1221 fission yeast

Feature 1                                                                                         
1RZU_B         67 kaDLLEVQh---------eRLDLLILDApayyersggpylgqtgkdypdnWKRFAALSLAAARIGagvl-pgwRPDMVHA 136  Agrobacterium...
2BIS_A         64 vqVKVSYEe---------rGNLRIYRIGgglldsedv-----ygpgwdglIRKAVTFGRASVLLLndllreepLPDVVHF 129  Pyrococcus ab...
XP_643268    2024 evGVHEGMd---------kGIHLHFLHHfeyfptpy------nsgspihqLKTIVLFAKASLELLcql---riLPSVVVT 2085 Dictyostelium...
XP_653076     966 scGVHYGRe---------nNVDLYFLHNydnfpmay------ppfnaerhLRSAVLLGKSSLQLLcdk---giHPSLIIT 1027 Entamoeba his...
XP_001323043 1158 evGVHYGVv---------dGVKLWFLHNytffstpy------ptgstsykLQYLIMMAKGALELLcqe---riIPSLVIT 1219 Trichomonas v...
XP_001446462 1286 imGVFEGVf---------nGVRLFWLHNeqyfpsay------agedasyvMKQLTVYAKGCLELLcqi---klIPSLIVT 1347 Paramecium te...
XP_001027120 1292 qvGVHFGEy---------kGVKIYFLHNadmfpapf------agddavytVKSIALYARVTLELLcrk---giIPALIVS 1353 Tetrahymena t...
NP_587978     325 evKVFYHYk---------dNIKYVLLDSpifrkrtshdp-ypprmddissAIFYSVWNQSIAAIIrr-----eKVDIYHI 389  Schizosacchar...
AAR97368     1217 evIIFGEPylievethkldNITYVILDSpvfraqtkadp-ypqrmddlssAIFYSTWNQAIAETIrr----npIVDIYHI 1291 Cryptococcus ...
BAA76559     1222 evRVYSHNl---------rNITYILLEApvfrkqtsaep-yparmddlssAIFYSAWNQCIAGIIrr-----yPIDVYHI 1286 fission yeast

Feature 1                                                                                         
1RZU_B        137 HDWQaaMTPVYMryae----tpeiPSLLTIHNIAFqgqfganifsklalpa----------hafgmegieyyndvsfLKG 202  Agrobacterium...
2BIS_A        130 HDWHtvFAGALIkky------fkiPAVFTIHRLNKsklpafyfheag------------------lselapypdidpEHT 185  Pyrococcus ab...
XP_643268    2086 NDWFtgLVPGYAksgafgttfngtTFFHLVHNLEEayqgriypdsgddlnwihh-----lhrelivdpyshqlclnaSRC 2160 Dictyostelium...
XP_653076    1028 NDWFtgMVPAYAkygfgd-yfkqcTFFHIVHNLEKgyigdlypdtdlsyihe---------lpgelvnnpgptalnmSMC 1097 Entamoeba his...
XP_001323043 1220 NDWPtgLVAAYArqtfgs-vfegtQFLHIFHNLGIgyagkiwpsdqntgalhyl-----hnlpdelivdnfdhsfdpSLS 1293 Trichomonas v...
XP_001446462 1348 NDWFcgLIPGYLrvrrygeafagtKSFHIVHNLDPlyegrlypkpnegkldyih----elpndffvdpywqnlvinpSRC 1423 Paramecium te...
XP_001027120 1354 NDWYsgLIPGYIknktfgetfsgtKIFHIAHNLDTtyegrqypnpqqgdlgwih----elpthwlidpywknlvvnpSRC 1429 Tetrahymena t...
NP_587978     390 NDYHgaLAPIYNlpe-------viPCAISLHNAEFqglwplqssiderevcglfnvskticreyiqfgnafnlmhcgVSY 462  Schizosacchar...
AAR97368     1292 NDYHgaLAPLYIlpk-------vvPVCLSLHNAEFqglwplrtkdemkevcaafnipkevcskyvqfgntfnllhaaASY 1364 Cryptococcus ...
BAA76559     1287 NDYHgaLAPCYLlpn-------viPCVLSLHNAEFqglwplrtqaeknevcavy----nistkictkyiqfgnvfnlLHA 1355 fission yeast

