Conserved Protein Domain Family
DEAH_box_HrpA

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TIGR01967: DEAH_box_HrpA 
RNA helicase HrpA
This model represents HrpA, one of two related but uncharacterized DEAH-box ATP-dependent helicases in many Proteobacteria and a few high-GC Gram-positive bacteria. HrpA is about 1300 amino acids long, while its paralog HrpB, also uncharacterized, is about 800 amino acids long. Related characterized eukarotic proteins are RNA helicases associated with pre-mRNA processing. The HrpA/B homolog from Borrelia is 500 amino acids shorter but appears to be derived from HrpA rather than HrpB. [Unknown function, Enzymes of unknown specificity]
Statistics
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PSSM-Id: 273900
Aligned: 5 rows
Threshold Bit Score: 2109.43
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
P43329         12 LQQRLDSLMLRDRLRFSRRLHGVKKVKNPDAQQA--IFQEMAKEIDQAAGKVLLREAARPEITYPDNLPVSQKKQDILEA 89   Escherichia c...
WP_011713535   13 WAEDVAHTMIRHRHGLRRALGALQQDHRQGRAIAphALEKFRQRLTASCDEVAKRRQQLPILRYPEQLPISSKREAIQQA 92   Magnetococcus...
WP_006767818   13 LYELLDGVSLTDERSFRRRLQKARSPR---------ALTAIRTDIDKARQRVEARAALVPEITYPQSLPVSARREDIAEA 83   Corynebacteri...
WP_011072251   11 SSAFLQQCFQSDASRIRRRLFKLHKEADSDKKTQ--ELAKLAEQAQAAFEKVEQRLKARPRINYPDNLPVSGMREDIAKA 88   Shewanella on...
WP_010955220    9 LLQNLDHAMIADRHCLRRQLHELRKRPD----EA--KLAQWVEKVQASCAQVTARQQSVPTVRYDDNLPIAAKRDEIKKA 82   Pseudomonas p...
P43329         90 IRDHQVVIVAGETGSGKTTQLPKICMELGRGIKGLIGHTQPRRLAARTVANRIAEELKTEPGGCIGYKVRFSDHVSDNTM 169  Escherichia c...
WP_011713535   93 IAQHQIIVLSGETGSGKTTQLPKICLELGLGVHGYIGVTQPRRIAASGIAQFLASDLGTPLGEKVGYKVRFHDQVGEHAL 172  Magnetococcus...
WP_006767818   84 ISENQVVIIAGETGSGKTTQIPKICLELGRGRRGLIGHTQPRRLAARTVAERIADELGQGIGETVGYAIRFDDRVSPSTS 163  Corynebacteri...
WP_011072251   89 ISANQVVIIAGETGSGKTTQLPKICLELGLGSRGFIGHTQPRRLAARSVASRVAEELQSPLGEVVGFKVRFADALKSESY 168  Shewanella on...
WP_010955220   83 LAENQVLVIAGETGSGKTTQLPKICLELGRGSHGLIAHTQPRRIAARSVAARVAEELGTPLGALVGYQVRFEDQSDSNTL 162  Pseudomonas p...
P43329        170 VKLMTDGILLAEIQQDRLLMQYDTIIIDEAHERSLNIDFLLGYLKELLPRRPDLKIIITSATIDPERFSRHFNNA----- 244  Escherichia c...
WP_011713535  173 VKVLTDGMLLAETQQDRFLSRYEAIIIDEAHERSLNIDFLLGLLKGITVRRPDLKIIISSATLDTDKFAAHFNHA----- 247  Magnetococcus...
WP_006767818  164 VKLMTDGILLAEMQRDRFLNAYDTIIIDEAHERSLNIDFLLGYLRQLLPKRPDLKVIITSATIDPERFATHFADAegkpa 243  Corynebacteri...
WP_011072251  169 IKLMTDGILLAELTSDRYLDQYDTIIIDEAHERSLNIDFILGYLKQILKKRPDLKIIITSATIDVERFSKHFNNA----- 243  Shewanella on...
