5OY4


Conserved Protein Domain Family
GSK-3_bind
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pfam05350: GSK-3_bind 
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Glycogen synthase kinase-3 binding
Glycogen synthase kinase-3 (GSK-3) sequentially phosphorylates four serine residues on glycogen synthase (GS), in the sequence SxxxSxxxSxxx-SxxxS(p), by recognising and phosphorylating the first serine in the sequence motif SxxxS(P) (where S(p) represents a phosphoserine). Interaction of GSK-3 with a peptide derived from GSK-3 binding protein (this family) prevents GSK-3 interaction with Axin. This interaction thereby inhibits the Axin-dependent phosphorylation of beta-catenin by GSK-3.
Links
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Statistics
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PSSM-Id: 428435
Aligned: 8 rows
Threshold Bit Score: 267.204
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
5OY4_X         1 MPCRREEEEEAGEEAEGEEEe-EDSFLLLQQSVALGSSGEVDRLVAQIGETLQLDAAQHSPASPCGPPGAPLRAPGPLAA 79 
1_pfamImport   1 EEEAGEEAEGEEEEEEEEEEe-EGSFLLLEQSVTLGGSGEVDRLVAQIGETLQLDAAQDSPASPCAPPGRHSSSPRGLRR 79 
XP_581986      1 MPCRREEEEEAGEEEEe-----EDSFLLLEQSVTVGGSVEVDRLVAQIGETLQLDAAQDRPASACAPPGPPLQPPRSPAA 75 
O75474         1 MPCRREEEEEAGEEAEGEEEe-DDSFLLLQQSVTLGSSGEVDRLVAQIGETLQLDAAQDSPASPCAPPGVPLRAPGPLAA 79  human
XP_005343099   1 MPCRREEEEEAGEEAEGEEEddDDSFLLLKQSVTLEGSGEVDRLVAQIGQTLQLDAAHDSPASRCVPPGPPLQPP---VA 77 
P70339         1 MPCRREEEEEAGDEAEGEED--DDSFLLLQQSVTLGGSTDVDQLIVQIGETLQLDAAHDRPASPCAAPGPP--PPQVLAA 76  house mouse
EGW12134       1 MQCQRAEKEEGGFEAEGEDK--DDSFLLLQQSVTLGSLTDVDQLIALIGETLKLDTAHDGPASPSAAPGPP--PLRVLAA 76 
XP_003787348   1 MPCRREEEEEAGEEAEGEEE--KDSFLLLEQSVTLGSSGEVDKLVAQIGETLQLDAAQDSPASPCASLGAPLRAPRPQAA 78 

5OY4_X        80 aVPADKARSPAVPLLLPPALAETVGPAPPGVLRCALGDRGRVRGRAAPYCVAELatgpsalsplppqadldgppgagkQG 159
1_pfamImport  80 -GEGGQGLVPRRAAAAPPIVGRGGVTAPPVLFAAPSGTVPPCLGGLPPIVWSEL------------------------QG 134
XP_581986     76 -VRADKARAPAQPLLLPAASIEAGGPAPLGALRCALGDRGRVRGRAAPYFVAELaagptalsplppqpsldgplgadkRG 154
O75474        80 aVPADKARPPAVPLLLPPASAETVGPAPSGALRCALGDRGRVRGRAAPYCVAEVaagp---------------------- 137 human
XP_005343099  78 -LPADKARSPAVPLLLRPVSAEAGGLAPPGALRCALGDRGRVRGRAAPYCVAELssgpsalsplssqpgldgppgagkQG 156
P70339        77 -LPADKTGTPARRLLRPTGSAETGNPAPPGAVRCVLGERGRVRGRSAPYCVAEIspgasalpqqp---gldgppgtgkLS 152 house mouse
EGW12134      77 -ISVEQNRSPSRQMLRSSVPAETGAPAHPRAISCMLWERWRLRSQAAPYCVAELtavtsalcpvsrqpglegppvtgkPS 155
XP_003787348  79 -VRADEGPAAAVQLLLPPSSSEGVGPAPPGALRCALGDRGRVRGRAAPYCVAELvagpsalptlplqpgqdgplgagkRG 157

5OY4_X       160 IPQPLSGPCRRGWLRGAAASRRLQQRRGSQPETRTG-DDDPHRLLQQLVLSGNLIKEAVRRLHSRRLQLRAKLPQRPLLG 238
1_pfamImport 135 IPQPLSGPCRRGWLRGAASSRRLQQRRGSQPETRTS-DDDPHRLLQQLVLSGNLIKEAVRRLHSRRLQLRPKLPPCQLPG 213
XP_581986    155 SPQPLSGPCRRGWLRDAAASRRLQHRRGLQPPARNG-DDDPHRLLQQLVLSGNLIKEAVRRLHSRRLQLHAKLPQRQLLG 233
O75474       138 --salpGPCRRGWLRDAVTSRRLQQRRWTQAGARAG-DDDPHRLLQQLVLSGNLIKEAVRRLQRAVAAVAATGPASA-PG 213 human
XP_005343099 157 IPQPLTGPCRRGWLRSAAASRRLQQRRGSQPDTCTG-DDDPHRLLQQLVLSGNLIKEAVRRLHSRRLQLHAKLPQHRLLG 235
P70339       153 TPQPLSGPCRRGWLRNAAASRRLQQRRGSQPETRTGdDDDPHRLLQQLVLSGNLIKEAVRRLHSRQLQLHAKLPAHPFLG 232 house mouse
EGW12134     156 TPQPLSGPCRRGWPQSTAMSLPLQQRPGSQPETHTS-DDDPHQLPQQLLLSGNLIKEAVQRLHSLQLQLQANLYSHRFLK 234
XP_003787348 158 VSQQLSGPCRRGWLRGAAASRRLQQRRGSQPETRTN-DDDPHRLLQQLVLSGNLIKEAVRRLHSRRLQLHTKLPQRPLLG 236

5OY4_X       239 P 239
1_pfamImport 214 P 214
XP_581986    234 P 234
O75474       214 P 214 human
XP_005343099 236 P 236
P70339       233 P 233 house mouse
EGW12134     235 R 235
XP_003787348 237 P 237
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