Feature 1                                                                                         
1RZU_B        203 GLQTAT------ALSTVSPSYAEEIltaef----gmglEGVIGSrahVLHGIVNGid---aDVWNPATDHlihdnysaan 269  Agrobacterium...
2BIS_A        186 GGYIAD------IVTTVSRGYLIDE-------------WGFFRNfegKITYVFNGid---cSFWNESYLTgs-------- 235  Pyrococcus ab...
XP_643268    2161 ALLTCN------NWGTVSKSYLYDLlrt--------shLANLLHrfpEAFAHSNGir---vKERKQAMKAvst------- 2216 Dictyostelium...
XP_653076    1098 ALKCSD------NWGTVSKSYMQDAlkg--------spLSYHLRqfpHPFACSNGis---vVHRTEALKKispt------ 1154 Entamoeba his...
XP_001323043 1294 ALHCTD------QWATVSKKYREELleg--------spYNYFLRqfpKPFAFSNGir---fQERLKALENlkm------- 1349 Trichomonas v...
XP_001446462 1424 PLITCD------NWGTVSQSYKYELles-------splASVLRRh-pHPFAFPNGir--reQRFKVIMDKtnn------- 1480 Paramecium te...
XP_001027120 1430 AFMTCD------NWGTVSHSYKYQLlre-------salTPILSNf-pNAFSFPNGln---iQERLQMIKNlpts------ 1486 Tetrahymena t...
NP_587978     463 VRRHQSg----yGVVGVSNKYGQRSwvryp---vfwslKKIGQLpnpDPTDIGLSvn--pvNQQLPDFAEyas------- 526  Schizosacchar...
AAR97368     1365 ISHHQKs----iGVAGVSDKYGKRSwarypalwtlrniDSLPNPdptDIAALDEQp----lAVDKIEVDQeae------- 1429 Cryptococcus ...
BAA76559     1356 GVSYIRihqkgyGVVGVSNKYGKRSka----------rYPIFWGl-kKVGKLPNPdpldtaQLDDPTNITeeitidl-ta 1423 fission yeast

Feature 1                                       ###                                               
1RZU_B        270 lknrALNKKAVAEHFrid---ddGSPLFCVISRLt-wQKGIDLMAEAVDEIVSlg----gRLVVLGAGDVALEGALLAAA 341  Agrobacterium...
2BIS_A        236 ---rDERKKSLLSKFgm-----dEGVTFMFIGRFdrgQKGVDVLLKAIEILSSkkefqemRFIIIGKGDPELEGWARSLE 307  Pyrococcus ab...
XP_643268    2217 --dhWSAKAELQKKYfgl--vdkSIPVLSFVGRIv-lQKGVHLILNAVRELIGhy---qgKIQILIGGMANMKDPYASSC 2288 Dictyostelium...
XP_653076    1155 -ldhWECKRRLQQKYfnn--vddSIPLFGFVGRIc-eQKGVFLLLDAIWSLVKet---ngKCQFIIGGMAPMDDPYAVAC 1227 Entamoeba his...
XP_001323043 1350 --nhTEAKAFIQKKYfgs--sdpSKCLFVFVGRIv-eQKGVHLITDTFEELNRefn-grlQFIVGGQAAPDDRSYGQPVC 1423 Trichomonas v...
XP_001446462 1481 --dhLKAKEQLQKKYfgcsqlenHIVVLGFVGRVt-kQKGVHLILEVAEELIQrs---qgTVQILVGGPADMKEEYSAFC 1554 Paramecium te...
XP_001027120 1487 -ddhLKAKEKIQQKYfgfqlldnSFCLFGFVGRIt-eQKGIHLILECAEDLIRqs---ngKIQIILGGNANYKEEYAQIC 1561 Tetrahymena t...
NP_587978     527 --vrKENKRKAQEWAglt--iddEADLLVFVGRWs-vQKGIDILADLAPTLLEkf---niQLIVVGPLIDLYGKFAAEKF 598  Schizosacchar...
AAR97368     1430 -skrPEQKRQAQEWAglk--qdpDADLFVFVGRWs-kQKGVDLIADVMPSLLDkkp--kiQLICVGPVIDLYGRFAAEKL 1503 Cryptococcus ...
BAA76559     1424 eaekRAFKRDAQKWTnle--lddSADLLVFVGRWs-mQKGIDLIADIAPTLLQdf---naQLITIGPIIDLYGKFAAEKL 1497 fission yeast