WP_010955220  163 VKLMTDGILLAETQHDRFLERYDTIIVDEAHERSLNIDFLLGYLKTLLHRRPDLKLIITSATIDLERFSRHFDGA----- 237  Pseudomonas p...
P43329        245 PIIEVSGRTYPVEVRYRPIVEEADD------TERDQLQAIFDAVDELSQESH------GDILIFMSGEREIRDTADALNK 312  Escherichia c...
WP_011713535  248 PIISVSGRTYPVAVRYNPLDEKNEP------DSDQRMEALLFAVEELFEDLPd-----GDVLIFLPGEREIKEAAEALRK 316  Magnetococcus...
WP_006767818  244 PIIEVSGRTFPVEIRYRPLEVVQGDk----vIDIDPLDGLCDAIEELMAEGP------GDILCFFPGERDIRDAMEIIEG 313  Corynebacteri...
WP_011072251  244 PIIEVSGRTYPVETRYRPLVQDTEA-------DLDQIEGIFAAVDELVAEGL------GDILIFMNGEREIRDTAEQLNR 310  Shewanella on...
WP_010955220  238 PIIEVSGRTFPVDTWYRPLTSEQDEegnqieDDLTVDQAILATLDELAQHERsegkgpGDVLIFLPGEREIRDAAEILRK 317  Pseudomonas p...
P43329        313 LNLRHTEILPLYARLSNSEQNRVFQSHSGRRIVLATNVAETSLTVPGIKYVIDPGTARISRYSYRTKVQRLPIEPISQAS 392  Escherichia c...
WP_011713535  317 HHPAHVEIVPLYARLSAKEQQRIFNPGSKRRIILSTNVAETSLTVPRIHGVIDTGLARMSRFSTRTQVQRLPIERISQAS 396  Magnetococcus...
WP_006767818  314 RRWKGVEVTPLFGRLSNEEQHRVFRPHSGRRIVLSTNIAETSLTVPGIHYVVDTGTARISRYSVRTKVQRLPIEPISQAS 393  Corynebacteri...
WP_011072251  311 RNYRDTEILPLYARLSYGEQSKVFSSHTGRRIVLATNVAETSLTVPGIRYVIDPGTARISRYSYRTKVQRLPIEPISQAS 390  Shewanella on...
WP_010955220  318 AQLRHTEILPLYARLSPAEQQRIFQPHTGRRVVLATNVAETSLTVPGIRYVIDTGTARISRYSYRAKVQRLPIEAVSQAS 397  Pseudomonas p...
P43329        393 ANQRKGRCGRVSEGICIRLYSEDDFLSRPEFTDPEILRTNLASVILQMTALGLGDIAAFPFVEAPDKRNIQDGVRLLEEL 472  Escherichia c...
WP_011713535  397 ANQRKGRCGRLAAGICIRLYSEDDFNQRPLYTDPEVLRTSLAAVILTMKALKLGDPHKFPFIDAPKPTAIREGIRLLKEL 476  Magnetococcus...
WP_006767818  394 ANQRSGRCGRVADGIAIRLYSEEDFESRPEFTDPEILRTNLASVILRMASLRLGDITDFPFVQAPEQRSIRDGLLLLHEL 473  Corynebacteri...
WP_011072251  391 ANQRQGRCGRVGPGICIRLYDEADFNNRPAFTDPEILRTNLASVILQMLAIGLGDIAAFPFIEPPDPRHIRDGFLLLEEL 470  Shewanella on...
WP_010955220  398 ANQRKGRCGRVEPGICVRLYSEEDFNSRPAFTDPEILRTNLAAVILQMLHLRLGAIDAFPFIEPPDGKAISDGFNLLQEL 477  Pseudomonas p...
P43329        473 GAITTDEqas-ayKLTPLGRQLSQLPVDPRLARMVLEAQKHGCVREAMIITSALSIQDPRERPMDKQQASDEKHRRFHDK 551  Escherichia c...
WP_011713535  477 DGLDDNE------NLTDIGRQLAHLPLDPRLARMLLAAERFHCLQELLILAAALSTQDPREFPEAEKGGAKQHHARFSEP 550  Magnetococcus...
WP_006767818  474 GALAEDVaedgspQLTPIGRDLAQIPVDPRMARMLVEAHRLGALHPVMIIVAAMTIQDVRERPLEFQAQADQAHARFKEI 553  Corynebacteri...
WP_011072251  471 QAVKQQKgn---iVLTPLGRQLSQIPVDPRLARMVIESHQLGCLNEVLVIASGLSIQDPRERPMDKKQASDEAHRRFADP 547  Shewanella on...
WP_010955220  478 SAVNREN------QLTPIGRQLARLPIDPRLGRMLLEGARLGSLQEVLIVTSALSVQDPRERPPERQQAADQAHAQWKDV 551  Pseudomonas p...
P43329        552 ESDFLAFVNLWNYLGEQ-QKALSSNAFRRLCRTDYLNYLRVREWQDIYTQLRQVVKELGIPVN-SEP--AEYREIHIALL 627  Escherichia c...
WP_011713535  551 RSEFIGRLRLWRHIEEMaEQARSKTQLRNALKKQYLSPLRVREWQDITHQLTRTVKELGLKLN-EAP--GDYAAIHKALL 627  Magnetococcus...
WP_006767818  554 TSDFLSYLKLWEYISDQ-RDNTSGNAFRKQMKKEFLHYMRIREWWDLVRQLEQVGLQLGWSAKeNVAgtASPDIIHQSLL 632  Corynebacteri...
WP_011072251  548 QSDFVSWVNLWQHLKEQ-QKELSASQFRKKCRDEYLAYLRVREWQDLYTQLKQAVHDLKWRLN-DTP--ANYDALHRALL 623  Shewanella on...
WP_010955220  552 DSDFAALVNLWRGFEEQ-RQALTANPLRNWCRKQFLNYLRLREWRDAHRQLALICRDLQLTVN-KEP--TDYQKLHKAIL 627  Pseudomonas p...
P43329        628 TGLLSHIGMKDAdKQEYTGARNARFSIFPGSGLFKKPPKWVMVAELVETSRLWGRIAARIDPEWVEPVAQHLIKRTYSEP 707  Escherichia c...
WP_011713535  628 AGLLGNLGMKGE-KHQYDGVRGLSFHIFPGSELFGKSPKWVVAAELVETSKLYARLLAQIEPEWVEEVAPHLVKKHPFDP 706  Magnetococcus...
WP_006767818  633 SGLLSQIGARDGdSREFSGSRGTKFMIFPGSPLSKKPPQFIMAGQLVETSRLWARDVAKIEPEWVEKIAGPLLKHQYSEP 712  Corynebacteri...
WP_011072251  624 SGLLSHIGFKDN-NNEYLGARNRKFFVFPGSPLAKKGPKWIMAAELMETSKLFARCCAKIEPEWLEPLAAHLIKKNHLEP 702  Shewanella on...
WP_010955220  628 SGLLSQIGQKTE-EGDYQGARQRRFWVHPSSGLGRKRPQWVMAAELVETTKLYARMVAKIEPDWIEPLAGHLIKKNHFEP 706  Pseudomonas p...
P43329        708 HWERAQGAVMATEKVTVYGLPIVAARKVNYSQIDPALCRELFIRHALVEGDWQTRHAFFRENLKLRAEVEELEHKSRRRD 787  Escherichia c...
WP_011713535  707 HWEKRAAQTMVYERVTLFGLTLIPKRSVPYAPIAPADARAMFIHNGLVAGDMHSNAPFYQHNRALIEEAEGLEHRTRERG 786  Magnetococcus...
WP_006767818  713 HWSTKRGAAMAHQKSTLYGVTIIADKVVPYHRVDPAAARDMFIRHALVQGEWTTHHRFFHDNAAKLEDIAELEAKARRRD 792  Corynebacteri...
WP_011072251  703 HFEAKQGSVIAFENQVLYGLTVVHRRRVQYGPINPVEAREIFIRSALAEGQLQTKEAFFIANQKLLEDVEALEHKSRRRD 782  Shewanella on...