Feature 1                            ##        #                 #    #                           
1RZU_B        342 srh--------hgRVGVAIGYn----EPLSHLMQAG-CDAIIIPSRFEPCGLTQLYALRYGCIPVVARTGGLADTVIDan 408  Agrobacterium...
2BIS_A        308 ek---------hgNVKVITEMl---sREFVRELYGS-VDFVIIPSYFEPFGLVALEAMCLGAIPIASAVGGLRDIITNe- 373  Pyrococcus ab...
XP_643268    2289 awsmqa--lckqfPQSFWADPd---sFFSDGPLVNLgSDFGLMPSLFEPSGVVQQEYFVAGTPVIAFKTGGLKDTVFEyn 2363 Dictyostelium...
XP_653076    1228 smkmke--mrqtfPQCFWCDPt---aFFTDGPLMNMgCDFTCMPSMFEPSGLVQQESFLGGTPVIAFQTGGLKDTVFEyn 1302 Entamoeba his...
XP_001323043 1424 grmwd---lknryPESFWADPs---aFFTDGLACCHgADYFLVPSMFEPSGIVQQEAFASGTPCIAFRTGGLADTVFEfd 1497 Trichomonas v...
XP_001446462 1555 aqnmir--lksiyPRNFWADPs---aFFMDGTLVNVgCDFGLMPSLFEPGGIVQHEFFIGSTPVIAFKTGGLRDTVHEyd 1629 Paramecium te...
XP_001027120 1562 aekinylrnkhpnNFWGDPDLf----FRDGPLINVG-CDFGLMPSKFEPGGIVQHEFFVGSTPVIAMKTGGLQDTVTDfn 1636 Tetrahymena t...
NP_587978     599 myim------eryPGRVFSKPe---fVHLPPFIFEG-ADFALIPSRDEPFGLVAVEFGRRGAICIGSRVGGLGEMPGW-- 666  Schizosacchar...
AAR97368     1504 ar---------lmEMYPDRVYskpefTALPPYLFSG-ADFALIPSRDEPFGLVAVEFGRKGALGVGSRLGGLGLMPGW-- 1571 Cryptococcus ...
BAA76559     1498 nalm------kkyPKRVYCRPe---fTHLPPCIFSG-ADFVLIPSRDEPFGLVAVEFGRKGALGIGARVGGLGQMPGW-- 1565 fission yeast

Feature 1                                                                                         
1RZU_B        409 haalaskaatGVQFSPvt-------lDGLKQAIRRTVRYYHd-------------------pKLWTQMQKLGMKsd---- 458  Agrobacterium...
2BIS_A        374 ---------tGILVKAgd-------pGELANAILKALELSR---------------------SDLSKFRENCKKram--- 413  Pyrococcus ab...
XP_643268    2364 tnt---etgnGFTFEAhkhtdyvqavHRAINIFNNTHHYEKi-------------------rKCAEESVLDMSVva---- 2417 Dictyostelium...
XP_653076    1303 pid---ktgnGFVFQGfahgdlvfaiQRAIKIFQNPEEYKVl-------------------rSNAAKSVLDLTDva---- 1356 Entamoeba his...
XP_001323043 1498 rek---rtgnGVVFWAhr-------hRDFIMAVERAIALFNe-------------------pDLYNTMRKNAFEsvlste 1548 Trichomonas v...
XP_001446462 1630 qkq---qkgsGFIFDQyn-------rGNFLYSIDRALQLYKn-------------------qDQYTQLRKNAFDaaid-- 1678 Paramecium te...
XP_001027120 1637 eqt---ekgsGFTFEHhn-------sHGFAYAVTKALKLFKn-------------------eSLYNKLRKSSFQaa---- 1683 Tetrahymena t...
NP_587978     667 ----------WYSVESss-------tAYLLKQLEKSCTLALks-----------------tpEMRHKLRIAALQqrfp-- 710  Schizosacchar...
AAR97368     1572 ----------WFPVESsa-------tVHMLSQLTKTIKLALks-----------------tpEERAILRARSAVqrfp-- 1615 Cryptococcus ...
BAA76559     1566 ----------WYSVESnats---hvlQQFEEACRKALSSSAekrallraksakqrfpvlewiSKLDHLMDNCIRlnvgqr 1632 fission yeast

Feature 1                                          
1RZU_B        459 -----------------vsWEKSAGLYAALYSQ 474  Agrobacterium tumefaciens
2BIS_A        414 ----------------sfsWEKSAERYVKAYTG 430  Pyrococcus abyssi
XP_643268    2418 -----------------eaWAKEFSRMRRSIWS 2433 Dictyostelium discoideum AX4
XP_653076    1357 -----------------iaWGTEFGRLKKKVFV 1372 Entamoeba histolytica HM-1:IMSS
XP_001323043 1549 --------------tvaraWAREFARLFQKIYD 1567 Trichomonas vaginalis G3
XP_001446462 1679 ---------------vadvSRAWAQEYYRLFEK 1696 Paramecium tetraurelia
XP_001027120 1684 -----------------idVSEVSKAYEGEFYR 1699 Tetrahymena thermophila SB210
NP_587978     711 ----------------vdeWVALYDRLIRNCIK 727  Schizosaccharomyces pombe 972h-
AAR97368     1616 ----------------vveWRQRLEDFQRRSII 1632 Cryptococcus neoformans var. neoformans
BAA76559     1633 qqgssshsmkfrskndlssIKLSTKEGLENEEN 1665 fission yeast

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