WP_010955220  707 HWEKKRGQVVAYEQITLYGLILVGRRPVHYGPIDPATSRELFIREGLVGGEIQSRAKCLAANKRLLGELDELEAKARRRD 786  Pseudomonas p...
P43329        788 ILVDDETLFEFYDQRISHDVISARHFDSWWKKVSRETPDLLNFEKSMLIKEGAEkISKLDYPNFWHQGNLKLRLSYQFEP 867  Escherichia c...
WP_011713535  787 YLADDQALFDFFDGVLPPDINNLQALDQWRRSAERKNPKALFLPREVVFQQRAN-LDDAQFPGHITLRDHELALIYQFNP 865  Magnetococcus...
WP_006767818  793 IIVDEDTLFDFYDSRLPETITTSRHFDSWWKKTSRNQPDLLDFDPEKLVNADAGvIPEEAFPDRWEKGGLIFDLSYHFEP 872  Corynebacteri...
WP_011072251  783 ILVDEQVLMDFYEPRIPEGIYNAPKFFSWWKEARCTQPDLLDFNKSLLMQRSADhISALDFPDTWHKGNIRLQLSYHFDP 862  Shewanella on...
WP_010955220  787 ILADEETLYAFYEARLPAEIHQTATFDSWYRMGSQKDANLLIMREEDVLAREASeVTAAQYPDSMQVGDLRLPLSYHFEP 866  Pseudomonas p...
P43329        868 GADADGVTVHIPLPLLNQVEESGFEWQIPGLRRELVIALIKSLPKPVRRNFVPAPNYAEAFLGRVKPLELPLLDSLEREL 947  Escherichia c...
WP_011713535  866 GQGNDGVTTVIPLPVLNQFRTADFQWLVPGLLEEKIVGLFKILPKRYRRHLVPLPQTAKWCAAQLPFNQGTLTALLARLI 945  Magnetococcus...
WP_006767818  873 GHRDDGVTVLIPVPVLGGLDNEGFDWLVPGVRLDLVTELIRTLPKALRRTVVPAPDFARRALPLLHPYASPLTSQLADAL 952  Corynebacteri...
WP_011072251  863 AASDDGVSVHIPVALLNQIDDTDFDWLVAGMREEKCVALIKSLPKGLRRNFVPAPDYARACVQAMQPFSASLLDAMCKQL 942  Shewanella on...
WP_010955220  867 GHPRDGVTVRVPAPLLPSLPGERLEWLVPGLLEAKCVALVRNLPKALRKNFVPVPDFVKASLARMTFGQGALPQALGQEL 946  Pseudomonas p...
P43329        948 RRMTGVTVDREDWH--WDQVPDHLKITFRVVDDKN-KKLKEGRSLQDLKDALKGKVQETLSAVAD--DGIEQSGLHIWSF 1022 Escherichia c...
WP_011713535  946 EPKVGEEIPPDAWQ--WENLPEHLQMNFRIVDDSNrKVLAQGRDLALLQEHYAEDARDRFEALPK--VSHEKSGLLNWNF 1021 Magnetococcus...
WP_006767818  953 RSLGGSGINASDFS--PGKLPDHLRITYAAVDKRG-KIIDRDKDLTALKERRASQIRASVSRVARtsEQDEVPSWTRETL 1029 Corynebacteri...
WP_011072251  943 LRMSGTRVNPEDFD--VSQMPVHLQMNFKIEDDKG-KLVAQGRVLDSLKAELQGVVAKAIRQVAN--KGIEKEALTEWSF 1017 Shewanella on...
WP_010955220  947 LRMTGARVSDEAWDesVNQVEGHLRMNIEVVDGQG-KFLGEGRDLAELTARFAAASQAALAVPRD--AKGEQ-PVQAKAF 1022 Pseudomonas p...
P43329       1023 GQLPESYEQKR-GNYKVKAWPALVDERDSVAIKLFDNPLEQKQAMWNGLRRLLLLNIPS-PIKYLHEKLPNKAKLGLYFN 1100 Escherichia c...
WP_011713535 1022 DPLPLRMALMTeRNRPITCYPALRDDGGSVGIAMAETQEQAQRMHHAGLRRLLLLQVHQ-QVKMVQKNPPISNQALAHYT 1100 Magnetococcus...
WP_006767818 1030 GTIDEEIDTTV-DGQKVTAFPALVVTPTGVSVKVFPTRAAADASMVTSTLTLLMREIEVnPKQMLKG-LPLQQRVAVDNY 1107 Corynebacteri...
WP_011072251 1018 GDLPKQFEQRK-GNYQVRAFPALIDNKDSVAIKLFDDEFEAEAAHRQGLRRLLLLNIPS-PVKHLQQALPNKAKLAMYFN 1095 Shewanella on...
WP_010955220 1023 SEVKQTAQQKI-AGLSMTVYPALVEDNGTVREGRFSTQAEAEFQHRRALQRLLLQQLAE-PAKFLRGKLPGLTELGLLYR 1100 Pseudomonas p...
P43329       1101 PYGKVLELIDDCISCGVDKLIDANGG----PVWTEEGFAALHEKVRAELNDTVVDIAKQVEQILTAVFNINKRLKGRVDM 1176 Escherichia c...
WP_011713535 1101 HLERKEVLVKSLLHAAADRVFFENQGvlpeQVRNQADFQKILAQGRAHLIPEVEAMGKLLDETFVQFGLLRNALKKPMYP 1180 Magnetococcus...
WP_006767818 1108 PHGGSEGLVADARVAAIRDLMFAHGG----AVRTPEEFEKLLATVKPAVAGEVRRTIVELAPALVRFANITAELEGWTGP 1183 Corynebacteri...
WP_011072251 1096 PFGQVQILIDDIIAAAVQQLLDEKAL----DVRDAAQFDAAKDWVRQELNPTAEQIALKVEQILTLYQGIKKRTKGKISL 1171 Shewanella on...
WP_010955220 1101 EMGRVEALVEDILLASLDSCILEGEQp---LPREGAALAALAERKRGSWAEHAERLARQTLEVLKLWHGLQKRFKGKIDL 1177 Pseudomonas p...
P43329       1177 TMALGLSDIKAQMGGLVYRGFVTGNGFKRLGDTLRYLQAIEKRLEKLAVDPHRDRAQMLKVENVQQAWQQWINKLPPARR 1256 Escherichia c...
WP_011713535 1181 TQQKVAMDIEAHLDKLLGQGFLRTTPPQWLSHLPRYLKAMLLRLERGRHNSGKDLERQAEYSVWQEKYDRLMEKYQHETH 1260 Magnetococcus...
WP_006767818 1184 ----AIDDMTAQLEFLLPAHAISIHGAQRLRHLPRYLHAMAIRLEEMNRDPDRDADRQDEIQGVEKYLEDRLAKLPSNRR 1259 Corynebacteri...
WP_011072251 1172 DIAFAMSDIQSQLDQLVFKGFVEACGWKRLADVARYLKAIETRIDKLPVDPTRDRLHMQSITKVQDALAAQLAKVPRSQP 1251 Shewanella on...
WP_010955220 1178 SQAVALNDIKQQLGNLVYPGFVRETPGVWFKELPRYLKAVELRLEKLGSQVQKDRVWSGELANLWAQYKARADKHAQEGK 1257 Pseudomonas p...
P43329       1257 EDEDVKEIRWMIEELRVSYFAQQLGTPYPISDKRILQAMEQ 1297 Escherichia coli K-12
WP_011713535 1261 LPAALVLFRWALEEYRVSLFAQDLKTAIPVSHKRMEGYYRD 1301 Magnetococcus marinus
WP_006767818 1260 NTREVRDIRWQIQELRVSLFAQRLGTPKPVSAQRVRKMVDK 1300 Corynebacterium efficiens
WP_011072251 1252 TPAALIEARWMIEEYRVSCFAQALGTAYPISEKRILNHILL 1292 Shewanella oneidensis
WP_010955220 1258 RDEQLTVYRWWLEEYRVSLFAQQLGTKVPISDKRLSKQWSQ 1298 Pseudomonas putida
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